Prevención eficiente de la demencia en sujetos con alto riesgo
PI14/01764
•
Nombre agencia financiadora Ministerio de Economía y Competitividad
Acrónimo agencia financiadora MINECO
Programa Programa Estatal de I+D+I Orientada a los Retos de la Sociedad
Subprograma Salud, cambio demográfico y bienestar
Convocatoria Proyectos de investigación en salud (AE Salud 2014)
Año convocatoria 2014
Unidad de gestión Instituto de Salud Carlos III (ISCIII)
Centro beneficiario UNIVERSIDAD DE NAVARRA
Centro realización UNIVERSIDAD DE NAVARRA
Identificador persistente http://dx.doi.org/10.13039/501100003329
Publicaciones
Found(s) 13 result(s)
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Validation study of a Spanish version of the modified Telephone Interview for Cognitive Status (STICS-m), Validación de la versión en español de la Telephone Interview for Cognitive Status modificada
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Muñoz-García, Mariana
- Cervantes, Sebastián
- Razquin, Cristina
- Guillén Grima, Francisco
- Toledo, Juan B.
- Martínez González, Miguel Ángel
- Toledo, Estefanía
Objetivo: Estudiar la correlación de la Telephone Interview for Cognitive Status modificada en español(STICS-m) con el Mini-Mental State Examination (MMSE) y predecir la capacidad de la primera para detectar el desarrollo de demencia. Método: Ciento seis sujetos de un estudio de intervención dietética fueron evaluados personalmente con el MMSE y por teléfono con la STICS-m. La correlación entre ambos se midió con el coeficiente de correlación intraclase (CCI) de consistencia. Además, 932 participantes mayores de 55 años de la cohorte 'Seguimiento Universidad de Navarra' fueron evaluados con la STICS-m. Durante una mediana de seguimiento de 6,5 años, se recogió información sobre el desarrollo de demencia. Mediante regresión logística se estudió la asociación entre la puntuación de la STICS-m o el cambio a 2 años en la puntuación y el riesgo de desarrollar demencia, ajustando por apolipoproteína E, edad y años de educación universitaria. Resultados: El CCI entre el MMSE y la STICS-m fue de 0,31 (intervalo de confianza del 95% [IC95%]:0,13-0,48). La odds ratio (OR) ajustada para el desarrollo de demencia para cada punto adicional en la puntuación basal de la STICS-m fue de 0,85 (IC95%: 0,72-1,02; p = 0,084). Al considerar el cambio en la puntuación a los 2 años como variable independiente, la OR fue de 0,79 (IC95%: 0,67-0,93; p = 0,006)., Objective: To compare the Spanish version of the modified Telephone Interview of Cognitive Status(STICS-m) with the Mini-Mental State Examination (MMSE) and predict its ability to detect the development of dementia. Method: 106 participants in a dietary intervention trial underwent face-to-face evaluation with the MMSE, and phone interview with the STICS-m. The correlation between STICS-m and MMSE was assessed with the intraclass correlation coefficient (ICC) of consistency. Secondly, 932 participants over 55 years old from the ‘Seguimiento Universidad de Navarra’ cohort were evaluated with the STICS-m and data ondementia diagnosis were gathered (median follow-up time of 6.5 years). A logistic regression model evaluated the association between STICS-m score or 2-year changes in STICS-m score and risk of developing dementia, adjusting for ApoE, age and years of university education. Results: The ICC between the MMSE and the STICS-m was 0.31 (95% confidence interval [95%CI]: 0.13-0.48). The adjusted odds ratio (OR) for the development of dementia for each additional point in the baseline STICS-m score was 0.85 (95%CI: 0.72-1.02; p = 0.084). When considering the 2-year change inthe STICS-m score as exposure, the OR for the development of dementia was 0.79 (95%CI: 0.67-0.93; p = 0.006). Conclusions: The weak correlation between the STICS-m and the MMSE reflects moderate-low concurrent validity. Even so, the STICS-m can be regarded as an useful tool in the epidemiological setting since increasing scores appear to be able to predict a lower risk of developing dementia., The SUN Project has received funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615,PI14/01668, PI14/01798, PI14/01764, and G03/140), the Navarra Regional Government (45/2011, 122/2014), and the University of Navarra. The PREDIMED Plus-NAVARRA trial has received fundingfrom the European Research Council (Advanced Research Grant2013-2018; 340918) granted to MAMG, the Instituto de Salud Carlos III (PI13/01090, PI16/01522).
Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- López-Herreros, J.
- Martínez González, Miguel Ángel
- Gea, A.
- Sánchez Villegas, María Almudena
- Dierssen Sotos, Trinidad
- Jiménez-Moleón, J. J.
- Ruiz Canela, Miguel
- Toledo, Estefanía
Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a
healthy middle-aged Mediterranean cohort.
Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university
graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36)
twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between
self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their
interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet).
Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent
vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model
with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend <
0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend =
0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with
repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these
associations.
Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the
Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous
comorbidities or adherence to the MedDiet., This project was made possible by funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI18/00631, PI20/00564 and G03/140), from the Government of Navarra (27/2011, 45/2011, 122/2014), from the National Plan on Drugs (2020/021) as well as from the University of Navarra.
healthy middle-aged Mediterranean cohort.
Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university
graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36)
twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between
self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their
interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet).
Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent
vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model
with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend <
0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend =
0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with
repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these
associations.
Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the
Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous
comorbidities or adherence to the MedDiet., This project was made possible by funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI18/00631, PI20/00564 and G03/140), from the Government of Navarra (27/2011, 45/2011, 122/2014), from the National Plan on Drugs (2020/021) as well as from the University of Navarra.
Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Valer-Martínez, A.
- Sayón-Orea, Carmen
- Martínez, J. Alfredo
- Basterra Gortari, Francisco Javier
- Martínez González, Miguel Ángel
- Bes-Rastrollo, Maira
Purpose: Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D in a large prospective cohort based on a Mediterranean population. Methods: The SUN project is a prospective and dynamic Spanish cohort that gathers university graduates who have answered lifestyle questionnaires, including a validated Food Frequency Questionnaire. The association between predicted serum vitamin D and the risk of T2D was assessed through Cox regression models according to quartiles (Q) of predicted vitamin D at baseline. The models were adjusted for potential confounders and sensitivity analyses were performed to ensure the robustness of our findings. Results: Our study included a total of 18,594 participants and after a total follow-up of 238,078 person-years (median follow-up of 13.5 years), 209 individuals were diagnosed with incident T2D. We found a significant inverse association between predicted levels of serum vitamin D and the risk of developing T2D, after adjusting for potential confounders and performing different sensitivity analyses (hazard ratio Q4 vs. Q1: 0.48, 95% CI 0.26¿0.88; p for trend = 0.032). Conclusion: The outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D., Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The SUN project has received funding from the Spanish Government-Instituto de Salud Carlos III, the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI20/00564, PI23/01332, and G03/140), the Navarra Regional Government (27/2011, 45/2011, 122/2014), the National Plan on Drugs (2020/021), and the University of Navarra.
The risk of incident depression when assessed with the lifestyle and well-being index
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Pano, O.
- Sayón-Orea, Carmen
- Hershey, María Soledad
- O, Víctor de la
- Fernández-Lázaro, César
- Bes-Rastrollo, Maira
- Martín-Moreno, José M.
- Sánchez Villegas, María Almudena
- Martínez Hernández, J. Alfredo
Objectives: Novel findings indicate links between unhealthy lifestyles and depression based on active inflammatory processes. Thus, identifying participants with poor habits could reveal differences in trends of incident depression. This study aimed to examine the association between an objective lifestyle assessment, as measured by the Lifestyle and Well-Being Index (LWB-I), and incident depression in healthy participants of a Spanish cohort. Study design: This was a longitudinal analysis of a subsample of 10,063 participants from the Seguimiento Universidad de Navarra cohort study. Methods: Group comparisons and Cox proportional hazard models were conducted using the LWB-I, which categorizes the sample into groups with healthy and unhealthy lifestyles and well-being. The main outcome was incident depression as well as secondary outcomes. Results: Those classified to the transition category of LWB-I were associated with a hazard ratio of 0.67 (95% confidence interval: 0.52-0.87), and those in the excellent category showed a hazard ratio of 0.44 (95% confidence interval: 0.33-0.58), which in both groups reflects a significantly lower risk of incident depression compared with the group including those classified in the poor LWB-I level. Moreover, the available sensitivity analyses concerning time of depression diagnosis or antidepressant treatment further supported the role of nutrition and physical activity on incident depression. Interestingly, throughout the follow-up, incident depression was inversely related to healthier daily habits as measured by the LWB-I. Conclusions: A global assessment of lifestyles such as the LWB-I provides valuable insight into the complex relationship between lifestyle factors and their link to depression risk., Funding was received from the Spanish Government-Instituto de Salud Carlos III , the European Regional Development Fund (FEDER; RD 06/0045, CIBER-OBN, grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI20/00564 and G03/140), the Navarra Regional Government (27/2011, 45/2011, 122/2014), the National Plan on Drugs (2020/021), and the University of Navarra.
Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study
Dadun. Depósito Académico Digital de la Universidad de Navarra
- López-Herreros, J. (J.)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Gea-Sánchez, A. (Alfredo)
- Sanchez-Villegas, A. (Almudena)
- Dierssen-Sotos, T. (T.)
- Jiménez-Moleón, J.J. (José Juan)
- Ruiz-Canela, M. (Miguel)
- Toledo, E. (Estefanía)
Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants -mean age 42.8 years at first HRQoL ascertainment, all university graduates-. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16-0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36-0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54-0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46-0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74-0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL -assessed as self-reported health, PCS-36 and MCS-36- obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.
Mortality prediction of the nutrient profile of the Chilean front-of-pack warning labels: Results from the Seguimiento Universidad de Navarra prospective cohort study
Dadun. Depósito Académico Digital de la Universidad de Navarra
- Bullón-Vela, M. V. (María Vanessa)
- Sayon-Orea, C. (Carmen)
- Gómez-Donoso, C. (Clara)
- Martínez-Hernández, J.A. (J. Alfredo)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Bes-Rastrollo, M. (Maira)
Background and aimsFront-of-Pack (FoP) nutrition labelling has been established as a policy, empowering consumers to choose healthy food options for preventing diet-related non-communicable diseases. This study aimed to evaluate the association between the nutrient profile underlying the Chilean warning label score and all-cause mortality and to conduct a calibration with the Nutri-Score in a large cohort of Spanish university graduates. Materials and methodsThis prospective cohort study analysed 20,666 participants (8,068 men and 12,598 women) with a mean (standard deviation) age of 38 years (+/- 12.4) from the SUN cohort. Dietary food intake was assessed by a validated semi-quantitative food-frequency questionnaire at baseline and after 10 years of follow-up. The warning label score was calculated by considering the threshold of nutrients (sugar, saturated fat, and sodium) and energy density per 100 g/ml of product, as established by Chilean Legislation. Participants were classified according to quartiles of consumption of daily label score: Q1 (<= 5.0), Q2 (>5.0-7.1), Q3 (>7.1-9.8), and Q4 (>9.8). Time-dependent, multivariable-adjusted Cox models were applied. To compare the performance of the warning label score and Nutri-Score to predict mortality, we used the Akaike information criterion (AIC) and Bayesian information criterion (BIC) methods. ResultsDuring a median of 12.2 years of follow-up, 467 deaths were identified. A higher score in the warning label values (lower nutritional quality) was associated with an increased risk of all-cause mortality [HR (95% CI) Q4 vs. Q1: 1.51 (1.07-2.13); p-trend = 0.010] and cancer mortality [HR (95% CI) Q4 vs. Q1: 1.91 (1.18-3.10); p-trend = 0.006]. However, no statistically significant association was found for cardiovascular mortality. Furthermore, the warning label score and Nutri-Score exhibited comparable AIC and BIC values, showing similar power of prediction for mortality. ConclusionA diet with a higher warning label score (>9.8 per day) was a good predictor of all cases and cancer mortality in a large Spanish cohort of university graduates. Also, the warning label score was capable to predict mortality as well as the Nutri-Score. Our findings support the validity of the warning label score as a FoP nutrition labelling policy since it can highlight less healthy food products.
Coffee consumption and the risk of metabolic syndrome in the 'Seguimiento Universidad de Navarra' project
Dadun. Depósito Académico Digital de la Universidad de Navarra
- Corbi-Cobo-Losey, M.J. (María J.)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Gribble, A.K. (Anne K.)
- Fernandez-Montero, A. (Alejandro)
- Navarro, A.M. (Adela M.)
- Dominguez, L.J. (Ligia J.)
- Bes-Rastrollo, M. (Maira)
- Toledo, E. (Estefanía)
(1) Background: Metabolic Syndrome (MetS) affects over a third of the United States population, and has similar prevalence in Europe. Dietary approaches to prevention are important. Coffee consumption has been inversely associated with mortality and chronic disease; however, its relation to the risk of MetS is unclear. We aimed to investigate the association between coffee consumption and incident MetS in the 'Seguimiento Universidad de Navarra' cohort. (2) Methods: From the SUN project, we included 10,253 participants initially free of MetS. Coffee consumption was assessed at baseline, and the development of MetS was assessed after 6 years of follow-up. All data were self-reported by participants. MetS was defined according to the Harmonizing Definition. We used multivariable logistic regression models to estimate odds ratios and 95% confidence intervals for incident MetS according to four categories of coffee consumption: <1 cup/month; >= 1 cup/month to <1 cup/day; >= 1 cup/day to <4 cups/day; >= 4 cups/day. (3) Results: 398 participants developed MetS. Coffee consumption of >= 1 to <4 cups/day was associated with significantly lower odds of developing MetS (multivariable adjusted OR = 0.71, 95% CI (0.50-0.99)) as compared to consumption of <1 cup/month. (4) Conclusions: In a Mediterranean cohort, moderate coffee consumption may be associated with a lower risk of MetS.
The Mediterranean diet and physical activity: better together than apart for the prevention of premature mortality
Dadun. Depósito Académico Digital de la Universidad de Navarra
- Hershey-de-la-Cruz, M.S. (María Soledad)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Álvarez-Álvarez, I. (Ismael)
- Martínez-Hernández, J.A. (J. Alfredo)
- Ruiz-Canela, M. (Miguel)
Diet and physical activity (PA) have been studied extensively in epidemiology as single or combined lifestyle factors; however, their interaction has not been studied thoroughly. Studying potential synergisms between lifestyle components with a comprehensive interaction analysis, including additive measures of interaction, provides key insights into the nature of their joint effect and helps target interventions more effectively. First, a comprehensive review was conducted to assess the potential research gap regarding reported interaction analyses conducted in studies assessing the Mediterranean diet (MedDiet) in combination with PA on all-cause mortality. Thereafter, we prospectively assessed the joint association of the MedDiet with PA on all-cause mortality in the Seguimiento Universidad de Navarra (SUN) cohort, followed by both multiplicative and additive interaction analyses. The conjoint effect of low adherence to the MedDiet and low PA observed an increased risk greater than the individual risk factors, suggesting a potential additive interaction or synergism between both exposures, with relative risk due to interaction (RERI) and (95 % confidence interval (95 % CI)) = 0.46 (-0.83 to 1.75) and attributable proportion (95 % CI) due to interaction of 36 % (-0.62, 1.34). No multiplicative interaction was detected. Studying interactions between lifestyle factors, such as the MedDiet and PA, is particularly relevant given the current research gaps in studying the complexities of combined aspects of lifestyle in comparison with isolated behaviours. Our findings underline the important public health message of adhering to both the MedDiet and PA for the prevention of premature mortality.
Mediterranean alcohol-drinking patterns and all-cause mortality in women more than 55 years old and men more than 50 years old in the "Seguimiento Universidad de Navarra" (SUN) Cohort
Dadun. Depósito Académico Digital de la Universidad de Navarra
- Barbería-Latasa, M. (María)
- Bes-Rastrollo, M. (Maira)
- Pérez-Araluce, R.M. (Rafael María)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Gea, A. (Alfredo)
Background: Most of the available epidemiological evidence on alcohol and chronic disease agrees on recommending alcohol abstention to young people, but some controversy exists about the most appropriate recommendation for alcohol abstention for people of older ages. A growing body of evidence suggests that the pattern of alcohol consumption is likely to be a strong effect modifier. The Mediterranean Alcohol Drinking Pattern (MADP) represents a score integrating several dimensions of drinking patterns (moderation, preference for red wine, drinking with meals, and avoiding binge drinking). Our aim was to clarify this issue and provide more precise recommendations on alcohol consumption. Methods: We prospectively followed-up 2226 participants (men older than 50 years and women older than 55 years at baseline) in the Seguimiento Universidad de Navarra (SUN) cohort. We classified participants into three categories of adherence to the MADP score (low, moderate, and high), and we added a fourth category for abstainers. Cox regression models estimated multivariable-adjusted hazard ratios (HR) of all-cause death and 95% confidence intervals (CI) using low MADP adherence as the reference category. Results: The strongest reduction in risk of mortality was observed for those with high adherence to the MADP, with an HR of 0.54 (95% CI: 0.37-0.80). The moderate adherence group (HR = 0.65, 95% CI: 0.44-0.96) and the abstention group (HR = 0.60, 95% CI: 0.36-0.98) also exhibited lower risks of mortality than the low MADP adherence group. Conclusions: based on the available evidence, a public health message can be provided to people older than 50 years as follows: among those who drink alcohol, high adherence to the MADP score could substantially reduce their risk of all-cause mortality.
Effect of binge-drinking on quality of life in the 'Seguimiento Universidad de Navarra' (SUN) cohort
Dadun. Depósito Académico Digital de la Universidad de Navarra
- Pérez-Araluce, R.M. (Rafael María)
- Bes-Rastrollo, M. (Maira)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Toledo, E. (Estefanía)
- Ruiz-Canela, M. (Miguel)
- Barbería-Latasa, M. (María)
- Gea, A. (Alfredo)
Background: Binge-drinking is one of the alcohol drinking patterns with the worst health consequences. Nonetheless, binge-drinking is highly prevalent. The perceived benefits that motivate it are ultimately related to subjective well-being. In this context, we analyzed the relationship between binge-drinking and quality of life.
Methods: We evaluated 8992 participants of the SUN cohort. We classified as binge-drinkers those who reported consuming six or more drinks on at least one occasion the year before recruitment (n = 3075). We fitted multivariable logistic regression models to calculate the odds ratios (ORs) of a worse physical and mental quality of life, measured with the validated SF-36 questionnaire at 8 years of follow-up (cut-off point = P75 or highest score).
Results: Binge-drinking was associated with greater odds of having a worse mental quality of life, even adjusting for quality of life at 4 years of follow-up, used as an approximation to a baseline measure (OR = 1.22 (1.07-1.38)). This value was mainly due to the effects on vitality (OR = 1.17 (1.01-1.34)) and mental health (OR = 1.22 (1.07-1.39)).
Conclusions: Binge-drinking may lead to poorer mental quality of life; therefore, binge-drinking for enhancement purposes does not seem to be justified by this effect.
Methods: We evaluated 8992 participants of the SUN cohort. We classified as binge-drinkers those who reported consuming six or more drinks on at least one occasion the year before recruitment (n = 3075). We fitted multivariable logistic regression models to calculate the odds ratios (ORs) of a worse physical and mental quality of life, measured with the validated SF-36 questionnaire at 8 years of follow-up (cut-off point = P75 or highest score).
Results: Binge-drinking was associated with greater odds of having a worse mental quality of life, even adjusting for quality of life at 4 years of follow-up, used as an approximation to a baseline measure (OR = 1.22 (1.07-1.38)). This value was mainly due to the effects on vitality (OR = 1.17 (1.01-1.34)) and mental health (OR = 1.22 (1.07-1.39)).
Conclusions: Binge-drinking may lead to poorer mental quality of life; therefore, binge-drinking for enhancement purposes does not seem to be justified by this effect.
Dimensions of leisure-time physical activity and risk of depression in the “Seguimiento Universidad de Navarra” (SUN) prospective cohort
Dadun. Depósito Académico Digital de la Universidad de Navarra
- Fernandez-Montero, A. (Alejandro)
- Moreno-Galarraga, L. (Laura)
- Sanchez-Villegas, A. (Almudena)
- Lahortiga, F. (Francisca)
- Ruiz-Canela, M. (Miguel)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Molero, P. (Patricio)
Background: An inverse association between total leisure-time physical activity (LTPA) and depression has been previously documented in the scientific literature. Our objective was to prospectively assess the association of LTPA with the risk of depression, focusing on several dimensions of LTPA (intensity, duration and type).
Methods: The SUN (Seguimiento Universidad de Navarra) project is a prospective cohort study formed by Spanish university graduates. A total of 15,488 adults (40.2% men, mean age 37 ± 12 years) initially free of depression were assessed. A report of a validated medical diagnosis of depression or the habitual use of antidepressants (any of both) were considered as incident cases of depression. LTPA was estimated through previously validated self-reported questionnaires. Participants were classified following Physical Activity recommendations from the World Health Organization, and according to the intensity, duration and type of LTPA. Cox proportional hazards regression models were run, adjusted for demographic, lifestyle, and dietary factors, to estimate adjusted hazard ratios (HR) of depression and 95% confidence intervals (CI).
Results: During 163,059 person-years of follow-up we registered 870 incident cases of depression. Participants with higher total LTPA (METs-h/wk) and higher duration of LTPA (hours/wk) exhibited a lower risk of depression HR = 0.84 (95% CI: 0.72-0.99) and HR = 0.83 (0.70-0.99) respectively, whereas intensity of LTPA (MET) did not show any association with depression.
Conclusion: Participants with higher LTPA had a lower risk of depression. The inverse association was stronger for total LPTA time than for its intensity. Higher duration of LTPA should be encouraged to prevent depression.
Methods: The SUN (Seguimiento Universidad de Navarra) project is a prospective cohort study formed by Spanish university graduates. A total of 15,488 adults (40.2% men, mean age 37 ± 12 years) initially free of depression were assessed. A report of a validated medical diagnosis of depression or the habitual use of antidepressants (any of both) were considered as incident cases of depression. LTPA was estimated through previously validated self-reported questionnaires. Participants were classified following Physical Activity recommendations from the World Health Organization, and according to the intensity, duration and type of LTPA. Cox proportional hazards regression models were run, adjusted for demographic, lifestyle, and dietary factors, to estimate adjusted hazard ratios (HR) of depression and 95% confidence intervals (CI).
Results: During 163,059 person-years of follow-up we registered 870 incident cases of depression. Participants with higher total LTPA (METs-h/wk) and higher duration of LTPA (hours/wk) exhibited a lower risk of depression HR = 0.84 (95% CI: 0.72-0.99) and HR = 0.83 (0.70-0.99) respectively, whereas intensity of LTPA (MET) did not show any association with depression.
Conclusion: Participants with higher LTPA had a lower risk of depression. The inverse association was stronger for total LPTA time than for its intensity. Higher duration of LTPA should be encouraged to prevent depression.
Binge Drinking and Risk of Breast Cancer: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project
Dadun. Depósito Académico Digital de la Universidad de Navarra
- Sanchez-Bayona, R. (Rodrigo)
- Gea, A. (Alfredo)
- Gardeazabal, I. (Itziar)
- Romanos-Nanclares, A. (Andrea)
- Martinez-Gonzalez, M.A. (Miguel Ángel)
- Bes-Rastrollo, M. (Maira)
- Santisteban, M. (Marta)
- Toledo, E. (Estefanía)
Alcohol intake is associated with the risk of breast cancer. Different patterns of alcoholdrinking may have different effects on breast cancer even when keeping constant the total amount of
alcohol consumed. We aimed to assess the association between binge drinking and breast cancer
risk. The SUN Project is a Spanish dynamic prospective cohort of university graduates initiated in
1999. In the 556-item lifestyle baseline questionnaire a validated food-frequency questionnaire was
embedded. Participants completed biennial follow-up questionnaires. Cox regression models were
used to estimate the hazard ratio (HR) for breast cancer associated with the exposure to binge drinking.
A stratified analysis was performed according to menopausal status. We included 9577 women (mean
age = 34 years, SD = 10 years), with a median follow-up of 11.8 years. Among 104,932 women-years
of follow-up, we confirmed 88 incident cases of breast cancer. Women in the binge drinking group
showed a higher risk of breast cancer (HR = 1.76; 95% CI: 1.03–2.99) compared to women in the
non-binge drinking category. In the stratified analysis, a 2-fold higher risk for premenopausal breast
cancer was associated with binge drinking habit (HR = 2.06; 95% CI: 1.11–3.82). This study adds new
evidence on the association of binge drinking with breast cancer risk.
alcohol consumed. We aimed to assess the association between binge drinking and breast cancer
risk. The SUN Project is a Spanish dynamic prospective cohort of university graduates initiated in
1999. In the 556-item lifestyle baseline questionnaire a validated food-frequency questionnaire was
embedded. Participants completed biennial follow-up questionnaires. Cox regression models were
used to estimate the hazard ratio (HR) for breast cancer associated with the exposure to binge drinking.
A stratified analysis was performed according to menopausal status. We included 9577 women (mean
age = 34 years, SD = 10 years), with a median follow-up of 11.8 years. Among 104,932 women-years
of follow-up, we confirmed 88 incident cases of breast cancer. Women in the binge drinking group
showed a higher risk of breast cancer (HR = 1.76; 95% CI: 1.03–2.99) compared to women in the
non-binge drinking category. In the stratified analysis, a 2-fold higher risk for premenopausal breast
cancer was associated with binge drinking habit (HR = 2.06; 95% CI: 1.11–3.82). This study adds new
evidence on the association of binge drinking with breast cancer risk.
Influencia de la obesidad y la ganancia de peso sobre la calidad de vida según el SF-36 en individuos de la cohorte dinámica Seguimiento Universidad de Navarra
Zaguán. Repositorio Digital de la Universidad de Zaragoza
- Barcones-Molero, M.F.
- Sánchez-Villegas, A.
- Martínez-González, M.A.
- Bes-Rastrollo, M.
- Martínez-Urbistondo, M.
- Santabárbara, J.
- Martínez, J.A.
Antecedentes
La calidad de vida relacionada con la salud es un elemento importante en la valoración integral del sobrepeso y la obesidad.
Objetivo
Evaluar el impacto de la obesidad y la ganancia de peso sobre la calidad de vida relacionada con la salud en la cohorte dinámica Seguimiento Universidad de Navarra.
Materiales y métodos
Los análisis incluyeron a 10.033 participantes de la cohorte dinámica prospectiva del Proyecto Seguimiento Universidad de Navarra, con una tasa de respuesta de aproximadamente el 90%. La calidad de vida fue medida con la versión abreviada de la Encuesta de Salud (SF-36) (0: peor calidad de vida, 100: mejor calidad de vida). El análisis estadístico se realizó con modelos lineales generalizados (media de cada dominio del SF-36 e IC al 95%). Una diferencia de 3 puntos fue considerada como clínicamente relevante.
Resultados
El análisis del SF-36 mostró que la función física, la salud general y la variable física sumario fueron inferiores en las personas con sobrepeso y obesidad al inicio del estudio que en los individuos con normopeso.
La población a estudio con sobrepeso u obesidad sin cambios tras 2 años de seguimiento presentó peores puntuaciones en los dominios del SF-36 correspondientes a la función física, dolor corporal, variable física sumario y salud general que los individuos que mantuvieron la categoría del normopeso según el IMC (kg/m2).
Conclusiones
La obesidad parece asociarse a un impacto negativo sobre la calidad de vida relacionada con la salud, que afecta más significativamente al área física que a la psicosocial.
Background: The health-related quality of life is an important element for the comprehensive assessment of overweight and obesity. Objective: To assess the impact of obesity and weight gain on the health-related quality of life of the dynamic cohort of the Follow-up Program of the University of Navarra.
Material and methods: The analysis included 10, 033 participants of the prospective dynamic cohort of the Follow-up Project of the University of Navarra, with a response rate of approximately 90%. The quality of life was measured with the Short Form 36 Health Survey (SF-36) (0, worst quality of life; 100, best quality of life). The statistical analysis was performed with generalized lineal models (mean of each SF-36 domain and 95% CI). A difference of 3 points was considered clinically relevant.
Results: The SF-36 analysis showed that physical function, general health and the physical component summary were inferior in individuals with excess weight and obesity at the start of the study, compared with individuals with normal weight. The study population with unchanged excess weight or obesity after 2 years of follow-up presented lower scores on the SF-36 domains corresponding to physical function, body pain, physical component summary and general health than individuals who maintained the normal weight category according to BMI (kg/m2).
Conclusions: Obesity appears to be associated with a negative impact on health-related quality of life, affecting the physical area more significantly than the psychosocial.
La calidad de vida relacionada con la salud es un elemento importante en la valoración integral del sobrepeso y la obesidad.
Objetivo
Evaluar el impacto de la obesidad y la ganancia de peso sobre la calidad de vida relacionada con la salud en la cohorte dinámica Seguimiento Universidad de Navarra.
Materiales y métodos
Los análisis incluyeron a 10.033 participantes de la cohorte dinámica prospectiva del Proyecto Seguimiento Universidad de Navarra, con una tasa de respuesta de aproximadamente el 90%. La calidad de vida fue medida con la versión abreviada de la Encuesta de Salud (SF-36) (0: peor calidad de vida, 100: mejor calidad de vida). El análisis estadístico se realizó con modelos lineales generalizados (media de cada dominio del SF-36 e IC al 95%). Una diferencia de 3 puntos fue considerada como clínicamente relevante.
Resultados
El análisis del SF-36 mostró que la función física, la salud general y la variable física sumario fueron inferiores en las personas con sobrepeso y obesidad al inicio del estudio que en los individuos con normopeso.
La población a estudio con sobrepeso u obesidad sin cambios tras 2 años de seguimiento presentó peores puntuaciones en los dominios del SF-36 correspondientes a la función física, dolor corporal, variable física sumario y salud general que los individuos que mantuvieron la categoría del normopeso según el IMC (kg/m2).
Conclusiones
La obesidad parece asociarse a un impacto negativo sobre la calidad de vida relacionada con la salud, que afecta más significativamente al área física que a la psicosocial.
Background: The health-related quality of life is an important element for the comprehensive assessment of overweight and obesity. Objective: To assess the impact of obesity and weight gain on the health-related quality of life of the dynamic cohort of the Follow-up Program of the University of Navarra.
Material and methods: The analysis included 10, 033 participants of the prospective dynamic cohort of the Follow-up Project of the University of Navarra, with a response rate of approximately 90%. The quality of life was measured with the Short Form 36 Health Survey (SF-36) (0, worst quality of life; 100, best quality of life). The statistical analysis was performed with generalized lineal models (mean of each SF-36 domain and 95% CI). A difference of 3 points was considered clinically relevant.
Results: The SF-36 analysis showed that physical function, general health and the physical component summary were inferior in individuals with excess weight and obesity at the start of the study, compared with individuals with normal weight. The study population with unchanged excess weight or obesity after 2 years of follow-up presented lower scores on the SF-36 domains corresponding to physical function, body pain, physical component summary and general health than individuals who maintained the normal weight category according to BMI (kg/m2).
Conclusions: Obesity appears to be associated with a negative impact on health-related quality of life, affecting the physical area more significantly than the psychosocial.