Resultados totales (Incluyendo duplicados): 34257
Encontrada(s) 3426 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329878
Dataset. 2022

ADDITIONAL FILE 9 OF OVEREXPRESSION OF WILD TYPE RRAS2, WITHOUT ONCOGENIC MUTATIONS, DRIVES CHRONIC LYMPHOCYTIC LEUKEMIA [DATASET]

  • Hortal, Alejandro
  • Oeste, Clara L.
  • Cifuentes, Claudia
  • Alcoceba, Miguel
  • Fernández-Pisonero, Isabel
  • Clavaín, Laura
  • Tercero, Rut
  • Mendoza, Pilar
  • Domínguez, Verónica
  • García-Flores, Marta
  • Pintado, Belén
  • Abia, David
  • García-Macías, Carmen
  • Navarro-Bailón, Almudena
  • Bustelo, Xosé R.
  • González, Marcos
  • Alarcón, Balbino
Fundación Científica Asociación Española Contra el Cáncer Ministerio de Ciencia, Innovación y Universidades H2020 European Research Council Instituto de Salud Carlos III Consejería de Educación, Junta de Castilla y León, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329878
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329878
HANDLE: http://hdl.handle.net/10261/329878
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329878
PMID: http://hdl.handle.net/10261/329878
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329878
Ver en: http://hdl.handle.net/10261/329878
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329878

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329880
Dataset. 2022

DATA_SHEET_2_INTEGRATIVE APPROACH FOR PRECISE GENOTYPING AND TRANSCRIPTOMICS OF SALT TOLERANT INTROGRESSION RICE LINES.DOCX

  • Bundó, Mireia
  • Martín-Cardoso, Héctor
  • Pesenti, Michele
  • Gómez-Ariza, Jorge
  • Castillo, Laia
  • Frouin, Julien
  • Serrat, Xavier
  • Nogués, Salvador
  • Courtois, Brigitte
  • Grenier, Cécile
  • Attilio Sacchi, Gian
  • San Segundo, Blanca
3 pages. -- Supplementary Methods: Transcriptome analysis by RNA-Seq and identification of introgressed indica regions, Rice is the most salt sensitive cereal crop and its cultivation is particularly threatened by salt stress, which is currently worsened due to climate change. This study reports the development of salt tolerant introgression lines (ILs) derived from crosses between the salt tolerant indica rice variety FL478, which harbors the Saltol quantitative trait loci (QTL), and the salt-sensitive japonica elite cultivar OLESA. Genotyping-by-sequencing (GBS) and Kompetitive allele specific PCR (KASPar) genotyping, in combination with step-wise phenotypic selection in hydroponic culture, were used for the identification of salt-tolerant ILs. Transcriptome-based genotyping allowed the fine mapping of indica genetic introgressions in the best performing IL (IL22). A total of 1,595 genes were identified in indica regions of IL22, which mainly located in large introgressions at Chromosomes 1 and 3. In addition to OsHKT1;5, an important number of genes were identified in the introgressed indica segments of IL22 whose expression was confirmed [e.g., genes involved in ion transport, callose synthesis, transcriptional regulation of gene expression, hormone signaling and reactive oxygen species (ROS) accumulation]. These genes might well contribute to salt stress tolerance in IL22 plants. Furthermore, comparative transcript profiling revealed that indica introgressions caused important alterations in the background gene expression of IL22 plants (japonica cultivar) compared with its salt-sensitive parent, both under non-stress and salt-stress conditions. In response to salt treatment, only 8.6% of the salt-responsive genes were found to be commonly up- or down-regulated in IL22 and OLESA plants, supporting massive transcriptional reprogramming of gene expression caused by indica introgressions into the recipient genome. Interactions among indica and japonica genes might provide novel regulatory networks contributing to salt stress tolerance in introgression rice lines. Collectively, this study illustrates the usefulness of transcriptomics in the characterization of new rice lines obtained in breeding programs in rice., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329880
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329880
HANDLE: http://hdl.handle.net/10261/329880
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329880
PMID: http://hdl.handle.net/10261/329880
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329880
Ver en: http://hdl.handle.net/10261/329880
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329880

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329881
Dataset. 2022

SUPPLEMENTARY MATERIAL SPONTANEOUS CHANGES IN BRAIN STRIATAL DOPAMINE SYNTHESIS AND STORAGE DYNAMICS EX VIVO REVEAL END-PRODUCT FEEDBACK-INHIBITION OF TYROSINE HYDROXYLASE

  • González-Sepúlveda, Marta
  • Omar, Muhammad Yusof
  • Hamdon, Sally
  • Rosell-Vilar, Santiago
  • Raivio, Noora
  • Abass, Doaa
  • Martínez-Rivas, Anna
  • Vila, Miquel
  • Giraldo, Jesús;
  • Carrascal, Montserrat
  • Abián, Joaquín
  • Gil, Carles
  • Sabriá, Josefa
  • Ortiz, Jordi
  • Moreno-Delgado, David
Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329881
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329881
HANDLE: http://hdl.handle.net/10261/329881
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329881
PMID: http://hdl.handle.net/10261/329881
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329881
Ver en: http://hdl.handle.net/10261/329881
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329881

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329887
Dataset. 2022

TABLE_1_INTEGRATIVE APPROACH FOR PRECISE GENOTYPING AND TRANSCRIPTOMICS OF SALT TOLERANT INTROGRESSION RICE LINES.XLSX

  • Bundó, Mireia
  • Martín-Cardoso, Héctor
  • Pesenti, Michele
  • Gómez-Ariza, Jorge
  • Castillo, Laia
  • Frouin, Julien
  • Serrat, Xavier
  • Nogués, Salvador
  • Courtois, Brigitte
  • Grenier, Cécile
  • Attilio Sacchi, Gian
  • San Segundo, Blanca
1 table. -- Supplementary Table2. The top 1000 SNPs associated with each of the traits: Cd leaf, Cd RRG, Hg leaf and Hg RRG., Rice is the most salt sensitive cereal crop and its cultivation is particularly threatened by salt stress, which is currently worsened due to climate change. This study reports the development of salt tolerant introgression lines (ILs) derived from crosses between the salt tolerant indica rice variety FL478, which harbors the Saltol quantitative trait loci (QTL), and the salt-sensitive japonica elite cultivar OLESA. Genotyping-by-sequencing (GBS) and Kompetitive allele specific PCR (KASPar) genotyping, in combination with step-wise phenotypic selection in hydroponic culture, were used for the identification of salt-tolerant ILs. Transcriptome-based genotyping allowed the fine mapping of indica genetic introgressions in the best performing IL (IL22). A total of 1,595 genes were identified in indica regions of IL22, which mainly located in large introgressions at Chromosomes 1 and 3. In addition to OsHKT1;5, an important number of genes were identified in the introgressed indica segments of IL22 whose expression was confirmed [e.g., genes involved in ion transport, callose synthesis, transcriptional regulation of gene expression, hormone signaling and reactive oxygen species (ROS) accumulation]. These genes might well contribute to salt stress tolerance in IL22 plants. Furthermore, comparative transcript profiling revealed that indica introgressions caused important alterations in the background gene expression of IL22 plants (japonica cultivar) compared with its salt-sensitive parent, both under non-stress and salt-stress conditions. In response to salt treatment, only 8.6% of the salt-responsive genes were found to be commonly up- or down-regulated in IL22 and OLESA plants, supporting massive transcriptional reprogramming of gene expression caused by indica introgressions into the recipient genome. Interactions among indica and japonica genes might provide novel regulatory networks contributing to salt stress tolerance in introgression rice lines. Collectively, this study illustrates the usefulness of transcriptomics in the characterization of new rice lines obtained in breeding programs in rice., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329887
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329887
HANDLE: http://hdl.handle.net/10261/329887
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329887
PMID: http://hdl.handle.net/10261/329887
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329887
Ver en: http://hdl.handle.net/10261/329887
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329887

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329889
Dataset. 2022

SUPPORTING INFORMATION SS2-ADRENERGIC STIMULATION POTENTIATES SPONTANEOUS CALCIUM RELEASE BY INCREASING SIGNAL MASS AND CO-ACTIVATION OF RYANODINE RECEPTOR CLUSTERS

  • Nolla-Colomer, Carme
  • Casabella, Sergi
  • Jiménez-Sábado, Verónica
  • Vallmitjana, Alexander
  • Tarifa, Carmen
  • Herraiz-Martínez, Adela
  • Llach, Anna
  • Tauron, Manel
  • Montiel, José
  • Cinca, Juan
  • Chen, S. R.
  • Wayne; Benítez, Raul
  • Hove-Madsen, Leif
Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329889
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329889
HANDLE: http://hdl.handle.net/10261/329889
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329889
PMID: http://hdl.handle.net/10261/329889
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329889
Ver en: http://hdl.handle.net/10261/329889
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329889

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329891
Dataset. 2022

ADDITIONAL FILE 10 OF OVEREXPRESSION OF WILD TYPE RRAS2, WITHOUT ONCOGENIC MUTATIONS, DRIVES CHRONIC LYMPHOCYTIC LEUKEMIA [DATASET]

  • Hortal, Alejandro
  • Oeste, Clara L.
  • Cifuentes, Claudia
  • Alcoceba, Miguel
  • Fernández-Pisonero, Isabel
  • Clavaín, Laura
  • Tercero, Rut
  • Mendoza, Pilar
  • Domínguez, Verónica
  • García-Flores, Marta
  • Pintado, Belén
  • Abia, David
  • García-Macías, Carmen
  • Navarro-Bailón, Almudena
  • Bustelo, Xosé R.
  • González, Marcos
  • Alarcón, Balbino
Fundación Científica Asociación Española Contra el Cáncer Ministerio de Ciencia, Innovación y Universidades H2020 European Research Council Instituto de Salud Carlos III Consejería de Educación, Junta de Castilla y León, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329891
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329891
HANDLE: http://hdl.handle.net/10261/329891
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329891
PMID: http://hdl.handle.net/10261/329891
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329891
Ver en: http://hdl.handle.net/10261/329891
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329891

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329896
Dataset. 2022

SUPPLEMENTARY MATERIALS FOR COP1 DYNAMICS INTEGRATE CONFLICTING SEASONAL LIGHT AND THERMAL CUES IN THE CONTROL OF ARABIDOPSIS ELONGATION

  • Nieto, Cristina
  • Catalán, Pablo
  • Luengo, Luis Miguel
  • Legris, Martina
  • López-Salmerón, Vadir
  • Davière, Jean Michel
  • Casal, Jorge J.
  • Ares, Saúl
  • Prat, Salomé
39 pages. -- This PDF file includes: Figs. S1 to S16. -- Supplementary Text. -- Tables S1 to S6. -- References., The CNB and CRAG Institutes also received the “Severo Ochoa” Centers of Excellence SEV 2017-0712 (CNB) and CEX2019-000902-S (CRAG) awards from the Spanish Ministerio de Ciencia e Innovación., With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000902-S), Peer reviewed

DOI: http://hdl.handle.net/10261/329896
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329896
HANDLE: http://hdl.handle.net/10261/329896
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329896
PMID: http://hdl.handle.net/10261/329896
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329896
Ver en: http://hdl.handle.net/10261/329896
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329896

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329907
Dataset. 2022

ADDITIONAL FILE 11 OF OVEREXPRESSION OF WILD TYPE RRAS2, WITHOUT ONCOGENIC MUTATIONS, DRIVES CHRONIC LYMPHOCYTIC LEUKEMIA [DATASET]

  • Hortal, Alejandro
  • Oeste, Clara L.
  • Cifuentes, Claudia
  • Alcoceba, Miguel
  • Fernández-Pisonero, Isabel
  • Clavaín, Laura
  • Tercero, Rut
  • Mendoza, Pilar
  • Domínguez, Verónica
  • García-Flores, Marta
  • Pintado, Belén
  • Abia, David
  • García-Macías, Carmen
  • Navarro-Bailón, Almudena
  • Bustelo, Xosé R.
  • González, Marcos
  • Alarcón, Balbino
Fundación Científica Asociación Española Contra el Cáncer Ministerio de Ciencia, Innovación y Universidades H2020 European Research Council Instituto de Salud Carlos III Consejería de Educación, Junta de Castilla y León, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329907
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329907
HANDLE: http://hdl.handle.net/10261/329907
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329907
PMID: http://hdl.handle.net/10261/329907
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329907
Ver en: http://hdl.handle.net/10261/329907
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329907

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329908
Dataset. 2022

PRESENTATION_1_ENVIRONMENTALLY DRIVEN TRANSCRIPTOMIC AND METABOLIC CHANGES LEADING TO COLOR DIFFERENCES IN “GOLDEN REINDERS” APPLES.PPTX

  • Fernández-Cancelo, Pablo
  • Iglesias-Sanchez, Ariadna
  • Torres-Montilla, Salvador
  • Ribas-Agustí, Albert
  • Teixidó, Neus
  • Rodríguez-Concepción, Manuel
  • Giné-Bordonaba, Jordi
10 pages. -- Supplementary Figure S1. Changes in the metabolic pathways related to carotenoids, chlorophylls and prenylquinones of apples grown in mountain or valley orchards. Substrates are shown as circles and enzymes as boxes. The scheme indicates if the genes encoding for the represented enzymes was up-regulated (green) or down-regulated (red) in Gotarta (yellow phenotype) apples peel based on the RNA-seq results. -- Supplementary Figure S2. Evolution of total carotenoids (A), total chlorophylls (B), γ-tocopherols (C) and α-tocopherols (D) levels during ‘Golden Reinders’ apples development/ripening at two different locations. Each point represents the mean of 4 biological replicates and vertical bars indicate the standard error. Different letters indicate significant differences between development stages and locations (p ≤ 0.05). Absence of letters indicates no significant differences between development stages or locations. -- Supplementary Figure S3. Expression profile of carotenoid biosynthetic and degradation related genes at the different developmental stages of ‘Golden Reinders’ apples in both locations. Each bar represents the mean of 4 biological replicates and error bars indicate the standard error. Different letters indicate significant differences between development stages and locations (p ≤ 0.05). Absence of letters indicates no significant differences between development stages or locations. -- Supplementary Figure S4. Relative gene expression of PAL genes at the different developmental stages of ‘Golden Reinders’ apples in both locations. Each point represents the mean of 4 biological replicates and vertical bars indicate the standard error. Different letters indicate significant differences between development stages (p ≤ 0.05). -- Supplementary Figure S5. Expression profile of ROS-scavenging (A to F) and AsA recycling (G to J) genes at the different developmental stages of ‘Golden Reinders’ apples in both locations. Each bar represents the mean of 4 biological replicates and error bars indicate the standard error. Different letters indicate significant differences between development stages and locations (p ≤ 0.05). Absence of letters indicates no significant differences between development stages or locations. -- Supplementary Figure S6. Expression profile of sirtuins genes at the different developmental stages of ‘Golden Reinders’ apples in both locations. Each bar represents the mean of 4 biological replicates and error bars indicate the standard error. Different letters indicate significant differences between development stages and locations (p ≤ 0.05). Absence of letters indicates no significant differences between development stages or locations. -- Supplementary Figure S7. Bivariate correlations among the different parameters (Hue angle, metabolites, enzymatic activities and gene expression) studied during the development of ‘Golden Reinders’ apples in both Vilanova and Gotarta orchards. The size of the circle for each correlation and the colour depict the significance and the correlation coefficient, respectively. Positive correlations coefficients are displayed in blue and negative correlations coefficients in red. -- Supplementary Figure S8. Evolution of maximum and minimum temperatures (A, B) and day-night temperature variation (C, D) 165 days before harvest in Vilanova (A, C) and Gotarta (B, D). -- Supplementary Figure S9. Evolution of total solar radiation (A), relative humidity (B) and evapotranspiration (C) 165 days before harvest in Vilanova (valley location, green) and Gotarta (mountain location, yellow). -- Supplementary Table S1. Real-time PCR primer set, including gene name and annotation, primer name and sequence, metabolic pathway and/or gene function, localization and primer source. Cellular localization was predicted by using the WoLF PSORT software (https://wolfpsort.hgc.jp/)., Apple is characterized by its high adaptation to diverse growing environments. However, little is still known about how different environments can regulate at the metabolic or molecular level specific apple quality traits such as the yellow fruit peel color. In this study, changes in carotenoids and chlorophylls, antioxidants as well as differences in the transcriptome were investigated by comparing the peel of “Golden Reinders” apples grown at different valley and mountain orchards. Mountain environment favored the development of yellow color, which was not caused by an enhanced accumulation of carotenoids but rather by a decrease in the chlorophyll content. The yellow phenotype was also associated to higher expression of genes related to chloroplast functions and oxidative stress. Time-course analysis over the last stages of apple development and ripening, in fruit from both locations, further revealed that the environment differentially modulated isoprenoids and phenylpropanoid metabolism and pointed out a key role for H2O2 in triggering apple peel degreening. Overall, the results presented herein provide new insights into how different environmental conditions regulate pigment and antioxidant metabolism in apple leading to noticeable differences in the apple peel color., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329908
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329908
HANDLE: http://hdl.handle.net/10261/329908
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329908
PMID: http://hdl.handle.net/10261/329908
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329908
Ver en: http://hdl.handle.net/10261/329908
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329908

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329909
Dataset. 2023

SUPPORTING INFORMATION FOR IN CELLULO BIOORTHOGONAL CATALYSIS BY ENCAPSULATED AUPD NANOALLOYS: OVERCOMING INTRACELLULAR DEACTIVATION

  • Rubio‐Ruiz, Belén
  • Pérez‐López, Ana M.
  • Usón, Laura
  • Ortega-Liébana, M. Carmen
  • Valero, Teresa
  • Arruebo, Manuel
  • Hueso, José L.
  • Sebastián, Víctor
  • Santamaría, Jesús
  • Unciti-Broceta, Asier
Preparation and characterization of NPs, prodye, and prodrug; methods and experimental procedures; biological assays; and Figures S1–S8., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/329909
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329909
HANDLE: http://hdl.handle.net/10261/329909
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329909
PMID: http://hdl.handle.net/10261/329909
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329909
Ver en: http://hdl.handle.net/10261/329909
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329909

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