author = "Carro E"
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Encontrado 6 documentos, página mostrada 1 de 1

The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

Description: Cellular and molecular processes leading to abnormal accumulation of β amyloid in the brain are slowly being uncovered. A potential involvement of insulin and insulin-like growth factor I (IGF-I) in this plausible pathogenic process in Alzheimer's disease has recently been proposed. Evidence favorin...
Language(s): Inglés

Insulin-like growth factor I and Alzheimer's disease: Therapeutic prospects?

Description: The search for a cure of Alzheimer's dementia is restless. In recent years, unexpected epidemiological data showing a protective effect of anti-inflammatory and cholesterol-lowering drugs gave way to clinical trials with these compounds. Now, a newly described mechanism indicating that brain amyloid...
Language(s): Inglés

Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons

Description: On systemic injection, insulin-like growth factor I (IGF-I) elicits a prolonged increase in the excitability of dorsal column nuclei (DCN) cells in the brain stem as well as other target neurons within the brain. We have explored the cellular mechanisms involved in the stimulatory effects of IGF-I a...
Language(s): Inglés

Insulin-like growth factor I treatment for cerebellar ataxia: Addressing a common pathway in the pathological cascade?

Description: In the present work we review evidence supporting the use of insulin-like growth factor I (IGF-I) for treatment of cerebellar ataxia, a heterogeneous group of neurodegenerative diseases of low incidence but high societal impact. Most types of ataxia display not only motor discoordination, but also a...
Language(s): Inglés

Western style diet impairs entrance of blood-borne insulin-like growth factor-1 into the brain

Description: It is increasingly recognized that life-style factors, such as physical exercise or diet influence brain health. In the present work we analyzed the effect of a western-style diet (>cafeteria diet>) on the entrance to the brain of circulating IGF-1, a neuroprotective agent that has been related to d...
Language(s): Inglés

Microspheres containing insulin-like growth factor I for treatment of chronic neurodegeneration

Description: The therapeutic potential of peptide growth factors as insulin-like growth factor I (IGF-I) is currently under intense scrutiny in a wide variety of diseases, including neurodegenerative illnesses. A new poly(lactic-co-glycolide) -based microsphere IGF-I controlled release formulation for subcutaneo...
Language(s): Inglés
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Encontrado 6 documentos, página mostrada 1 de 1

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