author = "Pallàs M"
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Encontrado 10 documentos, página mostrada 1 de 1

Hepatic gene expression changes in an experimental model of accelerated senescence: the SAM-P8 mouse.

Description: The senescence-accelerated mouse (SAM) is an experimental model of aging, established through phenotypic selection from a common genetic pool of AKR/J mice. Here we use complementary DNA microarray, Western blot, and electrophoretic mobility shift assay to consider whether changes in liver gene expr...
Language(s): Inglés

Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression.

Description: Aged rodents show increasing plasma and tissue triglycerides, and reductions in liver peroxisome proliferator-activated receptor alpha (PPARalpha) and its target genes. We determined whether a similar situation is present in a model of accelerated aging, the senescence-accelerated prone (SAM-P8) mou...
Language(s): Inglés

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents.

Description: Global obesity is a pandemic status, estimated to affect over 2 billion people, that has resulted in an enormous strain on healthcare systems worldwide. The situation is compounded by the fact that apart from the direct costs associated with overweight pathology, obesity presents itself with a numbe...
Language(s): Holandés

Resveratrol induces nuclear factor-?B activity in human cardiac cells.

Description: Resveratrol is a grape polyphenol that prevents cardiac hypertrophy and protects the heart from ischemic injury, metabolic dysregulation, and inflammatory processes in several murine models.
Language(s): Inglés

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease.

Description: The present study had focused on the behavioral phenotype and gene expression profile of molecules related to insulin receptor signaling in the hippocampus of 3 and 6 month-old APPswe/PS1dE9 (APP/PS1) transgenic mouse model of Alzheimer's disease (AD). Elevated levels of the insoluble Aß (1-42) were...
Language(s): Holandés

Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy.

Description: We used an experimental murine model of accelerated aging, the senescence-accelerated mouse (SAM), to examine the effect of age-associated cardiac hypertrophy on peroxisome proliferator-activated receptor alpha (PPARalpha) expression and activity in the heart. Senescence-accelerated prone mice (SAM-...
Language(s): Inglés

PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice.

Description: Mitochondrial dysfunction is involved in the development of aging. Here, we examined the effect of aging on the skeletal muscle expression of two isoforms of the transcriptional peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1 (PGC-1) in an experimental murine model of acce...
Language(s): Inglés

Cuestionario Español de Calidad de Vida en Pacientes con Cáncer de Próstata como medida de la calidad de vida de los pacientes con cáncer de próstata en España: aplicación a la actividad diaria

Description: Introducción: El cáncer de próstata (CP) supone el tumor más frecuente en los varones ancianos. A pesar de no ser responsable directo del fallecimiento, implica una merma importante en la calidad de vida de los pacientes. Diversos cuestionarios han sido adaptados al castellano para medir la calidad ...
Language(s): Español

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARß/d-null mice.

Description: The role of peroxisome proliferator activator receptor (PPAR)ß/d in the pathogenesis of Alzheimer's disease has only recently been explored through the use of PPARß/d agonists. Here we evaluated the effects of PPARß/d deficiency on the amyloidogenic pathway and tau hyperphosphorylation. PPARß/d-null...
Language(s): Holandés
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Encontrado 10 documentos, página mostrada 1 de 1

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