repositories = "Dipòsit Digital de la UB"

Encontrado 26,453 documentos, página mostrada 5 de 2646

Lestaurtinib inhibition of the JAK/STAT signaling pathway in Hodgkin lymphoma inhibits proliferation and induces apoptosis

Description: Standard cytotoxic chemotherapy for Hodgkin Lymphoma (HL) has changed little in 30 years; the treatment for patients with relapsed or refractory disease remains challenging and novel agents are under development. JAK/STAT constitutive activation plays an important role in the pathogenesis of HL. Les...
Language(s): Inglés

GD3 Synthase Overexpression Sensitizes Hepatocarcinoma Cells to Hypoxia and Reduces Tumor Growth by Suppressing the cSrc/NF-κB Survival Pathway

Description: Abstract Background: Hypoxia-mediated HIF-1a stabilization and NF-kB activation play a key role in carcinogenesis by fostering cancer cell survival, angiogenesis and tumor invasion. Gangliosides are integral components of biological membranes with an increasingly recognized role as signaling interme...
Language(s): Inglés

SSCP-polymorphism in intron 12 of the CFTR gene recognized by BclI

Description: Source/Description: SSCP analysis of intron 12 of the CFTR gene from PCR products showed an extra band in several DNA samples. Sequencing of the additional fragment extra band revealed a T- A change in the position 1898 + 152 of CFTR (Fig. 1). The change is a polymorphism which can be identified by ...
Language(s): Inglés

PCR detection of the pKM.19/ScrfI RFLP (D7S23), a marker closely linked to the cystic fibrosis mutation

Description: Source: Description: pKM-19 is a 1.0 kb EcoRI human genomic fragment inserted in pUC13, that detects a Scrfl (CC/NGG) RFLP (1, 2). We report here the primer sequences suitable for the detection of this RFLP by PCR...
Language(s): Inglés

Estrategias para afrontar el envejecimiento y diferencias asociadas a la edad: una aproximación a través del análisis de contenido.

Description: El objeto del presente estudio es examinar la naturaleza de las estrategias que las personas consideran a la hora de afrontar el envejecimiento, adenzás de comprobar la presencia de posibles efectos asociados a la edad en la preferencia por unas o por otras. Se entrevistaron 48 personas (16 jóvenes,...
Language(s): Español

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells.

Description: Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through Proliferator Activator Receptor (PPARα) -dependent d...
Language(s): Inglés

A polymorphic DNA probe from chromosome 7 (7q22)

Description: Source/Description: p6a-l is a O.9 kb HindIII/BamHl genomic fragment subclone or cosmic cNX.6a in pUC13. cNX.6a was isolated from a non-methylated enriched library from the CMGT cell line Cll (1,2).
Language(s): Inglés

New Species in the Old World: Europe as a Frontier in Biodiversity Exploration, a Test Bed for 21st Century Taxonomy

Description: The number of described species on the planet is about 1.9 million, with ca. 17,000 new species described annually, mostly from the tropics. However, taxonomy is usually described as a science in crisis, lacking manpower and funding, a politically acknowledged problem known as the Taxonomic Impedime...
Language(s): Inglés

Scrfl restriction fragment length polymorphism at the D7S23 locus (probe pKM.19), closely linked to cystic fibrosis

Description: Source/Description: pKM.19 is a 1.0 kb EcoRI genomic fragment in pUC13 (ref. 1,2). pPl was isolated independently but contains the same fragment as pKM.19 (ref. 3)...
Language(s): Inglés

Percepción de patrones de envejecimiento: ¿Unidireccionalidad o multidireccionalidad?

Description: El presente trabajo pretende comprobar si existe una percepción uniforme del proceso de envejecimiento o si bien esta percepción es múltiple y dependiente de las dimensiones o caracteristicas concretas que se tomen en consideración. Se administró un protocolo de respuesta en el que 186 universitario...
Language(s): Español

Encontrado 26,453 documentos, página mostrada 5 de 2646

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