LA PERMEABILIDAD INTESTINAL COMO CAUSA DE INFLAMACION CRONICA DE BAJO GRADO EN PACIENTES CON ESQUIZOFRENIA: RELACION CON LA DIETA, EL SINDROME METABOLICO Y LA GRAVEDAD DE LA ENFERMEDAD
PI17/00246
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Nombre agencia financiadora Instituto de Salud Carlos III
Acrónimo agencia financiadora ISCIII
Programa Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia
Subprograma Subprograma Estatal de Generación de Conocimiento
Convocatoria Proyectos de investigación en salud
Año convocatoria 2017
Unidad de gestión Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)
Centro beneficiario FUNDACION PARA LA INVESTIGACION Y DOCENCIA SANT JOAN DE DEU
Centro realización PARC SANITARI SANT JOAN DE DEU
Identificador persistente https://doi.org/10.13039/501100004587
Publicaciones
Resultados totales (Incluyendo duplicados): 2
Encontrada(s) 1 página(s)
Encontrada(s) 1 página(s)
From gut to brain: a network model of intestinal permeability, inflammation, and psychotic symptoms in schizophrenia.
RUO. Repositorio Institucional de la Universidad de Oviedo
- Dal Santo, F.
- González Blanco, Leticia
- García-Portilla González, María Paz
- Alfonso, M.
- Hernández, C.
- Sánchez Autet, M.
- Bernardo, M.
- Anmella, G.
- Amoretti, S.
- Safont, G.
- Marín Alcaraz, L.
- Arranz, B.
This study was supported by a grant from the Instituto de Salud
Carlos III (ISCIII, grant number PI17/00246) and by the program “Ajuts
per donar suport a l’activitat científica dels grups de recerca de Cata-
lunya (SGR-Cat 2021)”, Agència de Gestió d’Ajuts Universitaris i de
Recerca (AGAUR, grant 2021 SGR 01380).
Carlos III (ISCIII, grant number PI17/00246) and by the program “Ajuts
per donar suport a l’activitat científica dels grups de recerca de Cata-
lunya (SGR-Cat 2021)”, Agència de Gestió d’Ajuts Universitaris i de
Recerca (AGAUR, grant 2021 SGR 01380).
Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Ballasch, Iván
- López-Molina, Laura
- Galán-Ganga, Marcos
- Sancho-Balsells, Anna
- Rodríguez-Navarro, Irene
- Borràs-Pernas, Sara
- Rabadán, M. Ángeles
- Chen, Wanqi
- Pastó-Pellicer, Carlota
- Flotta, Francesca
- Maoyu, Wang
- Fernández Irigoyen, Joaquín
- Santamaría Martínez, Enrique
- Aguilar, Ruth
- Dobaño, Carlota
- Egri, Natalia
- Hernández, Carla
- Alfonso, Miqueu
- Juan, Manel
- Alberch, Jordi
- Toro, Daniel del
- Arranz, Belén
- Canals, Josep M.
- Giralt, Albert
Schizophrenia is a complex multifactorial disorder and increasing evidence suggests the involvement of immune dysregulations in its pathogenesis. We observed that IKZF1 and IKZF2, classic immune-related transcription factors (TFs), were both downregulated in patients' peripheral blood mononuclear cells (PBMCs) but not in their brain. We generated a new mutant mouse model with a reduction in Ikzf1 and Ikzf2 to study the impact of those changes. Such mice developed deficits in the three dimensions (positive-negative-cognitive) of schizophrenia-like phenotypes associated with alterations in structural synaptic plasticity. We then studied the secretomes of cultured PBMCs obtained from patients and identified potentially secreted molecules, which depended on IKZF1 and IKZF2 mRNA levels, and that in turn have an impact on neural synchrony, structural synaptic plasticity and schizophrenia-like symptoms in in vivo and in vitro models. Our results point out that IKZF1-IKZF2-dependent immune signals negatively impact on essential neural circuits involved in schizophrenia., This work was supported by grants from Ministerio de Ciencia e Innovaci\u00F3n/AEI/ https://doi.org/10.13039/501100011033 / and \u201CFEDER\u201D to A.G.: PID2021-122258OB-I00 and to J.A.: PID2020-119386RB-100 and from Instituto de Salud Carlos III (ISCIII): PI17/00246 to B.A. Our technician Ana L\u00F3pez, was supported by a Mar\u00EDa de Maeztu Unit of Excellence (Institute of Neurosciences, University of Barcelona, CEX2021-001159-M, Ministry of Science and Innovation). The project that gave rise to these results received the support of a fellowship from \u201Cla Caixa\u201D Foundation (ID 100010434). The fellowship code is LCF/BQ/DR21/11880016 to M.G.-G.