Two comma-separated values (CSV) files named 'lysins_rf.csv' and 'lysins_pf.csv', the first one containing the full list of lysin entries (with GenBank/RefSeq sequence identifiers, amino acid sequences, bacterial hosts data, architectural information and sequence-based physicochemical calculations) and the second one comprising the domain sequence predictions performed on the aforementioned lysins according to PfamScan (https://www.ebi.ac.uk/Tools/pfa/pfamscan/), Collection of phage lysin sequences retrieved from previously published genomic data; collected, curated, analysed and provided as part of the work "Sequence-function relationships in phage-encoded bacterial cell wall lytic enzymes and their implications for phage-derived products design", published in Journal of Virology (2021), doi: 10.1128/JVI.00321-21., Funded by a grant from the Ministerio de Economía y Competitividad (MINECO-FEDER) (SAF2017-88664-R). Additional funding was provided by the CIBER de Enfermedades Respiratorias (CIBERES), an initiative of the Instituto de Salud Carlos III. Roberto Vázquez was the recipient of a predoctoral fellowship from CIBERES., No