Dataset.

Genomic patterns of homozygosity and inbreeding depression in Murciano-Granadina goats

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/269731
Digital.CSIC. Repositorio Institucional del CSIC
  • Luigi-Sierra, Maria Gracia
Genotypic data from 1,040 Murciano-Granadina female goats genotyped with the Goat SNP50 BeadChip, as well as milk production records of 817 Murciano-Granadina goats for the traits milk yield measured in kilograms at 210 days (MY210), 240 days (MY240) and 305 days (MY305), the natural logarithm of the somatic cell count divided by 1,000 (lnSCC, to convert this value into a somatic cell count please use the formula: elnSCC × 103 cells/mL), fat percentage (FP), protein percentage (PP) and lactose percentage (LP)., Peer reviewed
 
DOI: http://hdl.handle.net/10261/269731
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/269731

HANDLE: http://hdl.handle.net/10261/269731
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/269731
 
Ver en: http://hdl.handle.net/10261/269731
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/269731

Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/266078
Artículo científico (article). 2022

GENOMIC PATTERNS OF HOMOZYGOSITY AND INBREEDING DEPRESSION IN MURCIANO-GRANADINA GOATS

Digital.CSIC. Repositorio Institucional del CSIC
  • Luigi-Sierra, Maria Gracia
  • Fernández, Almudena
  • Martínez, Amparo
  • Guan, Dailu
  • Delgado, Juan Vicente
  • Fernández Álvarez, Javier
  • Landi, Vincenzo
  • Such, Xavier
  • Jordana, Jordi
  • Saura, María
  • Amills, Marcel
[Background] Inbreeding depression can adversely affect traits related to fitness, reproduction and productive performance. Although current research suggests that inbreeding levels are generally low in most goat breeds, the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical data., [Results] We genotyped 1040 goats with the Goat SNP50 BeadChip. This information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity patterns. We detected 38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1, 2, 4, 6, 14, 16 and 17. Eight hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk phenotypes. Four regions on chromosomes 8 and 25 were significantly associated with inbreeding depression for the natural logarithm of the somatic cell count. Notably, these regions contain several genes related with immunity, such as SYK, IL27, CCL19 and CCL21. Moreover, one region on chromosome 2 was significantly associated with inbreeding depression for milk yield., [Conclusions] Although genomic inbreeding levels are low in Murciano-Granadina goats, significant evidence of inbreeding depression for the logarithm of the somatic cell count, a phenotype closely associated with udder health and milk yield, have been detected in this population. Minimising inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis, which is one of the main causes of dairy goat culling., This research was funded by the European Regional Development Fund (FEDER)/Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación/Project Reference grant: PID2019-105805RB-I00 and by the CERCA Programme/Generalitat de Catalunya. We also acknowledge the support of the Spanish Ministerio de Ciencia e Innovación for the Center of Excellence Severo Ochoa 2020–2023 (CEX2019–000902-S) grant awarded to the Centre for Research in Agricultural Genomics (CRAG, Bellaterra, Spain). We also acknowledge the support of the CERCA programme of the Generalitat de Catalunya. Dailu Guan was funded by a PhD fellowship from the China Scholarship Council (CSC). Maria Luigi-Sierra was funded with a PhD fellowship Formación de Personal Investigador (BES-C-2017-079709) awarded by the Spanish Ministry of Economy and Competitivity., With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019–000902-S)., Peer reviewed




Dipòsit Digital de Documents de la UAB
oai:ddd.uab.cat:258945
Artículo científico (article). 2022

GENOMIC PATTERNS OF HOMOZYGOSITY AND INBREEDING DEPRESSION IN MURCIANO-GRANADINA GOATS

Dipòsit Digital de Documents de la UAB
  • Luigi Sierra, Maria Gracia
  • Fernández, Almudena
  • Martinez, Amparo
  • Guan, Dailu
  • Delgado Bermejo, Juan Vicente
  • Fernández Álvarez, Javier
  • Landi, Vincenzo
  • Such i Martí, Francesc Xavier
  • Jordana i Vidal, Jordi
  • Saura, María
  • Amills i Eras, Marcel
Inbreeding depression can adversely affect traits related to fitness, reproduction and productive performance. Although current research suggests that inbreeding levels are generally low in most goat breeds, the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical data. We genotyped 1040 goats with the Goat SNP50 BeadChip. This information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity patterns. We detected 38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1, 2, 4, 6, 14, 16 and 17. Eight hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk phenotypes. Four regions on chromosomes 8 and 25 were significantly associated with inbreeding depression for the natural logarithm of the somatic cell count. Notably, these regions contain several genes related with immunity, such as SYK, IL27, CCL19 and CCL21. Moreover, one region on chromosome 2 was significantly associated with inbreeding depression for milk yield. Although genomic inbreeding levels are low in Murciano-Granadina goats, significant evidence of inbreeding depression for the logarithm of the somatic cell count, a phenotype closely associated with udder health and milk yield, have been detected in this population. Minimising inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis, which is one of the main causes of dairy goat culling.



Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/269731
Dataset. 2022

GENOMIC PATTERNS OF HOMOZYGOSITY AND INBREEDING DEPRESSION IN MURCIANO-GRANADINA GOATS

Digital.CSIC. Repositorio Institucional del CSIC
  • Luigi-Sierra, Maria Gracia
Genotypic data from 1,040 Murciano-Granadina female goats genotyped with the Goat SNP50 BeadChip, as well as milk production records of 817 Murciano-Granadina goats for the traits milk yield measured in kilograms at 210 days (MY210), 240 days (MY240) and 305 days (MY305), the natural logarithm of the somatic cell count divided by 1,000 (lnSCC, to convert this value into a somatic cell count please use the formula: elnSCC × 103 cells/mL), fat percentage (FP), protein percentage (PP) and lactose percentage (LP)., Peer reviewed




Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/307926
Dataset. 2022

GENOMIC PATTERNS OF HOMOZYGOSITY AND INBREEDING DEPRESSION IN MURCIANO-GRANADINA GOATS - DATASET

Digital.CSIC. Repositorio Institucional del CSIC
  • Luigi-Sierra, Maria Gracia
Files list: 1. Murciano-Granadina-1040F.ped: Genotypic information of 50,514 SNPs genotyped in 1,040 Murciano-Granadina female goats obtained with the Goat SNP50 BeadChip (Illumina Inc., San Diego, CA). 2. Murciano-Granadina-1040F.map: Genomic positional information of the SNPs genotyped in 1,040 Murciano-Granadina female goats. 3. Pheno_file.txt: Milk production records from 820 Murciano-Granadina goats. Milk composition traits are normalized to a lactation of 210 days. Relationship between files: “.map” and “.ped” files are complementary, “.map” contains the genomic position and name of the genotypes displayed in “.ped” file. Files can be opened and manipulated with PLINK software (https://www.cog-genomics.org/plink/)., Genotypic information from 1,040 female Murciano-Granadina goats and the phenotypic records for milk traits of 820 female Murciano-Granadina goats. The dataset includes a README file with the information about each file., This research was funded by the European Regional Development Fund (FEDER)/Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación/Project Reference grant: PID2019-105805RB-I00 and by the CERCA Programme/Generalitat de Catalunya. We also acknowledge the support of the Spanish Ministerio de Ciencia e Innovación for the Center of Excellence Severo Ochoa 2020-2023 (CEX2019-000902-S) grant awarded to the Centre for Research in Agricultural Genomics (CRAG, Bellaterra, Spain). We also acknowledge the support of the CERCA programme of the Generalitat de Catalunya. Dailu Guan was funded by a PhD fellowship from the China Scholarship Council (CSC). Maria Luigi-Sierra was funded with a PhD fellowship Formación de Personal Investigador (BES-C-2017-079709) awarded by the Spanish Ministry of Economy and Competitivity., With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000902-S), Peer reviewed




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