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Metabolic and Functional Improvements in a Patient with Charcot-Marie-Tooth Disease Type 2 after EGCG Administration: A Case Report

Repositorio: r-FISABIO. Repositorio Institucional de Producción Científica
Bustos A, Sabater P, Benlloch M, Drehmer E, Lopez-Rodriguez M, Platero F, Platero J, Escriba-Alepuz J, Orti J

Background and objectives: The aim of this study was to report a case of a patient with Charcot-Marie-Tooth disease type 2 (CMT2) treated with epigallocatechin gallate (EGCG) for 4 months in order to assess its therapeutic potential in CMT2. Materials and Methods: The study included a brother and a sister who have CMT2. The sister received 800 mg of EGCG for 4 months, while her brother received placebo for the same period of time. Both participants were assessed before and after daily…



Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer's Disease

Repositorio: r-FISABIO. Repositorio Institucional de Producción Científica
Monge-García V, García-Ayllón MS, Sáez-Valero J, Sánchez-Payá J, Navarrete-Rueda F, Manzanares-Robles J, Gasparini-Berenguer R, Romero-Lorenzo R, Cortés-Gómez MA, Monge-Argilés JA

Background: Alzheimer's disease (AD) is characterized by the presence of beta-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by alpha-synuclein (alpha-syn) inclusions. Some authors examine alpha-syn protein in the neurodegeneration process of AD and propose to consider cerebrospinal fluid (CSF) alpha-syn as a possible additional biomarker to the so-called "core" of AD. Objective: To determine whether there is a correlation between…



Mediterranean Diet Adherence and Eating Disorders in Spanish Nurses with Shift Patterns: A Cross-Sectional Study

Repositorio: r-FISABIO. Repositorio Institucional de Producción Científica
Leyva-Vela B, Reche-Garcia C, Hernandez-Morante J, Martinez-Olcina M, Miralles-Amoros L, Martinez-Rodriguez A

Background and Objectives: Shift work has a significant influence on the mental health of workers. Nursing is characterised by a rotational work system. This study aimed to determine whether there was a link between adherence to the Mediterranean diet (MD) and the risk of suffering an eating disorder (ED) in nurses according to their work shift. Materials and Methods: A total of 240 women (nurses and nursing assistants) were evaluated and completed the PREDIMED-PLUS questionnaire on adherence…



Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review.

Repositorio: r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Yoon S, Li H, Lee KH, Hong SH, Kim D, Im H, Rah W, Kim E, Cha S, Yang J, Kronbichler A, Kresse D, Koyanagi A, Jacob L, Ghayda RA, Shin JI, Smith L

Background and objectives: Characterization of pediatric coronavirus disease 2019 (COVID-19) is necessary to control the pandemic, as asymptomatic or mildly infected children may act as carriers. To date, there are limited reports describing differences in clinical, laboratory, and radiological characteristics between asymptomatic and symptomatic infection, and between younger and older pediatric patients. The objective of this study is to compare characteristics among: (1) asymptomatic…



Meta-Analysis of Prevalence of Depression in Dental Students during COVID-19 Pandemic.

Repositorio: r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Santabárbara J, Ozamiz-Etxebarria N, Idoiaga N, Olaya B, Bueno-Novitol J

Background and Objectives: The COVID-19 pandemic has a negative impact on the mental health of the population in general, and in college students in particular. Dental students have seen their teaching altered and their clinical practice reduced. This study was aimed at conducting a systematic review and meta-analysis of studies reporting levels of depression among dental students during the COVID-19 and estimating the pooled prevalence of depression. Materials and Methods: Medline via…



Prevenir y combatir los diferentes tipos de violencia contra la infancia y adolescencia LGTBI+: guía para profesionales, How to Prevent and Combat Violence Against LGBTI+ and Gender Non Conforming Children and Youth: A Handbook for Professionals working in: Education, Health, Family Associations and Child Protection Agencies, Media and Public Spaces, Kaip užkirsti kelią įvairių formų smurtui prieš LGBTI+ vaikus?: Vadovas profesionalams, dirbantiems švietimo, sveikatos apsaugos, paramos šeimoms, žiniasklaidos ir viešojo sektoriaus srityse, Jak zapobiegać i przeciwstawiać się dyskryminacji oraz przemocy wobec dzieci i młodzieży LGBTI+?: Podręcznik dla specjalistów i specjalistek pracujących w dziedzinie edukacji, ochrony zdrowia, mediów, administracji, w stowarzyszeniach rodzinnych i organizacjach zajmujących się ochroną praw dziecka, Kako spriječiti i suzbiti različite vrste nasilja nad LGBTI+ i rodno nenormativnom djecom: Priručnik za stručnjake_inje koji_e rade u područjima obrazovanja i zdravstva, u udrugama koje se bave obiteljskom tematikom i službama za zaštitu djece, u medijima i javnim prostorima, Hoe Verschillende Soorten Geweld Tegen LGBTI+- en Gendervariante Kinderen Voorkomen en Bestreden Kunnen Worden: Een Handboek voor Professionelen tewerkgesteld in het Onderwijs, de Gezondheidssector, Gezinsverenigingen en Kinderbeschermingsorganisaties, de Media en Publieke Ruimtes, Kako preprečevati različne oblike nasilja nad LGBTI+ otroki in mladimi, ki svojo spolno identiteto in spolni izraz izražajo na načine, ki so v družbi prepoznani kot spolno nenormativni?: Priročnik za strokovnjake, ki delujejo na področju izobraževanja, zdravstva, družinskih združenj in organizacij za zaščito otrok, medijev in javnih prostorov, Πώς να αποτρέψετε και να καταπολεμήσετε διάφορες μορφές βίας κατά των ΛΟΑΤΙ+ και των μη συμμορφούμενων με το φύλο τους παιδιών: Εγχειρίδιο για Επαγγελματίες που εργάζονται στους Τομείς: της Εκπαίδευσης, της Υγείας, της Οικογενειακής Μέριμνας και της Παιδικής Προστασίας, των Μέσων Μαζικής Ενημέρωσης και σε Δημόσιους Χώρους, Hogyan léphetünk fel az LMBTQI és nemileg nonkonform gyermekekkel és fiatalokkal szembeni erőszak ellen?: Kézikönyv az alábbi területeken dolgozó szakembereknek: oktatás, egészségügy, családszervezetek, családsegítő szolgálatok és gyermekvédelmi intézmények, média, közösségi terek, Como Prevenir e Combater a Violência contra Crianças e Jovens LGBTI+ e de Género Diverso: Áreas : Educação, Saúde, Trabalho com Famílias, Média, Espaços Públicos e Intervenção Comunitária

Repositorio: DUGiDocs – Universitat de Girona
Diversity and Childhood (Projecte), Sándor, Bea

Coordinador del projecte: Universitat de Girona; Autoria: Bea Sándor; Adaptació a l'espanyol: Núria Sadurní, Beatriz San Román, Jose Antonio Langarita, Marisela Montenegro, Pilar Albertín i Joan Pujol; Disseny gràfic: Zsolt S. Szabó; Adaptació gràfica de la guia: Cristina de Dios, This handbook was created within the framework of the Diversity and Childhood: Changing social attitudes towards gender diversity in children across Europe (DaC) project. As its main expected results, the project seeks to raise awareness and reduce prejudice, as well as to improve protection against violence and support for LGBTI+ and gender non-conforming children and youth.1 DaC also aims to provide effective tools to stakeholders and envisages strengthening the well-being and the…, Este manual ha sido elaborado en el marco del proyecto de Diversity and Childhood: Cambiando las actitudes sociales hacia la diversidad de género en la infancia en toda Europa (DaC). Dicho proyecto trata de sensibilizar y reducir los prejuicios, así como de mejorar los mecanismos de protección contra la violencia hacia la infancia y la adolescencia LGTBI+. El proyecto DaC también tiene como objetivo proporcionar instrumentos eficaces a las profesionales, 1 fortalecer el bienestar y los…, Projecte "Diversity and childhood: changing social attitudes towards gender diversity in children across Europe", finançat pel Programa de Drets, Igualtat i Ciutadania (2014-2020) de la Unió Europea (REC-RDAP-GBV-AG-2018-856680)



Interactive App: Frequently Asked Questions about violence against LGBTI+ children

Repositorio: DUGiDocs – Universitat de Girona
Diversity and Childhood (Projecte)

Frequently Asked Questions about violence against LGBTI+ children for Interactive App in English, Hungarian, Dutch, Croatian, Polish, Greek, Lithuanian, Portuguese, Slovenian, and Spanish, Projecte "Diversity and childhood: changing social attitudes towards gender diversity in children across Europe", finançat pel Programa de Drets, Igualtat i Ciutadania (2014-2020) de la Unió Europea (REC-RDAP-GBV-AG-2018-856680)



Oral Administration of Cannabis and Delta-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review

Repositorio: r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Poyatos, L, Perez-Acevedo, AP, Papaseit, E, Perez-Mana, C, Martin, S, Hladun, O, Siles, A, Torrens, M, Busardo, FP, Farre, M

Background and objective: Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for both recreational and therapeutic use. From a therapeutic perspective, oral cannabis containing Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is a promising route of administration but there is still little information about its pharmacokinetics (PK…



UHPLC-HRMS and GC-MS Screening of a Selection of Synthetic Cannabinoids and Metabolites in Urine of Consumers

Repositorio: r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Pellegrini, M, Marchei, E, Papaseit, E, Farre, M, Zaami, S

Background and Objectives: The use of synthetic cannabinoids has increased around the world. As a result, the implementation of accurate analysis in human biological matrices is relevant and fundamental. Two different analytical technologies, ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) and high-sensitivity gas chromatography-mass spectrometry (GC-MS) were used for the determination of three synthetic cannabinoids JWH-122, JWH 210, UR-144 and their…



Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data

Repositorio: r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Giorgi-Pierfranceschi, M, Monreal, M, Di Micco, P, Francisco, I, Hernandez-Blasco, L, Madridano, O, Lopez-Saez, JB, Hernando, E, Meireles, J, Dentali, F

Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbolica) registry to compare mortality, VTE recurrence, and major bleeding risk in smoking versus non-smoking patients with acute VTE. Results: 50,881 patients (43,426 non-smoking and 7455 smoking…



Fracture Resistance of New Metal-Free Materials Used for CAD-CAM Fabrication of Partial Posterior Restorations

Repositorio: r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Garcia-Engra G, Fernandez-Estevan L, Casas-Terron J, Fons-Font A, Castelo-Baz P, Agustin-Panadero R, Roman-Rodriguez J

Background and Objectives: To evaluate in vitro the fracture resistance and fracture type of computer-aided design and computer-aided manufacturing (CAD-CAM) materials. Materials and Methods: Discs were fabricated (10 x 1.5 mm) from four test groups (N = 80; N = 20 per group): lithium disilicate (LDS) group (control group): IPS e.max CAD(R); zirconium-reinforced lithium silicate (ZRLS) group: VITA SUPRINITY(R); polymer-infiltrated ceramic networks (PICN) group: VITA ENAMIC(R); resin…



Eating Disorders in Pregnant and Breastfeeding Women: A Systematic Review.

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Martínez-Olcina M, Rubio-Arias JA, Reche-García C, Leyva-Vela B, Hernández-García M, Hernández-Morante JJ, Martínez-Rodríguez A

Background: Pregnancy is a stage associated with various biopsychosocial changes. These changes, along with concerns about keeping an adequate weight, can modulate an individual's risk for psychological disorders, especially eating disorders (EDs). The aim of this review was to investigate the prevalence, associated risks, and consequences of eating disorders in pregnancy and in breastfeeding mothers. Materials and Methods: A systematic review was carried out following the PRISMA…



Mediterranean Diet Adherence and Eating Disorders in Spanish Nurses with Shift Patterns: A Cross-Sectional Study

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Leyva-Vela B, Reche-Garcia C, Jose Hernandez-Morante J, Martinez-Olcina M, Miralles-Amoros L, Martinez-Rodriguez A

Background and Objectives: Shift work has a significant influence on the mental health of workers. Nursing is characterised by a rotational work system. This study aimed to determine whether there was a link between adherence to the Mediterranean diet (MD) and the risk of suffering an eating disorder (ED) in nurses according to their work shift. Materials and Methods: A total of 240 women (nurses and nursing assistants) were evaluated and completed the PREDIMED-PLUS questionnaire on…



Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer's Disease

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Monge-Garcia V, Garcia-Ayllon M, Saez-Valero J, Sanchez-Paya J, Navarrete-Rueda F, Manzanares-Robles J, Gasparini-Berenguer R, Romero-Lorenzo R, Cortes-Gomez M, Monge-Argiles J

Background: Alzheimer's disease (AD) is characterized by the presence of beta-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by alpha-synuclein (alpha-syn) inclusions. Some authors examine alpha-syn protein in the neurodegeneration process of AD and propose to consider cerebrospinal fluid (CSF) alpha-syn as a possible additional biomarker to the so-called "core" of AD. Objective: To determine whether there is a correlation between…



Palliative Sedation in COVID-19 End-of-Life Care. Retrospective Cohort Study

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Ramos-Rincon J, Moreno-Perez O, Gomez-Martinez N, Priego-Valladares M, Climent-Grana E, Marti-Pastor A, Portilla-Sogorb J, Sanchez-Martinez R, Merino E

Background and Objectives: Descriptions of end-of-life in COVID-19 are limited to small cross-sectional studies. We aimed to assess end-of-life care in inpatients with COVID-19 at Alicante General University Hospital (ALC) and compare differences according to palliative and non-palliative sedation. Material and Methods: This was a retrospective cohort study in inpatients included in the ALC COVID-19 Registry (PCR-RT or antigen-confirmed cases) who died during conventional admission from 1…



Weight Loss Strategies in Male Competitors of Combat Sport Disciplines

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Martinez-Rodriguez A, Vicente-Salar N, Montero-Carretero C, Cervello-Gimeno E, Roche E

Background and objective: The use of suboptimal weight loss strategies in order to reach specific weight ranges as observed in combat sport disciplines can give rise to severe health problems. However, particular aspects regarding management of weight category comparing three sport disciplines remain to be investigated. Therefore, the aim of the present study was to obtain information regarding the weight loss strategies that competitors performed before a tournament. Materials and Methods:…



Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Caballero-Garcia A, Perez-Valdecantos D, Guallar P, Caballero-Castillo A, Roche E, Noriega D, Cordova A

Background and Objectives: Vitamin D, in addition to its effect on mineral homeostasis, plays a key role in muscle metabolism. Vitamin D supplementation is involved in muscle recovery after damage as a consequence of either pathology or after high-intensity exercise. In this context, the aim of this study was to analyze the effect of vitamin D on muscle fitness in elderly patients in the recovery phase after SARS-CoV-2 (COVID-19) infection. Materials and Methods: This pilot study was conducted…



The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Caballero-Garcia A, Noriega D, Bello H, Roche E, Cordova-Martinez A

Vaccines are the only way to reduce the morbidity associated to SARS-CoV-2 infection. The appearance of new mutations urges us to increase the effectiveness of vaccines as a complementary alternative. In this context, the use of adjuvant strategies has improved the effectiveness of different vaccines against virus infections such as dengue, influenza, and common cold. Recent reports on patients infected by COVID-19 reveal that low levels of circulating vitamin D correlate with a severe…



Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data.

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Giorgi-Pierfranceschi M, Monreal M, Di Micco P, Francisco I, Hernández-Blasco L, Madridano O, López-Sáez JB, Hernando E, Meireles J, Dentali F, The Riete Investigators

Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbólica) registry to compare mortality, VTE recurrence, and major bleeding risk in smoking versus non-smoking patients with acute VTE. Results: 50,881 patients (43,426 non-smoking and 7455…



Knowledge and Attitudes about the Flu Vaccine among Pregnant Women in the Valencian Community (Spain)

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Rodriguez-Blanco N, Tuells J

Background and Objectives: To describe the knowledge and attitudes related to the acceptance of the flu vaccine during pregnancy in women, from two Health Departments of the Valencian Community (VC), during the 2015-2016 season, after receiving prenatal care. Materials and Methods: A prospective observational study was conducted during the annual vaccine season of women ascribed to prenatal care. A midwife offered flu vaccine advice and afterwards conducted a telephone poll of a representative…



Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study.

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Caro-Martínez E, Abad-Collado S, Escrivá-Cerrudo B, García-Almarza S, García-Ródenas MDM, Gómez-Merino E, Serrano-Mateo MI, Ramos-Rincón JM

Background and Objectives. The aim of this study is to compare clinical and epidemiological characteristics and outcomes in patients with versus without nosocomial COVID-19 after exposure to SARS-CoV-2 and to analyze the risk factors for severe outcomes of COVID-19 in a long-term hospital in Spain. Materials and methods. This retrospective, single-center observational study included all inpatients in a long-term hospital during a COVID-19 outbreak from 21 January to 15 March 2021. Results…



Post-ERCP Pancreatitis: Prevention, Diagnosis and Management

Repositorio: r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Cahyadi O, Tehami N, De-Madaria E, Siau K

Endoscopic retrograde cholangiopancreatography (ERCP) carries a post-ERCP pancreatitis (PEP) rate of 2-10%, which could be as high as 30-50% in high-risk cases. PEP is severe in up to 5% of cases, with potential for life-threatening complications, including multi-organ failure, peripancreatic fluid collections, and death in up to 1% of cases. The risk of PEP is potentially predictable and may be modified with pharmacological measures and endoscopist technique. This review covers the definition…



Role of Biomarkers for the Diagnosis of Prion Diseases: A Narrative Review

Repositorio: r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Altuna, M, Ruiz, I, Zelaya, MV, Mendioroz, M

Prion diseases are progressive and irreversible neurodegenerative disorders with a low incidence (1.5-2 cases per million per year). Genetic (10-15%), acquired (anecdotal) and sporadic (85%) forms of the disease have been described. The clinical spectrum of prion diseases is very varied, although the most common symptoms are rapidly progressive dementia, cerebellar ataxia and myoclonus. Mean life expectancy from the onset of symptoms is 6 months. There are currently diagnostic criteria based on…