Resultados totales (Incluyendo duplicados): 14
Encontrada(s) 2 página(s)
Encontrada(s) 2 página(s)
CORA.Repositori de Dades de Recerca
doi:10.34810/data108
Dataset. 2021
EXPRESSION AND SPLICING QUANTITATIVE TRAIT LOCUS (E/SQTLS) SUMMARY STATISTICS FROM NORMAL COLON TISSUE
- Diez Obrero, Virginia
- Dampier, Christopher H.
- Moratalla Navarro, Ferran
- Devall, Matthew
- Plummer, Sarah J.
- Díez Villanueva, Anna
- Peters, Ulrike
- Bien, Stephanie
- Huyghe, Jeroen R.
- Kundaje, Anshul
- Ibáñez Sanz, Gemma
- Guinó, Elisabet
- Obón Santacana, Mireia
- Carreras Torres, Robert
- Casey, Graham
- Moreno Aguado, Víctor
We profiled gene expression and alternative splicing of non-neoplastic colon from biopsies of 445
healthy individuals. Here we provide summary statistics listings of BarcUVa-Seq eQTLs and sQTLs
(from SUPPA2 and from LeafCutter), and of GTEx v8 transverse colon and sigmoid colon sQLTs (from
SUPPA2). Filenames indicate the content of each file: {study}.{analysis}.{method}.
Proyecto: //
CORA.Repositori de Dades de Recerca
doi:10.34810/data132
Dataset. 2021
EXPRESSION QUANTITATIVE TRAIT LOCUS (EQTLS) SUMMARY STATISTICS FROM NORMAL COLON TISSUE. BASED ON TOPMED-IMPUTED SNPS AND STRATIFIED BY COLON LOCATION
- Diez Obrero, Virginia
- Dampier, Christopher H.
- Moratalla Navarro, Ferran
- Devall, Matthew
- Plummer, Sarah J.
- Díez Villanueva, Anna
- Peters, Ulrike
- Bien, Stephani
- Huyghe, Jeroen R.
- Kundaje, Anshul
- Ibáñez Sanz, Gemma
- Guinó, Elisabet
- Obón Santacana, Mireia
- Carreras Torres, Robert
- Casey, Graham
- Moreno Aguado, Víctor
We profiled gene expression of non-neoplastic colon from biopsies of 445 healthy individuals, as described in
Díez-Obrero, Virginia et al. “Genetic Effects on Transcriptome Profiles in Colon Epithelium Provide Functional Insights for Genetic Risk Loci.” Cellular and molecular gastroenterology and hepatology vol. 12,1 (2021): 181-197. doi:10.1016/j.jcmgh.2021.02.003.
Here we provide eQTL summary statistics for the entire sample size of BarcUVa-Seq data (n=445) as well as its strata by colon anatomic location, i.e. eQTLs from ascending (n=138), transverse (n= 143) and descending (n=164) colon.
Proyecto: //
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
Dataset. 2021
MATURATION AND ACTIVATION DENDRITIC CELLS BY TLR4LIG-PP3 AND TLR4LIG
- Losada Méndez, Jorge
- Palomares, Francisca
- Gómez, Francisca
- Ramírez-López, Pedro
- Ramos-Soriano, Javier
- Torres, María José
- Mayorga, Cristobalina
- Rojo, Francisco Javier
Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
HANDLE: http://hdl.handle.net/10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
PMID: http://hdl.handle.net/10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
Ver en: http://hdl.handle.net/10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243305
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
Dataset. 2021
MATURATION AND ACTIVATION DENDRITIC CELLS BY THE TLR7LIG-PP3 AND TLR7LIG
- Losada Méndez, Jorge
- Palomares, Francisca
- Góez, Francisca
- Ramírez-López, Pedro
- Ramos-Soriano, Javier
- Torres, María José
- Mayorga, Cristobalina
- Rojo, Francisco Javier
Data showed are changes in the maturation index of CD83, CD86 and PD-L1 in allergic patient and tolerant control., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
HANDLE: http://hdl.handle.net/10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
PMID: http://hdl.handle.net/10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
Ver en: http://hdl.handle.net/10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243309
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
Dataset. 2021
CYTOKINE PRODUCTION BY TLR4LIG-PP3 AND TLR4LIG
- Losada Méndez, Jorge
- Palomares, Francisca
- Gómez, Francisca
- Ramírez-López, Pedro
- Ramos-Soriano, Javier
- Torres, María José
- Mayorga, Cristobalina
- Rojo, Francisco Javier
Production of cytokine into the culture supernatant. In the case of TLR4, only significant increases of IL-5 were observed in allergic patients compared to tolerant controls when stimulating with TLR4lig-Pp3 and TLR4lig plus Pp3 peptide in separately way. No differences in the induction of IL-10 production were observed in allergic patients compared to tolerant controls, Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
HANDLE: http://hdl.handle.net/10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
PMID: http://hdl.handle.net/10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
Ver en: http://hdl.handle.net/10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243313
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
Dataset. 2021
CYTOKINE PRODUCTION BY TLR7LIG-PP3 AND TLR7LIG
- Losada Méndez, Jorge
- Palomares, Francisca
- Gómez, Francisca
- Ramírez-López, Pedro
- Ramos-Soriano, Javier
- Torres, María José
- Mayorga, Cristobalina
- Rojo, Francisco Javier
Production of cytokine into the culture supernatant from DCs. Our analysis in allergic patients compared to tolerant controls detected significant increases of IL-5 and IFN with all the conditions containing TLR7lig (TLR7lig, TLR7lig-Pp3 and TLR7lig plus Pp3 in separately way). we observed that TLR7lig-Pp3 induced significant lower IL-4 and IL-5 levels whilst higher IFNγ levels compared to the Pp3 only in allergic patients, indicating the specific immunomodulatory capacity of this compound., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
HANDLE: http://hdl.handle.net/10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
PMID: http://hdl.handle.net/10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
Ver en: http://hdl.handle.net/10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243314
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
Dataset. 2021
SPECIFIC LYMPHOCYTE PROLIFERATION IN THE PRESENCE OF BOTH TLR4LIG-PP3 AND TLR7LIG-PP3.
- Losada Méndez, Jorge
- Palomares, Francisca
- Gómez, Francisca
- Ramírez-López, Pedro
- Ramos-Soriano, Javier
- Torres, María José
- Mayorga, Cristobalina
- Rojo, Francisco Javier
Data indicated that only TLR7lig-Pp3 led to significantly increased in the proliferation index of CD3+T-cells in allergic patients compared to tolerant controls,
while TLR4lig-Pp3 seemed stimulate the T-cells proliferation without inducing a difference between groups. Moreover, in allergic patients there was a significant increase in CD3+ and CD4+ T-cells proliferation after stimulation with TLR4lig-Pp3 vs TLRlig and vs TLR4lig plus Pp3 peptide; additionally, TLR7lig-Pp3 induced a specific proliferative response of CD3+T-cells compared to TLR7lig and TLR7lig plus Pp3 peptide., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
HANDLE: http://hdl.handle.net/10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
PMID: http://hdl.handle.net/10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
Ver en: http://hdl.handle.net/10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243315
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
Dataset. 2021
TREG-CELL PERCENTAGES AND IL-10 PRODUCTION FOR PP3, TLRNLIG, TLRNLIG-PP3 AND TLRNLIG PLUS PP3 FOR ALLERGIC PATIENTS
- Losada Méndez, Jorge
- Palomares, Francisca
- Gómez, Francisca
- Ramírez-López, Pedro
- Ramos-Soriano, Jorge
- Torres, María José
- Mayorga, Cristobalina
- Rojo, Francisco Javier
Data indicated significantly higher percentages of Treg cells and IL-10 production in allergic patient compared to tolerant controls when stimulated with both TLRnlig-Pp3. Moreover, these effects were higher compared to Pp3 peptide alone, TLRnlig as well as TLRnlig plus Pp3 only in allergic patients except with TLR4lig-Pp3 for the IL-10 production. Regarding the TLR4 activation, they can induce a low production of IL-10., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
HANDLE: http://hdl.handle.net/10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
PMID: http://hdl.handle.net/10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
Ver en: http://hdl.handle.net/10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243324
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
Dataset. 2021
MATURATION AND ACTIVATION DENDRITIC CELLS BY THE COMBINATION OF TLR7LIG-PP3 PLUS TLR4LIG-PP3.
- Losada Méndez, Jorge
- Palomares, Francisca
- Gómez, Francisca
- Ramírez-López, Pedro
- Ramos-Soriano, Javier
- Torres, María José
- Mayorga, Cristobalina
- Rojo, Francisco Javier
Data indicated an opposite result, since the combination of both TLRnlig-Pp3 (TLR7lig-Pp3 plus TLR4lig-Pp3) together decreased the maturation already produced by each compound alone, being significant for CD80, Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
HANDLE: http://hdl.handle.net/10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
PMID: http://hdl.handle.net/10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
Ver en: http://hdl.handle.net/10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243330
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243338
Dataset. 2021
EFFECT OF THE COMBINATION OF BOTH TLRNLIG-PP3 IN THE PROLIFERATIVE RESPONSE.
- Losada Méndez, Jorge
- Palomares, Francisca
- Gómez, Francisca
- Ramírez-López, Pedro
- Ramos-Soriano, Javier
- Torres, María José
- Mayorga, Cristobalina
- Rojo, Francisco Javier
Regarding the effect of these interactions with DC on the proliferative response of the T-, B- and NK-cells, there was a decrease in comparison with the proliferation induced by the ligands incubated separately, Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/243338
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243338
HANDLE: http://hdl.handle.net/10261/243338
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243338
PMID: http://hdl.handle.net/10261/243338
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243338
Ver en: http://hdl.handle.net/10261/243338
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/243338
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