Resultados totales (Incluyendo duplicados): 33514
Encontrada(s) 3352 página(s)
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688
Dataset. 2022

TABLE_1_SPIKE PROTEIN OF SARS-COV-2 OMICRON VARIANT: AN IN-SILICO STUDY EVALUATING SPIKE INTERACTIONS AND IMMUNE EVASION.DOCX

  • Jiménez-Ruiz, José Antonio
  • López-Ramírez, Cecilia
  • López-Campos, J. L.
Table 1. Complete list of epitomes., [Background] The fundamentals of the infectivity and immune evasion of the SARS-CoV-2 Omicron variant are not yet fully understood. Here, we carried out an in-silico study analyzing the spike protein, the protein electrostatic potential, and the potential immune evasion., [Methods] The analysis was based on the structure of the spike protein from two SARS-CoV-2 variants, the original Wuhan and the Botswana (Omicron). The full-length genome sequences and protein sequences were obtained from databanks. The interaction of the spike proteins with the human Angiotensin Converting Enzyme 2 (ACE2) receptor was evaluated through the open-source software. The Immune Epitope Database was used to analyze the potential immune evasion of the viruses., [Results] Our data show that the Omicron spike protein resulted in 37 amino acid changes. The physicochemical properties of the spike had changed, and the electrostatic potentials differed between both variants. This resulted in a decrease in protein interactions, which does not establish a greater interaction with the ACE2 receptor. These changes compromise key receptor-binding motif residues in the SARS-CoV-2 spike protein that interact with neutralizing antibodies and ACE2., [Conclusions] These mutations appear to confer enhanced properties of infectivity. The Omicron variant appears to be more effective at evading immune responses., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331688
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688
HANDLE: http://hdl.handle.net/10261/331688
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688
PMID: http://hdl.handle.net/10261/331688
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688
Ver en: http://hdl.handle.net/10261/331688
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331688

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693
Dataset. 2022

SUPPLEMENTARY FILES OF THE ARTICLE REPOSITIONING SMALL MOLECULE DRUGS AS ALLOSTERIC INHIBITORS OF THE BFT-3 TOXIN FROM ENTEROTOXIGENIC BACTEROIDES FRAGILIS [DATASET]

  • Jiménez-Alesanco, Ana
  • Eckhard, Ulrich
  • Asencio del Río, Marta
  • Vega, Sonia
  • Guevara, Tibisay
  • Velázquez-Campoy, Adrián
  • Gomis-Rüth, F. Xavier
Figure S1 Proteolytic activity of proteases (inactive zymogen proBFT-3, trypsin-activated BFT-3, and trypsin). Figure S2 Overview representation of all proBFT-3 structures determined. Figure S3 Close-up views of the inhibitor-binding exosite, the identified protein-ligand interaction network, and the proteolytic active site. Figure S4 Molecular representation of the identified BFT-3 exosite inhibitors. Figure S5 Ligand-omitted and bulk solvent-excluding mFo–DFc electron density maps of the identified exosite inhibitors. Figure S6 Size-exclusion chromatography (SEC) of proBFT-3 prior protein crystallization experiments. Table S1 Primary and secondary antibodies. Table S2 Crystallographic data. Table S3 Therapeutic information for the identified compounds. Table S4 Dissociation constants of the activated BFT-3-compound complexes obtained by ITC at 25°C and pH 7.4., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331693
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693
HANDLE: http://hdl.handle.net/10261/331693
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693
PMID: http://hdl.handle.net/10261/331693
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693
Ver en: http://hdl.handle.net/10261/331693
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331693

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694
Dataset. 2022

LIST OF PARTICIPATING CENTERS. STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
S1 File. List of participating centers., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331694
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694
HANDLE: http://hdl.handle.net/10261/331694
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694
PMID: http://hdl.handle.net/10261/331694
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694
Ver en: http://hdl.handle.net/10261/331694
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331694

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699
Dataset. 2022

DEFINITIONS FOR MAIN TRIAL VARIABLES. STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
S2 File. Definitions for main trial variables., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331699
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699
HANDLE: http://hdl.handle.net/10261/331699
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699
PMID: http://hdl.handle.net/10261/331699
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699
Ver en: http://hdl.handle.net/10261/331699
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331699

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702
Dataset. 2022

STATISTICAL ANALYSIS PLAN. STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa bacteraemia: a multicentre, randomized clinical trial (SHORTEN-2) with a DOOR/RADAR analysis., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331702
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702
HANDLE: http://hdl.handle.net/10261/331702
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702
PMID: http://hdl.handle.net/10261/331702
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702
Ver en: http://hdl.handle.net/10261/331702
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331702

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703
Dataset. 2022

SUPPLEMENTARY INFORMATION SUB-NANOMETER MAPPING OF STRAIN-INDUCED BAND STRUCTURE VARIATIONS IN PLANAR NANOWIRE CORE-SHELL HETEROSTRUCTURES

  • Martí-Sànchez, Sara
  • Botifoll, Marc
  • Oksenberg, Eitan
  • Koch, Christian
  • Borja, Carla
  • Spadaro, Maria Chiara
  • Giulio, Valerio di
  • Ramasse, Quentin M.
  • García de Abajo, F. Javier
  • Joselevich, Ernesto
  • Arbiol, Jordi
52 pages. -- Supplementary Note 1. Growth directions, plane interactions and associated mismatches. -- Supplementary Note 2. Intermediate cases (gradual bending). -- Supplementary Note 3. Strain tensor maps (𝜀ij). -- Supplementary Note 4. Atomic modelling on non-faceted cores. -- Supplementary Note 5. Additional details on strain relaxation mechanisms and shell rotation. -- Supplementary Note 6. Details on the Core-shell misfit dislocations. -- Supplementary Note 7. Simulations on VEEL spectra. -- Supplementary Note 8. Methodology for band gap mapping., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703
HANDLE: http://hdl.handle.net/10261/331703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703
PMID: http://hdl.handle.net/10261/331703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703
Ver en: http://hdl.handle.net/10261/331703
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331703

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707
Dataset. 2022

RESULTS OF THE SURVEY AMONG PARTICIPATING CENTERS REGARDING DIAGNOSTIC AND CLINICAL ROUTINES FOR THE MANAGEMENT OF BSI-PA

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
S4 File. Results of the survey among participating centers regarding diagnostic and clinical routines for the management of BSI-PA, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707
HANDLE: http://hdl.handle.net/10261/331707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707
PMID: http://hdl.handle.net/10261/331707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707
Ver en: http://hdl.handle.net/10261/331707
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331707

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709
Dataset. 2022

FULL-LENGTH STUDY PROTOCOL (ENGLISH). STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa bacteraemia: a multicentre, randomized clinical trial (SHORTEN-2) with a DOOR/RADAR analysis., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331709
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709
HANDLE: http://hdl.handle.net/10261/331709
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709
PMID: http://hdl.handle.net/10261/331709
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709
Ver en: http://hdl.handle.net/10261/331709
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331709

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331712
Dataset. 2022

SUPPLEMENTAL INFORMATION BACK-CONTACT PEROVSKITE SOLAR CELL FABRICATION VIA MICROSPHERE LITHOGRAPHY

  • Deng, Siqi
  • Tan, Boer
  • Chesman, Anthony S. R.
  • Lu, Jianfeng
  • McMeekin, David P.
  • Ou, Qingdong
  • Scully, Andrew D.
  • Raga, Sonia R.
  • Rietwyk, Kevin James
  • Weissbach, Anton
  • Zhao, Boya
  • Voelcker, Nicolas H.
  • Cheng, Yi-Bing
  • Lin, Xiongfeng
  • Bach, Udo
22 pages. -- Table S1. Roughness data for samples shown in Figure 3. -- Figure S1. SEM images of a) a PS microsphere-lithography-fabricated honeycomb-shaped quasiinterdigitated back-contact electrode; defects present during the PS microsphere assembly process: b) vacancy (red dotted circle); c) dislocation (red dash line); d) secondary layer (red dotted circles). defects present in HQIDE: e) vacancy (red dotted circle); f) dislocation (red dash line); g) interconnecting circles (red dotted circles). -- Figure S2. Process for fabricating ML-BCE. -- Figure S3. Spectral response (external quantum efficiency – EQE, solid line) and the corresponding integrated short-circuit current density (J, dashed line) of champion BC-PSC based on ML-BCE (black) and PL-BCE (red). -- Figure S4. Statistic photovoltaic properties of BC-PSCs based on ML-BCE (black) and PL-BCE (red). -- Figure S5. Transient photovoltage (TPV) decay lifetime τ across a range of VOC for perovskites deposited on ML-BCE (black) and on PL-BCE (red). -- Figure S6. UV-visible spectroscopy of back-contact PSCs based on ML-BCE (black) and PL-BCE (red). -- Figure S7. Photovoltaic performance of p-i-n sandwich-type PSCs based on ITO/PTAA (black) and Ni/NiOx (red). -- Table S2. Photovoltaic parameters of champion p-i-n sandwich-type PSCs based on ITO/PTAA and Ni/NiOx substrates. -- Figure S8. a) J-V curves of PSCs based on ITO/PTAA measured from the glass side (black) and from the Au side (red); b) UV-visible transmittance spectra of glass (black), glass/40 nm Au (orange), glass/PCBM/BCP (blue) and glass/PCBM/BCP/Au (red) from 370 nm to 800 nm. a b. -- Table S3. Photovoltaic parameters of PSC based on ITO/PTAA measured from the glass side. -- Figure S9. a) Dark J-V of champion BC-PSCs based on ML-BCE (black) and PL-BCE (red) in forward scan direction; b) series resistance (Rseries) and c) shunt resistance (RSH) of BC-PSCs based on ML-BCE (black) and PL-BCE (red) fitted from the dark J-V curves and from the Au side. -- Figure S10. a) Bode (phase-frequency) plot and b) Nyquist plot of BC-PSCs based on ML-BCE and PL-BCE at a low applied bias at 0.6 V, 0.7 V and a high applied bias at 1.0 V, 1.1 V (c, d). e) Simplified equivalent AC circuit employed for the fitting of IS data. f) Fitted contact resistance at applied biases from 0.5 - 1.1 V. -- Figure S11. a) Resistances at 4 characteristic frequency ranges under various applied biases. b) J-V curves extracted during EIS measurement. c) R2 of devices based on ML-BCE and PL-BCE normalized by the pitch size (P) and gap size (G) of the corresponding electrode. -- Table S4. Radiative limit of back-contact PSCs. -- Table S5. Comparison of device PV parameters (reverse scan) with the radiative limit (with reflection optical loss). -- Figure S12. a) Photoluminescence decay of Cs0.05(FA0.83MA0.17)0.95Pb(I0.83Br0.17)3 perovskite on a PL-BCE (red) and a ML-BCE (black) at short-circuit condition. b) Photoluminescence emission spectra of perovskite film on glass (blue), a PL-BCE (red) and a ML-BCE (black). -- Table S6. Fitted parameters for photoluminescence decay measurements. -- Supplemental Experimental Procedures, Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331712
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331712
HANDLE: http://hdl.handle.net/10261/331712
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331712
PMID: http://hdl.handle.net/10261/331712
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331712
Ver en: http://hdl.handle.net/10261/331712
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331712

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331713
Dataset. 2022

FULL-LENGTH STUDY PROTOCOL (SPANISH). STUDY PROTOCOL FOR A RANDOMIZED CLINICAL TRIAL TO ASSESS 7 VERSUS 14-DAYS OF TREATMENT FOR PSEUDOMONAS AERUGINOSA BLOODSTREAM INFECTIONS (SHORTEN-2 TRIAL)

  • Molina, José
  • Rosso-Fernández, Clara
  • Montero-Mateos, Enrique
  • Paño, José Ramón
  • Solla, María
  • Guisado-Gil, Ana Belén
  • Álvarez-Marín, Rocío
  • Pachón Ibáñez, María Eugenia
  • Gimeno, Adelina
  • Martín-Gutiérrez, Guillermo
  • Lepe, José A.
  • Cisneros, José Miguel
Eficacia y seguridad de 7 versus 14 días de tratamiento antibiótico para la bacteriemia producida por Pseudomonas aeruginosa: un ensayo clínico multicéntrico, aleatorizado (SHORTEN-2) con un análisis DOOR/RADAR., Peer reviewed

Proyecto: //
DOI: http://hdl.handle.net/10261/331713
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331713
HANDLE: http://hdl.handle.net/10261/331713
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331713
PMID: http://hdl.handle.net/10261/331713
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331713
Ver en: http://hdl.handle.net/10261/331713
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331713

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