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ABSELL-FEDERICO-TENA WORLD TRADE HISTORICAL DATABASE 1948-2020 : LESOTHO
- Absell, Christopher
- Federico, Giovanni
- Tena Junguito, Antonio
ABSELL-FEDERICO-TENA WORLD TRADE HISTORICAL DATABASE 1948-2020 : PARAGUAY
- Absell, Christopher
- Federico, Giovanni
- Tena Junguito, Antonio
DYNAMICS OF OLIGODENDROCYTE POPULATIONS FOLLOWING PMCAO PROMOTES LONG-TERM SPONTANEOUS REMYELINATION OF DAMAGED AREA
- Martín López, Gerardo
- R. Mallavibarrena, Paula
- Villa González, Mario
- Vidal, Noemi
- Perez Alvarez, Maria Jose
Stroke is a major public health concern, whit limited clinically approved interventions available to enhance sensorimotor recovery beyond reperfusion. Remarkably, spontaneous recovery is observed in certain stroke patients, suggesting the existence of a self-brain repair mechanism not yet fully understood. In a rat model of permanent cerebral ischemia, we described an increase in oligodendrocytes expressing 3RTau in damaged area. Considering that restoration of myelin integrity ameliorates symptoms in many neurodegenerative diseases, here we hypothesize that this cellular response could trigger remyelination. Our results revealed after ischemia an early recruitment of OPCs to damaged area, followed by their differentiation into 3RTau+ pre-myelinating cells and subsequent into remyelinating oligodendrocytes. Using rat brain slices and mouse primary culture we confirmed the presence of 3RTau in pre-myelinating oligodendrocytes and a subset of mature. The myelin status analysis confirmed long-term remyelination in the damaged area. Postmortem samples from stroke subjects showed a reduction in oligodendrocytes, 3RTau+ cells, and myelin complexity in subcortical white matter. In conclusion, the dynamics of oligodendrocytes populations after ischemia reveals a spontaneous brain self-repair mechanism which restores the functionality of neuronal circuits long-term by remyelination of damage area. This is evidenced by the improvement of sensorimotor functions in ischemic rats. A deep understanding of this mechanism could be valuable in the search for alternative oligodendrocyte-based, therapeutic interventions to reduce the effects of stroke.
This dataset contains the raw data of cuantificación used in this study. It includes all the observations and measurements that were collected, which are essential for analysis and interpretation. The data is organized in a way that facilitates further exploration and analysis, ensuring that researchers can effectively utilize it for their own studies.
LLISTA DE MITJANS EN LLENGUA CATALANA AMB PRESÈNCIA A YOUTUBE
LIST OF MEDIA IN THE CATALAN LANGUAGE WITH A PRESENCE ON YOUTUBE
- Boté-Vericad, Juan-José
IDENTIFYING FUNCTIONAL URBAN AREAS IN ECUADOR USING A VARYING TRAVEL TIME APPROACH (CODE AND RAW DATA)
- Obaco Álvarez, Moisés Lenyn
- Royuela Mora, Vicente
DATASET OF THE WORK - THE SHORT-RUN RELATIONSHIP BETWEEN INEQUALITY AND GROWTH: EVIDENCE FROM OECD REGIONS DURING THE GREAT RECESSION
- Royuela Mora, Vicente
- Veneri, Paolo
- Ramos Lobo, Raúl
SPATIAL CONGRUENCE BETWEEN MULTIPLE STRESSORS IN THE MEDITERRANEAN SEA MAY REDUCE ITS RESILIENCE TO CLIMATE IMPACTS (MAPS - RAW DATA)
- Ramírez Benítez, Francisco José
- Coll Montón, Marta
- Navarro, Joan
- Bustamante, Javier
- Green, Andy J.
LES REVISTES CIENTÍFIQUES DE CATALUNYA 2014-2017 (RAW DATA)
- Navas, Miguel
- Abadal, Ernest
CROSSING THE PILLARS OF HERCULES: UNDERSTANDING TRANSOCEANIC MIGRATIONS OF SEABIRDS THROUGHOUT THEIR BREEDING RANGE (RAW DATA)
- Ramos i Garcia, Raül
FULL ANNUAL MONITORING OF SUBANTARCTIC EMILIANIA HUXLEYI POPULATIONS REVEALS HIGHLY CALCIFIED MORPHOTYPES IN HIGH-CO2 WINTER CONDITIONS [DATASET]
- Rigual Hernández, Andrés Salvador
- Trull, Thomas W.
- Flores Villarejo, José Abel
- Nodder, Scott D.
- Eriksen, Ruth S.
- Davies, Diana M.
- Hallegraeff, G. M.
- Sierro Sánchez, Francisco Javier
- Patil, S. M.
- Cortina, A.
- Ballegeer, Anne Marie Clara
- Northcote, Lisa C.
- Abrantes, Fátima
- Rufino, M. M.