INTERACCION GENOTIPO-FENOTIPO Y AMBIENTE. APLICACION A UN MODELO PREDICTIVO EN PRIMEROS EPISODIOS PSICOTICOS
08/1026
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Nombre agencia financiadora Ministerio de Ciencia e Innovación
Acrónimo agencia financiadora MICINN
Programa Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia
Subprograma Subprograma Estatal de Generación del Conocimiento
Convocatoria Proyectos de investigación en salud
Año convocatoria 2008
Unidad de gestión Subdirección General de Evaluación y Fomento de la Investigación
Centro beneficiario HOSPITAL VIRGEN DEL CAMINO
Centro realización FUNDACION MIGUEL SERVET
Identificador persistente http://dx.doi.org/10.13039/501100004837
Publicaciones
Resultados totales (Incluyendo duplicados): 1
Encontrada(s) 1 página(s)
Encontrada(s) 1 página(s)
Individual trajectories of cognitive performance in first episode psychosis: a 2-year follow-up study
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Sánchez Torres, Ana María
- Moreno-Izco, Lucía
- Lorente Omeñaca, Ruth
- Cabrera, Bibiana
- Lobo, Antonio
- González Pinto, Ana
- Merchán-Naranjo, Jessica
- Corripio, Iluminada
- Vieta, Eduard
- Serna, Elena de la
- Butjosa, Anna
- Contreras, Fernando
- Sarró, Salvador
- Mezquida, Gisela
- Ribeiro Fernández, María
- Bernardo, Miguel
- Cuesta, Manuel J.
- PEPs Group
Individual changes over time in cognition in patients with psychotic disorders have been studied very little, especially in
the case of frst episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition
over 2 years of a sample of 159 FEP patients was reliable and clinically signifcant, using the reliable change index (RCI)
and clinically signifcant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and
controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures.
We analysed the course of cognitive measures over time, using analysis of variance, and the individual trajectories in the
cognitive measures with the regression-based RCI (RCISRB) and the CSC. The RCISRB showed that between 5.4 and 31.2%
of the patients showed deterioration patterns, and between 0.6 and 8.8% showed improvement patterns in these tests over
time. Patients showing better cognitive profles according to RCISRB (worsening in zero to two cognitive measures) showed
better premorbid, clinical and functional profles than patients showing deterioration patterns in more than three tests. When
combining RCISRB and CSC values, we found that less than 10% of patients showed improvement or deterioration patterns
in executive function and attention measures. These results support the view that cognitive impairments are stable over the
frst 2 years of illness, but also that the analysis of individual trajectories could help to identify a subgroup of patients with
particular phenotypes, who may require specifc interventions., This work was supported by the Carlos III Health Institute
(European Regional Development Funds-ERDF) of the Spanish Ministry of Economic Afairs and Competitiveness (08/1026, 11/02831,
14/01621) and the Health Department of the Government of Navarra
(87/2014).
the case of frst episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition
over 2 years of a sample of 159 FEP patients was reliable and clinically signifcant, using the reliable change index (RCI)
and clinically signifcant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and
controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures.
We analysed the course of cognitive measures over time, using analysis of variance, and the individual trajectories in the
cognitive measures with the regression-based RCI (RCISRB) and the CSC. The RCISRB showed that between 5.4 and 31.2%
of the patients showed deterioration patterns, and between 0.6 and 8.8% showed improvement patterns in these tests over
time. Patients showing better cognitive profles according to RCISRB (worsening in zero to two cognitive measures) showed
better premorbid, clinical and functional profles than patients showing deterioration patterns in more than three tests. When
combining RCISRB and CSC values, we found that less than 10% of patients showed improvement or deterioration patterns
in executive function and attention measures. These results support the view that cognitive impairments are stable over the
frst 2 years of illness, but also that the analysis of individual trajectories could help to identify a subgroup of patients with
particular phenotypes, who may require specifc interventions., This work was supported by the Carlos III Health Institute
(European Regional Development Funds-ERDF) of the Spanish Ministry of Economic Afairs and Competitiveness (08/1026, 11/02831,
14/01621) and the Health Department of the Government of Navarra
(87/2014).