Found 131 result(s)
Found 14 page(s)
Found 14 page(s)
- Barret Nerín, Juan Pedro
Transplanting a head and brain is perhaps the final frontier of organ transplantation. The goal of body-to-head transplantation (BHT) is to sustain the life of individuals who suffer from terminal disease, but whose head and brain are healthy. Ideally BHT could provide a lifesaving treatment for several conditions where none currently exists. BHT is no ordinary experiment, to transfer a head to another body involves extraordinarily complex medical challenges as well as ethical and existential dilemmas that were previously confined to the imagination of writers of fiction. The possibility of replacing an incurably ill body with a healthy one tests not only our surgical limits, but also the social and psychological boundaries of physical life and alters what we recognize life to be. The purpose of this target article, the complementary manuscript focused on immunological issues in BHT, and the accompanying Commentaries by scholars and practitioners in medicine, immunology, and bioethics is to review major surgical and psychosocial-ethical and immunological considerations surrounding body-to-head transplantation. We hope that together these ideas will provide readers with a comprehensive overview of the possibilities and challenges associated with BHT and initiate professional discussion and debate through which this new frontier in medicine is considered and approached.
- Esquinas López, Cristina
- Miravitlles Fernández, Marc
In alpha-1 antitrypsin deficiency (AATD), the Z allele is present in 98% of cases with severe disease, and knowledge of the frequency of this allele is essential from a public health perspective. However, there is a remarkable lack of epidemiological data on AATD worldwide, and many of the data currently used are outdated. Therefore, the objective of this study was to update the knowledge of the frequency of the Z allele to achieve accurate estimates of the prevalence and number of Pi*ZZ genotypes worldwide based on studies performed according to the following criteria: 1) samples representative of the general population, 2) AAT phenotyping characterized by adequate methods, and 3) measurements performed using a coefficient of variation calculated from the sample size and 95% confidence intervals. Studies fulfilling these criteria were used to develop maps with an inverse distance weighted (IDW)-interpolation method, providing numerical and graphical information of Pi*Z distribution worldwide. A total of 224 cohorts from 65 countries were included in the study. With the data provided by these cohorts, a total of 253,404 Pi*ZZ were estimated worldwide: 119,594 in Europe, 91,490 in America and Caribbean, 3,824 in Africa, 32,154 in Asia, 4,126 in Australia, and 2,216 in New Zealand. In addition, the IDW-interpolation maps predicted Pi*Z frequencies throughout the world even in some areas that lack real data. In conclusion, the inclusion of new well-designed studies and the exclusion of the low-quality ones have significantly improved the reliability of results, which may be useful to plan strategies for future research and diagnosis and to rationalize the therapeutic resources available.
Aran : Ua identitat incomòda. Discorsi sus era identitat aranesa en Internet. Reaccions ath projècte de Lei de Vegueries.
- Vila Parcerisa, Mònica
Analisi des discorsi sus era identitat aranesa en Internet pendent era polemica pera aprobacion deth Projècte de Lei de Vegueries, en hereuèr de 2010. A trauès der estudi d'aguesti discorsi s'identifiquen quini son es principaus trèits identitaris damb es quaus se definissen es aranesi., Anàlisi dels discursos sobre la identitat aranesa a Internet durant la polèmica per l'aprovació del Projecte de Llei de Vegueries, el mes de febrer de 2010. A través de l'estudi d'aquests discursos s'identifiquen quins són els principals trets identitaris amb els quals es defineixen els aranesos., Análisis de los discursos sobre la identidad aranesa en Internet durante la polémica por la aprobación del Proyecto de Ley de Veguerías, el mes de febrero de 2010. A través del estudio de estos discursos se identifican cuáles son los principales rasgos identitarios con los que se definen los araneses., This paper analyses the discourses on Aranese identity on the Internet throughout the controversy over the adoption of the Vegueries Law, on February 2010. Through the study of these discourses are identified the main identitary traits with which Aranese define themselves.
See at: http://hdl.handle.net/10609/6762
- Muñiz, Kilian
The quest for the development of new protocols that provide general conditions for oxidative carbon–nitrogen bond formation has grown over recent years. Within this context, due to feasibility and benignity considerations in biochemical sciences, reactions that rely on main group oxidants as the only promoters have received particular interest. We have recently found that simple protonolysis events enable the incorporation of nitrogenated groups of the bissulfonimide family into the coordination sphere of common iodine(III) complexes such as diacetoxy iodobenzene. The products of the type ArI(OAc)(NTs2) represent rare examples of iodine(III) compounds displaying reactive iodine–nitrogen single bonds. Further protonolysis furnishes the corresponding iodine(III) compounds ArI(NTs2)2 containing two defined iodine–nitrogen single bonds for unprecedented dual transfer of both nitrogenated groups. It is of great synthetic importance that these new compounds contain iodine–nitrogen entities, which upon dissociation in solution lead to electrophilic iodine centers and nucleophilic nitrogen groups. This has enabled the development of a body of conceptually new amination reactions, which do not rely on conventional electrophilic nitrogen reagents but rather employ iodine(III) as an electrophilic activator and bissulfonimides as the source of subsequent nucleophilic amination. Additional diversification arises from the ambident nature of bissulfonimines enabling oxygenation pathways. The exciting chemistry covered in this Account comprises structural features of the reagents (including X-ray analysis), scope and limitation in synthetic amination of different hydrocarbons (including sp-, sp2-, and sp3-hybridized centers as in acetylenes, alkenes, enols, butadienes, allenes, arenes, and alkylketones), and physical-organic and theoretical analysis of the underlying reaction mechanisms. The oxidative transformations with all their rich diversifications originate from the versatile redox chemistry of the iodine(III) and iodine(I) pair, which shares several aspects of transition metal high oxidation state chemistry. For the present aryliodine(III) reagents, steric and electronic fine-tuning is possible through accurate engineering of the arene substituent. In addition to the general reactivity of the I–N bond, chiral aryliodine(III) reagents with defined stereochemical information in the aryl backbone are conceptually compatible with this approach. Thus, the development of enantioselective amination reactions with up to 99% ee was also successful. Several of the active enantioselective reagents have been isolated and structurally characterized. Following this approach for the important class of chiral vicinal diamines, an unprecedented direct diamination of alkenes could be conducted in an enantioselective catalytic manner under full intermolecular reaction control. This latter reaction is based on the precise engineering of a chiral aryliodine(III) catalyst in combination with bismesylimide as nitrogen source. It is the consequence of the precise understanding of the reaction behavior of structurally defined bisimidoiodine(III) reagents.
- Morata, Francesc
Descriu i analitza el procés d'integració europea des dels seus inicis, els anys cinquanta, fins als nostres dies. L'objectiu consisteix a oferir una visió de conjunt d'un procés que va començar modestament amb la integració dels mercats del carbó i de l'acer dels sis membres fundadors i que ha derivat en una Unió Europea de 27 estats membres i més de 500 milions d'habitants, amb polítiques comunes, una cooperació estreta en els àmbits més sensibles de la sobirania estatal i una moneda única en setze estats, Describe y analiza el proceso de integración europea desde sus inicios, en los años cincuenta, hasta nuestros días. El objetivo consiste en ofrecer una visión de conjunto de un proceso que comenzó modestamente con la integración de los mercados del carbón y del acero de los seis miembros fundadores y que ha derivado en una Unión Europea de 27 Estados miembros y más de 500 millones de habitantes, con políticas comunes, una cooperación estrecha en los ámbitos más sensibles de la soberanía estatal y una moneda única en dieciséis estados
- Marin, Emilio
- Claridge, Amanda
- Kolega, Marija
- Rodà, Isabel, 1948-
- Garcia Vilchez, Yaiza
The purpose of this study was to analyze the gap between the new technologies that the hotels offer to their guest and their ability or knowledge to use these technologies. With this study the hoteliers will be able to identify when exist a digital divide risk with their guests. Since, nowadays do not always match the technologic services offered by the hotels and the guest technological needs and abilities. This gap will be detect by the analysis of the hotel and of the guest based on the three main variables that affect the digital divide. To develop this study, firstly, a deductive theoretical part of the research question has been done, by analyzing the background of the digital divide, detecting and analyzing his main variables and an analyzing the technological services offered in the lodging industry. Secondly, to develop the fieldwork, a quantitative technique was used by collecting secondary data and using the sampling technique. Once analyzed the data collected it was possible to conclude that an hotelier can detect the gap between the guest technological domain and the technology offered by the hotel. In addition to that, it was possible to find out that the digital divide has three main variables, which are the geographic, generation and economic variable and also was possible to classify the hotels and guests based on these variables. Besides, it has been found out that the digital divide it is bigger when a guest is traveling and staying in a hotel of his or her same country than when is traveling to another country of their culture or continent. In addition, after the analysis of the results it can be also concluded that the economic variable it is very influential in the digital divide. Afterwards, some recommendations and further work were pointed out in order to continue improving on the detection of the digital divide on the lodging industry.
- Madrazo Agudín, Leandro
- Costa Jutglar, Gonçal
Is it possible to isolate inner space from the need to see it as a volume from outside and to concentrate on the design of space itself? IN-SPACE is a web-based modelling tool especially conceived to give form to space, within space itself. With this tool, space is shaped from within, as we move through it expanding and contracting its limits. Starting from a cell located at the center of a three-dimensional grid, voids are carved by projecting the position of the viewer outwards along each of the three axes. As the avatar moves in this grid, space is being shaped. Conversely, voids can be undone projecting the position of a cell inwards towards the position of the view. Sounds, images and texts can be added to the cells that make a space. Once a space is created, the avatar can move inside the space or it can be driven automatically along the paths that have generated the space. Architecture students use this tool to develop their capacities of space conception as well as of space perception and orientation.
- Casals, Xavier
The history of fascism in Spain tends to be presented in a standard chronological pattern that begins in 1933 with the creation of the Falange Española party, and follows with its subsequent development during the Civil War (1936-1939), and under the dictatorship of general Francisco Franco (1939-1975). This study offers a different perspective, beginning in 1918, with the appearance of the first fascist organization in Barcelona, and ends with an analysis of the legacy of fascism in today’s extreme right.
- Badalov, Alexey
- Calvo Gómez, Míriam
- Vilasís Cardona, Xavier
- LHCb Collaboration - CERN
The time-integrated CP asymmetry in the decay D 0 → K 0S K 0S is measured using 3 fb−1 of proton-proton collision data collected by the LHCb experiment at centre-of-mass energies of 7 and 8 TeV. The flavour of the D 0 meson is determined by use of the decay D *+ → D 0 π + and its charge conjugate mode. The result is ACP=−0.029±0.052±0.022, where the first uncertainty is statistical and the second systematic. The result is consistent with Standard Model expectations and improves the uncertainty with respect to the only previous measurement of this quantity by more than a factor of three.