Resultados totales (Incluyendo duplicados): 35611
Encontrada(s) 3562 página(s)
Encontrada(s) 3562 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351961
Dataset. 2023
POLYPLOID CELLS APPEAR TRANSIENTLY IN HEPATIC POSTEMBRYONIC GROWTH IN ZEBRAFISH [DATASET]
- Thomas, Laura
- Taleb Ismail, Basma
- Askjaer, Peter
- Seydoux, Geraldine
(A) Whole-mount of a 14-dpf zebrafish liver, displaying sparse multinucleated hepatocytes (N = 1, n = 2 livers; yellow arrowheads indicate binucleated cells). (B) Approximately 5 μm projection of a region of a juvenile liver. Fish SL = 11.16 mm (N = 3, n = 6 livers). (C) Segmentation shows variable nuclear volumes, which correlate with the sum intensity of DAPI, indicating that bigger nuclei have a higher amount of DNA (D). (E) Approximately 5 μm projection of an adult liver region (N = 3, n = 3 livers). (F) Segmented nuclei show only sparse variability in volume, with few bigger nuclei. Nuclear volume correlates with sum intensity of DAPI (G). (H) Schematics representing the transient appearance of polyploid cells over time; blue trajectory is manually approximated based on qualitative analysis. The numerical values that were used to generate the graphs in (D, G, H) can be found in S1 Data. DAPI, 4′,6-diamidino-2-phenylindole; dpf, day postfertilization; SL, standard length., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/351961
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351961
HANDLE: http://hdl.handle.net/10261/351961
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351961
PMID: http://hdl.handle.net/10261/351961
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351961
Ver en: http://hdl.handle.net/10261/351961
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351961
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351962
Dataset. 2023
ADDITIONAL FILE FOR: MONOCYTE-DERIVED CELLS INVADE BRAIN PARENCHYMA AND AMYLOID PLAQUES IN HUMAN ALZHEIMER’S DISEASE HIPPOCAMPUS
- Muñoz-Castro, Clara
- Mejías-Ortega, Marina
- Sánchez-Mejias, Elisabeth
- Navarro, Victoria
- Trujillo-Estrada, Laura
- Jiménez, Sebastián
- García-León, Juan Antonio
- Fernández-Valenzuela, Juan J.
- Sánchez-Mico, María V.
- Romero-Molina, Carmen
- Moreno-González, Inés
- Baglietto-Vargas, David
- Vizuete, Marisa
- Gutiérrez, Antonia
- Vitorica, Javier
© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data., Additional figures (S1-S7) and tables (S1-S2)., Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer's disease (AD). However, the contribution of nonparenchymal or brain-infiltrated myeloid cells to disease progression remains to be demonstrated. Here, we show that monocyte-derived cells (MDC) invade brain parenchyma in advanced stages of AD continuum using transcriptional analysis and immunohistochemical characterization in post-mortem human hippocampus. Our findings demonstrated that a high proportion (60%) of demented Braak V–VI individuals was associated with up-regulation of genes rarely expressed by microglial cells and abundant in monocytes, among which stands the membrane-bound scavenger receptor for haptoglobin/hemoglobin complexes or Cd163. These Cd163-positive MDC invaded the hippocampal parenchyma, acquired a microglial-like morphology, and were located in close proximity to blood vessels. Moreover, and most interesting, these invading monocytes infiltrated the nearby amyloid plaques contributing to plaque-associated myeloid cell heterogeneity. However, in aged-matched control individuals with hippocampal amyloid pathology, no signs of MDC brain infiltration or plaque invasion were found. The previously reported microglial degeneration/dysfunction in AD hippocampus could be a key pathological factor inducing MDC recruitment. Our data suggest a clear association between MDC infiltration and endothelial activation which in turn may contribute to damage of the blood brain barrier integrity. The recruitment of monocytes could be a consequence rather than the cause of the severity of the disease. Whether monocyte infiltration is beneficial or detrimental to AD pathology remains to be fully elucidated. These findings open the opportunity to design targeted therapies, not only for microglia but also for the peripheral immune cell population to modulate amyloid pathology and provide a better understanding of the immunological mechanisms underlying the progression of AD., This study was supported by Instituto de Salud Carlos III (ISCiii) of Spain, co-financed by FEDER funds from European Union, through grants PI18/01556 and PI21/00914 (to JV) and PI18/01557 and PI21/00915 (to AG); by Junta de Andalucia Consejería de Economía y Conocimiento through grants US-1262734 and P20-00843 (to JV), UMA18-FEDERJA-211 (to AG) and PI18-RT-2233 (to AG) co-financed by Programa Operativo FEDER 2014-2020; by Spanish Minister of Science and Innovation grant PID2019-108911RA-100 (to DBV), Beatriz Galindo Program BAGAL18/00052 (to DBV), grant PID2019-107090RA-I00 (to IMG) and Ramon y Cajal Program RYC-2017-21879 (to IMG); and by Malaga University grant B-2019_06 (to ESM)., Peer reviewed
DOI: http://hdl.handle.net/10261/351962
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351962
HANDLE: http://hdl.handle.net/10261/351962
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351962
PMID: http://hdl.handle.net/10261/351962
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351962
Ver en: http://hdl.handle.net/10261/351962
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351962
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351963
Dataset. 2023
ASSESSMENT OF POST-INFARCT VENTRICULAR SEPTAL DEFECTS THROUGH 3D PRINTING AND STATISTICAL SHAPE ANALYSIS: SUPPLEMENTARY TABLE
- Asif, Ashar
- Shearn, Andrew I. U.
- Turner, Mark S.
- Ordoñez, María V.
- Sophocleous, Froso
- Méndez-Santos, Ana
- Valverde, Israel
- Angelini, Gianni D.
- Caputo, Massimo
- Hamilton, Mark C. K.
- Biglino, Giovanni
Table 1: Examples of feedback from clinicians in relation to dominant themes from analysis of model evaluation., Background: Post-infarct ventricular septal defect (PIVSD) is a serious complication of myocardial infarction. We evaluated 3D-printing models in PIVSD clinical assessment and the feasibility of statistical shape modeling for morphological analysis of the defects. Methods: Models (n = 15) reconstructed from computed tomography data were evaluated by clinicians (n = 8). Statistical shape modeling was performed on 3D meshes to calculate the mean morphological configuration of the defects. Results: Clinicians’ evaluation highlighted the models’ utility in displaying defects for interventional/surgical planning, education/training and device development. However, models lack dynamic representation. Morphological analysis was feasible and revealed oval-shaped (n = 12) and complex channel-like (n = 3) defects. Conclusion: 3D-PIVSD models can complement imaging data for teaching and procedural planning. Statistical shape modeling is feasible in this scenario., The authors gratefully acknowledge the support of the British Heart Foundation (CH/17/1/32804), the Bristol BHF Accelerator Award (AA/18/1/34219), The Grand Appeal (Bristol Children’s Hospital Charity), and the Bristol National Institute for Health Research (NIHR) Biomedical Research Centre (BRC). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/351963
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351963
HANDLE: http://hdl.handle.net/10261/351963
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351963
PMID: http://hdl.handle.net/10261/351963
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351963
Ver en: http://hdl.handle.net/10261/351963
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351963
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351973
Dataset. 2023
LINEAGE TRACING REVEALS HETEROGENEOUS CLUSTER TOPOLOGIES DURING POSTEMBRYONIC GROWTH [DATASET]
- Unterweger, Iris. A.
- Klepstad, Julie
- Hannezo, Edouard
- Lundegaard, Pia R.
- Trusina, Ala
- Ober, Elke A.
(A) Schematic depicting key stages in postembryonic zebrafish liver development. (B) Experimental schematics of long-term lineage tracing experiments using fraeppli-nls embryos, inducing recombination by heat shock at 26 hpf to label hepatoblasts. At 120 hpf, embryos were screened by live imaging at the confocal microscope, and only sparsely labelled embryos were raised and fixed in either juvenile or adult stages. (C-H) Recombined livers showed different cluster topologies: clusters along central veins (C-C’) (n = 9 livers), proximal–distal stripes (D) (n = 23 livers) or giant clusters in the ventral lobe in adult (F-G’) (n = 3 livers). Large clusters in the ventral lobe can originate from one single-labelled cell at 5 dpf (n = 1 liver) (E). (F) Stereomicroscope image showing the spatial location of the giant clone originating from a single recombined cell (H). Recombined livers show a range of cluster sizes from small (H’) to medium (H”). (I) Schematics of characteristic cluster topologies in recombined livers. Red lines indicate the blood vessel orientation in the liver. (C-H) Total numbers are (N = 9, n = 79 livers). A, anterior; P, posterior; R, right; L, left; RL, right lobe; LL, left lobe; VL, ventral lobe., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/351973
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351973
HANDLE: http://hdl.handle.net/10261/351973
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351973
PMID: http://hdl.handle.net/10261/351973
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351973
Ver en: http://hdl.handle.net/10261/351973
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351973
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351980
Dataset. 2023
QUANTITATIVE LINEAGE TRACING OF HEPATOBLASTS DURING EMBRYONIC DEVELOPMENT IDENTIFIES HETEROGENEOUS GROWTH BEHAVIOUR [DATASET]
- Unterweger, Iris. A.
- Klepstad, Julie
- Hannezo, Edouard
- Lundegaard, Pia R.
- Trusina, Ala
- Ober, Elke A.
(A) Frequency of manually assigned pure hepatocyte clone sizes (N = 6, n = 190 clones). (B) Distribution of the corresponding number of cell divisions for each pure hepatocyte clone (N = 6, n = 190 clones). (A, B) Clone colours are plotted in blue (TagBFP), turquoise (mTFP1), magenta (mKate2), and orange (E2-Orange); the mean of all colours is represented in black. (C) Whole-mount of a 100-hpf liver showing several clones, including a mKate2+ 1-cell clone (N = 6, n = 15 livers). (D) Liver with a medium size 12-cell mTFP1+ clone (N = 6, n = 7 livers). (E) Whole-mount of a 100-hpf liver with a large 33-cell TagBFP+ clone (N = 1, n = 1 livers). (C-E) Labelled cells are represented as segmented nuclei, and an overall segmentation of the whole liver tissue is shown in transparent grey. The numerical values that were used to generate the graphs in (A, B) can be found in S1 Data., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/351980
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351980
HANDLE: http://hdl.handle.net/10261/351980
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351980
PMID: http://hdl.handle.net/10261/351980
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351980
Ver en: http://hdl.handle.net/10261/351980
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351980
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351982
Dataset. 2023
SUPPLEMENTARY INFORMATION: NAD POOL AS AN ANTITUMOR TARGET AGAINST CANCER STEM CELLS IN HEAD AND NECK CANCER
- Navas, Lola E.
- Blanco-Alcaina, Elena
- Suarez-Martinez, Elisa
- Verdugo-Sivianes, Eva M.
- Espinosa-Sánchez, Asunción
- Sánchez-Díaz, Laura
- Domínguez-Medina, Eduardo
- Fernández-Rozadilla, Ceres
- Carracedo, Ángel
- Wu, Lindsay E.
- Carnero, Amancio
Supplementary table 1. Analysis of CD10, CD184, CD19, CD133, CD166 and CD44 positive subpopulations by FACS in HNSCC cell lines.-- Supplementary Table 2. Differential genes common to CD10, CD184, CD19 and NAMPT subpopulations obtained from transcriptomic analysis. All the genes in color are related to tumorigenic process, acting as oncogenes (in red), tumor suppressor genes (in blue), ambiguous genes depending on the type of the tumor (in green).-- Supplementary Table 3: IC50s for NAMPT inhibitors in parental and NAMPT CRISPR clones of both cell lines.-- Supplementary figure 1: Verification of NAMPT overexpression in RPMI and Detroit HNSCC cell lines. A: Western blot showing increased NAMPT ectopic overexpression. B: increased NAD total and NAD+ pools in cells overexpressing NAMPT (in orange).-- Supplementary Figure 2. Overall survival of HNSCC patients from the TCGA database. Kaplan-Meier curves show the overall survival of HNSCC patients with high and low expression levels of CD10, CD184, CD19, CD133, CD166 and NAMPT genes from the TCGA (The Cancer Genome Atlas) database, N=520.-- Supplementary Figure 3. GO term analysis. Analysis of the genes by the terms GO biological process, molecular function and cellular component (p<0.05).-- Supplementary Figure 4. Transcriptomic analysis of differential genes common to CD10, CD184, CD19 and NAMPT subpopulations in HNSCC cell lines. Venn diagram represents the differential genes common to positive and negative CD10, CD184 and CD19 populations and NAMPT overexpression and CRISPRs in RPMI-2650 and Detroit-562 cell lines obtained by NGS sequencing.-- Supplementary Figure 5: Densitometric quantification of NAMPT expression in the WB of figure 2C.-- Supplementary Figure 6: Densitometric quantification of NAMPT and NAPRT expression in the WB of Figure 5C.-- Supplementary materials: Original images of western blots., Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that affect different anatomical locations. Despite this heterogeneity, HNSCC treatment depends on the anatomical location, TNM stage and resectability of the tumor. Classical chemotherapy is based on platinum-derived drugs (cisplatin, carboplatin and oxaliplatin), taxanes (docetaxel, paclitaxel) and 5-fluorouracil1. Despite advances in HNSCC treatment, the rate of tumor recurrence and patient mortality remain high. Therefore, the search for new prognostic identifiers and treatments targeting therapy-resistant tumor cells is vital. Our work demonstrates that there are different subgroups with high phenotypic plasticity within the CSC population in HNSCC. CD10, CD184, and CD166 may identify some of these CSC subpopulations with NAMPT as a common metabolic gene for the resilient cells of these subpopulations. We observed that NAMPT reduction causes a decrease in tumorigenic and stemness properties, migration capacity and CSC phenotype through NAD pool depletion. However, NAMPT-inhibited cells can acquire resistance by activating the NAPRT enzyme of the Preiss-Handler pathway. We observed that coadministration of the NAMPT inhibitor with the NAPRT inhibitor cooperated inhibiting tumor growth. The use of an NAPRT inhibitor as an adjuvant improved NAMPT inhibitor efficacy and reduced the dose and toxicity of these inhibitors. Therefore, it seems that the reduction in the NAD pool could have efficacy in tumor therapy. This was confirmed by in vitro assays supplying the cells with products of inhibited enzymes (NA, NMN or NAD) and restoring their tumorigenic and stemness properties. In conclusion, the coinhibition of NAMPT and NAPRT improved the efficacy of antitumor treatment, indicating that the reduction in the NAD pool is important to prevent tumor growth., This research was funded by Grants RTI2018-097455-B-I00 and PID2021-122629OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, by the “European Union”. Additional grants from CIBER de Cáncer (CB16/12/00275), from Consejeria de Salud (PI-0397–2017) and Project P18-RT-2501 from 2018 competitive research projects call within the scope of PAIDI 2020—80% co-financed by the European Regional Development Fund (ERDF) from the Regional Ministry of Economic Transformation, Industry, Knowledge and Universities. Junta de Andalucía. Special thanks to the AECC (Spanish Association of Cancer Research) Founding Ref. GC16173720CARR for supporting this work. AES was funded by a grant from the Fundación AECC. EMVS was funded by a postdoctoral fellowship from Junta de Andalucía (CTEICU/PAIDI 2020). LEN, ES-M and LS-D were funded by Spanish ministry of education (FPU16/0290; FPU17/02173; FPU18/01009)., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/351982
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351982
HANDLE: http://hdl.handle.net/10261/351982
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351982
PMID: http://hdl.handle.net/10261/351982
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351982
Ver en: http://hdl.handle.net/10261/351982
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351982
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351993
Dataset. 2023
QUANTITATIVE LINEAGE TRACING IDENTIFIES UNI- AND BIPOTENT HEPATOBLAST CONTRIBUTIONS DURING LINEAGE DECISIONS [DATASET]
- Unterweger, Iris. A.
- Klepstad, Julie
- Hannezo, Edouard
- Lundegaard, Pia R.
- Trusina, Ala
- Ober, Elke A.
(A) Schematic of FRaeppli-NLS cassette including attB and attP sites for PhiC31-mediated recombination and the 4 FRaeppli FPs: TagBFP, mTFP1, mKate2, and E2-Orange. Recombination is induced by combining fraeppli-nls with hsp70l:phiC31; prox1a:kalTA4; see S3A Fig. (B) Key steps of liver development in zebrafish: After hepatoblast specification, the differentiation into BECs and hepatocytes is initiated at around 42 hpf. Differentiated cells acquire polarity and form a functional architecture by 120 hpf. (C) Experimental strategy for tracing progeny of individual hepatoblasts using fraeppli-nls: Heat shock at 26 hpf controls PhiC31 expression followed by attB-attP recombination. Embryos were fixed at 100 hpf for analysis. (D-F) Whole-mount livers at 100 hpf showing (D) mixed clone composed of hepatocytes and BECs (D’) (N = 6, n = 23 clones); (E) clones formed by pure hepatocytes (E’-E”) (N = 6, n = 190 clones); and (F) example of pure BEC clone coexpressing TagBFP and mTFP1 (white, coexpressing cells were manually segmented and masked). (F’) (N = 2, n = 2 clones). (D-F) An overall segmentation of the whole liver tissue is shown in transparent grey. (G) Pie charts showing the total number of labelled embryos and clones with manually assigned lineage contributions (N = 6, n = 214 clones; in 2 of the 6 experiments, nuclear shape indicated BEC fate). The numerical values that were used to generate the graphs in (G) can be found in S1 Data. BEC, biliary epithelial cell; FP, fluorescent protein; hpf, hours post fertilization., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/351993
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351993
HANDLE: http://hdl.handle.net/10261/351993
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351993
PMID: http://hdl.handle.net/10261/351993
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351993
Ver en: http://hdl.handle.net/10261/351993
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/351993
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352006
Dataset. 2023
SUPPLEMENTARY MATERIAL: AN OPTIMAL SUPERCONDUCTING HYBRID MACHINE
- López, Rosa
- Lim, Jong Soo
- Kim, Kun Woo
Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/352006
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352006
HANDLE: http://hdl.handle.net/10261/352006
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352006
PMID: http://hdl.handle.net/10261/352006
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352006
Ver en: http://hdl.handle.net/10261/352006
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352006
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352014
Dataset. 2023
ESTABLISHMENT OF BEC AND HEPATOCYTE LINEAGES: IN VIVO CELL TYPE QUANTIFICATION AND IN SILICO MODELLING [DATASET]
- Unterweger, Iris. A.
- Klepstad, Julie
- Hannezo, Edouard
- Lundegaard, Pia R.
- Trusina, Ala
- Ober, Elke A.
(A) Schematic of a 5-dpf liver, highlighting the biliary network. (B-B’) Maximum projection (200 μm z-stack) of a 120-hpf liver expressing tp1:H2B-mCherry (BEC) and stained for Hnf4ɑ (hepatocyte). Autofluorescent blood cells appear in bright white. (N = 4, n ≥ 12 livers) (C) Relative distribution of BECs and hepatocytes at 120 hpf (N = 4, n ≥ 12 livers). (D-F) Mathematical models simulating hepatoblast differentiation employing different parameter combinations: proliferation rates of differentiated cell types is equal (D, F) or slower in BECs (E). Hepatoblasts either are all bipotent (D, E) or represent a heterogeneous population with mixed probabilities for uni-or bipotent differentiation (F). Plots showing the simulated cell proportions over simulation time (n = 10) and the final cell type ratio in bar graphs. The numerical values that were used to generate the graphs in (C-F) can be found in S1 Data. BEC, biliary epithelial cell; dpf, day postfertilization; Hb, hepatoblast; Hc, hepatocyte; hpf, hours post fertilization., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/352014
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352014
HANDLE: http://hdl.handle.net/10261/352014
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352014
PMID: http://hdl.handle.net/10261/352014
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352014
Ver en: http://hdl.handle.net/10261/352014
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352014
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352029
Dataset. 2022
ORDINAL ANALYSIS OF LEXICAL PATTERNS [DATASET]
- Sánchez, David
The Bible in 11 languages and a historical corpus of English works., Peer reviewed
Proyecto: //
DOI: http://hdl.handle.net/10261/352029
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352029
HANDLE: http://hdl.handle.net/10261/352029
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352029
PMID: http://hdl.handle.net/10261/352029
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352029
Ver en: http://hdl.handle.net/10261/352029
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/352029
Buscador avanzado