Encontrados 573 resultado(s)
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Encontradas 6 página(s)
The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
In the last decades cancer has been considered as an epigenetic dysfunction, given the profound role of diet and lifestyle in cancer prevention and the determination of cancer risk. A plethora of recent publications have addressed the specific role of several environmental factors, such as nutritional habits, behavior, stress and toxins in the regulation of the physiological and cancer epigenome. In particular, plant-derived bioactive nutrients have been seen to positively affect normal cell...
Exploring factors influencing the severity of pregnancy anemia in India: a study using proportional odds model
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Pregnancy-associated anemia is a significant health issue that poses negative consequences for both the mother and the developing fetus. This study explores the triggering factors of anemia among pregnant females in India, utilizing data from the Demographic and Health Survey 2019–21. Chi-squared and gamma tests were conducted to find out the relationship between anemia and various socioeconomic and sociodemographic elements. Furthermore, ordinal logistic regression and multinomial logistic...
Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder caused by mutations in the Cathepsin C (CTSC) gene, characterized by periodontitis and palmoplantar hyperkeratosis. The main inflammatory deficiencies include oxidative stress and autophagic dysfunction. Mitochondria are the main source of reactive oxygen species; their impaired function is related to skin diseases and periodontitis. The mitochondrial function has been evaluated in PLS and mitochondria have been targeted...
The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Cancer stem cells (CSCs) are a rare tumor subpopulation with high differentiation, proliferative and tumorigenic potential compared to the remaining tumor population. CSCs were first discovered by Bonnet and Dick in 1997 in acute myeloid leukemia. The identification and isolation of these cells in this pioneering study were carried out through the flow cytometry, exploiting the presence of specific cell surface molecular markers (CD34+/CD38−). In the following years, different strategies and...
RNA Interference Strategies for Future Management of Plant Pathogenic Fungi: Prospects and Challenges
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Plant pathogenic fungi are the largest group of disease-causing agents on crop plants and represent a persistent and significant threat to agriculture worldwide. Conventional approaches based on the use of pesticides raise social concern for the impact on the environment and human health and alternative control methods are urgently needed. The rapid improvement and extensive implementation of RNA interference (RNAi) technology for various model and non-model organisms has provided the initial...
Inhibition of the NLRP3 inflammasome prevents ovarian aging
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-...
Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also gained interest as an important source of phenolic compounds with potential for biomedical applications. The present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results showed that the antiproliferative effect was associated with...
Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The application of metallic nanoparticles (materials with size at least in one dimension ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in mitochondrial dysfunctions or whose progression is dependent on mitochondrial function. We aimed to study the subcellular distribution of 2-4 nm iron nanoparticles and its effect on mitochondrial DNA (mtDNA),...
The central role of mitochondria in the relationship between dietary lipids and cancer progression
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De novo lipogenesis is an important source of lipids for cancer cells, but exogenous lipid uptake remains essential for many cancer cells. Dietary lipids can modify lipids present in tumor microenvironment affecting cancer cell metabolism. Clinical trials have shown that diets rich in polyunsaturated fatty acids (PUFA) can negatively affect tumor growth. However, certain n-6 PUFAs can also contribute...
NLRP3 inflammasome inhibition rescues Hutchinson-Gilford Progeria cellular phenotype and extend longevity of an animal model
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Inflammation is a hallmark of aging and accelerated aging syndromes. In this context, inflammation has been associated to the pathophysiology of Hutchinson–Gilford progeria syndrome (HGPS). In this study, we report that progeroid skin fibroblasts and animal models present an hyperactivation of the NLRP3-inflammasome complex. High expression of NLRP3 and caspase 1 was also observed in skin fibroblasts from HGPS associated to the nuclei morphology. Lymphoblast from HGPS also showed increased...
Mislocalization of SMN from the I-band and M-band in human skeletal myofibers in spinal muscular atrophy associates with primary structural alterations of the sarcomere
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
pinal muscular atrophy (SMA) is caused by a deletion or mutation of the survival motor neuron 1 (SMN1) gene. Reduced SMN levels lead to motor neuron degeneration and muscular atrophy. SMN protein localizes to the cytoplasm and Cajal bodies. Moreover, in myofibrils from Drosophila and mice, SMN is a sarcomeric protein localized to the Z-disc. Although SMN participates in multiple functions, including the biogenesis of spliceosomal small nuclear ribonucleoproteins, its role in the sarcomere is...
Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Aging is the major risk factor for many metabolic chronic diseases. Several metabolic pathways suffer a progressive impairment during aging including body composition and insulin resistance which are associated to autophagy dysfunction and increased inflammation. Many of these alterations are aggravated by non-healthy lifestyle such as obesity and hypercaloric diet which have been shown to accelerate aging. Here, we show that the deleterious effect of hypercaloric diets is reverted by the NLRP3...
A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
ncreasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD...
The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such as lipid metabolism and fibrosis are reduced in aged mice lacking the NLRP3 inflammasome. We report reduced protein levels of lipid markers (MTP, FASN, DGAT1), SOD activity, oxidative stress marker PTPRG, and the fibrotic markers TPM2β, COL1-α1 associated with increased GATA4, in NLRP3 deficient...
Sequential Changes of NLRP3 Inflammasome Activation in Sepsis and its Relationship With Death
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Introduction:
Inflammasomes are recognized as key components of the innate immune response in sepsis. We aimed to describe the transcriptional expression of nucleotide-binding domain, leucine-rich repeat–containing receptor, pyrin domain–containing-3 (NLRP3), and serum interleukin-1β (IL-1 β) in critically ill patients, their changes over the first week and their prognostic value in septic patients.
Methods:
Prospective study including patients with sepsis based on Sepsis-3 definitions and a...
A novel dominant mutation inCRYABgene leading to a severe phenotype with childhood onset
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Background
αB-crystallin is a promiscuous protein involved in numerous cell functions. Mutations in CRYAB have been found in patients with different pathological phenotypes that are not properly understood. Patients can present different diseases like cataracts, muscle weakness, myopathy, cardiomyopathy, respiratory insufficiency or dysphagia, but also a variable combination of these pathologies has been found. These mutations can show either autosomal dominant or recessive mode of inheritance...
VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Background
Distal motor neuropathies with a genetic origin have a heterogeneous clinical presentation with overlapping features affecting distal nerves and including spinal muscular atrophies and amyotrophic lateral sclerosis. This indicates that their genetic background is heterogeneous.
Patient and methods
In this work, we have identified and characterized the genetic and molecular base of a patient with a distal sensorimotor neuropathy of unknown origin. For this study, we performed whole-...
NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related diseases in NLRP3-deficient mice. In this article, we determine whether, in old mice C57BL6J, the NLRP3 inflammasome inhibitor MCC950 is able to attenuate age-related metabolic syndrome to providing health benefits. We report that MCC950 attenuates metabolic and hepatic dysfunction in aged mice. In addition, MCC950 inhibited the Pi3K/AKT/mTOR pathway, enhanced autophagy, and activated peroxisome...
Is AMP-Activated Protein Kinase Associated to the Metabolic Changes in Primary Ovarian Insufficiency?
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Primary ovarian insufficiency (POI) is a critical fertility defect characterized by anticipated impairment of the follicular reserve, which pathophysiological mechanisms have not yet been identified. We have investigated the possible relationship between AMP-activated protein kinase (AMPK) and the pathophysiology of POI. We studied 35 POI patients with altered levels of follicle-stimulating hormone (FSH) and estradiol and increased percentage of overweight compared with 20 healthy women. Blood...
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own. While analyzing macrophages lodged within the healthy myocardium, we discovered that they actively took up material, including mitochondria, derived from cardiomyocytes. Cardiomyocytes ejected dysfunctional mitochondria and other cargo in dedicated membranous particles...
Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: A focus on human studies
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted and repetitive behaviors. On the other hand, transplantation of hematopoietic and mesenchymal stem cells in ASD children has been shown promising to stimulate the recruitment,...
Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate cancer immunosurveillance, reducing the migration of immunosuppressive regulatory T cells towards the tumor bulk. Autophagy stimulation via...
Edible flowers as a health promoter: An evidence-based review
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The consumption of edible flowers has increased in recent years because of their wide use in gastronomy as a decorative element or as an ingredient in dishes. In addition to influencing texture, taste or appearance, flowers are rich in bioactive compounds.
Scope and approach
This review focuses on the composition and nutritional features of edible flowers and their extracts, and their health benefits related to cardiovascular diseases, cancer, neurological diseases, diabetes, obesity, in...
Mitochondrial Adaptations in the Growing Heart
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The heart pumps blood throughout the whole life of an organism, without rest periods during which to replenish energy or detoxify. Hence, cardiomyocytes, the working units of the heart, have mechanisms to ensure constitutive production of energy and detoxification to preserve fitness and function for decades. Even more challenging, the heart must adapt to the varying conditions of the organism from fetal life to adulthood, old age, and pathological stress. Mitochondria are at the nexus of these...
Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal Fibroblast
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria...
Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Berry fruits are rich in nutrients and polyphenols, providing potential health benefits. Understanding the factors that affect their bioavailability is becoming of utmost importance for evaluating their biological significance and efficacy as functional food. In this study, the phytochemical composition and the total antioxidant capacity of different varieties of five berries (blackberry, blackcurrant, blueberry, raspberry, and strawberry) were evaluated after an in vitro gastrointestinal...
Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties?
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 and MUD 2 on liver hepatocellular carcinoma. Our results showed that MUD 1 presented the highest (...
Strawberry-Tree Honey Induces Growth Inhibition of Human Colon Cancer Cells and Increases ROS Generation: A Comparison with Manuka Honey
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Honey is a natural product known to modulate several biological activities including cancer. The aim of the present study was to examine the phytochemical content and the antioxidant activity of Strawberry tree (Arbutus unedo) honey (STH) and its cytotoxic properties against human colon adenocarcinoma (HCT-116) and metastatic (LoVo) cell lines in comparison with Manuka (Leptospermum scoparium) honey (MH). Several unifloral STH and MH were analyzed for their phenolic, flavonoid, amino acid and...
The protective effect of acerola (Malpighia emarginata) against oxidative damage in human dermal fibroblasts through the improvement of antioxidant enzyme activity and mitochondrial functionality
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Acerola fruits (Malpighia emarginata DC.) from the central region of Cuba were analyzed to determine their chemical composition and protective capacity against oxidative damage using an in vitro human dermal fibroblast (HDFa) model. The chemical composition analyses showed a high content of vitamin C, total polyphenols, β-carotene and folates in the acerola fruit. From the HPLC-DAD/ESI-MSn analyses, two anthocyanins (cyanidin 3-O-rhamnoside and pelargonidin 3-O-rhamnoside), three...
Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Dyslipidemia and oxidation of low density lipoproteins (LDL) are recognized as critical factors in the development of atherosclerosis. Healthy dietary patterns, with abundant fruit and vegetable consumption, may prevent the onset of these risk factors due to the presence of phytochemical compounds. Strawberries are known for their high content of polyphenols; among them, flavonoids are the major constituents, and it is presumed that they are responsible for the biological activity of the fruit...
Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Irisin seems to play an important role in several chronic diseases, however, the interactions between chronic training and irisin are still unclear. The purpose of this systematic review and meta-analysis was to examine the effect of chronic resistance training on circulating irisin in adults. Literature search was conducted in PubMed, Web of Science and EBSCOhost (Academic Search Complete) until December 2020. Randomized controlled trials researching irisin levels after a resistance training...
International Competition Kinematic Demands in Male Field Hockey
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The objective of this research was to describe kinematic characteristics during international men’s field hockey matches. Sixteen players (age: 25.12±3.66 years; height:
177.12±4.96 cm; weight: 72.45±5.01 kg; caps: 79.12 ±78.96) belonging to the Spanish national team were monitored by means of Global Positioning Systems (GPS) and
accelerometry in the course of five matches in the 2017 European Championships. The
analyses were performed by game quarter (Q1, Q2, Q3 and Q4), positions (defenders,...
Differences on Motor Competence in 4-Year-Old Boys and Girls Regarding the Quarter of Birth: Is There a Relative Age Effect?
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The aim of this study was to evaluate the differences on motor competence between boys and girls aged 4 years old and investigate the existence of Relative Age Effect on their motor competence. In total, 132 preschool children were evaluated, of whom 60 (45.50%) were girls and 72 (54.5%) were boys. The distribution of the participants was from quarter 1 [n = 28 (21.2%)], quarter 2 [n = 52 (39.4%)], quarter 3 [n = 24 (18.2%)], and quarter 4 [(n = 28 (21.2%)], respectively. The Movement...
Relative Age Effect on Motor Competence in Children Aged 4–5 Years
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The purpose of this study was to evaluate whether a Relative Age Effect (RAE) exists in
motor competence of preschool children. The hypothesis was that motor competence, assessed by the
Movement Assessment Battery for Children-2 (MABC-2), would be higher in preschool children born
in the first quarter of the year compared to those who were born in the last quarter of the same year. A
total of 360 preschool children were evaluated of whom 208 (57.8%) were boys and 152 (42.8%) were
girls, with a...
Validity, Reliability and Reproducibility of OctoBalance Test as Tool to Measure the Upper Limb Compared to Modified-Upper Quarter Y-Balance Test
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The articular evaluation of range of motion (ROM) is currently used to observe imbalance or limitations as possible risk factors or predispositions to suffer future injures. The main aim of this study is to verify the concurrent validity, reliability and reproducibility of the OctoBalance Test (OB) as a valid and reliable tool to measure articular ROM of the upper limb compared to the modified-Upper Quarter Y-Balance Test (mUQYBT). The twenty-five participants were male athletes. All of them...
Most running demand passages of match play in youth soccer congestion period
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The objective of this study was to determine whether there is a decrease in the physical performance of the players in the most demanding passages (MDP) during periods of competition congestion. The study involved 15 under-19 players, belonging to a club in Spain's first division (age: 18.1 ± 0.8 years, weight: 70.2 ± 4.9 kg and height: 1.78 ± 0.06 m), who were monitored during 23 national and international official matches in the 2018/19 season. The Youth League matches were played...
Effect of the Menstrual Cycle When Estimating 1 Repetition Maximum From the Load-Velocity Relationship During the Bench Press Exercise
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
This study aimed to examine the effect of the ovulatory menstrual cycle (MC) when estimating the 1 repetition maximum (1RM) from the individual load-velocity relationship during the bench press (BP) exercise. Nine resistance-trained eumenorrheic women (age: 28.7 ± 3.6 years) were tested in 3 different phases across the MC: menstrual or early follicular phase (i.e., testing between days 1–3), follicular or late follicular phase (i.e., testing between days 7–10), and luteal or mid-luteal phase (i...
Strength Training Habits in Amateur Endurance Runners in Spain: Influence of Athletic Level
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
This study determined the strength training (ST) habits of amateur endurance runners in Spain regarding athletic level. A sixteen-item online questionnaire comprised of (i) demographic information, (ii) performance, and (iii) training contents was completed by 1179 athletes. Five group levels were determined according to the personal best times of the athletes in a 10-km trial (LG1: level group 1, 50–55 min; LG2: level group 2, 45–50 min; LG3: level group 3, 40–45 min; LG4: level group 4, 35–40...
Jump-Rope Training: Improved 3-km Time-Trial Performance in Endurance Runners via Enhanced Lower-Limb Reactivity and Foot-Arch Stiffness
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Context: Plyometric training promotes a highly effective neuromuscular stimulus to improve running performance. Jumping rope (JR) involves mainly foot muscles and joints, due to the quick rebounds, and it might be considered a type of plyometric training for improving power and stiffness, some of the key factors for endurance-running performance. Purpose: To determine the effectiveness of JR during the warm-up routine of amateur endurance runners on jumping performance, reactivity, arch...
Validity and Reliability of a New Device to Measure Type of Actions in Indoor Sports
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The purpose of this study was to analyze the validity and the reliability of the intensity ranges, number of actions and changes of direction measured by a commercial inertial measurement unit. Eleven elite youth futsal players performed a circuit with different type of displacements as sprinting, running at low-medium intensity, standing up and changes of direction. Data recorded by the Overtraq system were compared with video-analyzer during the six trials of each player. Standard error mean...
Epidemiology of Injuries in Elite Female Futsal Players: A Prospective Cohort Study
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
njuries are one of the worst case scenarios for an athlete and a team. The aim of this study was to analyze the injury incidence, characteristics and burden among a cohort of elite female futsal players. A prospective cohort study was designed over a season. Eighty-nine players from seven elite female futsal teams were monitored during the whole season. Eight different variables were recorded when an injury happened, as well as exposure time. A total of 90 injuries were recorded so that 54 out...
Monitoring Workloads of a Professional Female Futsal Team over a Season: A Case Study
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The aims of this study were to describe the external and internal workloads in a professional female futsal team during a whole season and to compare workloads during different periods of the season. Ten professional female futsal players (age 22.8 ± 4.3 years; 5.1 ± 2.4 years of experience; weight 61.9 ± 7.1 kg; height 1.66 ± 0.06 m) participated voluntarily in this study during the whole season. The internal workload was measured by the session-Rate of perceived exertion (session-RPE) method...
Perceptions of the technical staff of professional teams regarding injury prevention in Spanish national futsal leagues: a cross-sectional study
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Futsal is a sport with increasing popularity and level of performance, both in male and female categories. Also, there are several injuries along a season, so it is needed to know how to reduce this burden. The purpose of this study was to describe the perceptions of technical staff on injury risk factors, risk testing and preventive measures, and the strategies used by them within professional male and female futsal teams. A cross-sectional study was designed during the 2017–2018 season. A...
Anthropometric and conditional profile in semiprofessional futsal players: differences between sexes. A case study. [Perfil antropométrico y condicional en jugadores semiprofesionales de futbol sala: diferencias entre sexos. Un estudio de caso].
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Anthropometrical profile is one of the indicators associated to optimal performance of futsal players. However, no
studies have analyzed these factors in both sexes neither created an anthropometrical profile of each sex. For these
reasons, the goals of this study were: to describe and compare the anthropometric and conditional profiles of sub-elite
futsal players, and to analyze possible correlations between anthropometric and conditional parameters. 11 female
and 8 male sub-elite futsal...
The Relative Age Effect in Professional Futsal Players
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The objective of this study was to verify the occurrence and effect size of relative age effect in professional futsal players, by observing how its presence and impact change according to the season, team level and player position. The sample was composed of 1873 professional futsal players who played in the First Division of the Spanish National Futsal League between seasons 2006-2007 and 2014-2015. The players’ birthdates were divided into quarters (Q1, Q2, Q3 and Q4). A relative age effect...
Different race pacing strategies among runners covering the 2017 Berlin Marathon under 3 hours and 30 minutes
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The purposes of this study were 1) to analyse the different pacing behaviours based on athlete's performance and 2) to determine whether significant differences in each race split and the runner's performance implied different race profiles. A total of 2295 runners, which took part in Berlin’s marathon (2017), met the inclusion criteria. 4 different groups were created based on sex and performance. Men: Elite (<02:19:00 h), Top 1 (<02:30:00 h), Top 2 (<02:45:00 h) and Top 3...
Gestational Exercise and Maternal and Child Health: Effects until Delivery and at Post-Natal Follow-up
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
We studied the influence of pregnancy exercise on maternal/offspring cardiometabolic health until delivery and at follow-up. We pooled data from two randomized controlled trials from our group that were performed following the same methodology (one unpublished). We also collected follow-up data de novo from the participants of both trials and their offspring. In total, 1348 women with uncomplicated, singleton gestations were assigned to an intervention (n = 688, performing a supervised,...
The psychometric properties of the person-centered therapeutic relationship in physiotherapy scale
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Objective
To determine the psychometric properties of the Person-Centered Therapeutic Relationship in Physiotherapy Scale (PCTR-PT) in order to find the most appropriate fit for the tool.
Methods
Patients who had received treatment at the physiotherapy service of nine hospitals in Spain were invited to complete the 31 items of the PCTR-PT scale. To select the most appropriate items of the PCTR-PT, an exploratory factorial analysis (EFA) was performed using the maximum likelihood and oblique...
Analysis of congested schedule on competition external load in field hockey. [Análisis de la carga externa de competición en un periodo de congestión en hockey hierba].
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
This study aimed to investigate the variation in players’ physical demands profile during a major national men fieldhockey tournament which consisted of 3 matches on consecutive days. Ten Spanish National League hockey players participated in the study (age: 24.2 ± 2.6 years; body mass: 74.2 ± 5.7 kg; height 176.8 ± 5.1 cm). Participants´ physical demands were monitored using global positioning system devices (SPI Elite, GPSports). Activity was categorized into total distance (m), relative...
Changes in External Load When Modifying Rules of 5-on-5 Scrimmage Situations in Elite Basketball
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Vazquez-Guerrero, J, Reche, X, Cos, F, Casamichana, D, and Sampaio, J. Changes in external load when modifying rules of 5-on- 5 scrimmage situations in elite basketball. J Strength Cond Res 34(11): 3217–3224, 2020—Constraining tasks are very frequent during the team sports training process; however, most of the effects of these coaching decisions are unknown, which leads to less controlled performing environments, with less chances to promote improvements. The aim of this study was to determine...
The most demanding passages of play in football competition: a comparison between halves
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The purpose of this investigation was to determine the differences between halves in the most
demanding passages of play in football players according to playing position and duration-specific activity.Global positioning system data were collected from twenty-three football players from a reserve squad of the Spanish La Liga. A total of 265 individual match half data were analysed across the competitive season. Players were categorised based on positional groups: full-back (FB), central...
Looking for Complementary Intensity Variables in Different Training Games in Football
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The main aim of this study was to identify which combination of external intensity training load (iTL) metrics capture similar or unique information for different training game (TG) formats and official matches (OMs) in football using principal component (PC) analysis. Ten metrics of iTL were collected from 24 professional male football players using global positioning technology. A total of 348, 383, 120, 127, 148, and 207 individual files for small-sided possession games, medium-sided...
Positional demands for various-sided games with goalkeepers according to the most demanding passages of match play in football
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The main aim was to determine the differences between four training games and competitive matches (CM) according to position and compared to the most demanding passages (MDP) of competitive match play. Global Positioning System data were obtained from 21 football players belonging to the reserve squad of a Spanish La Liga club during the 2015/16 season. The training games were small-sided games (SSGs) with 5 and 6 and large-sided games with 9 and 10 outfield players per team. The players were...
Demandas cinemáticas de competición internacional en el hockey sobre hierba femenino
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Objetivo. Comparar las demandas cinemáticas de jugadoras internacionales de hockey sobre hierba durante partidos de competición oficial. Material y métodos. Dieciséis jugadoras (edad: 24.7±2.8 años; peso: 57.9±5.9 kg; altura: 165.2±4.9 cm) pertenecientes a la selección absoluta española fueron monitorizadas mediante sistemas de posicionamiento global (GPS) durante 5 partidos del Campeonato de Europa. Los análisis fueron llevados a cabo en función de la demarcación de las jugadoras (defensas,...
Protective Effect of Exercise in Pregnant Women Including Those Who Exceed Weight Gain Recommendations: A Randomized Controlled Trial
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Objective: To investigate the effect of supervised moderate to vigorous exercise on gestational weight gain, its related risks (gestational diabetes [GD]), macrosomia, and type of delivery), and the preventive effects on women who exceed the weight gain recommendations.
Patients and methods: We conducted a single-center, 2-armed, randomized controlled trial between October 1, 2009, and June 30, 2011, in which 678 women were assessed and 345 were randomized by a central computer system to an...
Influence of maternal physical exercise on fetal and maternal heart rate responses
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
This study aims to determine if regular maternal physical exercise leads to measurable adaptations of the fetal autonomic nervous system (fANS) tested by fetal heart rate recovery time. A randomized controlled trial enrolled 131 pregnant women into two study groups, Exercise Group (EG) and Control Group (CG). All participants signed an informed consent, study was approved by the local Clinical Research Ethics Committee. Data was analyzed on 81 participants.
EG participants (n = 43) received a...
Assessment of the external load of amateur soccer players during four consecutive training microcycles in relation to the external load during the official match
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Aim:
The aim of this study was to assess the external load of amateur male players during 4 consecutive training microcycles (M) at the beginning of the in-season according to the training session in absolute external load demands and in relation to the competition demands.
Methods:
Regional-level players (n = 10; age, 20.8 ± 1.7 years; height, 175.5 ± 3.8 cm; body mass, 69.7 ± 2.9 kg; soccer experience, 13.2 ± 2.5 years) were monitored using GPS devices during training sessions and matches....
Acute muscle fatigue and CPR quality assisted by visual feedback devices: A randomized-crossover simulation trial
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Objective
To analyse the acute muscular fatigue (AMF) in triceps brachii and rectus abdominis during compression-only and standard cardiopulmonary resuscitation (CPR) performed by certified basic life support providers.
Methods
Twenty-six subjects were initially recruited and randomly allocated to two study groups according to the muscles analysed; eighteen finally met the inclusion criteria (nine in each group). Both groups carried out two CPR tests (compression-only and standard CPR) of 10...
Jugadores comodines durante diferentes juegos de posición
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
El objetivo de este trabajo fue estudiar las demandas cinemáticas impuestas a los jugadores comodines y regulares, además de comparar la demanda impuesta a los comodines en diferentes juegos de posición (JP; 4v4+3, 5v5+3, 7v7+3 y 8v8+3). La demanda cinemática fue monitorizada a través de dispositivos GPS de 10 Hz. En el estudio participaron 25 jugadores de fútbol (20.5 ± 1.8 años, 178.4 ± 6.6 cm, 69.7 ± 6.1 kg) pertenecientes al equipo filial de un club de 1ª división española durante la...
Effects of Core Strength Training Using Stable and Unstable Surfaces on Physical Fitness and Functional Performance in Professional Female Futsal Players
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The aim of this study was to assess the effect of core strength training performed on a stable surface (CTS) compared with core strength training performed on an unstable surface (CTU) on physical fitness (jump performance, sprint, and repeated sprint ability (RSA)) and quality of movement (Fundamental Movement Screen) in professional female futsal players. Fourteen professional female futsal players (mean age: 23.7 ± 5.1 years, age range: 18-28 years) were randomly assigned to a CTS (n = 7) or...
Positional Comparisons in the Impact of Fatigue on Movement Patterns in Hockey
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Purpose: To examine the influence of the match period on the movement patterns of hockey players according to their playing positions under the introduction of quarters (QTRs). Methods: Sixteen subelite-level Spanish National League male hockey players participated in the study (age: 25.5 [2.9] y; body mass: 74.6 [5.5] kg). Global positioning system devices were used to monitor players’ running performance during 17 competitive matches (113 match-play profiles). Only players who played for at...
Training intensity distribution and performance of a recreational male endurance runner. A case report
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The polarized training intensity distribution model (PTM) has demonstrated to achieve larger improvements than
lactate threshold model (LTM) in elite and well-trained endurance athletes. However, there is a lack of
knowledge about the effectivity of PTM with novice recreational runners. This research aimed to compare the
impact of LTM vs PTM on a novice recreational runner’s performance. The athlete (age 32 y, body mass 73 kg,
height 179 cm, basal HR 43 bpm, Σ6 skinfolds 51.6 mm) trained...
Practical Active and Passive Recovery Strategies for Soccer Players
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
As a result of training and competition load in soccer, the majority of the body's physiological systems are stressed. To accelerate the recovery process and enhance performance in soccer, different postexercise recovery modes have been suggested and are broadly classified into 2 categories: active recovery or passive recovery. despite the popularity, there is a lack of scientific evidence for the validity of these recovery interventions: This review summarizes the evidence base for using...
Prehospital Emergency Medicine at the Beach: What Is the Effect of Fins and Rescue Tubes in Lifesaving and Cardiopulmonary Resuscitation After Rescue?
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Objective
To analyze the influence of fins and rescue tube use in a water rescue, assessed by time and distance to salvage position, physiological parameters, and cardiopulmonary resuscitation (CPR).
Methods
Twenty professional lifeguards (10 men, 10 women) conducted 3 tests: a baseline test of 5 minutes of CPR and 2 water rescues, 1 without rescue equipment (NRE), and the other with fins and rescue tube (FRT). They also had to perform 5 minutes of CPR after each rescue. Time and distance of...
Is Marathon Training Harder than the Ironman Training? An ECO-method Comparison
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Purpose: To compare the absolute and relative training load of the Marathon (42k) and the Ironman (IM) training in recreational trained athletes.
Methods: Fifteen Marathoners and Fifteen Triathletes participated in the study. Their performance level was the same relative to the sex's absolute winner at the race. No differences were presented neither in age, nor in body weight, height, BMI, running VO2max max, or endurance training experience (p > 0.05). They all trained systematically...
Heart Rate, Technical Performance, and Session-RPE in Elite Youth Soccer Small-Sided Games Played With Wildcard Players
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The aim of this study was to compare heart rate (HR), rating of perceived exertion (RPE), and technical-tactical actions during small-sided games (SSGs) played without (CTR), with internal (IW), and with IW and external (IEW) wildcard players. A total of 22 young male soccer players (age 17.2 ± 0.9 years) randomly completed six 4vs4 SSG situations. The control conditions occurred with goals scored without goalkeeper (4vs4-NO) and with goalkeeper (4vs4-GK). During the experimental conditions,...
Reliability and Usefulness of the 30-15 Intermittent Fitness Test in Male and Female Professional Futsal Players
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The purpose of this study was to determine the reliability and usefulness of the 30-15 Intermittent Fitness Test (30-15IFT) in professional male and female futsal players. Thirteen male (24.4 ± 5.6 years; 174.5 ± 10.3 cm; 70.3 ± 9.9 kg) and fourteen female (23.3 ± 4.5 years; 165.8 ± 6.2 cm; 61.7 ± 5.5 kg) professional futsal players performed the 30-15IFT on two occasions, separated by 5 days. Maximal intermittent running velocity (VIFT) and heart rate at exhaustion (HRpeak) data were collected...
Assessing the efficacy of rescue equipment in lifeguard resuscitation efforts for drowning
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Purpose
The whole drowning process usually occurs within seconds to a few minutes. An early rescue may stop and/or prevent most medical complications. Fins, rescue tube, and rescue board (RB) are the equipment most frequently used by lifeguards. Our objective was to compare, in a water rescue quasiexperimental trial, these different pieces of rescue equipment to define the safest and with the lower rescue time as well as to assess their effects on the lifeguards' physiological state and...
The Relationship Between Intensity Indicators in Small-Sided Soccer Games
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The aim of the present study was to examine the relationship between different kinds of intensity indicators in small-sided soccer games. This descriptive correlational study included 14 semi-professional male soccer players (21.3 ± 2.3 years, 174 ± 4.0 cm, 73.4 ± 5.1 kg) from the same team. The players were monitored by means of heart rate monitors and GPS devices during 27 small-sided games of nine different formats, yielding a total of 217 recordings. After each game the Borg scale was used...
Cardiac Parasympathetic Reactivation in Elite Soccer Players During Different Types of Traditional High-Intensity Training Exercise Modes and Specific Tests: Interests and Limits
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Background: The cardiac parasympathetic reactivation is currently used in soccer with a daily or weekly monitoring. However, previous
studies have not investigated how this cardiac parasympathetic reactivation is in elite soccer players along different types of traditional
high-intensity training exercise and specific tests. In this context, the present study aim to analyse it and to determine the interests and
limits of this type of physiological information.
Objectives: The present study aims...
Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of...
Links between Nutrition, Infectious Diseases, and Microbiota: Emerging Technologies and Opportunities for Human-Focused Research
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The interaction between nutrition and human infectious diseases has always been recognized. With the emergence of molecular tools and post-genomics, high-resolution sequencing technologies, the gut microbiota has been emerging as a key moderator in the complex interplay between nutrients, human body, and infections. Much of the host–microbial and nutrition research is currently based on animals or simplistic in vitro models. Although traditional in vivo and in vitro models have helped to...
Effect of antimony in soils of an Sb mine on the photosynthetic pigments and antioxidant system of Dittrichia viscosa leaves
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Antimony is a toxic element whose concentration in soil and water has been rising due to anthropogenic activities. This study focuses on its accumulation in leaves of Dittrichia viscosa growing in soils of an abandoned Sb mine, and the effect on oxidant/antioxidant systems and photosynthetic efficiency. The results showed leaves to have a high Sb accumulation capacity. The amount of total chlorophyll decreased depending on Sb concentration and of carotenoids increased slightly, with a...
Phenolic Compounds in Honey and Their Associated Health Benefits: A Review
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Honey is a natural substance appreciated for its therapeutic abilities since ancient times. Its content in flavonoids and phenolic acids plays a key role on human health, thanks to the high antioxidant and anti-inflammatory properties that they exert. Honey possesses antimicrobial capacity and anticancer activity against different types of tumors, acting on different molecular pathways that are involved on cellular proliferation. In addition, an antidiabetic activity has also been highlighted,...
Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
We describe the biological effects of a polyphenol-rich strawberry extract (PRSE), obtained from the “Alba” variety, on the highly aggressive and invasive basal-like breast cancer cell line A17. Dose-response and time-course experiments showed that PRSE is able to decrease the cellular viability of A17 cells in a time- and dose-dependent manner. PRSE effect on cell survival was investigated in other tumor and normal cell lines of both mouse and human origin, demonstrating that PRSE is more...
The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity?
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Current evidence indicates that the consumption of strawberries, a natural source of a wide range of nutritive and bioactive compounds, is associated with the prevention and improvement of chronic-degenerative diseases.. Studies involving cells and animals provide evidence on the anti-inflammatory, anticarcinogenic and antiproliferative activity of the strawberry. Epidemiological and clinical studies demonstrate that its acute consumption increases plasma antioxidant capacity, improves...
Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory...
Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Regulation of lipid metabolism is essential for treatment and prevention of several chronic diseases such as obesity, diabetes, and cardiovascular diseases, which are responsible for most deaths worldwide. It has been demonstrated that the AMP-activated protein kinase (AMPK) has a direct impact on lipid metabolism by modulating several downstream-signaling components. The main objective of the present work was to evaluate the in vitro effect of a methanolic strawberry extract on AMPK and its...
Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-...
Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
A common denominator in the pathogenesis of most chronic inflammatory diseases is the involvement of oxidative stress, related to ROS production by all aerobic organisms. Dietary antioxidants from plant foods represent an efficient strategy to counteract this condition. The aim of the present study was to evaluate the protective effects of strawberry extracts on inflammatory status induced by E. Coli LPS on RAW 264.7 macrophages by measuring the main oxidative and inflammatory biomarkers and...
Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced by E. coli LPS on human dermal fibroblast cells was performed in...
The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
It is generally accepted that a fruit and vegetable–enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have...
The use of natural compounds for the targeting and chemoprevention of ovarian cancer
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated...
Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Colon cancer is one of the most prevalent diseases across the world. Numerous epidemiological studies indicate that diets rich in fruit, such as berries, provide significant health benefits against several types of cancer, including colon cancer. The anticancer activities of berries are attributed to their high content of phytochemicals and to their relevant antioxidant properties. In vitro and in vivo studies have demonstrated that berries and their bioactive components exert therapeutic and...
Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive...
Coenzyme Q and Its Role in the Dietary Therapy against Aging
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is particularly abundant. Since then, more additional roles in cell physiology have been reported, including antioxidant, signaling, death prevention, and others. It is known that all cells are able to synthesize functionally...
Strawberry as a health promoter: an evidence based review
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Since a high intake of fruits and vegetables is inversely related to the incidence of several degenerative diseases, the importance of a balanced diet in relation to human health has received increased consumer attention worldwide. Strawberries (Fragaria X ananassa, Duch.) are a rich source of a wide variety of nutritive compounds such as sugars, vitamins, and minerals, as well as non-nutritive, bioactive compounds such as flavonoids, anthocyanins and phenolic acids. All of these compounds...
Targeting Glioblastoma with the Use of Phytocompounds and Nanoparticles
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Glioblastoma multiforme (GBM) are extremely lethal and still poorly treated primary brain tumors, characterized by the presence of highly tumorigenic cancer stem cell (CSC) subpopulations, considered responsible for tumor relapse. In order to successfully eradicate GBM growth and recurrence, new anti-cancer strategies selectively targeting CSCs should be designed. CSCs might be eradicated by targeting some of their cell surface markers and transporters, inducing their differentiation, impacting...
Inequality in times of pandemics: How online media are starting to treat the economic consequences of the coronavirus crisis
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
n December 2019, Chinese authorities informed the World Health Organization about a new coronavirus disease that would come to be called Covid-19. The world media began reporting on this new virus and its consequences. However, reports about Covid-19 would not appear in the European and American media until their societies became aware of both the health and economic consequences of Covid-19 in March 2020. This article analyzes the online media coverage of economic inequality. The goal is to...
El tratamiento de la desigualdad económica en cibermedios internacionales: análisis de contenido desde la perspectiva del nuevo sistema híbrido
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
La configuración de la opinión pública es un proceso en el que los medios de comunicación han tenido un papel fundamental. Sin embargo, desde la llegada de Internet, el rol de los medios de comunicación no nativos digitales (legacy media) se ha visto cuestionado debido a la aparición de nuevos actores que han generado el establecimiento de un sistema híbrido de medios, compartiendo este nuevo espacio mediático con los medios tradicionales. En este contexto, el objetivo de este artículo es...
Las relaciones de las influencias en los procesos de producción informativa y sus efectos en la calidad periodística. Una visión desde Latinoamérica
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Este artículo busca determinar cómo los condicionantes de los procesos de producción informativa afectan a la calidad periodística. Para ello, la investigación parte de 120 entrevistas semiestructuradas a periodistas chilenos, ecuatorianos y mexicanos. Los resultados muestran que las rutinas son el elemento determinante en la creación de un periodismo de calidad en el actual ecosistema mediático. Asimismo, se observa el vínculo existente entre los diferentes condicionantes propios de la...
Changes in Motor Competence after a Brief Physical Education Intervention Program in 4 and 5-Year-Old Preschool Children
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Low motor competence (MC) can cause low participation in physical activities in preschool children, and together with a high caloric intake, it can lead to obesity. Interventions on motor skills are effective in the short term to improve MC, therefore the objectives of this study were (1) to investigate the effect of a short six-week program on levels of motor competence in preschool children, and (2) to examine the effects of gender-based intervention. A total of 156 preschool children (5.20...
Effect of a 6-Week Physical Education Intervention on Motor Competence in Pre-School Children with Developmental Coordination Disorder
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The objective of this research was to analyze the impact of an intervention program performed by a specialist in physical education (PE) to contribute to the development of motor competence (MC) in pre-school children with motor development problems. The sample consisted of 28 children (12 from the intervention group and 16 from the control group) aged between 4.1 and 5.9 years (mean = 4.71 ± 0.54) who were in the fifth and sixth grades of pre-school education in two schools from Lugo, Spain....
When Populists Govern the Country: Strategies of Legitimization of Anti-Immigration Policies in Salvini’s Italy
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The study aims at disclosing the narrative of immigration and the construction of the otherness in Italian Interior Minister, Matteo Salvini’s discourse, geared towards the legitimization of anti-immigration policies. For this purpose, the author analyzes a sample of the Italian Interior Minister’s discourses related to three cases of migrant landings, drawing on Proximization Theory, revealing how the concepts of closeness and remoteness are manipulated for the construction of threat and the...
The influence of emotional state on risk perception in pedestrians: A psychophysiological approach
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Traffic accidents involving pedestrians represent one of the most relevant causes of death and injury around the world. Several studies have underlined the role of risk perception as a clear predictor of risky behaviour in pedestrians. However, risk perception is an ability susceptible to be altered as a consequence of some circumstances and psychological issues, such as emotional states. The present research aimed to study the influence of two emotions (happiness and sadness) on risk...
Social cognition, personality dimensions and clinical symptoms as variable predictors in people with polydrug abuse in treatment
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The consumption of substances has been related to difficulties in terms of social cognition and personality. Our objective was to estimate the relationship between social cognition, personality variables and clinical symptoms as variable predictors of addictive behavior. The study included a total of 54 participants from different drug associations in Spain. Statistically significant differences in reaction time in emotional recognition were observed in happiness, disgust, sadness and anger....
Development of the Pedestrian Anger Scale. A Pilot Study
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Anger has been closely related to risky behavior, and this last has been related to road accidents. The current research aimed to develop and validate a self-report questionnaire to measure anger in pedestrians (n = 550, 40.73% male) of a wide age rage (14-65 years, M = 27.91, SD = 13.21). The Parallel Analysis showed that the 15 items of the Pedestrian Anger Scale fitted satisfactorily in a four-factor solution: Anger because of obstructions or slowdowns caused by other pedestrians (α = .79),...
Validation of a Scale for Assessing Social Validity in Mindfulness-Based Educational Programs
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
The CaMir-R is a short version of the original questionnaire which assesses attachment cognitions. Specifically, it is focused on subjects´ evaluations of their past and present attachment experiences, and their personal interpretations of parents´ attitudes during childhood. The aim of this study was to validate the CaMir-R in Spanish adult population. A total of 433 university students (121 men and 350 women) and 38 anorexic women completed the CaMir-R and other measures of eating disorder...
Psychometrics of the SCL-90-R and Development and Testing of Brief Versions SCL-45 and SCL-9 in Infertile Couples
Repositorio: UNEATLANTICO. Repositorio Institucional de la Universidad Europea del Atlántico
Background
Although infertile couples are mentally healthy, dealing with infertility and assisted reproductive technology (ART) treatment is usually associated with psychological distress. It would therefore be useful to have short, multidimensional instruments to be able to identify people who present more intense emotional reactions and follow up their emotional distress throughout the ART.
Objectives
The goals of the study were to analyze the psychometric adequacy of the original 90-item...