author = "Pandiella, Atanasio"

Encontrado 189 documentos, página mostrada 1 de 19

Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer

Author(s): Pandiella, Atanasio
Description: The final signal for triggering the formation of lamellipodia that initiate directional migration of mammalian cells is binding of the Wiskott-Aldrich syndrome (WASP)/WASP family verproline-homologous protein 2 (WAVE2) to the actin-related protein 2 and 3 (Arp2/3) complex. This WAVE2-Arp2/3 signal i...
Language(s): Inglés

Transforming growth factor β engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

Author(s): Pandiella, Atanasio
Description: In HER2-overexpressing mammary epithelial cells, transforming growth factor β (TGF-β) activated phosphatidylinositol-3 kinase (PI3K)/Akt and enhanced survival and migration. Treatment with TGF-β or expression of an activated TGF-β type I receptor (Alk5 with the mutation T204D [Alk5 T204D]) induced p...
Language(s): Inglés

Autocrine regulation of membrane transforming growth factor-α cleavage

Author(s): Pandiella, Atanasio
Description: Transforming growth factor α (TGF-α) is biosynthesized as a membrane- bound precursor protein, proTGF-α, that undergoes sequential endoproteolytic cleavages to release a soluble form of the factor. In the present study, we have analyzed the biosynthesis and regulation of TGF-α production in huma...
Language(s): Inglés

Autocrine regulation of membrane transforming growth factor-α cleavage

Author(s): Pandiella, Atanasio
Description: Transforming growth factor α (TGF-α) is biosynthesized as a membrane- bound precursor protein, proTGF-α, that undergoes sequential endoproteolytic cleavages to release a soluble form of the factor. In the present study, we have analyzed the biosynthesis and regulation of TGF-α production in huma...
Language(s): Inglés

Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer

Author(s): Pandiella, Atanasio
Description: The final signal for triggering the formation of lamellipodia that initiate directional migration of mammalian cells is binding of the Wiskott-Aldrich syndrome (WASP)/WASP family verproline-homologous protein 2 (WAVE2) to the actin-related protein 2 and 3 (Arp2/3) complex. This WAVE2-Arp2/3 signal i...
Language(s): Inglés

Transforming growth factor β engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

Author(s): Pandiella, Atanasio
Description: In HER2-overexpressing mammary epithelial cells, transforming growth factor β (TGF-β) activated phosphatidylinositol-3 kinase (PI3K)/Akt and enhanced survival and migration. Treatment with TGF-β or expression of an activated TGF-β type I receptor (Alk5 with the mutation T204D [Alk5 T204D]) induced p...
Language(s): Inglés

Receptores tirosina quinasa en cáncer

Author(s): Pandiella, Atanasio
Description: Máster Universitario en Biología y Clínica del Cáncer: Programa, Objetivos y Metodología. , Peer Reviewed
Language(s): Español

Impaired trafficking and activation of tumor necrosis factor-α-converting enzyme in cell mutants defective in protein ectodomain shedding

Description: Protein ectodomain shedding is a specialized type of regulated proteolysis that releases the extracellular domain of transmembrane proteins. The metalloprotease disintegrin tumor necrosis factor-α-converting enzyme (TACE) has been convincingly shown to play a central role in ectodomain shedding, bu...
Language(s): Inglés

Novel tyrosine kinase inhibitors in the treatment of cancer

Description: In summary, multi-TK inhibitors are being designed to target multiple activated kinases. The future design plan for these compounds should take into consideration the activated array of kinases in a given tumor. This undoubtedly will increase the efficacy, also avoiding toxicity. Furthermore, irreve...
Language(s): Inglés

Preclinical development of molecular-targeted agents for cancer

Description: Molecular-targeted agents are increasingly used for the treatment of cancer. However, the attrition rate for drugs that enter early clinical trials is higher than for other branches of internal medicine, suggesting that preclinical development has not been successful in identifying agents that can m...
Language(s): Inglés

Encontrado 189 documentos, página mostrada 1 de 19

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