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Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243280
Dataset

SIGE TO PRU P 3

  • Losada Mendez, Jorge
  • Palomares, Francisca
  • Gómez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Pru p 3-specific IgE values obtained by ImmunoCAP in LTP-allergic patients and tolerant controls., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243280
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243280
HANDLE: http://hdl.handle.net/10261/243280
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243280
PMID: http://hdl.handle.net/10261/243280
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243280
Ver en: http://hdl.handle.net/10261/243280
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243280

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243304
Dataset

INTERNALIZATION AND LOCALIZATION OF TLR4LIG-PP3 AND TLR7LIG-PP3 IN DENDRITIC CELLS (DC).

  • Losada Mendez, Jorge
  • Palomares, Francisca
  • Gómez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
The difference in the localization / internalization of the toll-like receptors was determined by confocal microscopy and flow cytometre. These differences between both was due to the differential location of them, since the expression of TLR4 is at the cell surface, while TLR7 is at intracellular compartments, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243304
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243304
HANDLE: http://hdl.handle.net/10261/243304
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243304
PMID: http://hdl.handle.net/10261/243304
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243304
Ver en: http://hdl.handle.net/10261/243304
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243304

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
Dataset

MATURATION AND ACTIVATION DENDRITIC CELLS BY TLR4LIG-PP3 AND TLR4LIG

  • Losada Méndez, Jorge
  • Palomares, Francisca
  • Gómez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
HANDLE: http://hdl.handle.net/10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
PMID: http://hdl.handle.net/10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
Ver en: http://hdl.handle.net/10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
Dataset

MATURATION AND ACTIVATION DENDRITIC CELLS BY THE TLR7LIG-PP3 AND TLR7LIG

  • Losada Méndez, Jorge
  • Palomares, Francisca
  • Góez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Data showed are changes in the maturation index of CD83, CD86 and PD-L1 in allergic patient and tolerant control., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
HANDLE: http://hdl.handle.net/10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
PMID: http://hdl.handle.net/10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
Ver en: http://hdl.handle.net/10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
Dataset

CYTOKINE PRODUCTION BY TLR4LIG-PP3 AND TLR4LIG

  • Losada Méndez, Jorge
  • Palomares, Francisca
  • Gómez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Production of cytokine into the culture supernatant. In the case of TLR4, only significant increases of IL-5 were observed in allergic patients compared to tolerant controls when stimulating with TLR4lig-Pp3 and TLR4lig plus Pp3 peptide in separately way. No differences in the induction of IL-10 production were observed in allergic patients compared to tolerant controls, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
HANDLE: http://hdl.handle.net/10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
PMID: http://hdl.handle.net/10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
Ver en: http://hdl.handle.net/10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
Dataset

CYTOKINE PRODUCTION BY TLR7LIG-PP3 AND TLR7LIG

  • Losada Méndez, Jorge
  • Palomares, Francisca
  • Gómez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Production of cytokine into the culture supernatant from DCs. Our analysis in allergic patients compared to tolerant controls detected significant increases of IL-5 and IFN with all the conditions containing TLR7lig (TLR7lig, TLR7lig-Pp3 and TLR7lig plus Pp3 in separately way). we observed that TLR7lig-Pp3 induced significant lower IL-4 and IL-5 levels whilst higher IFNγ levels compared to the Pp3 only in allergic patients, indicating the specific immunomodulatory capacity of this compound., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
HANDLE: http://hdl.handle.net/10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
PMID: http://hdl.handle.net/10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
Ver en: http://hdl.handle.net/10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
Dataset

SPECIFIC LYMPHOCYTE PROLIFERATION IN THE PRESENCE OF BOTH TLR4LIG-PP3 AND TLR7LIG-PP3.

  • Losada Méndez, Jorge
  • Palomares, Francisca
  • Gómez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Data indicated that only TLR7lig-Pp3 led to significantly increased in the proliferation index of CD3+T-cells in allergic patients compared to tolerant controls, while TLR4lig-Pp3 seemed stimulate the T-cells proliferation without inducing a difference between groups. Moreover, in allergic patients there was a significant increase in CD3+ and CD4+ T-cells proliferation after stimulation with TLR4lig-Pp3 vs TLRlig and vs TLR4lig plus Pp3 peptide; additionally, TLR7lig-Pp3 induced a specific proliferative response of CD3+T-cells compared to TLR7lig and TLR7lig plus Pp3 peptide., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
HANDLE: http://hdl.handle.net/10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
PMID: http://hdl.handle.net/10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
Ver en: http://hdl.handle.net/10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243321
Dataset

CYTOKINE PRODUCTION IN SUPERNATANTS FROM LYMPHOCYTE PROLIFERATION ASSAY

  • Losasa Méndez, Jorge
  • Palomares, Francisca
  • Gómez-Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Regarding the cytokine profile produced during the proliferative response, the most interesting results indicated that both TLRnlig-Pp3 induced a decrease of IL-4 and IL-5 levels compared to Pp3 peptide (alone), being significant for IL-5 with TLR4lig-Pp3, and an increase of IFN being significant only for TLR7lig-Pp3 in allergic patients., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243321
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243321
HANDLE: http://hdl.handle.net/10261/243321
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243321
PMID: http://hdl.handle.net/10261/243321
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243321
Ver en: http://hdl.handle.net/10261/243321
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243321

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
Dataset

TREG-CELL PERCENTAGES AND IL-10 PRODUCTION FOR PP3, TLRNLIG, TLRNLIG-PP3 AND TLRNLIG PLUS PP3 FOR ALLERGIC PATIENTS

  • Losada Méndez, Jorge
  • Palomares, Francisca
  • Gómez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Jorge
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Data indicated significantly higher percentages of Treg cells and IL-10 production in allergic patient compared to tolerant controls when stimulated with both TLRnlig-Pp3. Moreover, these effects were higher compared to Pp3 peptide alone, TLRnlig as well as TLRnlig plus Pp3 only in allergic patients except with TLR4lig-Pp3 for the IL-10 production. Regarding the TLR4 activation, they can induce a low production of IL-10., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
HANDLE: http://hdl.handle.net/10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
PMID: http://hdl.handle.net/10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
Ver en: http://hdl.handle.net/10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
Dataset

MATURATION AND ACTIVATION DENDRITIC CELLS BY THE COMBINATION OF TLR7LIG-PP3 PLUS TLR4LIG-PP3.

  • Losada Méndez, Jorge
  • Palomares, Francisca
  • Gómez, Francisca
  • Ramírez-López, Pedro
  • Ramos-Soriano, Javier
  • Torres, María José
  • Mayorga, Cristobalina
  • Rojo, Francisco Javier
Data indicated an opposite result, since the combination of both TLRnlig-Pp3 (TLR7lig-Pp3 plus TLR4lig-Pp3) together decreased the maturation already produced by each compound alone, being significant for CD80, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
HANDLE: http://hdl.handle.net/10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
PMID: http://hdl.handle.net/10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
Ver en: http://hdl.handle.net/10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330

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