Resultados de investigación

Metal–organic frameworks (MOFs) are attractive porous materials for electrocatalytic applications associated with carbon-free energy storage and conversion. This type of material usually requires a post-treatment to be used as electrocatalyst. The present work comprehensively investigates the electrochemical activation of a cobalt-MOF@Nafion composite that produces outstanding electrocatalytic performance for the water oxidation reaction at neutral pH. A detailed electrochemical characterization reveals that the electroactivation of the composite requires the participation of the oxygen evolution reaction (OER) and leads to a significant increase in the electroactive population of cobalt centers. It is shown that an increase of the applied activation potential in the OER region results in a faster electroactivation of the Co-MOF without affecting the intrinsic electrocatalytic properties of the active cobalt centers, as evidenced by the unique linear correlation between the electrocatalytic OER current and the population of electroactive cobalt. In addition, at structural level, it is shown that the electrochemical activation causes the partial disruption of the Nafion adlayer, as well as morphological changes of the Co–MOF particles from a compact, rounded morphology, before electrochemical activation, to a more open and expanded structure, after electroactivation; with the concomitant increase of the number of surface–exposed cobalt centers. Interestingly, these cobalt centers retain their coordinative chemistry and their laminar distribution in the nanosheets at the nanoscale, which is consistent with the preservation of their intrinsic electrocatalytic activity after potential–induced activation. In this scenario, these results suggest that only the electroactivated cobalt centers with good accessibility to the electrolyte are electrochemically active. This work provides a better understanding of the processes and structural changes underlying the electrochemical activation at neutral pH of a Co–MOF for boosting the electrocatalytic water oxidation reaction., File name:ASS_2023_Olloqui_Figuras.docx Description: A Word file with the figure images File name:Figure_1.jnb Description: A sigmaplot file with figure 1. File name:Figure_2.jnb Description: A sigmaplot file with figure 2. File name: Raw_data.zip Description: .nox files with the raw data of voltammetry

Metal-organic frameworks (MOFs) are receiving increased attention as new functional nanomaterials for the development of electrochemical sensors. Herein, we develop an electrochemical platform for non-enzymatic hydrogen peroxide detection built with a composite of two-dimensional cobalt MOF nanosheets and Nafion (2D-Co-MOF@Nafion). The feasibility of the 2D-Co-MOF@Nafion composite as active material for high performance hydrogen peroxide sensor was investigated by using cyclic voltammetry and chronoamperometry. Its voltammetric response reveals an efficient charge transport through the MOF composite, and rapid electron exchange between MOF and electrode. Notably, these MOF nanosheets exhibit enzyme-like activity for the non-common catalytic oxidation of hydrogen peroxide, leading to an electrochemical sensor with rapid quantitative detection, outstanding sensitivity, selectivity, stability, and durability at the desirable neutral pH. In particular, for a cobalt metal loading of 1.2 nanomol, the sensor yields amperometric H2O2 detection with characteristic electrocatalytic parameters of imax= 5.7 mA cm−2 and KM = 13 mM. Moreover, linear ranges of up to either 1 mM or 10 mM are achieved, with sensitivities as high as 570 ± 5 A cm−2 mM−1 or 395 ± 10 A cm−2 mM−1 for the low and high concentration ranges, respectively. The particular coordination chemistry of the MOF consisting of a regular arrangement of multiple Co(II) redox metal sites connected by appropriate organic ligands can provide inherent enzyme-mimicking properties, thereby explaining the higher oxidase-like activity of the present MOF. This work raises the new idea of using two-dimensional cobalt-based MOFs as active nanozymes, offering exciting opportunities in the design of non-enzymatic electrochemical sensing devices., File name: raw data.zip Description: .ocw files with the raw data File name: ASS_2023_Olloqui_Figuras.docx Description: A Word file with the figure images File name: Figure_2_S4.jnb Description: A sigmaplot file with figures 1 and S4. File name: Figure_3_y_4.jnb Description: A sigmaplot file with figures 3 and 4. File name: Figure_6.jnb Description: A sigmaplot file with figure 6. File name: Figure_S3.jnb Description: A sigmaplot file with figure S3.

Se incluyen datos del Proyecto Pintura, poder, sociedad y naturaleza en el Quito barroco (PID2020-112852GB-I00): bibliografías, relación de instituciones en las que se ha investigado, publicaciones de los miembros del Proyecto vinculadas directamente al mismo, tabla, carteles y programas de actividades desarrolladas desde el Proyecto, A) Bibliografías (PDF): -Bibliografía del Proyecto (PDF) -Bibliografía de la monografía Pintura, poder, sociedad y naturaleza en el Quito barroco (PDF) B) Relación de publicaciones generadas por el Proyecto (PDF) C) Tablas (PDF): -Tabla de las especies citadas en las cartelas de los Tipos de la Real Audiencia de Quito (Salgueiro González 2023) (PDF) D) Relación de instituciones en las que se ha realizado el trabajo de campo del Proyecto (PDF) E) Carteles y programas de las actividades organizadas por el Proyecto (PDF y JPG): -Programa del I Simposio Internacional “Arte, historia y cultura en el Quito virreinal” (PDF) -Programa del II Simposio Internacional “Arte, historia y cultura en el Quito virreinal” (PDF) -Programa del Simposio “Mujeres pintoras y la imagen de la mujer en el Quito barroco” (PDF) -Programa del Taller del Seminario de Investigación en Historia Moderna de América (abril de 2022) (PDF) -Programa del Taller del Seminario de Investigación en Historia Moderna de América (abril de 2023) (PDF) -Programa del Taller del Seminario de Investigación en Historia Moderna de América (junio de 2024) (PDF) -Programa del Congreso “Pintura, poder, sociedad y naturaleza en el Quito barroco”. (PDF) -Cartel de Congreso “Pintura, poder, sociedad y naturaleza en el Quito barroco” (JPG) -Cartel del Simposio “Mujeres pintoras y la imagen de la mujer en el Quito barroco” (JPG) F) Publicaciones en Open Access: Se relacionan las publicaciones en Open Access. Se depositarán en idUS aquellas que cuenten con los correspondientes permisos de las editoriales. Las que pertenecen a editoriales con repositorios en línea, y que ya han publicado investigaciones del Proyecto, son las siguientes: buleria.nileon.es, e-revistes.uji.es, rio.upo.es, journals.uco.es, revistas.icanh.gov.co, editorial.ucuenca.edu.ec Martín Rodríguez, P. (2022). Del dibujo de campo a la lámina botánica: Análisis del proceso de trabajo tras una estampa de la Flora peruviana et chilensis. UCOARTE. Revista De Teoría E Historia Del Arte, 11, 67–82. https://doi.org/10.21071/ucoarte.v11i.14231 Justo Estebaranz, Á., Vásquez Hahn, M. A. y Chiva Beltrán, J. (2025, en prensa). «A fin de acreditar la alegría y congratulación que demanda un asunto tan remarcable»: Fiestas en Quito por la Independencia (1822-1830)". Potestas, nº 26. En prensa. Justo-Estebaranz, Á. (2023). La clave está en el herrero: artesanado local y robos de obras de arte y de útiles de trabajo en Quito durante los siglos XVII y XVIII. En A. Contreras-Guerrero, Á. Justo-Estebaranz, & F. Quiles (Eds.), En las sombras del Barroco. Una mirada introspectiva (pp. 305-337). Publicación Enredars/ Andavira Editora. https://rio.upo.es/rest/api/core/bitstreams/b6e40273-bc09-4cc9-b74e-37067b2b64e1/content Justo-Estebaranz, Á. (2023). El Órgano de la Iglesia del Sagrario de Cuenca: Historia e Iconografía. En Memorias del III Encuentro Nacional de Historia de la Provincia del Azuay (pp. 69-86). Universidad de Cuenca. https://editorial.ucuenca.edu.ec/omp/index.php/ucp/catalog/view/78/235/415 Montes Sánchez, M. y Justo-Estebaranz, Á. (2024). Entre retablos, adulterio y cárcel: el batihoja Vicente Egas en Cuenca. En “Y VERÉIS TODA ESTA ARENA DE CARROS DE PLATA LLENA”. ESTUDIOS SOBRE LA PLATA EN IBEROAMÉRICA De los orígenes al siglo XIX (pp. 799-814). Secretaría de Cultura. INAH. Instituto Nacional de Antropología e Historia Coordinación Nacional de Monumentos Históricos (México), Instituto de Humanismo y Tradición Clásica Universidad de León (España).

Mitochondria play a crucial role in cellular energy production, signaling and homeostasis. Respiratory supercomplexes represent evolutionary well-conserved, stable associations between membrane complexes and molecules, including proteins and lipids, within the inner mitochondrial membrane. They dynamically respond to metabolic demands and enhance the electron transfer rate, thereby reducing the production of ROS. Recent research has unveiled cytochrome c, a mobile electron carrier between complexes III and IV, as a potential key player in orchestrating the formation of these supra-associations. This study centers on elucidating the role of cytochrome c in modulating the assembly of supercomplexes, using the Saccharomyces cerevisiae yeast as a model system for mitochondrial metabolism. BN-PAGE and mass spectrometry-based proteomic analysis were employed to examine supercomplex organization in yeast strains expressing different cytochrome c isoforms, grown under fermentative and respiratory conditions. Our results demonstrate that both isoforms of cytochrome c contribute to supercomplex assembly, with isoform-2 significantly improving electron transfer and lowering ROS levels. We propose a model in which cytochrome c acts as a scaffold for the recruitment of assembly factors, facilitating the formation of higher order supercomplexes such as III2IV2. This model highlights cytochrome c's role beyond electron transfer, as it regulates supercomplex assembly and mitochondrial homeostasis., File name: Otras-figuras_Ms_IJBM.docx Description: A Word file with the figure images File name: Raw_data.zip Description: .nox files with the raw data of voltammetry File name: Fig_2+S5+S6+S7.jnb Description: A sigmaplot file with figures 2+S5+S6+S7

Post-translational modifications (PTMs) of proteins are ubiquitous processes present in all life kingdoms, involved in the regulation of protein stability, subcellular location and activity. In this context, cytochrome c (Cc) is an excellent case study to analyze the structural and functional changes induced by PTMS as Cc is a small, moonlighting protein playing different roles in different cell compartments at different cell-cycle stages. Cc is actually a key component of the mitochondrial electron transport chain (ETC) under homeostatic conditions but is translocated to the cytoplasm and even the nucleus under apoptotic conditions and/or DNA damage. Phosphorylation does specifically alter the Cc redox activity in the mitochondria and the Cc non-redox interaction with apoptosis-related targets in the cytoplasm. However, little is known on how phosphorylation alters the interaction of Cc with histone chaperones in the nucleus. Here, we report the effect of Cc Tyr48 phosphorylation by examining the protein interaction with SET/TAF-Iβ in the nuclear compartment using a combination of molecular dynamics simulations, biophysical and structural approaches such as isothermal titration calorimetry (ITC) and nuclear magnetic resonance (NMR) and in cell proximity ligation assays. From these experiments, we infer that Tyr48 phosphorylation allows a fine-tuning of the Cc-mediated inhibition of SET/TAF-Iβ histone chaperone activity in vitro. Our findings likewise reveal that phosphorylation impacts the nuclear, stress-responsive functions of Cc, and provide an experimental framework to explore novel aspects of Cc post-translational regulation in the nucleus., File name: Figuras_Ms_Protein_science.docx Description: A Word file with the figure images File name: Figure_S6a,b,c.jnb Description: A sigmaplot file with figures S6 File name: Raw_data_061023.zip Description: .nox files with the raw data

Este archivo proporciona una versión digital de los caminos por Juan Villuga en 1543. El archivo consta de 139 entidades geográficas de tipo línea, cada entidad representa un camino documentado por Juan Villuga con su respectivo nombre. Se ha utilizado la proyección ETRS89 30N. La vectorización ha sido realizada a partir de dos fuentes: 1) Villuga, Juan. 1543. Repertorio de todos los caminos de España en el año de gracia de 1543. Barcelona: Institut Cartografic i Geològic de Catalunya, R: RL 3419. (Consulta 14/05/2014). http://cartotecadigital.icgc.cat/cdm/singleitem/collection/espanya/id/2618/rec/1; y 2) Villuga, Juan. 1950 [1543]. Repertorio de todos los caminos de España. Madrid: Reimpresiones Bibliográficas., Base de datos espacial en formato shapefiles con 139 entidades geográficas de tipo línea, cada entidad representa un camino documentado por Juan Villuga.

The data presented this work results from the investigation on the pozzolanic activity and environmental impact of Portland cement CEM II produced with calcined slate waste (https://doi.org/10.1016/j.jobe.2024.110044). The data include information on the physical, chemical, and mineralogical characteristics of slate, as well as an indication of its pozzolanic activity. The dataset concerning the environmental impact assessment includes information on the processes of slate extraction, grinding, transportation, and calcination. Additionally, data on the inputs required for the production of 1 tonne of cement and the environmental impact for each studied impact category are provided., Summary Abstract 1 Value 2 Data Description 2.1 Technical assesment 2.2 Environmental assesment 3. Experimental design, materials and methods 3.1 Experimental design 3.2 Materials 3.3 Methods 3.3.1 X-ray diffraction test 3.3.2 X-ray fluorescence test 3.3.3 Loss of ignition test 3.3.4 Furier Transform Infrared Spectrophotometer test 3.3.5 Strength comparison method 3.3.6 Strength Activity Index comparison method 3.3.7 Frattini Test and Saturated lime test 3.3.8 Life cycle assesment 3.4 Equations used 3.4.1 Weight loss on ognition 3.4.2 Strength Activity Index 3.4.3 Frattini test and Saturated lime test 3.4.4 Calculation of the amount of mass to be calcined 3.4.5 Calcination energy calculation 4 References

There is vast amount of research that links implicit theories of intelligence with several learning-relevant variables in both learners and teachers alike. However, there is a gap in the literature, as there is almost no research done with university teachers. Furthermore, most scientific research polarizes incremental and fixed views of intelligence in spite of data that show there is heterogeneity in participants’ views. This study explores the implicit theories of intelligence of university teachers. The sample comprised 20 university teachers (10 men and 10 women) from the University of Seville. Four participants were selected from each field of knowledge, according to the category system in place at the university in question, namely: Arts and Humanities (A&H), Sciences (S), Health Sciences (HS), Social and Legal Sciences (S&LS), and Engineering and Architecture (E&A). Also, the selection process ensured that half the participants had less than 15 years' teaching experience at the university and the other half more than 15 years' experience. A semi-structured interview called "Views on Intelligence within the Educational Field" was designed. Participants were asked to express their opinión about several small vignettes regarding intelligence. The instrument comprises short cases or vignettes, highlighting different dimensions of intelligence. We identified 12 relevant dimensions in which a view on intelligence could be expressed and contextualized. They were: Control, Heredity, Effort, Culture, Training, Critical Period, Context, Expectations, Associated Qualities, People, Gender, and Diversity of Intelligence. Data from interviews were analysed employing a category system designed to capture heterogeneity. The utterances were segmented and analyzed using a coding manual. From the units of meaning extracted from the participant’s responses, we constructed 116 different categories related to intelligence. These categories were later organized into 18 different topics, as several themes arose from the interviews. These topics were: Effort, Genetic Influence, Development in Non-Specific Terms, Global Environment, Formal Education, Culture, Activities, Teacher Influence, Parental Influence, Developmental Characteristics, Motivational and Emotional Influence, Others’ Expectations Influence, Own Expectations Influence, Other Personal Characteristics Influence, Characteristics Associated to Intelligent People, Gender, Presence of Intelligence in Activities Outside Academic Fields, and Social and Emotional Intelligence. Finally, an upper-level hierarchical categorization was developed, where different categories were put together taking into account different criteria in order to obtain global results. These categories are Global Influences of Change (all categories that relate to modifiability of the intelligence), Specific Influences of Change (all categories that expresses the relation of something specific on intelligence), Non-Specific Influences of Change (all categories that expresses that intelligence can or cannot be modified, but not telling how), Individual Influences of Change (all categories related to the individual’s actions and characteristics linked to intelligence malleability), Environmental Influences of Change (all categories related to the environment that may or may not affect the development of intelligence), and Total Genetic Influence (all categories related to genetic influence)., - Base de Datos Concepciones de Inteligencia - Manual de Codificación Concepciones de Inteligencia

The dataset contains the results from transmission electron microscopy, particle size distribution, Raman spectroscopy and optical absorbance of Boron nitride nanosheet (BNNS) suspensions obtained by kitchen blender exfoliation at three rotor velocities. It also contains the results of the microstructural chracterization by scanning electron microscopy of spark plasma sintered ceramic composites with 3 mol% yttria tetragonal zirconia policrystal (3YTZP) matrix and different BNNS contents (1, 2.5 and 5 vol%), and their low temperature hydrothermal degradation study., Absorbance spectra Particle size distributions Raman spectra Scanning electron microscopy images from the fracture surfaces and polished cross section surfaces of the analyzed composites Hydrothermal ageing data