author = "Barroso E"

Encontrado 38 documentos, página mostrada 1 de 4

Criatividade e Inovação na Escola: contributo das TIC para o sucesso escolar

Description: A presente investigação pretende abordar a importância das plataformas colaborativas para a informação e formação dos professores do 1º Ciclo do Ensino Básico, que no exercício da prática letiva têm que aplicar pedagogias diferenciadas para as crianças com dificuldades de aprendizagem. Verificamos q...
Language(s): Portugués

PPAR beta/delta and lipid metabolism in the heart

Description: Cardiac lipid metabolism is the focus of attention due to its involvement in the development of cardiac disorders. Both a reduction and an increase in fatty acid utilization make the heart more prone to the development of lipotoxic cardiac dysfunction. The ligand-activated transcription factor perox...
Language(s): Holandés

Targeting endoplasmic reticulum stress in insulin resistance.

Description: The endoplasmic reticulum (ER) is involved in the development of insulin resistance and progression to type 2 diabetes mellitus (T2DM). Disruption of ER homeostasis leads to ER stress, which activates the unfolded protein response (UPR). This response is linked to different processes involved in the...
Language(s): Inglés

The peroxisome proliferator-activated receptor ß/d (PPARß/d) agonist GW501516 prevents TNF-a-induced NF-?B activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1.

Description: Nuclear factor (NF)-?B is a ubiquitously expressed transcription factor controlling the expression of numerous genes involved in inflammation. The aim of this study was to evaluate whether activation of the peroxisome proliferator-activated receptor (PPAR) ß/d prevented TNF-a-induced NF-?B activatio...
Language(s): Inglés

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.

Description: Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus are all linked to cardiovascular diseases such as cardiac hypertrophy and heart failure. Diabetic cardiomyopathy in particular, is characterized by structural and functional alterations in the heart muscle of people...
Language(s): Inglés

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus.

Description: Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palm...
Language(s): Inglés

Peroxisome proliferator-activated receptor (PPAR) beta/delta: a new potential therapeutic target for the treatment of metabolic syndrome.

Description: Metabolic syndrome is defined as the clustering of multiple metabolic abnormalities, including abdominal obesity, dyslipidemia (high serum triglycerides and low serum HDL-cholesterol levels), glucose intolerance and hypertension. The pathophysiology underlying metabolic syndrome involves a complex i...
Language(s): Inglés

Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.

Description: Although the substitution of saturated fatty acids with oleate has been recommended in the management of type 2 diabetes mellitus, the mechanisms by which oleate improves insulin resistance in skeletal muscle cells are not completely known. Here, we examined whether oleate, through activation of AMP...
Language(s): Inglés

Targeting PPARß/d for the treatment of type 2 diabetes mellitus.

Description: The nuclear receptors Peroxisome Proliferator-Activated Receptors (PPAR)a and PPAR? are therapeutic targets for hypertriglyceridemia and insulin resistance, respectively. Evidence is now emerging that the PPARß/d isotype is a potential pharmacological target for the treatment of insulin resistance a...
Language(s): Inglés

Oral administration of a new HRI activator as a new strategy to improve High-Fat-Diet-induced glucose intolerance, hepatic steatosis and hypertriglyceridemia through FGF21.

Description: Fibroblast growth factor 21 (FGF21) has emerged as a therapeutic strategy for treating type 2 diabetes mellitus due to its antidiabetic effects, and this has led to the development of FGF21 long-acting analogs. These compounds have some limitations, including requiring subcutaneous injection and the...
Language(s): Inglés

Encontrado 38 documentos, página mostrada 1 de 4

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