The field of stimuli-responsive supramolecular biomaterials has rapidly advanced in recent years, with potential applications in diverse areas such as cancer theranostics, tissue engineering, and catalysis. However, designing molecular materials that exhibit predetermined hierarchical self-assembly to control the size, morphology, surface chemistry, and responsiveness of the final nanostructures remains a significant challenge. In this study, we present a divergent synthetic approach for the fabrication of spherical micelles and functional 1D-glyconanotube-based photoresponsive gels from structurally related diazobenzene/diacetylene glycolipids. The resulting nanostructures were characterized using NMR, TEM, and SEM, confirming the formation of spherical and tubular nanostructures in both the gel and solution states. Upon UV irradiation, a reversible gel-sol transition was observed, resulting from the photoswitching of the azobenzene unit from the stretched trans form to the compact, metastable cis form. Our gels were shown to enable spatio-temporal control of the adhesion and release of the lectin Concanavalin A, demonstrating potential use as regenerable biomaterials to fight against infections with toxins and pathogens. Additionally, our micelles and gels were evaluated as nanocontainers for loading and controlled release of hydrophobic dyes and antitumoural agents, suggesting their possible use as smart theranostic drug delivery systems., Financial support was provided by the Spanish Ministry of Science and Innovation (Ref: PID2020-119949RB-I00/AEI/10.13039/501100011033), the Andalusian Ministry of Economy, Science and Innovation cofinanced by the European Regional Development Fund (ERDF) from FEDER and the European Social Fund (ESF) (PY20_00882 and CV20-04221), the CSIC (CSIC-COV19-047) the PAIDI Program from the Andalusian Government (FQM-313). The COST action CA-18132 ‘‘Functional Glyconanomaterials for the Development of Diagnostic and Targeted Therapeutic Probe’’ is also acknowledged. ERB, was supported by FPU predoctoral fellowship (FPU15/04267), from Spanish Ministry of Education, Culture and Sports. We also thank the Centre of Research Technology and Innovation of the University of Seville (CITIUS) for the use of TEM, SEM,
FESEM, and NMR facilities, No

Zirconium-based MOFs, such as PCN-222 (MOF-545), have gained attention due to their regular porosity, tuneable pore size, versatile structure and exceptional thermal/chemical stability. However, the synthesis of PCN-222 using traditional batch processes suffers from limitations in productivity, scalability, and control over size and morphology. This study presents a paradigm shift from batch to continuous flow (c.f.) synthesis for the efficient production of PCN-222. The optimization of batch conditions and exploration of c.f. parameters enabled the synthesis of high-quality PCN-222 with Space-Time-Yield (STY) exceeding 950 kg m−3 day−1. The c.f. approach offered advantages including improved resource efficiency, safer chemical handling, and scalability. The integration of ultrasound-assisted technique into the c.f. facilitated the shaping of PCN-222 into prolate ellipsoids, making it suitable for applications in drug delivery and catalysis. The successful substitution of hazardous solvents with greener alternatives further enhanced the sustainability of the process. Finally, the loading of a thio-N-acetylgalactosamine-PEG-sulfate ligand on PCN-222 in tandem c.f., expanded the potentialities of the flow synthetic approach. This study not only advances the field of MOF synthesis but also paves the way for efficient and sustainable manufacturing processes in c.f. synthesis of nanoparticles and functionalized nanoparticles for active drug delivery., Financial support was provided by the Andalusian Ministry of Economy, Science and Innovation in the framework of the Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020, programme 54ª “Investigación científica e innovación”, “POSTDOC_21_00594”), the Spanish Ministry of Science and Innovation (Ref: PID2020-119949RB-I00/AEI/10.13039/501100011033), the Andalusian Ministry of Economy, Science and Innovation cofinanced by the European Regional Development Fund (ERDF) from FEDER and the European Social Fund (ESF) (PY20_00882 and CV20-04221). The COST action CA-18132 “Functional Glyconanomaterials for the Development of Diagnostic and Targeted Therapeutic Probe” is also acknowledged. The authors acknowledge Dr. Carolina Carrillo-Carrión for her technical assistance in the initial batch experiments conducted for this work., No