BUSCADOR RECOLECTA

To investigate the safety and immunogenicity of a modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B), a phase-I, doubled-blind placebo-controlled trial was performed., Peer reviewed

Attenuated poxvirus vectors expressing human immunodeficiency virus type 1 (HIV-1) antigens are considered promising HIV/AIDS vaccine candidates. Here, we describe the nature of T cell immune responses induced in healthy volunteers participating in a phase I clinical trial in Spain after intramuscular administration of three doses of the recombinant MVA-B-expressing monomeric gp120 and the fused Gag-Pol-Nef (GPN) polyprotein of clade B. The majority (92.3%) of the volunteers immunized had a positive specific T cell response at any time postvaccination as detected by gamma interferon (IFN-γ) intracellular cytokine staining (ICS) assay. The CD4(+) T cell responses were predominantly Env directed, whereas the CD8(+) T cell responses were similarly distributed against Env, Gag, and GPN. The proportion of responders after two doses of MVA-B was similar to that obtained after the third dose of MVA-B vaccination, and the responses were sustained (84.6% at week 48). Vaccine-induced CD8(+) T cells to HIV-1 antigens after 1 year were polyfunctional and distributed mainly within the effector memory (TEM) and terminally differentiated effector memory (TEMRA) T cell populations. Antivector T cell responses were mostly induced by CD8(+) T cells, highly polyfunctional, and of TEMRA phenotype. These findings demonstrate that the poxvirus MVA-B vaccine candidate given alone is highly immunogenic, inducing broad, polyfunctional, and long-lasting CD4 and CD8 T cell responses to HIV-1 antigens, with preference for TEM. Thus, on the basis of the immune profile of MVA-B in humans, this immunogen can be considered a promising HIV/AIDS vaccine candidate., Peer reviewed

8 programes especials del programa "Fora d'hores" de Ràdio 4 produït pel "Laboratori de Produccions Sonores de Ficció i Entreteniment" de la Llicenciatura de Comunicació Audiovisual de la UAB, Emesos entre el juny i el setembre de 2011

Lámina perteneciente a "Preceptos generales sobre las operaciones de los partos". Disponible en http://hdl.handle.net/10396/531

Lámina perteneciente a "Preceptos generales sobre las operaciones de los partos". Disponible en http://hdl.handle.net/10396/531

Lámina perteneciente a "Preceptos generales sobre las operaciones de los partos". Disponible en http://hdl.handle.net/10396/531

Lámina perteneciente a "Preceptos generales sobre las operaciones de los partos". Disponible en http://hdl.handle.net/10396/531

Lámina perteneciente a "Preceptos generales sobre las operaciones de los partos". Disponible en http://hdl.handle.net/10396/531

Lámina perteneciente a "Preceptos generales sobre las operaciones de los partos". Disponible en http://hdl.handle.net/10396/531

Lámina perteneciente a "Preceptos generales sobre las operaciones de los partos". Disponible en http://hdl.handle.net/10396/531