BUSCADOR RECOLECTA

This appendix contains additional materials that are referenced in the main body of this paper., Peer reviewed

Table 2: List of UV fluxes for the sample of AGN and references. Table 3: Chemical abundances estimated from HCm-UV, using the grid of AGN models for alpha(OX) = -1.2 and the stopping criteria of 98% of free electrons. Dust-free or grain-included models are selected based on their C3C4 value., We present an adapted version of the code HII-CHI-mistry-UV (Perez-Montero & Amorin 2017) to derive chemical abundances from emission lines in the ultraviolet, for use in narrow line regions (NLR) of Active Galactic Nuclei (AGN). We evaluate different ultraviolet emission line ratios and how different assumptions about the models, including the presence of dust grains, the shape of the incident spectral energy distribution, or the thickness of the gas envelope around the central source, may affect the final estimates as a function of the set of emission lines used. We compare our results with other published recipes for deriving abundances using the same emission lines and show that deriving the carbon-to-oxygen abundance ratio using C iii] λ 1909 Å and O iii] λ 1665 Å emission lines is a robust indicator of the metal content in AGN that is nearly independent of model assumptions, similar to the case of star-forming regions. Moreover, we show that a prior determination of C/O allows for a much more precise determination of the total oxygen abundance using carbon UV lines, as op- posed to assuming an arbitrary relationship between O/H and C/O, which can lead to non-negligible discrepancies., This work has been partly funded by projects Estallidos7 PID2019-107408GB-C44 (Spanish Ministerio de Ciencia e Innovacion), and the Junta de Andalucia for grant EXC/2011 FQM-7058. This work has been also supported by the State Agency for Research of the Spanish MCIU 'Centro de Excelencia Severo Ochoa' Program under grant SEV-2017-0709. EPM also acknowledges the assistance from his guide dog Rocko without whose daily help this work would have been much more difficult. RA acknowledges financial support from ANID Fondecyt Regular 1202007. RGB acknowledges financial support from grant PID2019-109067-GB100., Peer reviewed

Spearmans Rank correlation of gene expression with response to compound in the cell line screening data., DLBCL are aggressive, rapidly proliferating tumors that critically depend on the ATF4-mediated integrated stress response (ISR) to adapt to stress caused by uncontrolled growth, such as hypoxia, amino acid deprivation, and accumulation of misfolded proteins. Here, we show that ISR hyperactivation is a targetable liability in DLBCL. We describe a novel class of compounds represented by BTM-3528 and BTM-3566, which activate the ISR through the mitochondrial protease OMA1. Treatment of tumor cells with compound leads to OMA1-dependent cleavage of DELE1 and OPA1, mitochondrial fragmentation, activation of the eIF2α-kinase HRI, cell growth arrest, and apoptosis. Activation of OMA1 by BTM-3528 and BTM-3566 is mechanistically distinct from inhibitors of mitochondrial electron transport, as the compounds induce OMA1 activity in the absence of acute changes in respiration. We further identify the mitochondrial protein FAM210B as a negative regulator of BTM-3528 and BTM-3566 activity. Overexpression of FAM210B prevents both OMA1 activation and apoptosis. Notably, FAM210B expression is nearly absent in healthy germinal center B-lymphocytes and in derived B-cell malignancies, revealing a fundamental molecular vulnerability which is targeted by BTM compounds. Both compounds induce rapid apoptosis across diverse DLBCL lines derived from activated B-cell, germinal center B-cell, and MYC-rearranged lymphomas. Once-daily oral dosing of BTM-3566 resulted in complete regression of xenografted human DLBCL SU-DHL-10 cells and complete regression in 6 of 9 DLBCL patient-derived xenografts. BTM-3566 represents a first-of-its kind approach of selectively hyperactivating the mitochondrial ISR for treating DLBCL., Peer reviewed

Crystallographic data for the structural analysis have been deposited with the Cambridge Crystallographic data Center, CCDC 1451708 for the complex. Copies of the data can be obtained free of charge at www.ccdc.cam.ac.uk/conts/retrieving.html., Peer reviewed

The basement membrane (BM) is a specialized extracellular matrix (ECM), which underlies or encases developing tissues. Mechanical properties of encasing BMs have been shown to profoundly influence the shaping of associated tissues. Here, we use the migration of the border cells (BCs) of the Drosophila egg chamber to unravel a new role of encasing BMs in cell migration. BCs move between a group of cells, the nurse cells (NCs), that are enclosed by a monolayer of follicle cells (FCs), which is, in turn, surrounded by a BM, the follicle BM. We show that increasing or reducing the stiffness of the follicle BM, by altering laminins or type IV collagen levels, conversely affects BC migration speed and alters migration mode and dynamics. Follicle BM stiffness also controls pairwise NC and FC cortical tension. We propose that constraints imposed by the follicle BM influence NC and FC cortical tension, which, in turn, regulate BC migration. Encasing BMs emerge as key players in the regulation of collective cell migration during morphogenesis., Peer reviewed

-1H and 13C{1H} NMR spectra of L2, 3, and 7; 1H and 31P{1H} NMR spectra of the outcome of the reaction of 1 with 3; images and metric parameters of the DFT-optimized structures of 3, 4, 6, and 7; results of catalytic experiments; crystal, measurement, and refinement data for the compounds studied by XRD (PDF). -Atomic coordinates for the calculated structures (XYZ)., Peer reviewed

1 file, Supporting information for article https://doi.org/10.1021/acsomega.3c10052, Peer reviewed

Supplementary PIC simulation movies for the MNRAS article titled ''3D PIC Simulations for Relativistic Jets with a Toroidal Magnetic Field'', by Meli, Nishikawa, Kohn, et al, With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S)., Peer reviewed

(A) Proposed model for the forces exerted over BCs as they migrate. (B–D) Schematic drawing showing the consequences of altering the forces exerted over BCs on their migration. BC, border cell; BM, basement membrane; FC, follicle cell; NC, nurse cell., Peer reviewed

[Descripción de los métodos utilizados para la recopilación/generación de datos] La evaluación de La Noche de l@s Investigador@s por parte de sus protagonistas se ha realizado a partir de tres cuestionarios online habilitados en la web nocheinvestiga.es adaptados a tres perfiles diferentes: 1) investigadores/as, 2) asistentes y 3) menores de 18 años. La aplicación de encuestas online ha sido desarrollada íntegramente por IESA CSIC sin apoyo de ningún software comercial, garantizando de este modo la privacidad, seguridad y calidad de los datos. El trabajo de campo se realizó entre el 23 de noviembre y el 20 de diciembre de 2020. La crisis sobrevenida ha implicado cambios y adaptaciones importantes. La realización online de la práctica totalidad de las actividades ha determinado cambios en la metodología de evaluación prevista, adaptándola a esta situación condicionante. Así, la evaluación dirigida a los asistentes se ha realizado totalmente online, en parte cumplimentando el cuestionario tras la realización de la actividad y en parte tras invitación dirigida al correo electrónico suministrado por el participante en el momento de inscribirse en la misma, en las actividades que así lo requerían. La evaluación dirigida a investigador@s y organizador@s se ha realizado igualmente online, tras invitación mediante correo electrónico. Por otro lado, en esta edición se ha optado por administrar un cuestionario específico a los y las participantes menores de 18 años, con preguntas orientadas a detectar sus potenciales vocaciones científicas. Por lo tanto, se ha dispuesto de tres cuestionarios diferentes. La metodología empleada en la evaluación de La Noche de l@s investigador@s ha permitido recabar casi 1.225 cuestionarios que se distribuyen por perfiles del siguiente modo: • Un cuestionario destinado a l@s participantes en las actividades mayores de 17 años, administrado y cumplimentado de manera online tras la realización de las actividades respectivas (acceso directo) o tras una invitación vía email. En total se ha cumplimentado el cuestionario por 475 personas, 330 en acceso directo y 145 por email tras invitación. • Un cuestionario dirigido a las personas que han realizado las actividades (investigador@s, técnic@s, voluntari@s, ...), cumplimentado igualmente de manera online. En concreto este cuestionario ha sido cumplimentado por 554 “investigadores”. • Un cuestionario destinado a participantes menores de 18 años, con preguntas orientadas a captar su potencial vocación científica, y administrado también directamente tras la realización de la actividad y tras invitación por email. En total se han cumplimentado 196 cuestionarios a menores., [Modalidades de tratamiento de los datos] La grabación de los datos fue automática y la codificación de preguntas abiertas se realizó manualmente. En la depuración de los datos se han eliminado los casos que no habían cumplimentado el 75% del cuestionario., El libro de códigos está disponible en español y en traducción al inglés., [ES] La Noche Europea de los Investigadores es un evento de divulgación científica de alcance europeo que muestra de forma divertida e inspiradora la diversidad de la ciencia y su repercusión en la vida cotidiana de los ciudadanos. El evento es una iniciativa de la Comisión Europea y se financia a través de las Acciones Marie Sklodowska Curie (MSCA) del Programa Marco de Investigación e Innovación de la UE. La novena edición se celebró en 371 ciudades europeas, entre ellas las ocho capitales andaluzas el 27 de noviembre de 2020. Esta edición de La Noche en Andalucía ha sido mayoritariamente online, debido igualmente a la crisis sanitaria, de modo que se ha podido disfrutar directamente desde la web. Han sido más de 650 actividades para acercar la ciencia y a las personas que investigan al público en general, llevadas a cabo por casi 3.000 investigadores. Este informe presenta datos significativos para medir el impacto de la Noche Europea de los Investigadores en Andalucía, así como la evaluación realizada por sus participantes: asistentes e investigadores., [EN] The European Researchers' Night is a Europe-wide scientific dissemination event that displays the diversity of science and its impact on citizens' daily lives in fun, inspiring ways. The event is an initiative of the European Commission and is funded through the Marie Sklodowska Curie Actions (MSCA) of the EU’s Framework-Programme for Research and Innovation. The ninth edition was held in 371 European cities, including the eight Andalusian capitals on November 27, 2020. This edition of La Noche en Andalucía was mostly online, also due to the health crisis, so it could be enjoyed directly from the web. There have been more than 650 activities to bring science and researchers closer to the general public, carried out by almost 3,000 researchers. This report presents significant data to measure the impact of the European Researchers' Night in Andalusia, as well as the evaluation conducted by its participants: attendees and researchers., Project funded by the European Commission’s Horizon Europe Research Framework Programme, in the framework of Marie Sktodowska-Curie actions., 1. Lista de archivos: - THE NIGHT 2020 Readme_EN.pdf - THE NIGHT 2020 Readme_SP.pdf A) Archivos para el dataset de Asistentes: - THE NIGHT 2020 (Attendees)_Data file.csv - THE NIGHT 2020 (Attendees)_Data file.sav - THE NIGHT 2020 (Attendees)_Codebook_EN.pdf - THE NIGHT 2020 (Attendees)_Codebook_SP.pdf - THE NIGHT 2020 (Attendees)_Questionnaire.pdf B) Archivos para el dataset de Investigadores - THE NIGHT 2020 (Researchers)_Data file.csv - THE NIGHT 2020 (Researchers)_Data file.sav - THE NIGHT 2020 (Researchers)_Codebook_EN.pdf - THE NIGHT 2020 (Researchers)_Codebook_SP.pdf - THE NIGHT 2020 (Researchers)_Questionnaire.pdf C) Archivos para el dataset de Asistentes jóvenes: - THE NIGHT 2020 (Young attendees)_Data file.csv - THE NIGHT 2020 (Young attendees)_Data file.sav - THE NIGHT 2020 (Young attendees)_Codebook_EN.pdf - THE NIGHT 2020 (Young attendees)_Codebook_SP.pdf - THE NIGHT 2020 (Young attendees)_Questionnaire.pdf, Peer reviewed