Resultados totales (Incluyendo duplicados): 34260
Encontrada(s) 3426 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331681
Dataset. 2022

ADDITIONAL FILE 1 OF RECOVERY OF SERUM TESTOSTERONE LEVELS IS AN ACCURATE PREDICTOR OF SURVIVAL FROM COVID-19 IN MALE PATIENTS [DATASET]

  • Toscano-Guerra, Emily
  • Martínez-Gallo, Mónica
  • Arrese-Muñoz, Iria
  • Gine, Anna
  • Diaz, Noelia
  • Gabriel-Medina, Pablo
  • Riveiro-Barciela, Mar
  • Labrador-Horrillo, Moisés
  • Martínez-Valle, Fernando
  • Sánchez Montalvá, Adrián
  • Hernández-González, Manuel
  • Pujol Borrell, Ricardo
  • Rodríguez-Frías, Francisco
  • Ferrer, Roser
  • Thomson, Timothy M.
  • Paciucci, Rosana
Additional file 1: Table ST1. Treatments comparison by outcome in male patients. Table ST2. Treatments comparison by outcome in female patients. Table ST3. WHO classification of disease outcome. Table ST4. Panels and antibodies used for immunophenotyping. Figure SF1. Patients distribution by outcome, age, and comorbidities. Figure SF2. Distribution of male patients with comorbidities according to age and testosterone levels. Figure SF3. Longitudinal analysis of serum levels of IL-6, C-reactive protein (CRP), ferritin and lactate dehydrogenase (LDH) in male patients. Figure SF4. Bioavailable testosterone serum levels and correlation between age and sex-hormone binding globulin (SHBG). Figure SF5. Flow cytometry analysis of circulating immune subpopulations in three illustrative cases with moderate, severe survivor and severe deceased outcomes., Ministerio de Ciencia, Innovación y Universidades Consejo Superior de Investigaciones Científicas Agència de Gestió d’Ajuts Universitaris i de Recerca Conselleria d'Educació, Investigació, Cultura i Esport Instituto de Salud Carlos III, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331681
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331681
HANDLE: http://hdl.handle.net/10261/331681
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331681
PMID: http://hdl.handle.net/10261/331681
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331681
Ver en: http://hdl.handle.net/10261/331681
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331681

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331683
Dataset. 2022

SUPPLEMENTAL INFORMATION. SELECTIVE RIBOSOME PROFILING REVEALS A ROLE FOR SECB IN THE CO-TRANSLATIONAL INNER MEMBRANE PROTEIN BIOGENESIS

  • Eismann, Lena
  • Fijalkowski, Igor
  • Galmozzi, Carla Verónica
  • Koubek, Jiří
  • Tippmann, Frank
  • Van Damme, Petra
  • Kramer, Günter
Document S1. Figures S1–S5. Table S1. Ranked list of co-translational SecB substrates, related to Figure 1. Table contains rank, gene name, coverage (number of reads in the total translatome divided by gene length), low_CI (see STAR Methods for details), and subcellular localization. Table S2. Protein quantification of SecB-bound RNCs compared with all ribosomes, related to Figure 1. Table contains UniProt identifier, LFQ intensities of quantified proteins, and protein descriptors (name, biological function, biological processes). Table S3. Ranked list of co-translational SecB substrates in Δtig background, related to Figure 6. Table contains rank, gene name, coverage (number of reads in the total translatome divided by gene length), low_CI (see STAR Methods for details), and subcellular localization. Document S2. Article plus supplemental information., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331683
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331683
HANDLE: http://hdl.handle.net/10261/331683
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331683
PMID: http://hdl.handle.net/10261/331683
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331683
Ver en: http://hdl.handle.net/10261/331683
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331683

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688
Dataset. 2022

TABLE_1_SPIKE PROTEIN OF SARS-COV-2 OMICRON VARIANT: AN IN-SILICO STUDY EVALUATING SPIKE INTERACTIONS AND IMMUNE EVASION.DOCX

  • Jiménez-Ruiz, José Antonio
  • López-Ramírez, Cecilia
  • López-Campos, J. L.
Table 1. Complete list of epitomes., [Background] The fundamentals of the infectivity and immune evasion of the SARS-CoV-2 Omicron variant are not yet fully understood. Here, we carried out an in-silico study analyzing the spike protein, the protein electrostatic potential, and the potential immune evasion., [Methods] The analysis was based on the structure of the spike protein from two SARS-CoV-2 variants, the original Wuhan and the Botswana (Omicron). The full-length genome sequences and protein sequences were obtained from databanks. The interaction of the spike proteins with the human Angiotensin Converting Enzyme 2 (ACE2) receptor was evaluated through the open-source software. The Immune Epitope Database was used to analyze the potential immune evasion of the viruses., [Results] Our data show that the Omicron spike protein resulted in 37 amino acid changes. The physicochemical properties of the spike had changed, and the electrostatic potentials differed between both variants. This resulted in a decrease in protein interactions, which does not establish a greater interaction with the ACE2 receptor. These changes compromise key receptor-binding motif residues in the SARS-CoV-2 spike protein that interact with neutralizing antibodies and ACE2., [Conclusions] These mutations appear to confer enhanced properties of infectivity. The Omicron variant appears to be more effective at evading immune responses., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331688
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688
HANDLE: http://hdl.handle.net/10261/331688
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688
PMID: http://hdl.handle.net/10261/331688
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688
Ver en: http://hdl.handle.net/10261/331688
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693
Dataset. 2022

SUPPLEMENTARY FILES OF THE ARTICLE REPOSITIONING SMALL MOLECULE DRUGS AS ALLOSTERIC INHIBITORS OF THE BFT-3 TOXIN FROM ENTEROTOXIGENIC BACTEROIDES FRAGILIS [DATASET]

  • Jiménez-Alesanco, Ana
  • Eckhard, Ulrich
  • Asencio del Río, Marta
  • Vega, Sonia
  • Guevara, Tibisay
  • Velázquez-Campoy, Adrián
  • Gomis-Rüth, F. Xavier
Figure S1 Proteolytic activity of proteases (inactive zymogen proBFT-3, trypsin-activated BFT-3, and trypsin). Figure S2 Overview representation of all proBFT-3 structures determined. Figure S3 Close-up views of the inhibitor-binding exosite, the identified protein-ligand interaction network, and the proteolytic active site. Figure S4 Molecular representation of the identified BFT-3 exosite inhibitors. Figure S5 Ligand-omitted and bulk solvent-excluding mFo–DFc electron density maps of the identified exosite inhibitors. Figure S6 Size-exclusion chromatography (SEC) of proBFT-3 prior protein crystallization experiments. Table S1 Primary and secondary antibodies. Table S2 Crystallographic data. Table S3 Therapeutic information for the identified compounds. Table S4 Dissociation constants of the activated BFT-3-compound complexes obtained by ITC at 25°C and pH 7.4., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331693
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693
HANDLE: http://hdl.handle.net/10261/331693
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693
PMID: http://hdl.handle.net/10261/331693
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693
Ver en: http://hdl.handle.net/10261/331693
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694
Dataset. 2022

LIST OF PARTICIPATING CENTERS. STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
S1 File. List of participating centers., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331694
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694
HANDLE: http://hdl.handle.net/10261/331694
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694
PMID: http://hdl.handle.net/10261/331694
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694
Ver en: http://hdl.handle.net/10261/331694
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699
Dataset. 2022

DEFINITIONS FOR MAIN TRIAL VARIABLES. STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
S2 File. Definitions for main trial variables., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331699
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699
HANDLE: http://hdl.handle.net/10261/331699
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699
PMID: http://hdl.handle.net/10261/331699
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699
Ver en: http://hdl.handle.net/10261/331699
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702
Dataset. 2022

STATISTICAL ANALYSIS PLAN. STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa bacteraemia: a multicentre, randomized clinical trial (SHORTEN-2) with a DOOR/RADAR analysis., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331702
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702
HANDLE: http://hdl.handle.net/10261/331702
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702
PMID: http://hdl.handle.net/10261/331702
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702
Ver en: http://hdl.handle.net/10261/331702
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703
Dataset. 2022

SUPPLEMENTARY INFORMATION SUB-NANOMETER MAPPING OF STRAIN-INDUCED BAND STRUCTURE VARIATIONS IN PLANAR NANOWIRE CORE-SHELL HETEROSTRUCTURES

  • Martí-Sànchez, Sara
  • Botifoll, Marc
  • Oksenberg, Eitan
  • Koch, Christian
  • Borja, Carla
  • Spadaro, Maria Chiara
  • Giulio, Valerio di
  • Ramasse, Quentin M.
  • García de Abajo, F. Javier
  • Joselevich, Ernesto
  • Arbiol, Jordi
52 pages. -- Supplementary Note 1. Growth directions, plane interactions and associated mismatches. -- Supplementary Note 2. Intermediate cases (gradual bending). -- Supplementary Note 3. Strain tensor maps (𝜀ij). -- Supplementary Note 4. Atomic modelling on non-faceted cores. -- Supplementary Note 5. Additional details on strain relaxation mechanisms and shell rotation. -- Supplementary Note 6. Details on the Core-shell misfit dislocations. -- Supplementary Note 7. Simulations on VEEL spectra. -- Supplementary Note 8. Methodology for band gap mapping., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703
HANDLE: http://hdl.handle.net/10261/331703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703
PMID: http://hdl.handle.net/10261/331703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703
Ver en: http://hdl.handle.net/10261/331703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707
Dataset. 2022

RESULTS OF THE SURVEY AMONG PARTICIPATING CENTERS REGARDING DIAGNOSTIC AND CLINICAL ROUTINES FOR THE MANAGEMENT OF BSI-PA

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
S4 File. Results of the survey among participating centers regarding diagnostic and clinical routines for the management of BSI-PA, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707
HANDLE: http://hdl.handle.net/10261/331707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707
PMID: http://hdl.handle.net/10261/331707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707
Ver en: http://hdl.handle.net/10261/331707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709
Dataset. 2022

FULL-LENGTH STUDY PROTOCOL (ENGLISH). STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa bacteraemia: a multicentre, randomized clinical trial (SHORTEN-2) with a DOOR/RADAR analysis., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331709
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709
HANDLE: http://hdl.handle.net/10261/331709
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709
PMID: http://hdl.handle.net/10261/331709
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709
Ver en: http://hdl.handle.net/10261/331709
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709

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