Resultados totales (Incluyendo duplicados): 34260
Encontrada(s) 3426 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331760
Dataset. 2022

STRAINS USED IN THIS STUDY. TARGETING EDEM PROTECTS AGAINST ER STRESS AND IMPROVES DEVELOPMENT AND SURVIVAL IN C. ELEGANS

  • Ghenea, Simona
  • Chiritoiu, Marioara
  • Tacutu, Robi
  • Miranda-Vizuete, Antonio
  • Petrescu, Stefana Maria
S1 Table. Strains used in this study., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331760
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331760
HANDLE: http://hdl.handle.net/10261/331760
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331760
PMID: http://hdl.handle.net/10261/331760
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331760
Ver en: http://hdl.handle.net/10261/331760
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331760

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331764
Dataset. 2022

PRIMERS USED IN THIS STUDY. TARGETING EDEM PROTECTS AGAINST ER STRESS AND IMPROVES DEVELOPMENT AND SURVIVAL IN C. ELEGANS

  • Ghenea, Simona
  • Chiritoiu, Marioara
  • Tacutu, Robi
  • Miranda-Vizuete, Antonio
  • Petrescu, Stefana Maria
S2 Table. Primers used in this study., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331764
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331764
HANDLE: http://hdl.handle.net/10261/331764
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331764
PMID: http://hdl.handle.net/10261/331764
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331764
Ver en: http://hdl.handle.net/10261/331764
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331764

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331766
Dataset. 2022

ADDITIONAL FILE 9 OF A COARSE-GRAINED APPROACH TO MODEL THE DYNAMICS OF THE ACTOMYOSIN CORTEX [DATASET]

  • Hernández del Valle, Miguel
  • Valencia-Expósito, Andrea
  • López-Izquierdo, Antonio
  • Casanova-Ferrer, Pau
  • Tarazona, Pedro
  • Martín-Bermudo, María D.
  • Míguez, David G.
Additional file 9: Movie S5. Oscillations in D. Melanogaster basal follicle cells. Experimental conditions. Time-lapse movie of the D. Melanogaster basal follicle cells stained with Lifeact-GFP in conditions of over-expression of the two subunits of the integrin molecule., Ministerio de Ciencia, Innovación y Universidades, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331766
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331766
HANDLE: http://hdl.handle.net/10261/331766
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331766
PMID: http://hdl.handle.net/10261/331766
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331766
Ver en: http://hdl.handle.net/10261/331766
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331766

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331769
Dataset. 2022

RAW NUMERICAL DATA OF ALL THE FIGURES. TARGETING EDEM PROTECTS AGAINST ER STRESS AND IMPROVES DEVELOPMENT AND SURVIVAL IN C. ELEGANS

  • Ghenea, Simona
  • Chiritoiu, Marioara
  • Tacutu, Robi
  • Miranda-Vizuete, Antonio
  • Petrescu, Stefana Maria
S3 Table. Raw numerical data of all the figures., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331769
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331769
HANDLE: http://hdl.handle.net/10261/331769
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331769
PMID: http://hdl.handle.net/10261/331769
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331769
Ver en: http://hdl.handle.net/10261/331769
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331769

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331777
Dataset. 2022

COST-EFFECTIVENESS ANALYSIS OF MOLECULAR DIAGNOSIS BY NEXT-GENERATION SEQUENCING VERSUS SEQUENTIAL SINGLE TESTING IN METASTATIC NON-SMALL CELL LUNG CANCER PATIENTS FROM A SOUTH SPANISH HOSPITAL PERSPECTIVE [DATASET]

  • Álava, Enrique de
  • Pareja, María Jesús
  • Carcedo, David
  • Arrabal, Natalia
  • García, José Francisco
  • Bernabé Caro, Reyes
Table S1. Treatment allocation based on the molecular profile. Table S2. Median PFS and OS and parameters for exponential extrapolation. Table S3. Dosage and estimated monthly costs of the treatments included in the analysis. References only cited in the supplementary material., To assess the cost-effectiveness of using next-generation sequencing (NGS) compared to sequential single-testing (SST) for molecular diagnostic and treatment of patients with advanced non-small cell lung cancer (NSCLC) from a Spanish single-center perspective, the Hospital Universitario Virgen del Rocio (HUVR). A decision-tree model was developed to assess the alterations detection alterations and diagnostic cost in patients with advanced NSCLC, comparing NGS versus SST. Model inputs such as testing, positivity rates, or treatment allocation were obtained from the literature and the clinical practice of HUVR experts through consultation. Several sensitivity analyses were performed to test the robustness of the model. Using NGS for molecular diagnosis of a 100-patients hypothetical cohort, 30 more alterations could be detected and 3 more patients could be enrolled in clinical-trials than using SST. On the other hand, diagnostic costs were increased up to €20,072 using NGS instead of SST. Using NGS time-to-results would be reduced from 16.7 to 9 days. The implementation of NGS at HUVR for the diagnostic of patients with advanced NSCLC provides significant clinical benefits compared to SST in terms of alterations detected, treatment with targeted-therapies and clinical-trial enrollment, and could be considered a cost-effective strategy., This work was funded by Roche Farma S.A., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331777
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331777
HANDLE: http://hdl.handle.net/10261/331777
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331777
PMID: http://hdl.handle.net/10261/331777
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331777
Ver en: http://hdl.handle.net/10261/331777
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331777

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331783
Dataset. 2022

S1 FIG - CROSSLINKING ASSAY TO STUDY A SPECIFIC CARGO-COAT INTERACTION THROUGH A TRANSMEMBRANE RECEPTOR IN THE SECRETORY PATHWAY

  • Manzano-López, Javier
  • Rodríguez-Gallardo, Sofía
  • Sabido-Bozo, Susana
  • Cortés-Gómez, Alejandro
  • Pérez-Linero, Ana María
  • Lucena, Rafael
  • Cordones Romero, Antonio
  • López, Sergio
  • Aguilera-Romero, Auxiliadora
  • Muñíz, Manuel
Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331783
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331783
HANDLE: http://hdl.handle.net/10261/331783
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331783
PMID: http://hdl.handle.net/10261/331783
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331783
Ver en: http://hdl.handle.net/10261/331783
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331783

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331785
Dataset. 2022

S1 PROTOCOLS - CROSSLINKING ASSAY TO STUDY A SPECIFIC CARGO-COAT INTERACTION THROUGH A TRANSMEMBRANE RECEPTOR IN THE SECRETORY PATHWAY

  • Manzano-López, Javier
  • Rodríguez-Gallardo, Sofía
  • Sabido-Bozo, Susana
  • Cortés-Gómez, Alejandro
  • Pérez-Linero, Ana María
  • Lucena, Rafael
  • Cordones Romero, Antonio
  • López, Sergio
  • Aguilera-Romero, Auxiliadora
  • Muñíz, Manuel
Intracellular trafficking through the secretory organelles depends on transient interactions between cargo proteins and transport machinery. Cytosolic coat protein complexes capture specific luminal cargo proteins for incorporation into transport vesicles by interacting with them indirectly through a transmembrane adaptor or cargo receptor. Due to their transient nature, it is difficult to study these specific ternary protein interactions just using conventional native co-immunoprecipitation. To overcome this technical challenge, we have applied a crosslinking assay to stabilize the transient and/or weak protein interactions. Here, we describe a protocol of protein cross-linking and co-immunoprecipitation, which was employed to prove the indirect interaction in the endoplasmic reticulum of a luminal secretory protein with a selective subunit of the cytosolic COPII coat through a specific transmembrane cargo receptor. This method can be extended to address other transient ternary interactions between cytosolic proteins and luminal or extracellular proteins through a transmembrane receptor within the endomembrane system., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331785
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331785
HANDLE: http://hdl.handle.net/10261/331785
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331785
PMID: http://hdl.handle.net/10261/331785
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331785
Ver en: http://hdl.handle.net/10261/331785
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331785

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331789
Dataset. 2022

ADDITIONAL FILE 10 OF A COARSE-GRAINED APPROACH TO MODEL THE DYNAMICS OF THE ACTOMYOSIN CORTEX [DATASET]

  • Hernández del Valle, Miguel
  • Valencia-Expósito, Andrea
  • López-Izquierdo, Antonio
  • Casanova-Ferrer, Pau
  • Tarazona, Pedro
  • Martín-Bermudo, María D.
  • Míguez, David G.
Additional file 10 Figure S5. Oscillations at lower resolution for different energies. Oscillations of the model at lower resolution, at different energies E=1 (left) and E=5 (right). When resolution is lowered, the lower part of the oscillation is filtered out and the increase in energy results in a net increase in the average levels of the actin in cortex, more similar to the effect observed experimentally (Fig. 6 F)., Ministerio de Ciencia, Innovación y Universidades (España), Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331789
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331789
HANDLE: http://hdl.handle.net/10261/331789
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331789
PMID: http://hdl.handle.net/10261/331789
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331789
Ver en: http://hdl.handle.net/10261/331789
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331789

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331791
Dataset. 2023

DATASET INFORMATION AND CODE USED IN EXTRA NESTLINGS THAT ARE CONDEMNED-TO-DIE INCREASE REPRODUCTIVE SUCCESS IN HOOPOES

  • Barón, M. Dolores
  • Martín-Vivaldi, Manuel
  • Martínez-Renau, Ester
  • Soler, Juan José
[How to contribute] For any problems downloading the data or for additional information, please send us an email and we will provide you with the necessary information. We would also appreciate your feedback regarding potential errors., [Ethics statement] All procedures were conducted according to relevant Spanish national (Decreto 105/2011, 19 de abril) and regional guidelines. Necessary permits for hoopoe manipulation were provided by Consejería de Medio Ambiente de la Junta de Andalucía, Spain (Ref: SGYB/FOA/AFR/CFS and SGMN/GyB/JMIF). All applicable guidelines for the care and use of animals were followed., We discuss the potential adaptive functions of laying optimistic clutch sizes that hatch asynchronously in hoopoes, a bird species with frequent sibling cannibalism. The production of extra eggs could serve as insurance against hatching failures, while the surplus hatchlings can be used as food and increase the probability of survival of their older siblings. Two experiments were conducted to explore the adaptative functions of producing extra offspring, one involving food supplementation during the egg-laying period, and the other manipulating brood size and hatching span. Results showed that females with extra food laid one more egg on average and that adding an extra egg that hatched the last increased sibling cannibalism and fledging success. These findings suggest that hoopoes are able to recover part of the cost of producing large clutches by consuming surplus chicks., The research group received funds from the projects PID2020-117429GB-C21 and PID2020-117429GB-C22, funded by the Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación/10.13039/501100011033 and by “Fondo Europeo de Desarrollo Regional, a way of making Europe”. We also benefited from facilities, including an apartment, provided by the city authorities of Guadix., Peer reviewed

DOI: http://hdl.handle.net/10261/331791
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331791
HANDLE: http://hdl.handle.net/10261/331791
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331791
PMID: http://hdl.handle.net/10261/331791
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331791
Ver en: http://hdl.handle.net/10261/331791
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331791

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331792
Dataset. 2022

SUPPORTING INFORMATION CONTROLLED OXYGEN DOPING IN HIGHLY DISPERSED NI-LOADED G-C3N4 NANOTUBES FOR EFFICIENT PHOTOCATALYTIC H2O2 PRODUCTION

  • Du, Ruifeng
  • Xiao, Ke
  • Li, Baoying
  • Han, Xu
  • Zhang, Chaoqi
  • Wang, Xiang
  • Zuo, Yong
  • Guardia, Pablo
  • Li, Junshan
  • Chen, Jianbin
  • Arbiol, Jordi
  • Cabot, Andreu
16 pages. -- PDF file includes: 1.Characterization. -- 2. Electrocatalysis measurement. -- 3. Photocatalytic reduction of oxygen to hydrogen peroxide. -- 4. RRDE test. -- 5. Computational method. -- 6. Apparent quantum yield (AQY) calculations. -- 7. Structural characterization. -- 8. Elemental analysis. -- 9. Band structure. -- 10. Surface area and porosity. -- 11. Calibration for H2O2 quantification. -- 12. Photocatalytic activity. -- 13. Linear sweep voltammetry. -- 14. DFT calculation results. -- 15. Reaction mechanisms., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331792
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331792
HANDLE: http://hdl.handle.net/10261/331792
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331792
PMID: http://hdl.handle.net/10261/331792
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331792
Ver en: http://hdl.handle.net/10261/331792
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331792

Buscador avanzado