BUSCADOR RECOLECTA

1 table., miR-7142 seed binding interrogation on the 3’ UTR of DEGs, Peer reviewed

Lápida situada a los pies del altar de la Piedad. La inscripción está en dos partes, en el extremo superior sobre la cabeza de la estatua yacente del tesorero, y a sus pies. El extremo derecho de la línea de los pies está cortado por el muro, por lo cual es ilegible al final, aunque se puede restituir. Se puede identificar al personaje enterrado en este sepulcro con Gómez Carrillo de Albornoz, citado en la inscripción del arco en el altar. La inscripción ha sido publicada por A. Sanz Serrano, La Catedral de Cuenca, Cuenca (1959), 136 y J. Bermejo, La Catedral de Cuenca, Cuenca (1977), 210., CSIC. Proyecto intramural: “Epigrafía latina inédita de los siglos XV al XVIII en monumentos civiles y eclesiásticos de la provincia de Cuenca (2006-2007). Referencia: 2006 | 0| 011., Peer reviewed

Lápida en el centro del pavimento de la Capilla de los Caballeros, próxima a la pila bautismal. Texto grabado en la piedra, enmarcado por una línea simple., CSIC. Proyecto intramural: “Epigrafía latina inédita de los siglos XV al XVIII en monumentos civiles y eclesiásticos de la provincia de Cuenca (2006-2007). Referencia: 2006 | 0| 011., Peer reviewed

1 table., Meaningful co-expression network between negatively correlated DEGs and DE miRNAs according to n-6/n-3 PUFA ratio., Peer reviewed

1 table., Meaningful mRNA-mRNA co-expression of ARRDC3 gene and other DEGs according to n-6/n-3 PUFA ratio, Peer reviewed

1 table., Meaningful mRNA-mRNA co-expression of METTL21C gene and other DEGs according to n-6/n-3 PUFA ratio., Peer reviewed

1 table., List of genes significantly correlated with ARRDC3 and METTL21C and their related functions., Peer reviewed

[Description of methods used for collection/generation of data] 1. Extraction and GC-MS determination (DOI 10.1002/bmc.3480); 2. UV Spectrophotometry method for OA-HSA association (DOI 10.1021/jf1039537); 3. Enzymatic methods were used to determine serum glucose, total cholesterol, HDL and triglycerides, whereas LDL was estimated by the Friedewald formula (14). Total lipoprotein Apo B (Apo B48 + Apo B100) was quantified by an immunoturbidimetric assay (Tinaquant; Roche Diagnostics, Mannheim, Germany), and serum insulin using an ELISA kit (Diaclone, Besançon, France)., [Methods for processing the data] The variables were expressed as mean ± standard deviation (SD), unless otherwise stated. Differences between the study groups were evaluated by one- or two-way ANOVA, following by Bonferroni´s multiple-comparison test or Kruskal-Wallis test., Evidence of the pharmacological activity of oleanolic acid (OA) suggests its potential therapeutic application. However, its use in functional foods, dietary supplements, or nutraceuticals is hindered by limited human bioavailability studies. The BIO-OLTRAD trial is a double-blind, randomized controlled study with 22 participants that received a single dose of 30 mg OA formulated as a functional olive oil. The study revealed that the maximum serum concentration of OA ranged from 500 to 600 ng/mL, with an AUC0–∞ value of 2862.50 ± 174.50 ng·h/mL. Furthermore, we discovered a physiological association of OA with serum albumin and triglyceride-rich lipoproteins (TRL). UV absorption spectra showed conformational changes in serum albumin due to the formation of an adduct with OA. Additionally, we demonstrated that TRL incorporate OA, reaching a maximum concentration of 140 ng/mL after 2-4 hours. We conjecture that both are efficient carriers to reach target tissues and to yield high bioavailability. This dataset includes the raw data used in the elaboration of the results reported in the article (DOI)., This research is part of the R+D+i project PID2019-107837RB-I00, funded by the Spanish Ministry of Science and Innovation/Spanish Research Agency, grant number MCIN/AEI/10.13039/501100011033/., 1.Row data OA pharmacokinetics in human serum; 2. Raw data OA-HSA association; 3. Row data OA in TRL; 4. Raw data blood biochemistry, Peer reviewed

Supplementary Figure S1. Nlgn1 protein levels in female and male Nlgn1 Thr271fs mice, related to Figure 1.-- Supplementary Figure S2. Analysis of Nlgn1 Thr271fs mouse in behavioral tests related to neurodevelopmental disorders, related to STAR Methods.-- Supplementary Figure S3. Permanence of specific memory deficits in HTZ Nlgn1 Thr271fs mice at an old age, related to Figures 3 and 4.-- Supplementary Figure S4. Neuronal density in HTZ Nlgn1 Thr271fs mice, related to Figure 7., Peer reviewed

Additional file 1: QIIME2 pipeline used to process and combine the two 16S sequence datasets., Agencia Nacional de Investigación e Innovación., Peer reviewed