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Dades primàries associades a un article publicat a la revista PeerJ https://doi.org/10.7717/peerj.5440

Dades primàries associades a l'article publicat a la revista PeerJ disponible a l'adreça http://dx.doi.org/10.7717/peerj.1083, Podeu consultar l'article associat a: http://hdl.handle.net/2445/66497, El material que es diposita correspon a les dades experimentals, i part del procés de tabulació d'aquestes, d'un estudi de distribució d'àcids grassos en el lípids d'un nou compartiment lipídic dels glòbuls vermells de rata.

Dades primàries associades a un article enviat a la revista PeerJ i pendent d'avaluació (Abril 2016), Podeu consultar l'article a: http://hdl.handle.net/2445/101599, Dades experimentals de la recerca on s'ha provat de veure si l'administració d'una dieta hiperlipídics (dieta de cafeteria) a rates mascles durant 30 dies, modifica la distribució del fluxs de sang entre els diferents teixits. Això s'ha fet mitjançant l'administració de microesferes fluorescents. S'ha pogut comprobar que hi ha un augment de flux cap el teixit adipós marró, pulmons i cor i una disminució cap a la pell. Això confirma l'augmenten en els teixits que controlen l'energia disipada.

Dades primàries associades a l'article publicat a PLoS Neglected Tropical Diseases, vol. 10, num. 10, p. e0005009 [http://dx.doi.org/10.1371/journal.pntd.0005009], P. vivax infection during pregnancy has been associated with poor outcomes such as anemia, low birth weight and congenital malaria, thus representing an important global health problem. However, no vaccine is currently available for its prevention. Vir genes were the first putative virulent factors associated with P. vivax infections, yet very few studies have examined their potential role as targets of immunity. We investigated the immunogenic properties of five VIR proteins and two long synthetic peptides containing conserved VIR sequences (PvLP1 and PvLP2) in the context of the PregVax cohort study including women from five malaria endemic countries: Brazil, Colombia, Guatemala, India and Papua New Guinea (PNG) at different timepoints during and after pregnancy. Antibody responses against all antigens were detected in all populations, with PNG women presenting the highest levels overall. P. vivax infection at sample collection time was positively associated with antibody levels against PvLP1 (fold-increase: 1.60 at recruitment -first antenatal visit-) and PvLP2 (fold-increase: 1.63 at delivery), and P. falciparum co-infection was found to increase those responses (for PvLP1 at recruitment, fold-increase: 2.25). Levels of IgG against two VIR proteins at delivery were associated with higher birth weight (27 g increase per duplicating antibody levels, p<0.5). Peripheral blood mononuclear cells from PNG uninfected pregnant women had significantly higher antigen-specific IFN-g TH1 responses (p=0.006) and secreted less pro-inflammatory cytokines TNF and IL-6 after PvLP2 stimulation than P. vivax-infected women (p<0.5). These data demonstrate that VIR antigens induce the natural acquisition of antibody and T cell memory responses that might be important in immunity to P. vivax during pregnancy in very diverse geographical settings.

Dades primàries associades a l'article publicat a BMC Pediatrics, vol. 17 [https://doi.org/10.1186/s12887-017-0816-x], Background: Young children bear the world’s highest prevalence of anaemia, the majority of which is of multifactorial aetiology, which in turn hampers its successful prevention. Even moderate degrees of anaemia are associated with increased mortality and morbidity. Despite this evidence, there is a lack of effective preventive programs and absence of consensus in the safety of iron supplementation in malaria areas, which reflects the poor understanding of the contribution of different aetiologies to anaemia. In order to reduce the anaemia burden in the most vulnerable population, a study to determine the aetiology of anaemia among pre-school Mozambican children was performed. Methods: We undertook a case-control study of 443 preschool hospitalized children with anaemia (haemoglobin concentration <11g/dl) and 289 community controls without anaemia. Inclusion criteria were: age 1-59 months, no blood transfusion in the previous month, residence in the study area and signed informed consent. Both univariable and multivariable logistic regression analyses were performed to identify factors associated with anaemia and adjusted attributable fractions (AAF) were estimated when appropriate. Results: Malaria (adjusted odds ratio (AOR)=8.39, p<0.0001; AAF=37%), underweight (AOR=8.10, p<0.0001; AAF=43%), prealbumin deficiency (AOR=7.11, p<0.0001; AAF=77%), albumin deficiency (AOR=4.29, p=0.0012; AAF=30%), HIV (AOR=5.73, p=0.0060; AAF=18%), and iron deficiency (AOR=4.05, p<0.0001; AAF=53%) were associated with anaemia. Vitamin A deficiency and α-thalassaemia were frequent (69% and 64%, respectively in cases) but not independently related to anaemia. Bacteraemia (odds ratio (OR)=8.49, p=0.004), Parvovirus-B19 (OR=6.05, p=0.017) and Epstein-Barr virus (OR=2.10, p=0.0015) infections were related to anaemia only in the unadjusted analysis. Neither vitamin B12 deficiency nor intestinal parasites were associated with anaemia. Folate deficiency was not observed. Conclusions: Undernutrition, iron deficiency, malaria, and HIV are main factors related to anaemia in hospitalised Mozambican preschool children. Effective programs and strategies for the prevention and management of these conditions need to be reinforced. Specifically, prevention of iron deficiency that accounted in this study for more than half of anaemia cases would have a high impact in reducing the burden of anaemia in children living under similar conditions. However this deficiency, a common preventable and treatable condition, remains neglected by the international public health community.

Dades primàries associades a la publicació disponible a https://doi.org/10.1371/journal.pone.0178172, Podeu consultar l'article a: http://hdl.handle.net/2445/113259, Registre de ressonància magnètica funcional de subjectes diagnosticats de Diabetes Tipus I aparellats per edat i nivell educatiu amb un grups de controls. El registre de senyal cerebral està fet a partir de dues tasques vinculades amb llenguatge. Una d'elles amb components de working memory i l'altra no. Són dades analitzables amb eines específiques de R, MathLab, SMP o FSL.

Dades primàries associades l'article publicat a PLoS Neglected Tropical Diseases, vol. 11, num. 6, p. e0005606 [https://doi.org/10.1371/journal.pntd.0005606], P. vivax is a major parasite responsible for malaria in humans. While it is well known that pregnant women have an increased risk of P. falciparum infection and disease, less is known on the epidemiology and the impact of P. vivax in pregnancy. We conducted a health-facility based observational study in pregnant women from five endemic countries aimed to determine the burden of P. vivax infection in pregnancy and its impact on the mother and the newborn. We found that the prevalence of P. vivax malaria in pregnant women was overall low across sites, however submicroscopic infections were significantly higher in some areas. Pregnant women with clinical malaria experienced an increased risk of anaemia, which may have an impact on infant health. The results of this study can be useful to guide maternal health programs in settings where vivax malaria is endemic, and they highlight the importance to address a special population such as pregnant women while embracing malaria elimination in endemic countries.

Dades primàries associades a un article publicat a la revista PLoS ONE http://doi.org/10.1371/journal.pone.0184698, Podeu consultar l'article a: http://hdl.handle.net/2445/119911, Dades obtingudes en assajos on es presenta una pista audiovisual associada a un esdeveniment futur ('target') que apareix a la dreta o a l'esquerra de la pantalla, després d'un interval de temps curt o llarg, segons la pista. Els assajos estan codificats de tal manera que es pot saber què ha vist cada particpant en cada un dels assajos (pista E= Elmo / pista G = Big Birg; S = Slow (4 sec interval) / F = Fast (2 sec interval); R = Right (right location) / L = Left (left location). Per tots els participants es va associaciar E/S i G/F. L'associació d'espai (R-L) i temps (S-F) es va contrabalancejar entre els participants. Dades generades amb raw data eye tracking system (Tobii). Els arxius contenen informació de l'edat dels participants per poder separar els dos grups (12 mesos i 15 mesos), codi del participant i una inicial (per a comprovacions internes).

Dades primàries associades a l'article publicat a PLoS ONE., Podeu consultar l'article a: http://hdl.handle.net/2445/119909, Datos brutos correspondientes al estudio "The Moral Foundations of Illusory Correlation" (Rodríguez-Ferreiro y Barberia, enviado) incluyendo resultados de cuestionarios de identidad política y moral así como de una tarea de correlación ilusoria.

Dades primàries associades a un article acceptat publicat a la revista Scientific Reports https://doi.org/10.1038/s41598-018-34100-8, Palate breadth of South American sea lions (Otaria flavescens), South American fur seals (Arctocephalus australis) and Franciscana dolphins (Pontoporia blainvillei) from Río de la Plata estuary. Stable isotope values (δ13C and δ15N) and standard length of the Franciscana dolphin (Pontoporia blainvillei) and potential prey species off Río de la Plata estuary. δ13C and δ15N: values not corrected for isotopic baseline shifts; δ13Ccor and δ15Ncor: values corrected for isotopic baseline shifts.