Resultados totales (Incluyendo duplicados): 62
Encontrada(s) 7 página(s)
Encontrada(s) 7 página(s)
CORA.Repositori de Dades de Recerca
doi:10.34810/data405
Dataset. 2016
CANCER BIOMARKERS DATABASE
- Tamborero Noguera, David
- Rubio Pérez, Carlota
- Déu Pons, Jordi
- Schroeder, Michael Philipp, 1986-
- Vivancos Prellezo, Ana
- Rovira Guerín, Ana
- Tusquets, Ignasi
- Albanell Mestres, Joan
- Rodon, Jordi
- Tabernero Cartula, Josep
- Dienstmann, Rodrigo
- González-Pérez, Abel
- López Bigas, Núria
The cancer bioMarkers database is curated and maintained by several clinical and scientific experts in the field of precision oncology supported by the European Union’s Horizon 2020 funding. This database is currently being integrated with knowledge databases of other institutions in a collaborative effort of the Global Alliance for Genomics and Health.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data406
Dataset. 2023
ONCOPAD
- Tamborero Noguera, David
- López Bigas, Núria
- González-Pérez, Abel
- Rubio Pérez, Carlota
- Déu Pons, Jordi
A tool aimed at the rational design of cancer gene panels. It estimates the cost-effectiveness of the designed panel on a cohort of tumors and provides reports on the importance of individual mutations for tumorigenesis or therapy.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data407
Dataset. 2023
INTOGEN - PIPELINE
- González-Pérez, Abel
- Pérez Llamas, Christian, 1976-
- Tamborero Noguera, David
- Schroeder, Michael Philipp, 1986-
- Jené i Sanz, Alba, 1984-
- Santos, Alberto
- López Bigas, Núria
- Déu Pons, Jordi
Analyses somatic mutations in thousands of tumor genomes to identify cancer driver genes.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data408
Dataset. 2016
GITOOLS
- Pérez Llamas, Christian, 1976-
- López Bigas, Núria
- Schroeder, Michael Philipp, 1986-
- Déu Pons, Jordi
Gitools is a framework for analysis and visualization of multidimensional genomic data using interactive heat-maps.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data409
Dataset. 2023
ONCODRIVEFML
- Mularoni, Loris
- Sabarinathan, Radhakrishnan
- González-Pérez, Abel
- López Bigas, Núria
- Déu Pons, Jordi
Method to identify genomic regions, both coding and non-coding, bearing mutations with significant shift towards high functional impact across a cohort of tumos (FMbias), which are candidates to function as cancer drivers, through a local test.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data412
Dataset. 2023
ONCODRIVECLUST
- Tamborero Noguera, David
- González-Pérez, Abel
- López Bigas, Núria
OncodriveCLUST is a method aimed to identify genes whose mutations are biased towards a large spatial clustering. This method is designed to exploit the feature that mutations in cancer genes, especially oncogenes, often cluster in particular positions of the protein. We consider this as a sign that mutations in these regions change the function of these proteins in a manner that provides an adaptive advantage to cancer cells and consequently are positively selected during clonal evolution of tumours, and this property can thus be used to nominate novel candidate driver genes./nThe method does not assume that the baseline mutation probability is homogeneous across all gene positions but it creates a background model using silent mutations. Coding silent mutations are supposed to be under no positive selection and may reflect the baseline clustering of somatic mutations. Given recent evidences of non-random mutation processes along the genome, the assumption of homogenous mutation probabilities is likely an oversimplication introducing bias in the detection of meaningful events.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data413
Dataset. 2023
ONCODRIVEFM
- González-Pérez, Abel
- López Bigas, Núria
OncodriveFM detects candidate cancer driver genes and pathways from catalogs of somatic mutations in a cohort of tumors by computing the bias towards the accumulation of functional mutations (FM bias).This novel approach avoids some known limitations of recurrence-based approaches, such as the dif?culty to estimate background mutation rate, and the fact that they usually fail to identify lowly recurrently mutated driver genes.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data416
Dataset. 2023
ONCODRIVEROLE
- Schroeder, Michael Philipp, 1986-
- Rubio Pérez, Carlota
- Tamborero Noguera, David
- González-Pérez, Abel
- López Bigas, Núria
Machine-learning based approach to classify cancer driver genes into to Activating or Loss of Function roles for cancer gene development.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data418
Dataset. 2023
C10-HDAC7
- Barneda Zahonero, Bruna
- Román González, Lidia
- Collazo, Olga
- Rafati, Haleh
- Islam, Abul
- Bussmann, Lars
- Di Tullio, Alessandro
- Andrés, Luisa De
- Graf, T. (Thomas)
- López Bigas, Núria
- Mahmoudi, Tokameh
- Parra, Maribel
HDAC7 is a repressor of myeloid genes whose downregulation in pre-B cells is required for transdifferentiation into macrophages.
Proyecto: //
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