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Corpus Oral Dialectal (COD). Puigcerdà

  • Perea, Maria Pilar, 1960-
  • Viaplana, Joaquim, 1942-
Aquest document conté la transcripció fonètica, la fonoortogràfica i l'arxiu de so d'un fragment de conversa lliure amb un informant de Puigcerdà que forma part del Corpus Oral Dialectal (COD). El COD és un component del Corpus de Català Contemporani de la Universitat de Barcelona (CCCUB), un arxiu de corpus de llengua catalana oral contemporània que ha estat confegit pel grup de recerca Grup d'Estudi de la Variació (GEV) amb la finalitat de contribuir a l'estudi de la variació dialectal, social i funcional en la llengua catalana. Aquest i altres materials del CCCUB són accessibles directament al Dipòsit Digital de la UB (http://diposit.ub.edu) o a través del web del CCCUB (http://www.ub.edu/cccub).
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Corpus Oral Dialectal (COD). Reus

  • Perea, Maria Pilar, 1960-
  • Viaplana, Joaquim, 1942-
Aquest document conté la transcripció fonètica, la fonoortogràfica i l'arxiu de so d'un fragment de conversa lliure amb un informant de Reus que forma part del Corpus Oral Dialectal (COD). El COD és un component del Corpus de Català Contemporani de la Universitat de Barcelona (CCCUB), un arxiu de corpus de llengua catalana oral contemporània que ha estat confegit pel grup de recerca Grup d'Estudi de la Variació (GEV) amb la finalitat de contribuir a l'estudi de la variació dialectal, social i funcional en la llengua catalana. Aquest i altres materials del CCCUB són accessibles directament al Dipòsit Digital de la UB (http://diposit.ub.edu) o a través del web del CCCUB (http://www.ub.edu/cccub).
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Corpus Oral Dialectal (COD). Tortosa

  • Perea, Maria Pilar, 1960-
  • Viaplana, Joaquim, 1942-
Aquest document conté la transcripció fonètica, la fonoortogràfica i l'arxiu de so d'un fragment de conversa lliure amb un informant de Tortosa que forma part del Corpus Oral Dialectal (COD). El COD és un component del Corpus de Català Contemporani de la Universitat de Barcelona (CCCUB), un arxiu de corpus de llengua catalana oral contemporània que ha estat confegit pel grup de recerca Grup d'Estudi de la Variació (GEV) amb la finalitat de contribuir a l'estudi de la variació dialectal, social i funcional en la llengua catalana. Aquest i altres materials del CCCUB són accessibles directament al Dipòsit Digital de la UB (http://diposit.ub.edu) o a través del web del CCCUB (http://www.ub.edu/cccub).
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Corpus Oral Dialectal (COD). La Seu d'Urgell1

  • Carrera i Sabaté, Josefina
  • Viaplana, Joaquim, 1942-
Aquest document conté la transcripció fonètica, la fonoortogràfica i l'arxiu de so d'un fragment de conversa lliure amb un informant de la Seu d'Urgell que forma part del Corpus Oral Dialectal (COD). El COD és un component del Corpus de Català Contemporani de la Universitat de Barcelona (CCCUB), un arxiu de corpus de llengua catalana oral contemporània que ha estat confegit pel grup de recerca Grup d'Estudi de la Variació (GEV) amb la finalitat de contribuir a l'estudi de la variació dialectal, social i funcional en la llengua catalana. Aquest i altres materials del CCCUB són accessibles directament al Dipòsit Digital de la UB (http://diposit.ub.edu) o a través del web del CCCUB (http://www.ub.edu/cccub).
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Corpus Oral Dialectal (COD). Tamarit de Llitera1

  • Carrera i Sabaté, Josefina
  • Viaplana, Joaquim, 1942-
Aquest document conté la transcripció fonètica, la fonoortogràfica i l'arxiu de so d'un fragment de conversa lliure amb un informant de Tamarit de Llitera que forma part del Corpus Oral Dialectal (COD). El COD és un component del Corpus de Català Contemporani de la Universitat de Barcelona (CCCUB), un arxiu de corpus de llengua catalana oral contemporània que ha estat confegit pel grup de recerca Grup d'Estudi de la Variació (GEV) amb la finalitat de contribuir a l'estudi de la variació dialectal, social i funcional en la llengua catalana. Aquest i altres materials del CCCUB són accessibles directament al Dipòsit UB o a través del web del CCCUB (http://www.ub.edu/cccub).
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Corpus Oral Dialectal (COD). Tàrrega

  • Carrera i Sabaté, Josefina
  • Viaplana, Joaquim, 1942-
Aquest document conté la transcripció fonètica, la fonoortogràfica i l'arxiu de so d'un fragment de conversa lliure amb un informant de Tàrrega que forma part del Corpus Oral Dialectal (COD). El COD és un component del Corpus de Català Contemporani de la Universitat de Barcelona (CCCUB), un arxiu de corpus de llengua catalana oral contemporània que ha estat confegit pel grup de recerca Grup d'Estudi de la Variació (GEV) amb la finalitat de contribuir a l'estudi de la variació dialectal, social i funcional en la llengua catalana. Aquest i altres materials del CCCUB són accessibles directament al Dipòsit UB o a través del web del CCCUB (http://www.ub.edu/cccub).
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Aplastic anemia and severe pancytopenia during treatment with peg-interferon, ribavirin and telaprevir for chronic hepatitis C

  • Lens Garcia, Sabela
  • Calleja, José L.
  • Campillo, Ana
  • Carrion, José A.
  • Broquetas, Teresa
  • Perello, Chrostoe
  • Revilla, Juan de la
  • Mariño, Zoe
  • Londoño, María Carlota
  • Sanchez Tapias, José M.
  • Urbano Ispizua, Álvaro
  • Forns, Xavier
Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin. Pancytopenia due to myelotoxicity caused by these drugs may occur, but severe hematological abnormalities or aplastic anemia (AA) have not been described. We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011. Among 142 cirrhotic patients receiving treatment, 7 cases of severe pancytopenia (5%) were identified and three were consistent with the diagnosis of AA. Mean age was 59 years, five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation. Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy. Three patients had pre-treatment hematological abnormalities related to splenomegaly. In six patients, antiviral treatment was interrupted at the onset of hematological abnormalities. Two patients died due to septic complications and one patient due to acute alveolar hemorrhage. The remaining patients recovered. Severe pancytopenia and especially AA, are not rare during triple therapy with telaprevir in patients with advanced liver disease. Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.
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Biological and Pharmacological aspects of the NK1-Receptor.

  • Garcia-Recio, Susana
  • Gascón, Pere
The neurokinin 1 receptor (NK-1R) is the main receptor for the tachykinin family of peptides. Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is associated with multiple processes: hematopoiesis, wound healing, microvasculature permeability, neurogenic inflammation, leukocyte trafficking, and cell survival. It is also considered a mitogen, and it has been associated with tumorigenesis and metastasis. Tachykinins and their receptors are widely expressed in various human systems such as the nervous, cardiovascular, genitourinary, and immune system. Particularly, NK-1R is found in the nervous system and in peripheral tissues and are involved in cellular responses such as pain transmission, endocrine and paracrine secretion, vasodilation, and modulation of cell proliferation. It also acts as a neuromodulator contributing to brain homeostasis and to sensory neuronal transmission associated with depression, stress, anxiety, and emesis. NK-1R and SP are present in brain regions involved in the vomiting reflex (the nucleus tractus solitarius and the area postrema). This anatomical localization has led to the successful clinical development of antagonists against NK-1R in the treatment of chemotherapy-induced nausea and vomiting (CINV). The first of these antagonists, aprepitant (oral administration) and fosaprepitant (intravenous administration), are prescribed for high and moderate emesis.
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Comparison of strategies to reduce meticillin-resistant Staphylococcus aureus rates in surgical patients: a controlled multicentre intervention trial.

  • Lee, Andie S.
  • Cooper, Ben S.
  • Malhotra-Kumar, S.
  • Chalfine, Annie
  • Daikos, George L.
  • Fankhauser, Carolina
  • Carevic, Biljana
  • Lemmen, Sebastian
  • Martínez, José Antonio (Martínez Martínez)
  • Masuet Aumatell, Cristina
  • Pan, Angelo
  • Phillips, Gabby
  • Rubinovitch, Bina
  • Goossens, Herman
  • Brun-Buisson, Christian
  • Harbarth, Stephan
Objective: To compare the effect of two strategies (enhanced hand hygiene vs meticillin-resistant Staphylococcus aureus (MRSA) screening and decolonisation) alone and in combination on MRSA rates in surgical wards. Design: Prospective, controlled, interventional cohort study, with 6-month baseline, 12-month intervention and 6-month washout phases. Setting: 33 surgical wards of 10 hospitals in nine countries in Europe and Israel. Participants: All patients admitted to the enrolled wards for more than 24 h. Interventions: The two strategies compared were (1) enhanced hand hygiene promotion and (2) universal MRSA screening with contact precautions and decolonisation (intranasal mupirocin and chlorhexidine bathing) of MRSA carriers. Four hospitals were assigned to each intervention and two hospitals combined both strategies, using targeted MRSA screening. Outcome measures: Monthly rates of MRSA clinical cultures per 100 susceptible patients (primary outcome) and MRSA infections per 100 admissions (secondary outcome). Planned subgroup analysis for clean surgery wards was performed. Results: After adjusting for clustering and potential confounders, neither strategy when used alone was associated with significant changes in MRSA rates. Combining both strategies was associated with a reduction in the rate of MRSA clinical cultures of 12% per month (adjusted incidence rate ratios (aIRR) 0.88, 95% CI 0.79 to 0.98). In clean surgery wards, strategy 2 (MRSA screening, contact precautions and decolonisation) was associated with decreasing rates of MRSA clinical cultures (15% monthly decrease, aIRR 0.85, 95% CI 0.74 to 0.97) and MRSA infections (17% monthly decrease, aIRR 0.83, 95% CI 0.69 to 0.99). Conclusions: In surgical wards with relatively low MRSA prevalence, a combination of enhanced standard and MRSA-specific infection control approaches was required to reduce MRSA rates. Implementation of single interventions was not effective, except in clean surgery wards where MRSA screening coupled with contact precautions and decolonisation was associated with significant reductions in MRSA clinical culture and infection rates. Trial registration clinicaltrials.gov identifier: NCT00685867
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Aspirin in the 21st century-common mechanisms of disease and their modulation by aspirin: a report from the 2015 scientific conference of the international aspirin foundation, 28 August, London, UK.

  • Smith, Tom
  • Hutchison, Pippa
  • Schrör, Karsten
  • Clària i Enrich, Joan
  • Lanas, Angel
  • Patrignani, Paola
  • Chan, Andrew T.
  • Din, Farhat
  • Langley Ruth
  • Elwood, Peter
  • Freedman, Andrew
  • Eccles, Ron
Professor Peter Rothwell of Oxford University chaired the annual Scientific Conference of the International Aspirin Foundation in London on 28 August 2015. It took the form of four sessions. Aspirin has more than one action in its effects on disease. Its acetylation of cyclooxygenase 2 (COX-2) in platelets leads to the blockade of pro-inflammatory chemicals and generation of anti-inflammatory mediators and increase in nitrous oxide (NO) production, which helps to preserve arterial endothelium. But platelets are not its only target. There is now evidence that aspirin has a direct antitumour effect on intestinal mucosal cells that block their potential transformation into cancer cells. Randomised placebo-controlled trials (RCTs) in people with histories of colorectal neoplasia have shown that aspirin reduces the risk of recurrent adenomas and reduces long-term cancer incidence in patients with Lynch syndrome. Among women given aspirin for cardiovascular disease, there were fewer cancers than in those given placebo. Epidemiological evidence has suggested that aspirin treatment after cancer is diagnosed reduces the incidence of metastases and prolongs survival, and long-term studies of anticancer treatment with aspirin are under way to confirm this. Apart from cancer studies, aspirin use is now firmly established as treatment for antiphospholipid syndrome (Hughes syndrome) and is being used to prevent and treat the heightened risk of cardiovascular disease in diabetes mellitus and in patients with HIV.
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