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1 Documentos relacionados
1 Documentos relacionados
Recercat. Dipósit de la Recerca de Catalunya
oai:recercat.cat:2072/315592
Artículo científico (article).
ONCODRIVEROLE CLASSIFIES CANCER DRIVER GENES IN LOSS OF FUNCTION AND ACTIVATING MODE OF ACTION
Recercat. Dipósit de la Recerca de Catalunya
- Schroeder, Michael Philipp, 1986-
- Rubio Pérez, Carlota, 1990-
- Tamborero Noguera, David
- González-Pérez, Abel
- López Bigas, Núria
MOTIVATION: Several computational methods have been developed to identify cancer drivers genes-genes responsible for cancer development upon specific alterations. These alterations can cause the loss of function (LoF) of the gene product, for instance, in tumor suppressors, or increase or change its activity or function, if it is an oncogene. Distinguishing between these two classes is important to understand tumorigenesis in patients and has implications for therapy decision making. Here, we assess the capacity of multiple gene features related to the pattern of genomic alterations across tumors to distinguish between activating and LoF cancer genes, and we present an automated approach to aid the classification of novel cancer drivers according to their role. RESULT: /nOncodriveROLE is a machine learning-based approach that classifies driver genes according to their role, using several properties related to the pattern of alterations across tumors. The method shows an accuracy of 0.93 and Matthew's correlation coefficient of 0.84 classifying genes in the Cancer Gene Census. The OncodriveROLE classifier, its results when applied to two lists of predicted cancer drivers and TCGA-derived mutation and copy number features used by the classifier are available at http://bg.upf.edu/oncodrive-role. AVAILABILITY AND IMPLEMENTATION: The R implementation of the OncodriveROLE classifier is available at http://bg.upf.edu/oncodrive-role. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online., This work was supported by the Spanish Ministry of Economy and Competitivity (grant number SAF2012-36199) and the Spanish National Institute of Bioinformatics (INB). M.P.S. and C.R.-P. are supported by FPI fellowships
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1 Versiones
1 Versiones
CORA.Repositori de Dades de Recerca
doi:10.34810/data416
Dataset. 2023
ONCODRIVEROLE
CORA.Repositori de Dades de Recerca
- Schroeder, Michael Philipp, 1986-
- Rubio Pérez, Carlota
- Tamborero Noguera, David
- González-Pérez, Abel
- López Bigas, Núria
Machine-learning based approach to classify cancer driver genes into to Activating or Loss of Function roles for cancer gene development.