Resultados totales (Incluyendo duplicados): 45402
Encontrada(s) 4541 página(s)
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
oai:repositorio.imdeananociencia.org:20.500.12614/3316
Dataset. 2023

DATA - AUTOMATED STATISTICAL ANALYSIS OF RAMAN SPECTRA OF NANOMATERIALS

  • Martín Sabanés, N.
  • Eaton, M. D.
  • Moreno-Da Silva, S.
  • Naranjo, A.
  • Pérez, Emilio M.
A computational tool to automatically analyze the Raman spectral features of nanomaterials. Codes and experimental data.

Proyecto: //
DOI: http://hdl.handle.net/20.500.12614/3316
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
oai:repositorio.imdeananociencia.org:20.500.12614/3316
HANDLE: http://hdl.handle.net/20.500.12614/3316
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
oai:repositorio.imdeananociencia.org:20.500.12614/3316
PMID: http://hdl.handle.net/20.500.12614/3316
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
oai:repositorio.imdeananociencia.org:20.500.12614/3316
Ver en: http://hdl.handle.net/20.500.12614/3316
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
oai:repositorio.imdeananociencia.org:20.500.12614/3316

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357664
Dataset. 2024

DATASET - NANOPARTICULATED BIMODAL CONTRAST AGENT FOR ULTRA-HIGH-FIELD MAGNETIC RESONANCE IMAGING AND SPECTRAL X-RAY COMPUTED TOMOGRAPHY

  • González-Mancebo, Daniel
  • Becerro, Ana Isabel
  • Caro, Carlos
  • Gómez-González, Elisabet
  • García-Martín, María L.
  • Ocaña, Manuel
File List: Fig 1 F1b: Size histogram of Ba40Dy60 NPs F1c: EDX spectrum of Ba40Dy60 NPs F1e: Size histogram of Ba51Dy49 NPs F1f: F1c: EDX spectrum of Ba51Dy49 NPs Fig 2 F2: Experimental XRD patterns of Ba40Dy60 and Ba51Dy49 samples Fig 3 F3b: XRD patterns of the precipitates obtained in the conditions used for the synthesis of Ba51Dy49 NPs but using different aging times F3c: Unit cell parameters and Ba/(Ba+Dy) ratio of the precipitates versus aging time Fig 4 F4a: DLS intensity curves of the Ba51Dy49 NPs suspended in water after different periods of time at rest F4b: FTIR spectrum of the Ba51Dy49 NPs Fig 5 F5g: Total number of cells per well after exposure to increasing concentration of NPs F5h: Percentage of dead cells after exposure to increasing concentration of Ba51Dy49 NPs. F5i: MTT assay of cells exposed to increasing concentration of Ba51Dy49 NPs Fig 6 F6a: 1/T2 values obtained in aqueous suspensions of Ba51Dy49 NPs at 9.4 T and 1.44 T versus Dy concentration of the suspensions Fig 7 F7b: X-ray attenuation at 80 kVp, in Hounsfield Units (HU), of aqueous suspensions containing Ba51Dy49 NPs and Iohexol, versus suspension concentration. F7c: X-ray attenuation, in HU, of aqueous suspensions containing 20.0 mg·mL-1 of Ba51Dy49 and DyF3 NPs, versus working voltage, Bimodal medical imaging based on Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) is a well-known strategy to increase diagnostic accuracy. The most recent advances in MRI and CT instrumentation are related to the use of ultrahigh magnetic fields (UHF-MRI) and different working voltages (spectral CT), respectively. Such advances require the parallel development of bimodal contrast agents (CAs) that are efficient under the new instrumental conditions. In this work, we have synthesized, through a precipitation reaction from a glycerol solution of the precursors, uniform barium dysprosium fluoride nanospheres with cubic fluorite structure, whose size was found to depend on the Ba/(Ba+Dy) ratio of the starting solution. Moreover, irrespective of the starting Ba/(Ba+Dy) ratio, the experimental Ba/(Ba+Dy) values were always lower than those used in the starting solutions. This result was assigned to a lower precipitation kinetics of barium fluoride compared to dysprosium fluoride, as inferred from the detailed analysis of the effect of reaction time on the chemical composition of the precipitates. A sample composed of 34 nm nanospheres with a Ba0.51Dy0.49F2.49 stoichiometry, showed a transversal relaxivity (r2) value of 147.11 mM-1·s-1 at 9.4 T and gave a high negative contrast in the phantom image. Likewise, it produced high X-ray attenuation in a large range of working voltages (from 80 KVp to 140 KVp), which can be attributed to the presence of different K-edge values, high Z elements (Ba and Dy) in the nanospheres. Finally, these nanospheres showed negligible cytotoxicity for different biocompatibility tests. Taken together, these results show that the reported nanoparticles (NPs) are excellent candidates as UHF MRI/Spectral CT bimodal imaging CAs., This publication is part of the I + D + I Grants PID2021-122328OB-I00 and PID2020-118448RB-C21 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. This work was supported as well by Junta de Andalucía under grant no. P20_00182, co-financed by EU FEDER funds. High-field relaxivity measurements were performed at the ICTS “NANBIOSIS”, specifically in Unit 28 at the “Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND)”., Peer reviewed

DOI: http://hdl.handle.net/10261/357664, https://doi.org/10.20350/digitalCSIC/16267
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357664
HANDLE: http://hdl.handle.net/10261/357664, https://doi.org/10.20350/digitalCSIC/16267
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357664
PMID: http://hdl.handle.net/10261/357664, https://doi.org/10.20350/digitalCSIC/16267
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357664
Ver en: http://hdl.handle.net/10261/357664, https://doi.org/10.20350/digitalCSIC/16267
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357664

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357675
Dataset. 2023

TCGA INDIVIDUAL TISSUE HMT CORRELATION MATRICES [DATASET]

  • Pérez, Marcos Francisco
  • Sarkies, Peter
The N-terminal tails of eukaryotic histones are frequently posttranslationally modified. The role of these modifications in transcriptional regulation is well-documented. However, the extent to which the enzymatic processes of histone posttranslational modification might affect metabolic regulation is less clear. Here, we investigated how histone methylation might affect metabolism using metabolomics, proteomics, and RNA-seq data from cancer cell lines, primary tumour samples and healthy tissue samples. In cancer, the expression of histone methyltransferases (HMTs) was inversely correlated to the activity of NNMT, an enzyme previously characterised as a methyl sink that disposes of excess methyl groups carried by the universal methyl donor S-adenosyl methionine (SAM or AdoMet). In healthy tissues, histone methylation was inversely correlated to the levels of an alternative methyl sink, PEMT. These associations affected the levels of multiple histone marks on chromatin genome-wide but had no detectable impact on transcriptional regulation. We show that HMTs with a variety of different associations to transcription are co-regulated by the Retinoblastoma (Rb) tumour suppressor in human cells. Rb-mutant cancers show increased total HMT activity and down-regulation of NNMT. Together, our results suggest that the total activity of HMTs affects SAM metabolism, independent of transcriptional regulation., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/357675
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357675
HANDLE: http://hdl.handle.net/10261/357675
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357675
PMID: http://hdl.handle.net/10261/357675
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357675
Ver en: http://hdl.handle.net/10261/357675
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357675

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357676
Dataset. 2024

ISOTOPES, TRACE ELEMENTS AND U-TH DATES OF PYRENEAN STALAGMITES COVERING LAST 2500 YEARS [DATASET]

  • Bartolomé, Miguel
  • Moreno Caballud, Ana
The excel file includes different spreadsheet including, first, every stalagmite (age model, d18O and d13C, Mg/Ca and other trace elements when available) and, second, every composite record produced by ISCAM. The word document is the U-Th table with all the dates used in constructing the age models. This dataset corresponds to our manuscript published as a preprint in Climate of the Past: https://cp.copernicus.org/preprints/cp-2023-54/, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/357676
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357676
HANDLE: http://hdl.handle.net/10261/357676
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357676
PMID: http://hdl.handle.net/10261/357676
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357676
Ver en: http://hdl.handle.net/10261/357676
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357676

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357696
Dataset. 2022

PHYSICAL OCEANOGRAPHY, INORGANIC NUTRIENTS, DISSOLVED AND PARTICULATE ORGANIC CARBON AND NITROGEN DURING FLUXES-1 CRUISE TO THE CAPE VERDE FRONTAL ZONE IN 2017

  • Valiente Rodríguez, Sara
  • Fernández-Castro, Bieito
  • Campanero, Rubén
  • Marrero-Díaz, Ángeles
  • Rodríguez-Santana, Ángel
  • Gelado-Caballero, María Dolores
  • Nieto-Cid, Mar
  • Delgado Huertas, Antonio
  • Arístegui, Javier
  • Álvarez-Salgado, Xosé Antón
1 file, The Cape Verde Frontal Zone (CVFZ) is a highly dynamic region located in the southern boundary of the Canary Current Eastern Boundary Upwelling Ecosystem. Due to the interaction of the Cape Verde Front with the Mauritanian coastal upwelling, the area features large vertical and horizontal export fluxes of organic matter. Full-depth profiles were recorded during FLUXES I cruise, with four consecutive transects defining a box embracing the giant filament of Cape Blanc and the Cape Verde front. Fifteen levels were sampled in medium and long stations (down to 4000 dbar) and 10 levels in short stations (down to 2000 dbar) where inorganic nutrients (NO3, NO2, Si(OH)4 and PO4), dissolved organic carbon/total dissolved nitrogen (DOC/TDN), and suspended particulate organic carbon and nitrogen (POC and PON) were sampled. Micromolar concentrations of nutrient salts were determined simultaneously by segmented flow analysis in an Alliance Futura autoanalyser. The determination of suspended POC and PON was carried out by high temperature catalytic oxidation at 900 °C in a Perkin Elmer 2400 elemental analyser. DOC and TDN were analysed by high temperature catalytic oxidation at 680 °C with a Shimadzu TOC-V analyser connected in line with a TNM1 measuring unit. Alongside with water samples conductivity, temperature and depth (CTD; SeaBird SBE911 plus), and dissolved oxygen (SeaBird SBE43), fluorescence of chlorophyll (SeaPoint SCF), and turbidity (SeaPoint STM) were measured. CTD conductivity was calibrated with water samples taken from the rosette and analysed on board with a Guildline 8410-A Portasal salinometer. Samples for dissolved oxygen (O2) determination were analysed on board by the Winkler potentiometric method. The chlorophyll (Chl) fluorescence sensor was calibrated with water samples taken at 4 depths in the photic layer which were estimated fluorometrically by means of a Turner Designs bench fluorometer 10-AU, Horizon 2020 (H2020), grant/award no. 817806: Sustainable management of mesopelagic resources; Ministerio de Ciencia e Innovación (MICINN), grant/award no. CTM2015-69392-C3: Constraining organic carbon fluxes in an eastern boundary upwelling ecosystem (NW Africa): the role of non-sinking carbon in the context of the biological pump; Ministerio de Ciencia e Innovación (MICINN), grant/award no. PID2019-109084RB-C21: Biogeochemical impact of mesoscale and sub-mesoscale processes along the life history of cyclonic and anticyclonic eddies: plankton variability and productivity, Peer reviewed

DOI: http://hdl.handle.net/10261/357696
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357696
HANDLE: http://hdl.handle.net/10261/357696
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357696
PMID: http://hdl.handle.net/10261/357696
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357696
Ver en: http://hdl.handle.net/10261/357696
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357696

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357706
Dataset. 2023

GTEX PEMT-HMT CORRELATION ALL TISSUES FULL LABELLED PLOTS [DATASET]

  • Pérez, Marcos Francisco
  • Sarkies, Peter
GTEx PEMT-HMT correlation all tissues full labelled plots., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/357706
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357706
HANDLE: http://hdl.handle.net/10261/357706
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357706
PMID: http://hdl.handle.net/10261/357706
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357706
Ver en: http://hdl.handle.net/10261/357706
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357706

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357717
Dataset. 2023

GTEX NNMT-HMT CORRELATION ALL TISSUES FULL LABELLED PLOTS [DATASET]

  • Pérez, Marcos Francisco
  • Sarkies, Peter
GTEx NNMT-HMT correlation all tissues full labelled plots., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/357717
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357717
HANDLE: http://hdl.handle.net/10261/357717
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357717
PMID: http://hdl.handle.net/10261/357717
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357717
Ver en: http://hdl.handle.net/10261/357717
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357717

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357733
Dataset. 2023

TCGA NNMT-HMT CORRELATION ALL CANCERS FULL LABELLED PLOTS [DATASET]

  • Pérez, Marcos Francisco
  • Sarkies, Peter
TCGA NNMT-HMT correlation all cancers full labelled plots., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/357733
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357733
HANDLE: http://hdl.handle.net/10261/357733
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357733
PMID: http://hdl.handle.net/10261/357733
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357733
Ver en: http://hdl.handle.net/10261/357733
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357733

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357747
Dataset. 2023

CCLE NNMT-HMT CORRELATION ALL CANCERS FULL LABELLED PLOTS [DATASET]

  • Pérez, Marcos Francisco
  • Sarkies, Peter
CCLE NNMT-HMT correlation all cancers full labelled plots., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/357747
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357747
HANDLE: http://hdl.handle.net/10261/357747
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357747
PMID: http://hdl.handle.net/10261/357747
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357747
Ver en: http://hdl.handle.net/10261/357747
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357747

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357753
Dataset. 2022

DIVING INTO THE VERTICAL DIMENSION OF ELASMOBRANCH MOVEMENT ECOLOGY [DATASET]

  • Curnick, David J.
  • Mucientes, Gonzalo
  • Block, Barbara
7 files, Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understanding their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Significant vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps towards incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasising the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/357753
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357753
HANDLE: http://hdl.handle.net/10261/357753
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357753
PMID: http://hdl.handle.net/10261/357753
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357753
Ver en: http://hdl.handle.net/10261/357753
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/357753

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