language = "Holandés"

Encontrado 44 documentos, página mostrada 5 de 5

Cardiac and placental mitochondrial characterization in a rabbit model of intrauterine growth restriction.

Author(s):
Description: Intrauterine growth restriction (IUGR) is associated with cardiovascular remodeling persisting into adulthood. Mitochondrial bioenergetics, essential for embryonic development and cardiovascular function, are regulated by nuclear effectors as sirtuins. A rabbit model of IUGR and cardiovascular remod...
Language(s): Holandés

Deficiency of perforin and hCNT1, a novel inborn error of pyrimidine metabolism, associated with a rapidly developing lethal phenotype due to multi-organ failure.

Author(s):
Description: Pyrimidine nucleotides are essential for a vast number of cellular processes and dysregulation of pyrimidine metabolism has been associated with a variety of clinical abnormalities. Inborn errors of pyrimidine metabolism affecting enzymes in the pyrimidine de novo and degradation pathway have been i...
Language(s): Holandés

Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms

Author(s):
Description: Pharmacological chaperones are small compounds that correct the folding of mutant proteins, and represent a promising therapeutic strategy for misfolding diseases. We have performed a screening of 10,000 compounds searching for pharmacological chaperones of tyrosine hydroxylase (TH), the tetrahydrob...
Language(s): Holandés

Encontrado 44 documentos, página mostrada 5 de 5

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