Determinantes clínicos y neurobiológicos de segundos episodios de esquizofrenia. Estudio longitudinal de primeros episodios psicóticos

PI11/02831

Nombre agencia financiadora Ministerio de Ciencia e Innovación
Acrónimo agencia financiadora MICINN
Programa Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia
Subprograma Subprograma Estatal de Generación del Conocimiento
Convocatoria Proyectos de Investigación en Salud
Año convocatoria 2011
Unidad de gestión Subdirección General de Evaluación y Fomento de la Investigación
Centro beneficiario FUNDACIÓN MIGUEL SERVET
Centro realización HOSPITAL DE NAVARRA
Identificador persistente http://dx.doi.org/10.13039/501100004837

Publicaciones

Found(s) 3 result(s)
Found(s) 1 page(s)

Influence of social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis

Zaguán. Repositorio Digital de la Universidad de Zaragoza
  • González-Ortega, I.
  • González-Pinto, A.
  • Alberich, S.
  • Echeburuá, E.
  • Bernardo, M.
  • Cabrera, B.
  • Amoretti, S.
  • Lobo, A.
  • Arango, C.
  • Corripio, I.
  • Vieta, E.
  • De La Serna, E.
  • Rodriguez-Jimenez, R.
  • Segarra, R.
  • López-Ilundain, J.M.
  • Sánchez-Torres, A.M.
  • Cuesta, M.J.
  • Zorrilla, I.
  • López, P.
  • Bioque, M.
  • Mezquida, G.
  • Barcones, F.
  • De-La-Cámara, C.
  • Parellada, M.
  • Espliego, A.
  • Alonso-Solís, A.
  • Grasa, E.M.
  • Varo, C.
  • Montejo, L.
  • Castro-Fornieles, J.
  • Baeza, I.
  • Dompablo, M.
  • Torio, I.
  • Zabala, A.
  • Eguiluz, J.I.
  • Moreno-Izco, L.
  • Sanjuan, J.
  • Guirado, R.
  • Cáceres, I.
  • Garnier, P.
  • Contreras, F.
  • Bobes, J.
  • Al-Halabí, S.
  • Usall, J.
  • Butjosa, A.
  • Sarró, S.
  • Landin-Romero, R.
  • Ibáñez, A.
  • Selva, G.
Background. Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the direction of their associations is not clear. Therefore, the main aim of this study was to analyze the influence of social cognition as a mediator between cognitive reserve and cognitive domains on functioning in FEP both at baseline and at 2 years.
Methods. The sample of the study was composed of 282 FEP patients followed up for 2 years. To analyze whether social cognition mediates the influence of cognitive reserve and cognitive domains on functioning, a path analysis was performed. The statistical significance of any mediation effects was evaluated by bootstrap analysis.
Results. At baseline, as neither cognitive reserve nor the cognitive domains studied were related to functioning, the conditions for mediation were not satisfied. Nevertheless, at 2 years of follow-up, social cognition acted as a mediator between cognitive reserve and functioning. Likewise, social cognition was a mediator between verbal memory and functional outcome. The results of the bootstrap analysis confirmed these significant mediations (95% bootstrapped CI (-10.215 to -0.337) and (-4.731 to -0.605) respectively).
Conclusions. Cognitive reserve and neurocognition are related to functioning, and social cognition mediates in this relationship.




Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History

Dipòsit Digital de Documents de la UAB
  • González-Pinto, Ana|||0000-0002-2568-5179
  • González-Ortega, Itxaso|||0000-0001-7074-4353
  • Alberich, Susana|||0000-0002-4945-3428
  • Ruiz de Azúa, Sonia
  • Bernardo, Miquel|||0000-0001-8748-6717
  • Bioque, Miquel|||0000-0001-6887-7149
  • Cabrera, Bibiana|||0000-0002-7749-5449
  • Corripio, Iluminada|||0000-0003-2562-711X
  • Arango, Celso|||0000-0003-3382-4754
  • Lobo, Antonio|||0000-0002-9098-655X
  • Sánchez-Torres, Ana Maria|||0000-0002-9505-2406
  • Cuesta, Manuel J.|||0000-0003-0250-5718
The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.




Influence of social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis

Dipòsit Digital de Documents de la UAB
  • González-Ortega, Itxaso|||0000-0001-7074-4353
  • González-Pinto, Ana|||0000-0002-2568-5179
  • Alberich, Susana|||0000-0002-4945-3428
  • Echeburuá, Enrique|||0000-0001-7654-0781
  • Bernardo, Miquel|||0000-0001-8748-6717
  • Cabrera, Bibiana|||0000-0002-7749-5449
  • Amoretti, Silvia|||0000-0001-6017-2734
  • Lobo, Antonio|||0000-0002-9098-655X
  • Arango, C.
  • Corripio, Iluminada|||0000-0003-2562-711X
  • Vieta, Eduard|||0000-0002-0548-0053
  • de la Serna, Elena|||0000-0002-7869-9881
  • Rodriguez-Jimenez, Roberto|||0000-0003-2251-7249
  • Segarra, Rafael|||0000-0002-2033-8151
  • López-Ilundain, Jose Manuel|||0000-0003-0361-0667
  • Sánchez-Torres, Ana Maria|||0000-0002-9505-2406
  • Cuesta, Manuel J.|||0000-0003-0250-5718
  • Zorrilla, Iñaki|||0000-0001-6444-8208
  • López, Platas
  • Bioque, Miquel|||0000-0001-6887-7149
  • Mezquida, Gisela|||0000-0002-6080-2203
  • Barcones, Fe
  • De-la-Cámara, Concepción|||0000-0003-2284-7862
  • Parellada, Mara|||0000-0001-7977-3601
  • Espliego, Ana
  • Alonso-Solís, Anna|||0000-0002-5393-9391
  • Grasa, Eva|||0000-0003-1100-7489
  • Varo, Cristina|||0000-0002-8859-3052
  • Montejo, Laura|||0000-0003-4407-9454
  • Castro-Fornieles, Josefina|||0000-0003-0632-2687
  • Baeza, Illyana
  • Dompablo, Mónica|||0000-0002-7195-3816
  • Torio, Iosune|||0000-0002-1771-1891
  • Zabala, Arantzazu
  • Eguiluz, J.I.
  • Moreno-Izco, Lucía
  • Sanjuan, Julio
  • Guirado, Ramon|||0000-0003-0259-5709
  • Cáceres, Iris
  • Garnier, P.
  • Contreras, Fernando|||0000-0003-2929-2804
  • Bobes, Julio|||0000-0003-2187-4033
  • Al-Halabí, Susana|||0000-0003-1162-2115
  • Usall, Judith|||0000-0002-1746-7737
  • Butjosa Molines, Anna|||0000-0001-5317-9508
  • Sarró, Salvador|||0000-0003-1835-2189
  • Landin-Romero, Ramón|||0000-0003-0485-8090
  • Ibañez, Angela|||0000-0003-2751-0150
  • Selva, Gabriel
Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the direction of their associations is not clear. Therefore, the main aim of this study was to analyze the influence of social cognition as a mediator between cognitive reserve and cognitive domains on functioning in FEP both at baseline and at 2 years. The sample of the study was composed of 282 FEP patients followed up for 2 years. To analyze whether social cognition mediates the influence of cognitive reserve and cognitive domains on functioning, a path analysis was performed. The statistical significance of any mediation effects was evaluated by bootstrap analysis. At baseline, as neither cognitive reserve nor the cognitive domains studied were related to functioning, the conditions for mediation were not satisfied. Nevertheless, at 2 years of follow-up, social cognition acted as a mediator between cognitive reserve and functioning. Likewise, social cognition was a mediator between verbal memory and functional outcome. The results of the bootstrap analysis confirmed these significant mediations (95% bootstrapped CI (-10.215 to-0.337) and (-4.731 to-0.605) respectively). Cognitive reserve and neurocognition are related to functioning, and social cognition mediates in this relationship.