Resultados totales (Incluyendo duplicados): 35684
Encontrada(s) 3569 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372306
Dataset. 2024

ADDITIONAL FILE 1 OF EVOLUTIONARY AND FUNCTIONAL ANALYSES OF LRP5 IN ARCHAIC AND EXTANT MODERN HUMANS

  • Roca-Ayats, Neus
  • Maceda, Iago
  • Bruque, Carlos David
  • Martínez-Gil, Núria
  • Garcia-Giralt, Natàlia
  • Cozar, Mónica
  • Mellibovsky, Leonardo
  • Van Hul, Wim
  • Lao, Oscar
  • Grinberg, Daniel
  • Balcells, Susanna
Additional file1., Ministerio de Ciencia e Innovación Generalitat de Catalunya Catalan Government Ministerio de Economía y Competitividad Consejo Superior de Investigaciones Cientificas (CSIC), Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372306
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372306
HANDLE: http://hdl.handle.net/10261/372306
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372306
PMID: http://hdl.handle.net/10261/372306
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372306
Ver en: http://hdl.handle.net/10261/372306
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372306

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372315
Dataset. 2024

SSR AND SNP PROFILES OBTAINED FOR 40 NON-REDUNDANT GRAPEVINE GENOTYPES FOUND IN THE LIVING COLLECTION OF AIN TAOUJDATE (MOROCCO)

  • Zinelabidine, Lalla Hasna
  • Charafi, Jamal
  • Haddioui, Abdelmajid
  • Martínez-Zapater, José M.
  • Ibáñez Marcos, Javier
  • Tello, Javier
This dataset includes the genetic profiles (13 SSR and 240 SNP markers) of 40 grapevine genotypes identified in the living collection of Ain Taoujdate (Morocco), Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372315, https://digital.csic.es/handle/10261/372311
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372315
HANDLE: http://hdl.handle.net/10261/372315, https://digital.csic.es/handle/10261/372311
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372315
PMID: http://hdl.handle.net/10261/372315, https://digital.csic.es/handle/10261/372311
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372315
Ver en: http://hdl.handle.net/10261/372315, https://digital.csic.es/handle/10261/372311
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372315

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372393
Dataset. 2024

SUPPLEMENTARY MATERIALS: DESIGNING ANTITRYPANOSOMAL AND ANTILEISHMANIAL BODIPY DERIVATIVES: A COMPUTATIONAL AND IN VITRO ASSESSMENT

  • Gonçalves, Raquel C. R.
  • Teixeira, Filipe
  • Peñalver, Pablo
  • Costa, Susana P. G.
  • Morales, Juan Carlos
  • Raposo, María Manuela M.
Synthesis and characterization of meso-substituted BODIPY derivatives 1f–i; Synthesis and characterization of formylated BODIPY derivatives 2f, 3c and 3d; Figure S1. Analysis of the chemical structure—antitrypanosomal activity relationship according to the selectivity index (SI) values of the BODIPY derivatives; Figure S2. Analysis of the chemical structure—antileishmanial activity relationship according to the selectivity index values of the BODIPY derivatives; Table S1. Inter-compound distances based on difference counts of Morgan fingerprints of radius 2, normalized so that the maximum distance between the BODYPI derivatives reported in this work was 1.0; Figure S3. Images of the most stable complexes of 1a (a), 1b (b), 1c (c), 1d (d), 1e (e), and 1f (f) with PRLm, as found in the molecular docking studies; Figure S4. Images of the most stable complexes of 1g (a), 1i (b), 1h (c), 2a (d), 2b (e), and 2c (f) with PRLm, as found in the molecular docking studies; Figure S5. Images of the most stable complexes of 2d (a), 2e (b), 2f (c), 3a (d), 3b (e), and 3c (f) with PRLm, as found in the molecular docking studies; Figure S6. Images of the most stable complexes of 3d (a) and 4c (b) with PRLm, as found in the molecular docking studies; Figure S7. Images of the most stable complexes of 1a (a), 1b (b), 1c (c), 1d (d), 1e (e), and 1f (f) with PRTb, as found in the molecular docking studies. Figure S8. Images of the most stable complexes of 1g (a), 1i (b), 1h (c), 2a (d), 2b (e), and 2c (f) with PRTb, as found in the molecular docking studies; Figure S9. Images of the most stable complexes of 2d (a), 2e (b), 2f (c), 3a (d), 3b (e), and 3c (f) with PRTb, as found in the molecular docking studies; Figure S10. Images of the most stable complexes of 3d (a), 4c (b) with PRTb, as found in the molecular docking studies; Figure S11. Adimensional affinities towards the amino acid residues in PRLm impacting the antileishmanial activity of BODIPY derivatives; Table S2. Population of each binding mode for each complex PRLm-BODIPY derivative complex; Table S3. Population of each binding mode for each complex PRTb-BODIPY derivative; Configuration of Autodock Vina used in the docking studies; Python Scripts., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372393
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372393
HANDLE: http://hdl.handle.net/10261/372393
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372393
PMID: http://hdl.handle.net/10261/372393
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372393
Ver en: http://hdl.handle.net/10261/372393
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372393

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372408
Dataset. 2024

SUPPLEMENTARY MATERIALS: GENETIC VARIANTS IN RANK AND OPG COULD INFLUENCE DISEASE SEVERITY AND BONE REMODELING IN PATIENTS WITH EARLY ARTHRITIS

  • Triguero-Martínez, Ana
  • Pardines, Marisa
  • Montes, Nuria
  • Ortiz, Ana María
  • Iglesia-Cedeira, Alba de la
  • Valero-Martínez, Cristina
  • Martín, Javier
  • González-Álvaro, Isidoro
  • Castañeda, Santos
  • Lamana, Amalia
Table S1: Single-nucleotide polymorphisms (SNPs) selected in the study, chromosomal location, minor allele frequency and association with outcomes; Table S2: Multivariable model of relationship between activity at 2-year follow-up assessed by HUPI and rs3134058 in TNFRSF11B; Table S3: Multivariable model of relationship between activity at 2-year follow-up assessed by HUPI and Combined Genotypic Model of SNPs related to TNFRSF11B gene., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372408
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372408
HANDLE: http://hdl.handle.net/10261/372408
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372408
PMID: http://hdl.handle.net/10261/372408
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372408
Ver en: http://hdl.handle.net/10261/372408
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372408

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372438
Dataset. 2024

SUPPLEMENTARY MATERIALS: PICEID OCTANOATE PROTECTS RETINAL CELLS AGAINST OXIDATIVE DAMAGE BY REGULATING THE SIRTUIN 1/POLY-ADP-RIBOSE POLYMERASE 1 AXIS IN VITRO AND IN RD10 MICE

  • Moshtaghion, Seyed Mohamadmehdi
  • Caballano-Infantes, Estefanía
  • Plaza Reyes, Álvaro
  • Valdés-Sánchez, María Lourdes
  • Gallego Fernández, Patricia
  • Cerda, Berta de la
  • Riga, Maurizio S.
  • Álvarez-Dolado, Manuel
  • Peñalver, Pablo
  • Morales, Juan Carlos
  • Díaz-Corrales, Francisco J.
Figure S1: Cell viability of 661W pretreated with PIC and exposed to H2O2. Figure S2: Cell viability of 661W cells pretreated with PIC-OCT and chronically exposed to H2O2. Figure S3: Nuclear and cytoplasmic SIRT1 expression in PIC-OCT-treated cells. Figure S4: Mitochondrial morphology in PIC-OCT-treated cells., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372438
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372438
HANDLE: http://hdl.handle.net/10261/372438
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372438
PMID: http://hdl.handle.net/10261/372438
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372438
Ver en: http://hdl.handle.net/10261/372438
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372438

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372451
Dataset. 2024

SUPPORTING INFORMATION: PHARMACOPHORE IDENTIFICATION AND STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF A SERIES OF SUBSTITUTED AZAINDOLES AS INHIBITORS OF TRYPANOSOMA BRUCEI

  • Ferrins, Lori
  • Díaz, Rosario
  • Cordon-Obras, Carlos
  • Rojas-Barros, Domingo I.
  • Quotadamo, Antonio
  • Oehme, Daniel P.
  • Ceballos-Pérez, Gloria
  • Swaminathan, Uma
  • Pérez-Moreno, Guiomar
  • Bosch-Navarrete, Cristina
  • García-Hernández, Raquel
  • Gómez-Liñán, Claudia
  • Saura, Andreu
  • Ruiz-Pérez, Luis Miguel
  • Gamarro, Francisco
  • Martínez-Martínez, María S.
  • Manzano, Pilar
  • González-Pacanowska, Dolores
  • Navarro, Miguel
  • Pollastri, Michael P.
-Molecular formula strings (CSV)., -Additional data for compounds not included in the text, kinase panel data for 1 and 4s, additional ADME data, T. cruzi and L. donovani data on compounds where available, top-scoring pharmacophore hypothesis (AADDHHR) superimposed on 5i, further profiling information about advanced compounds, washout study of 4h, correlation plot between rate of kill and cidality, PK parameters for 4s, efficacy study information (parasitemia levels and survival means) of 4s, and LCMS chromatogram of 4s (PDF)., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372451
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372451
HANDLE: http://hdl.handle.net/10261/372451
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372451
PMID: http://hdl.handle.net/10261/372451
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372451
Ver en: http://hdl.handle.net/10261/372451
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372451

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372489
Dataset. 2024

SUPPORTING INFORMATION: STRUCTURE-ACTIVITY STUDY ON SUBSTITUTED, CORE-EXTENDED, AND DYAD NAPHTHALENE DIIMIDE G-QUADRUPLEX LIGANDS LEADING TO POTENT ANTITRYPANOSOMAL AGENTS

  • Benassi, Alessandra
  • Peñalver, Pablo
  • Pérez Soto, Manuel
  • Pirota, Valentina
  • Freccero, Mauro
  • Morales, Juan Carlos
  • Doria, Filippo
-CD data; absorption and fluorescence spectra; and 1H NMR, 13C NMR, HPLC, and LC–MS spectra for final compounds (PDF)., -SMILES molecular formula strings (CSV)., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372489
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372489
HANDLE: http://hdl.handle.net/10261/372489
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372489
PMID: http://hdl.handle.net/10261/372489
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372489
Ver en: http://hdl.handle.net/10261/372489
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372489

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372513
Dataset. 2024

SUPPLEMENTARY INFORMATION FOR SYSTEMIC CELLULAR MIGRATION: THE FORCES DRIVING THE DIRECTED LOCOMOTION MOVEMENT OF CELLS

  • De la Fuente, Ildefonso M.
  • Carrasco-Pujante, José
  • Camino-Pontes, Borja
  • Fedetz, María
  • Bringas, Carlos
  • Pérez-Samartín, Alberto
  • Pérez-Yarza, Gorka
  • López, Jose I.
  • Malaina, Iker
  • Cortés, Jesús M.
This PDF file includes: Supplementary text; Figures S1 to S4; Tables S1 to S10; SI References., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372513
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372513
HANDLE: http://hdl.handle.net/10261/372513
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372513
PMID: http://hdl.handle.net/10261/372513
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372513
Ver en: http://hdl.handle.net/10261/372513
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372513

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372519
Dataset. 2024

APPENDIX A. SUPPLEMENTARY DATA: THE ALLERGENIC POTENTIAL OF GREEN URBAN AREAS IN THE MACARONESIAN ISLANDS: THE CASE OF FUNCHAL CITY (MADEIRA)

  • Camacho, Irene
  • Macías de la Rosa, Álvaro
  • Camacho, Roberto
  • Grinn-Gofrón, Agnieszka
  • Cariñanos, Paloma
Supplementary material. Diversity of species, genera and families of trees observed in Municipal Garden and in Santa Catarina Park., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372519
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372519
HANDLE: http://hdl.handle.net/10261/372519
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372519
PMID: http://hdl.handle.net/10261/372519
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372519
Ver en: http://hdl.handle.net/10261/372519
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372519

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372569
Dataset. 2024

SUPPORTING INFORMATION 1: DECIPHERING HOST-PARASITE INTERPLAY IN LEISHMANIA INFECTION THROUGH A ONE HEALTH VIEW OF PROTEOMICS STUDIES ON DRUG RESISTANCE

  • Tagliazucchi, Lorenzo
  • Pinetti, Diego
  • Genovese, Filippo
  • Malpezzi, Giulia
  • Perea Martínez, Ana
  • Manzano, José Ignacio
  • García-Hernández, Raquel
  • Cole, Alexander R.
  • Kwon, Ba Reum
  • Aiello, Daniele
  • Brooks, Bryan W.
  • Thoré, Eli S. J.
  • Bertram, Michael G.
  • Gamarro, Francisco
  • Costi, Maria Paola
DEPs identified in LINF 3323 (antimony resistant) vs control differential analysis (Table S1); DEPs identified in LINF 2126 (paromomycin resistant) vs control differential analysis) (Table S2); DEPs identified in LINF 5159 (miltefosine resistant) vs control differential analysis (Table S3); parameters associated with the three STRING networks generated with all the DEPs from the three resistant lines (Table S4); L. infantum DEGs from García-Hernández et al., 2022 (Table S5); GO′s obtained from the DEPs analysis for proteins-transcripts comparison (Table S6); STRING network generated with all the DEPs from the three resistant strains and their corresponding KEGGS pathways with the FDR value before network enrichment (Figure S1); Leishmania STRING network generated with all the DEPs from the three resistant strains and their corresponding GOs (Biological Process) and REACTOME pathways with the FDR value and the associated FDR after network enrichment (Figure S2); STRING network generated with all the DEPs from the three THP-1 Human proteomes infected with the resistant strains [Tagliazucchi et al.] (Figure S3); GOs (Biological Process) associated with the enriched STRING network in Figure 4, main text, with their corresponding statistics and significance (Table S7); REACTOME Pathways associated with the enriched STRING network in Figure 4, main text, with their corresponding statistics and significance) (Table S8); GOs (Biological Processes) emerged from the network represented in Figure 3, Supporting Information, with their associated statistical parameters (Table S9); REACTOME Pathways emerged from the network represented in Figure 3, Supporting Information, with their associated statistical parameters (Table S10); GOs terms emerged from Venn’s diagram generated by the intersection between GOs from Human and Parasitic biochemical pathways (Table S11); REACTOME Pathways terms emerged from the Venn diagram generated by intersection between GOs from Human and Parasitic biochemical pathways (Table S12); terms of the enriched STRING network generated with the DEPs that do not share the same GOs as the DEPs belonging to the THP-1 cells (Table S13); results from Level 1 SeqAPASS analysis for a novel antiparasitic drug (Table S14); boxplot describing SeqAPASS data illustrating the percent similarity of (A) all protein sequences across species compared to the primary amino acid sequences and (B) functional domain of L. infantum trypanothione Reductase (Figure S5); boxplot describing SeqAPASS data illustrating the percent similarity of (A) all protein sequences across species compared to the primary amino acid sequences and (B) functional domain of L. infantum ATP-Binding cassette protein (Figure S6); boxplot describing SeqAPASS data illustrating the percent similarity of (A) all protein sequences across species compared to the primary amino acid sequences, (B) functional domain of COG1196 Smc and (C) cd99121 MATH domain of L. infantum MATH-domain-containing protein (putative) (Figure S7); boxplot describing SeqAPASS data illustrating the percent similarity of (A) all protein sequence across species compared to the primary amino acid sequences and (B) functional domain of L. infantum Calpain-like cysteine peptidase (Figure S8) (PDF)., Sequence alignment to predict across species susceptibility (SeqAPASS) raw data (XLSX) id4c00185_si_001.pdf (0.98 MB)., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/372569
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372569
HANDLE: http://hdl.handle.net/10261/372569
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372569
PMID: http://hdl.handle.net/10261/372569
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372569
Ver en: http://hdl.handle.net/10261/372569
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/372569

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