Resultados de investigación

[ES]Superficies de Energía Potencial y otros datos generados durante el proyecto., Proyectos I+D+i Modalidad "Generación de Conocimiento" Financiado por Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación MCIN/AEI/10.13039/501100011033, For each Specific Objective (SO) of the project, a dedicated folder named SO has been created. Each SO folder contains several files or compressed archives, which include the Supplementary Information corresponding to individual publications (see main text for further details). The folder names are aligned with the DOI of the respective articles (e.g., stad1261 for 10.1093/mnras/stad1261). The main texts are accessible through Gredos, when at least one author is affiliated with the University of Salamanca, or through equivalent institutional repositories. Related Publications: https://doi.org/10.1021/acs.jcim.1c01109 https://doi.org/10.1093/mnras/stad1261 https://doi.org/10.1021/acs.jpca.2c08021 https://doi.org/10.1021/acs.jpca.1c10309 https://doi.org/10.1063/5.0062147 https://doi.org/10.1039/D1CP02755G https://doi.org/10.1021/acs.jpclett.2c00587 https://doi.org/10.1103/PhysRevLett.130.033002 https://doi.org/10.3390/ijms24087424 https://doi.org/10.1039/D3SC03044J https://doi.org/10.1021/acs.jpca.3c03763 https://doi.org/10.1021/acs.jctc.3c01379 https://doi.org/10.1039/D4CP01737D https://doi.org/10.1039/D4CP01711K https://doi.org/10.1063/5.0250522 https://doi.org/10.1063/5.0266360 https://doi.org/10.1051/0004-6361/202555202 https://doi.org/10.1016/j.aichem.2023.100017 https://doi.org/10.1039/D3CP03316C https://doi.org/10.1093/MNRAS/STAE2187 https://doi.org/10.3847/1538-4357/AD055E https://doi.org/10.1063/5.0282270 https://doi.org/10.1093/MNRAS/STAF728 https://doi.org/10.1088/1402-4896/ADCE43 https://doi.org/10.3390/polym15143020 https://doi.org/10.3390/ijms25041968 https://doi.org/10.3390/ijms25158027 https://doi.org/10.1021/acs.jcim.5c00991 https://doi.org/10.1021/acs.jcim.5c01338 https://doi.org/10.1002/anie.202515743

[ES]Datos obtenidos del análisis físico-químico y por espectroscoía NIR de 300 lomos de cerdo de diferentes razas y procedencias geográficas (España) recogidas a lo largo de los años 2023-2024 y que forman parte del proyecto mEATquality financiado por el programa de Investigación e Innovación Horizonte 2020 de la Unión Europea (Nº 101000344), El data set incluye mEATquality_datosFQ mEATquality_datosNIR

[EN]This dataset contains raw spectral flow cytometry files (FCS format) generated in a mouse immunization study evaluating an mRNA–lipid nanoparticle (mRNA-LNP) vaccine candidate encoding the Fasciola hepatica fatty-acid–binding protein (FABP). BALB/c mice (n = 6 per group) received a prime–boost immunization regimen (3 weeks apart) with either mRNA-LNP–FABP or control formulations. Peripheral blood was collected longitudinally at multiple time points post-vaccination, and spleens were harvested at study endpoint for immune profiling. Samples were acquired using a spectral flow cytometer (model, manufacturer) with a XX-color panel designed to assess innate and adaptive immune populations. Each FCS file corresponds to an individual sample (blood or spleen) and includes metadata identifying the animal ID, group, time point, and tissue of origin. The dataset enables analysis of vaccine-induced immune responses, including innate activation, T-cell differentiation, and B-cell maturation., Financial support from Grant PID2022-136462NB-I00 funded by “Ministerio de Ciencia e Innovación” and cofinanced by “European Union”. T.S. and M.A.G.-B. Acknowledge funding from the University of Virginia. J.S.-M. acknowledges the predoctoral fellowship program of Junta de Castilla y León, co-funded by “Fondo Social Europeo” (Orden EDU875/2021). CT was supported by an Andrés Laguna fellowship (Junta de Castilla y León, co-financed by the Fondo Social Europeo Plus, FSE+; ORDEN EDU/300/2025).

[EN]Diatom, coccolithophores and key environmental parameters were analyzed during January and early February 2020 at the Drake Passage and Antarctic Peninsula onboard of the research vessel Hespérides. In these data sets we present the results on the temporal variability of diatom and coccolithophore abundance, species composition and variability of key environmental parameters (sea surface temperature, nutrients, …) before and during the onset of an Antarctic marine heat wave. A detailed description of the field experiment, sample processing and counting methods can be found in Rigual-Hernández et al. (2025; Biogeosciences)., Project BASELINE (PID2021- 126495NB-741 C33) funded by the Spanish MCIN/AEI/10.13039/5011000110 33, Diatom abundance and relative abundance of diatom species Coccolithophore abundance and relative abundance of diatom species Environmental parameters

[EN]Qualitative data set - focus groups - students, MCIN/ AEI /10.13039/501100011033/ y FEDER Una manera de hacer Europa

[EN]Qualitative data set - focus groups - migrant parents, MCIN/ AEI /10.13039/501100011033/ y FEDER Una manera de hacer Europa

[EN]Qualitative data set - focus groups - students, MCIN/ AEI /10.13039/501100011033/ y FEDER Una manera de hacer Europa

[EN]Quantitative data set - survey - stakeholders, MCIN/ AEI /10.13039/501100011033/ y FEDER Una manera de hacer Europa

[EN]Quantitative data set - survey - stakeholders, MCIN/ AEI /10.13039/501100011033/ y FEDER Una manera de hacer Europa

[EN]Presbycusis or age-related hearing loss (ARHL) is one of the most prevalent chronic health problems facing aging populations. Along the auditory pathway, the stations involved in transmission and processing, function as a system of interconnected feedback loops. Regulating hierarchically auditory processing, auditory cortex (AC) neuromodulation can, accordingly, activate both peripheral and central plasticity after hearing loss. However, previous ARHL-prevention interventions have mainly focused on preserving the structural and functional integrity of the inner ear, overlooking the central auditory system. In this study, using an animal model of spontaneous ARHL, we aim at assessing the effects of multisession epidural direct current stimulation of the AC through stereotaxic implantation of a 1-mm silver ball anode in Wistar rats. Consisting of 7 sessions (0.1 mA/10 min), on alternate days, in awake animals, our stimulation protocol was applied at the onset of hearing loss (threshold shift detection at 16 months). Click- and pure-tone auditory brainstem responses (ABRs) were analyzed in two animal groups, namely electrically stimulated (ES) and non-stimulated (NES) sham controls, comparing recordings at 18 months of age. At 18 months, NES animals showed significantly increased threshold shifts, decreased wave amplitudes, and increased wave latencies after click and tonal ABRs, reflecting a significant, spontaneous ARHL evolution. Conversely, in ES animals, no significant differences were detected in any of these parameters when comparing 16 and 18 months ABRs, indicating a delay in ARHL progression. Electrode placement in the auditory cortex was accurate, and the stimulation did not cause significant damage, as shown by the limited presence of superficial reactive microglial cells after IBA1 immunostaining. In conclusion, multisession DC stimulation of the AC has a protective effect on auditory function, delaying the progression of presbycusis