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Supplementary files of the article KSR induces RAS-independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors [Dataset]

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329692
Digital.CSIC. Repositorio Institucional del CSIC
  • Paniagua, Guillem
  • Jacob, Harrys K.C.
  • Brehey, Oksana
  • García-Alonso, Sara
  • Lechuga, Carmen G.
  • Pons, Tirso
  • Musteanu, Mónica
  • Guerra, Carmen
  • Drosten, Matthias
  • Barbacid, Mariano
Fig. S1. KSR1ΔCA1 localizes to the plasma membrane and binds BRAF. Fig. S2. 3D model of the mKSR1 kinase domain. Fig. S3. Purification of recombinant KSR1 protein. Fig. S4. RAS-independent proliferation in the absence of p53 does not involve KSR. Fig. S5. Western blot analysis of KSR1 expression levels in parental and resistant MIA PaCa-2 (A) as well as PDX-dc1 (B) cell lines. Fig. S6. Model of KSR-driven proliferation in RASless cells., Peer reviewed
 
DOI: http://hdl.handle.net/10261/329692, https://doi.org/10.20350/digitalCSIC/15373
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329692

HANDLE: http://hdl.handle.net/10261/329692, https://doi.org/10.20350/digitalCSIC/15373
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329692
 
Ver en: http://hdl.handle.net/10261/329692, https://doi.org/10.20350/digitalCSIC/15373
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329692
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Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/329692
Dataset. 2022

SUPPLEMENTARY FILES OF THE ARTICLE KSR INDUCES RAS-INDEPENDENT MAPK PATHWAY ACTIVATION AND MODULATES THE EFFICACY OF KRAS INHIBITORS [DATASET]

Digital.CSIC. Repositorio Institucional del CSIC
  • Paniagua, Guillem
  • Jacob, Harrys K.C.
  • Brehey, Oksana
  • García-Alonso, Sara
  • Lechuga, Carmen G.
  • Pons, Tirso
  • Musteanu, Mónica
  • Guerra, Carmen
  • Drosten, Matthias
  • Barbacid, Mariano
Fig. S1. KSR1ΔCA1 localizes to the plasma membrane and binds BRAF. Fig. S2. 3D model of the mKSR1 kinase domain. Fig. S3. Purification of recombinant KSR1 protein. Fig. S4. RAS-independent proliferation in the absence of p53 does not involve KSR. Fig. S5. Western blot analysis of KSR1 expression levels in parental and resistant MIA PaCa-2 (A) as well as PDX-dc1 (B) cell lines. Fig. S6. Model of KSR-driven proliferation in RASless cells., Peer reviewed

DOI: https://doi.org/10.20350/digitalCSIC/15373

HANDLE: http://hdl.handle.net/10261/329692


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