Dataset.
Supplementary Information for Engineering pan-HIV-1 neutralization potency through multispecific antibody avidity
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331427
Digital.CSIC. Repositorio Institucional del CSIC
- Rujas, Edurne
- Cui, Hong
- Burnie, Jonathan
- Burn Aschner, Clare
- Zhao, Tiantian
- Insausti, Sara
- Muthuraman, Krithika
- Semesi, Anthony
- Ophel, Jasper
- Seaman, Michael S.
- Guzzo, Christina
- Treanor, Bebhinn
- Julien, Jean-Philippe
13 pages. -- This PDF file includes: Figures S1 to S7 and Tables S1 to S2. -- Fig. S1. Characterization of scFab-apoferritin fusions. -- Fig. S2. Multabody affinity-purification scheme. Protein A and Protein L sequential affinity purification. -- Fig. S3. Generation of a Multabody that cross-targets the HIV-1 Env and the CD4 receptor. -- Fig. S4. Biophysical characterization of HIV-1 Multabodies. Comparison of the Tm and Tagg temperatures of T-01/T-02 MB, 12-mer ferritin fusions, parental IgGs and the N6/PGDM1400x10E8v4 trispecific antibody. -- Fig. S5. Binding characteristics of IgGs binding to four different antigens. -- Fig. S6. Multabody v2 features. -- Fig. S7. PsV neutralization and inhibition of primary PBMC infection by Multabodies. -- Table S1. IC50 of individual and IgG mixtures, PGDM1400/N6x10E8v4 trispecific and HIV-1 Multabodies
against a 14-PsV panel and 25-PsV panel (additional 11 HIV-1 strains highly resistant to PGDM1400). -- Table S2. Potency of parental and IgG mixtures and T-01 Multabody versions against a 118-PsV panel., Peer reviewed
DOI: http://hdl.handle.net/10261/331427
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331427
HANDLE: http://hdl.handle.net/10261/331427
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331427
Ver en: http://hdl.handle.net/10261/331427
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331427
No hay resultados en la búsqueda
×
1 Versiones
1 Versiones
Digital.CSIC. Repositorio Institucional del CSIC
oai:digital.csic.es:10261/331427
Dataset. 2022
SUPPLEMENTARY INFORMATION FOR ENGINEERING PAN-HIV-1 NEUTRALIZATION POTENCY THROUGH MULTISPECIFIC ANTIBODY AVIDITY
Digital.CSIC. Repositorio Institucional del CSIC
- Rujas, Edurne
- Cui, Hong
- Burnie, Jonathan
- Burn Aschner, Clare
- Zhao, Tiantian
- Insausti, Sara
- Muthuraman, Krithika
- Semesi, Anthony
- Ophel, Jasper
- Seaman, Michael S.
- Guzzo, Christina
- Treanor, Bebhinn
- Julien, Jean-Philippe
13 pages. -- This PDF file includes: Figures S1 to S7 and Tables S1 to S2. -- Fig. S1. Characterization of scFab-apoferritin fusions. -- Fig. S2. Multabody affinity-purification scheme. Protein A and Protein L sequential affinity purification. -- Fig. S3. Generation of a Multabody that cross-targets the HIV-1 Env and the CD4 receptor. -- Fig. S4. Biophysical characterization of HIV-1 Multabodies. Comparison of the Tm and Tagg temperatures of T-01/T-02 MB, 12-mer ferritin fusions, parental IgGs and the N6/PGDM1400x10E8v4 trispecific antibody. -- Fig. S5. Binding characteristics of IgGs binding to four different antigens. -- Fig. S6. Multabody v2 features. -- Fig. S7. PsV neutralization and inhibition of primary PBMC infection by Multabodies. -- Table S1. IC50 of individual and IgG mixtures, PGDM1400/N6x10E8v4 trispecific and HIV-1 Multabodies
against a 14-PsV panel and 25-PsV panel (additional 11 HIV-1 strains highly resistant to PGDM1400). -- Table S2. Potency of parental and IgG mixtures and T-01 Multabody versions against a 118-PsV panel., Peer reviewed
No hay resultados en la búsqueda
1106