author = "Botteri G"
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Encontrado 9 documentos, página mostrada 1 de 1

PPAR beta/delta and lipid metabolism in the heart

Description: Cardiac lipid metabolism is the focus of attention due to its involvement in the development of cardiac disorders. Both a reduction and an increase in fatty acid utilization make the heart more prone to the development of lipotoxic cardiac dysfunction. The ligand-activated transcription factor perox...
Language(s): Holandés

PPARß/d: A Key Therapeutic Target in Metabolic Disorders.

Description: Research in recent years on peroxisome proliferator-activated receptor (PPAR)ß/d indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARß/d activation might help prevent the development of metabolic disorders, i...
Language(s): Inglés

miR-146a targets Fos expression in human cardiac cells

Description: miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-?B, a transcription factor induced by pro-inflammatory molecules (such as TNF-a) that is strongly related to the pathogenesis of cardiac disorders. The main goal of this study consisted of studying new role...
Language(s): Inglés

PPAR beta/delta attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells

Description: Chronic endoplasmic reticulum (ER) stress contributes to the apoptotic cell death in the myocardium, thereby playing a critical role in the development of cardiomyopathy. ER stress has been reported to be induced after high-fat diet feeding in mice and also after saturated fatty acid treatment in vi...
Language(s): Inglés

VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells.

Description: Here, our aim was to examine whether VLDL and apolipoprotein (apo) CIII induce endoplasmic reticulum (ER) stress, inflammation and insulin resistance in skeletal muscle.
Language(s): Inglés

The BACE1 product sAPPß induces ER stress and inflammation and impairs insulin signaling.

Description: ß-secretase/ß-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is a key enzyme involved in Alzheimer's disease that has recently been implicated in insulin-independent glucose uptake in myotubes. However, it is presently unknown whether BACE1 and the product of its activity, soluble AP...
Language(s): Inglés

Tissue Compatibility of SN-38-Loaded Anticancer Nanofiber Matrices

Description: Delivery of chemotherapy in the surgical bed has shown preclinical activity to control cancer progression upon subtotal resection of pediatric solid tumors, but whether this new treatment is safe for tumor-adjacent healthy tissues remains unknown. Here, Wistar rats are used to study the anatomic and...
Language(s): Inglés

Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01

Description: Retinoblastoma is a pediatric solid tumor of the retina activated upon homozygous inactivation of the tumor suppressor RB1 VCN-01 is an oncolytic adenovirus designed to replicate selectively in tumor cells with high abundance of free E2F-1, a consequence of a dysfunctional RB1 pathway. Thus, we re...
Language(s): Inglés
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Encontrado 9 documentos, página mostrada 1 de 1

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