BUSCADOR RECOLECTA

This dataset in an Excel file compares the wave of globalization before the outbreak of the Great Recession in 2007 with its alleged historical antecedent before the outbreak of World War One. We describe trends in trade and openness, estimate the gains from trade and investigate the proximate causes of the growth of openness. We argue that the conventional wisdom has to be revised. The first wave of globalization started around 1820 and culminated around 1870. In the next century, trade continued to grow, with the exception of the Great Depression, but openness and gains fluctuated widely. Growth resumed in the early 1970s. By 2007, the world was more open than a century earlier and its inhabitants gained from trade substantially more than their ancestors did. The current wave of globalization, in spite of some similarities with previous trends, has no historical antecedents. This dataset is related to the working paper "A tale of two globalizations : gains for trade and openness 1800-2010" by by Giovanni Federico and Antonio Tena Junguito, available on: http://hdl.handle.net/10016/22354

This dataset is supporting information to the paper pubished in the Working papers in Economic History series, n. 16-01., This dataset in an Excel file presents our data-base on world trade from 1800 to 1938. We have collected or estimated series of imports and exports, at current and constant (1913) prices and at current and at constant (1913) borders, for 149 polities. After a short review of the available series, we describe the methods for the construction of the data-base. We then deal with the criteria for the inclusion of polities, the representativeness of our series, the main types of sources, the procedures of deflation and, when necessary, of adjustments to 1913 borders. We discuss the details of the estimation of our polity series in Appendix B. Following Feinstein and Thomas (2001), we assess the reliability of our polity estimates. In the last two sections we present our trade series at current and 1913 borders and compare them with other available series. This dataset is related to the working paper "World trade, 1800-1938 : a new data-set" by Giovanni Federico and Antonio Tena Junguito, available on: http://hdl.handle.net/10016/22222.

The cancer bioMarkers database is curated and maintained by several clinical and scientific experts in the field of precision oncology supported by the European Union’s Horizon 2020 funding. This database is currently being integrated with knowledge databases of other institutions in a collaborative effort of the Global Alliance for Genomics and Health.

A tool aimed at the rational design of cancer gene panels. It estimates the cost-effectiveness of the designed panel on a cohort of tumors and provides reports on the importance of individual mutations for tumorigenesis or therapy.

Analyses somatic mutations in thousands of tumor genomes to identify cancer driver genes.

Method to identify genomic regions, both coding and non-coding, bearing mutations with significant shift towards high functional impact across a cohort of tumos (FMbias), which are candidates to function as cancer drivers, through a local test.

OncodriveCLUST is a method aimed to identify genes whose mutations are biased towards a large spatial clustering. This method is designed to exploit the feature that mutations in cancer genes, especially oncogenes, often cluster in particular positions of the protein. We consider this as a sign that mutations in these regions change the function of these proteins in a manner that provides an adaptive advantage to cancer cells and consequently are positively selected during clonal evolution of tumours, and this property can thus be used to nominate novel candidate driver genes./nThe method does not assume that the baseline mutation probability is homogeneous across all gene positions but it creates a background model using silent mutations. Coding silent mutations are supposed to be under no positive selection and may reflect the baseline clustering of somatic mutations. Given recent evidences of non-random mutation processes along the genome, the assumption of homogenous mutation probabilities is likely an oversimplication introducing bias in the detection of meaningful events.

OncodriveFM detects candidate cancer driver genes and pathways from catalogs of somatic mutations in a cohort of tumors by computing the bias towards the accumulation of functional mutations (FM bias).This novel approach avoids some known limitations of recurrence-based approaches, such as the dif?culty to estimate background mutation rate, and the fact that they usually fail to identify lowly recurrently mutated driver genes.

Machine-learning based approach to classify cancer driver genes into to Activating or Loss of Function roles for cancer gene development.

Oncodrive-CIS is a method aimed to identify those copy number alterations (CNAs) leading to larger in cis expression changes that may be useful in elucidating the role of these aberrations in cancer. This is based on the hypothesis that a gene driving oncogenesis through copy number changes is more prone to bias towards overexpression (or underexpression) as compared to bystanders. The effect of the gene dosage is assessed by observing expression changes not only among tumors but also taking into account normal samples data, when available./nOncodrive-CIS has several potential benefits: first, it did not examine the frequency of the CNAs across samples and therefore the detection of low-recurrent driver alterations was not impaired. Second, amplifications and deletions were evaluated separately to obtain a fair ranking of genes, because the expression change measured in deletions was lower than the one obtained from multi-copy amplifications. Third, the expression of genes in tumor samples was analyzed according to the copy number status but was also compared to normal samples, thus better revealing the gene misregulation role of CNAs in cancer cells. And finally, it should be emphasized that the relationship between expression changes and their functional impact is complex, thus Oncodrive-CIS is proposed as a method to elucidate the role of CNAs in cancer which may be complementary to analyses based on other criteria.