Resultados totales (Incluyendo duplicados): 34416
Encontrada(s) 3442 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331206
Dataset. 2022

BOXPLOT DISTRIBUTION OF THE 3 PROTEINS SELECTED FOR VALIDATION (NT-PROBNP, ST-2 AND TIMP-2) ACCORDING TO THE METHODOLOGY USED FOR AF DIAGNOSIS

  • Palà, Elena
  • Bustamante, Alejandro
  • Clúa-Espuny, Josep Lluis
  • Acosta, Juan
  • Gonzalez-Loyola, Felipe
  • Dos Santos, Sara
  • Ribas-Segui, Domingo
  • Ballesta-Ors, Juan
  • Penalba, Anna
  • Giralt, Marina
  • Lechuga-Duran, Iñigo
  • Gentille-Lorente, Delicia
  • Pedrote, Alonso
  • Muñoz, Miguel Ángel
  • Montaner, Joan
Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331206
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331206
HANDLE: http://hdl.handle.net/10261/331206
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331206
PMID: http://hdl.handle.net/10261/331206
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331206
Ver en: http://hdl.handle.net/10261/331206
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331206

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331208
Dataset. 2022

TOP TABLE OF THE DIFFERENTIAL EXPRESSED PROTEINS BETWEEN AF AND NO AF

  • Palà, Elena
  • Bustamante, Alejandro
  • Clúa-Espuny, Josep Lluis
  • Acosta, Juan
  • Gonzalez-Loyola, Felipe
  • Dos Santos, Sara
  • Ribas-Segui, Domingo
  • Ballesta-Ors, Juan
  • Penalba, Anna
  • Giralt, Marina
  • Lechuga-Duran, Iñigo
  • Gentille-Lorente, Delicia
  • Pedrote, Alonso
  • Muñoz, Miguel Ángel
  • Montaner, Joan
S1 Table: Top table of the differential expressed proteins between AF and no AF. Results from the discovery study., Results from the discovery study. Proteins selected to be verified in the whole Phase 1 are highlighted in grey. Proteins in bold but not highlighted were already tested in the whole phase 1 as part of a previous published work., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331208
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331208
HANDLE: http://hdl.handle.net/10261/331208
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331208
PMID: http://hdl.handle.net/10261/331208
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331208
Ver en: http://hdl.handle.net/10261/331208
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331208

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331211
Dataset. 2022

SUPPORTING INFORMATION FOR SMALL, DOI: 10.1002/SMLL.202105915 BOOSTING CHOLESTEROL EFFLUX FROM FOAM CELLS BY SEQUENTIAL ADMINISTRATION OF RHDL TO DELIVER MICRORNA AND TO REMOVE CHOLESTEROL IN A TRIPLE-CELL 2D ATHEROSCLEROSIS MODEL

  • Jebari Benslaiman, Shifa
  • Uribe, Kepa B.
  • Benito-Vicente, Asier
  • Galicia-García, Unai
  • Larrea, Asier
  • Santin, Izortze
  • Alloza, Iraide
  • Vanderbroeck, Koen
  • Ostolaza, Helena
  • Martín, César
13 pages. -- PDF file includes: 1. Supplementary Methods: 1.1. LDL Acetylation; 1.1. Quantitative and Qualitative Analysis of Foam Cell Formation; 1.2. Immunofluorescent Imaging of Co-culture Inserts; 1.4. Western Blot Analysis. -- Supplementary Figure 1. miRNA transfer capacity by DPPC:CE:LPC rHDL to foam cells cultured in monolayer. -- Supplementary Figure 2. Combination of TO901317 and antagomiR-33a-rHDL caused a synergistic upregulation of ABCA1 and ABCG1 protein levels in foam cells. -- Supplementary Figure 3. Intracellular Cholesterol Levels in Foam Cells After TO901317 Treatment, AntagomiR-33a-rHDL Delivery or Combined Treatment of TO901317 and AntagomiR-33a-rHDL in 1D Grown Foam Cells or 2D Atheroma Model Foam Cells. -- Supplementary Figure 4. Cholesterol efflux promoted in foam cells by sequential rHDL administration in a triple cell 2D atheroma model. -- Supplementary Figure 5. Agarose gel electrophoresis of acetylated LDL (LDLac). -- Supplementary Figure 6. Quantitative and Qualitative Analysis of Foam Cell Formation. -- Supplementary Figure 7. Development of triple-compartment cell culture 2D atheroma model. -- Supplementary Figure 8. Timeline showing cholesterol efflux experimental design., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331211
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331211
HANDLE: http://hdl.handle.net/10261/331211
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331211
PMID: http://hdl.handle.net/10261/331211
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331211
Ver en: http://hdl.handle.net/10261/331211
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331211

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331214
Dataset. 2022

ALL PATIENT DATA AND BIOMARKER MEASUREMENTS

  • Palà, Elena
  • Bustamante, Alejandro
  • Clúa-Espuny, Josep Lluis
  • Acosta, Juan
  • Gonzalez-Loyola, Felipe
  • Dos Santos, Sara
  • Ribas-Segui, Domingo
  • Ballesta-Ors, Juan
  • Penalba, Anna
  • Giralt, Marina
  • Lechuga-Duran, Iñigo
  • Gentille-Lorente, Delicia
  • Pedrote, Alonso
  • Muñoz, Miguel Ángel
  • Montaner, Joan
Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331214
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331214
HANDLE: http://hdl.handle.net/10261/331214
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331214
PMID: http://hdl.handle.net/10261/331214
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331214
Ver en: http://hdl.handle.net/10261/331214
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331214

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331238
Dataset. 2022

APPENDIX A. SUPPLEMENTARY DATA FOR DIETARY ECOLOGY OF TWO MIGRANT FLYCATCHERS IN HABITATS WITH AND WITHOUT CATTLE DURING THE BREEDING SEASON IN CENTRAL ARGENTINA

  • Rebollo, María Emilia
  • Jahn, Alex E.
  • Stella, César Adrián
  • Pérez-Rodríguez, Lorenzo
  • Sarasola, José Hernán
  • Cereghetti, Joaquín
Multimedia component 1: Fig. S1. Espinal biome, La Pampa Province, Argentina, characterized by a) open Caldén (Prosopis caldenia) forest, b) closed Caldén forest with shrubs, and c) and d) Caldén forest with grassland. Fig. S2. Location of sites sampled to evaluate arthropod prey abundance of Vermilion Flycatchers and Fork-tailed Flycatchers in the Espinal biome, La Pampa Province, Argentina, during a) 2016–17, and b) 2017-18 and 2018-19 breeding seasons. Fig. S3. Location of sites sampled to evaluate diet of Vermilion Flycatchers (VEFL) and Fork-tailed Flycatchers (FTFL) in the Espinal biome, La Pampa Province, Argentina, during a) 2015–16, b) 2016–17, c) 2017–18 and d) 2018-19 breeding seasons. Fig. S4. Location of control and nest sites sampled to evaluate the effect of arthropod prey abundance on breeding habitat selection of Vermilion Flycatchers (VEFL) and Fork-tailed Flycatchers (FTFL) in the Espinal biome, La Pampa Province, Argentina. All arthropod abundance samples were obtained during the 2016-17 breeding season., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331238
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331238
HANDLE: http://hdl.handle.net/10261/331238
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331238
PMID: http://hdl.handle.net/10261/331238
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331238
Ver en: http://hdl.handle.net/10261/331238
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331238

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331253
Dataset. 2022

APPENDIX A. SUPPLEMENTARY MATERIAL: IS SEROLOGY A REALISTIC APPROACH FOR MONITORING RED DEER TUBERCULOSIS IN THE FIELD?

  • Ferreras-Colino, Elisa
  • Moreno, Inmaculada
  • Arnal, Maria Cruz
  • Balseiro, Ana
  • Acevedo, Pelayo
  • Domínguez, Mercedes
  • Fernández de Luco, Daniel
  • Gortázar, Christian
  • Risalde, María Ángeles
Fig. S1. Ddiagram of flow of participants used in this study., Identification as a study of diagnostic accuracy using at least one measure of accuracy (such as sensitivity, specificity, predictive values, or AUC). Structured summary of study design, methods, results, and conclusions (for specific guidance, see STARD for Abstracts)., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331253
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331253
HANDLE: http://hdl.handle.net/10261/331253
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331253
PMID: http://hdl.handle.net/10261/331253
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331253
Ver en: http://hdl.handle.net/10261/331253
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331253

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331254
Dataset. 2022

SUPPLEMENTARY MATERIAL FOR ARTICLE BROAD TRANSCRIPTOMIC IMPACT OF SORAFENIB AND ITS RELATION TO THE ANTITUMORAL PROPERTIES IN LIVER CANCER CELLS

  • Contreras, Laura
  • Rodríguez-Gil, Alfonso
  • Muntané, Jordi
  • Cruz, Jesús de la
Table S1. List of DEGs in Sfb-treated HepG2 and SNU423 cells. See supplementary Table S1 Excel file. Table S2. List of DEGs with log2(FC) higher than 1.5 or lower than -1.5 in Sfb-treated HepG2 and SNU423 cells. See supplementary Table S2 Excel file. Table S3. List of pathways activated or inhibited upon a Sfb treatment in HepG2 cells. See supplementary Table S3 Excel file. Figure S1. Quantitative RT-PCR validation of RNA-Seq data for HepG2 cells. A selection of down-regulated and up-regulated genes were assessed for gene expression through qPCR. Cells were grown for 24 h and then treated with 10 μM Sorafenib for 12 h before RNA extraction. The table compared the fold expression obtained by RNA-Seq versus the relative expression calculated by RT-PCR. Note that the corresponding mRNA levels quantified by RT-PCR from untreated cells (control) were arbitrarily set at 1.0. The ACTB, BAX, BIRC3, CEBP, CPEB4, DUSP1, EIF4E2, EPOP, FEN1, GADD45B, IDI1, PCNA, SMAD7, TPI and VEGFA genes were analysed. Expression levels were relativized to levels of 28S rRNA of each sample. Values are the mean ± S.D. values of at least three independent experiments performed in triplicate. Statistical significances were analysed by the Student's test (*p< 0.05, **p< 0.01, *** p< 0.001, ****p< 0.0001). Values for upregulated genes are shown in red, while those for downregulated genes are shown in green. Figure S2. Quantitative RT-PCR validation of RNA-Seq data for SNU423 cells. A selection of down-regulated and up-regulated genes were assessed for gene expression through qPCR. Cells were grown for 24 h and then treated with 10 μM Sorafenib for 12 h before RNA extraction. The table compared the fold expression obtained by RNA-Seq versus the relative expression calculated by RT-PCR. Note that the corresponding mRNA levels quantified by RT-PCR from untreated cells (control) were arbitrarily set at 1.0. The BIM, BOP1, BIRC3, CPEB4, DUSP1, EIF4E2, EPOP, GADD45B, IDI1, PHB, PCNA, SMAD7 and TPI genes were analysed. Expression levels were relativized to levels of 28S rRNA of each sample. Values are the mean ± S.D. values of at least three independent experiments performed in triplicate. Statistical significances were analysed by the Student's test (*p< 0.05, **p< 0.01, ***p< 0.001, ****p< 0.0001). Values for upregulated genes are shown in red, while those for downregulated genes are shown in green. Figure S3. Sorafenib lead to translation inhibition in HCC cells. Polysome profiles in HepG2 and SNU423 cells treated or not with Sorafenib (10 μM, 12 h). Cell extracts and polysome profile analysis were performed following the procedure described in Material and Methods. Ten A260 units of each extract were resolved in 7 to 50% sucrose gradients. The A254 was continuously monitored. Sedimentation is from left to right. The identity of the different peaks is indicated. Figure S4. Cholesterol biosynthesis pathway in humans. This outline shows the cholesterol biosynthesis process with those enzymes whose genes were down-regulated by Sfb in red as suggested by our RNA-Seq analysis. The log2(FC) for each one is indicated in brackets. Figure S5. Categories with opposite NES values in HepG2 and SNU423 cell lines. Reactome categories which show NES in opposite directions in the two cell lines analysed with the GSEA. NES and False Discovery Rate (FDR) q-Value are shown for each category. Panel (A) shows categories with FDR lower than 0.3 for HepG2 cells and its value in SNU423 cell line whereas panel (B) shows categories with FDR more significative for SNU423 cells and its respective value for HepG2 cells. Figure S6. Uncropped Western Blots., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331254
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331254
HANDLE: http://hdl.handle.net/10261/331254
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331254
PMID: http://hdl.handle.net/10261/331254
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331254
Ver en: http://hdl.handle.net/10261/331254
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oai:digital.csic.es:10261/331254

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331261
Dataset. 2022

IMAGE_1_CARB-ES-19 MULTICENTER STUDY OF CARBAPENEMASE-PRODUCING KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI FROM ALL SPANISH PROVINCES REVEALS INTERREGIONAL SPREAD OF HIGH-RISK CLONES SUCH AS ST307/OXA-48 AND ST512/KPC-3.PDF

  • Cañada-García, Javier E
  • Moure, Zaira
  • Sola-Campoy, Pedro J.
  • Delgado-Valverde, Mercedes
  • Cano, María Eugenia
  • Gijón, Desirèe
  • González-Bardanca, Mónica
  • Gracia-Ahufinger, Irene
  • Larrosa, M. N.
  • Mulet, Xavier
  • Pitart, Cristina
  • Rivera, Alba
  • Bou, Germán
  • Calvo-Montes, Jorge
  • Cantón, Rafael
  • González-López, Juan José
  • Martínez-Martínez, Luis
  • Navarro, Ferrán
  • Oliver, Antonio
  • Palacios-Baena, Zaira Raquel
  • Pascual, Álvaro
  • Ruiz Carrascoso, Guillermo
  • Vila, Jordi
  • Aracil, Belén
  • Pérez-Vázquez, María
  • Oteo-Iglesias, Jesús
[Objectives] CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain., [Methods] In total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis., [Results] In total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5)., [Conclusion] This study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331261
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331261
HANDLE: http://hdl.handle.net/10261/331261
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331261
PMID: http://hdl.handle.net/10261/331261
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331261
Ver en: http://hdl.handle.net/10261/331261
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331261

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331262
Dataset. 2022

SEXUAL DIFFERENCES IN PHENOTYPICAL PREDICTORS OF FLOATING STATUS: BODY CONDITION INFLUENCES MALE BUT NOT FEMALE REPRODUCTIVE STATUS IN A WILD PASSERINE [DATASET]

  • Redondo, Iraida
Datasets used in the analysis of the manuscript entitled: Sexual differences in phenotypical predictors of floating status: body condition influences male but not female reproductive status in a wild passerine. In Oecologia., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331262
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331262
HANDLE: http://hdl.handle.net/10261/331262
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331262
PMID: http://hdl.handle.net/10261/331262
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331262
Ver en: http://hdl.handle.net/10261/331262
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331262

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331265
Dataset. 2022

TABLE_1_CARB-ES-19 MULTICENTER STUDY OF CARBAPENEMASE-PRODUCING KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI FROM ALL SPANISH PROVINCES REVEALS INTERREGIONAL SPREAD OF HIGH-RISK CLONES SUCH AS ST307/OXA-48 AND ST512/KPC-3.PDF

  • Cañada-García, Javier E
  • Moure, Zaira
  • Sola-Campoy, Pedro J.
  • Delgado-Valverde, Mercedes
  • Cano, María Eugenia
  • Gijón, Desirèe
  • González-Bardanca, Mónica
  • Gracia-Ahufinger, Irene
  • Larrosa, M. N.
  • Mulet, Xavier
  • Pitart, Cristina
  • Rivera, Alba
  • Bou, Germán
  • Calvo-Montes, Jorge
  • Cantón, Rafael
  • González-López, Juan José
  • Martínez-Martínez, Luis
  • Navarro, Ferrán
  • Oliver, Antonio
  • Palacios-Baena, Zaira Raquel
  • Pascual, Álvaro
  • Ruiz Carrascoso, Guillermo
  • Vila, Jordi
  • Aracil, Belén
  • Pérez-Vázquez, María
  • Oteo-Iglesias, Jesús
[Objectives] CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain., [Methods] In total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis., [Results] In total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5)., [Conclusion] This study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331265
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331265
HANDLE: http://hdl.handle.net/10261/331265
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331265
PMID: http://hdl.handle.net/10261/331265
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331265
Ver en: http://hdl.handle.net/10261/331265
Digital.CSIC. Repositorio Institucional del CSIC
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