3-Nitrotyrosine (NT) is generated by the action of peroxynitrite and other reactive nitrogen species (RNS), and as a consequence it is accumulated in inflammation-associated conditions. This is particularly relevant in kidney disease, where NT concentration in blood is considerably high. Therefore, NT is a crucial biomarker of renal damage, although it has been underestimated in clinical diagnosis due to the lack of an appropriate sensing method. Herein we report the first fluorescent supramolecular sensor for such a relevant compound: Fluorescence by rotational restriction of tetraphenylethenes (TPE) in a covalent cage is selectively quenched in human blood serum by 3-nitrotyrosine (NT) that binds to the cage with high affinity, allowing a limit of detection within the reported physiological concentrations of NT in chronic kidney disease., This work was financially supported by Ministerio de Ciencia e Innovación (PGC2018-094503-B-C21, PID2019-110430GB-C21, PID2019-107335RA-I00 and PGC2018-096880-A-I00 MCIU/ AEI/FEDER, UE) and Gobierno Autónomo de Canarias (ProID2020010067). L.A.P.-M. and M.D.P thanks the ACIISI of the Consejería de Economía, Industria, Comercio y Conocimiento and the European Social Fund (ESF) Canary Islands Integrated Operational Program 2014–2020, Area 3 Priority Theme 74 (85 %), for a predoctoral grant. R.G.R. thanks the EU (ESF) for Ramon y Cajal contract (R. G.-R., RYC-2015-19035). The authors thank Prof. Carlos Perretti V. for his support with the statistical analysis, Prof. Javier Hernandez-Borges for helpful discussions, and “Servicio de análisis y determinación estructural” at IPNA-CSIC, particularly Nieves M. Rodríguez and Manuel Cabrera for their technical support in this research., Peer reviewed

Currently, breast cancer is the most common type of cancer worldwide, being the so-called estrogen receptor (ER) positive the subtype with highest prevalence. For decades, the most successful strategy to prevent recurrence of ER + breast cancers is tamoxifen coadjuvant therapy. However, the involvement of the different estrogen receptors (ERα, ERβ and GPER) and the interaction in their signaling pathways, the evidence for side-effects in chronic tamoxifen treatments, as well as the appearance of tamoxifen-resistant breast cancers, have encouraged the need for novel receptor-targeted fluorescent probes. In line with this, multifunctional antiestrogen conjugates, exhibiting fluorescent properties while retaining the ability to antagonize estrogen actions, have been synthesized and proven to be particularly useful in the study of the molecular biology of ER + breast cancers. These novel fluorescent tamoxifen derivatives (FTDs) exhibit pharmacological features of pure antiestrogens, with similar or even greater affinity for ERα than tamoxifen, inhibit ER-dependent gene transcription and cell proliferation, and are devoid of uterotrophic effects. In the present study we have aim at providing a detailed view of their biophotonic potential, including their spectroscopic properties, their usefulness for fluorescent labelling of cellular compartments and intracellular targets, their application in the identification of non-ER antiestrogen binding sites thought fluorescence competition assays, and finally, in their ability to function as efficient ER-targeted photosensitizers., This work was partly funded by the Spanish AEI-MICINN and EU FEDER (Grant numbers PID2019-110430GB-C21, PID2019-107335RA-I00) and Gobierno Autónomo de Canarias, ACIISI (Grant numbers ProID2020010067 and ProID2020807 010075). F. Lobo and C.V.B. are financed by subsidised contracts from 'Agustín de Betancourt' program (Cabildo de Tenerife, Gobierno de Canarias, Spain). D.H. also acknowledges her current contract (TRANSALUDAGRO) financed by Cabildo de Tenerife, Program TF INNOVA 2016–21 (with MEDI & FDCAN Funds)., Peer reviewed

Large amount of wastewater is produced by washing machines and dishwashers, which are used in a daily basis. This domestic wastewater generated in households or office buildings (also called greywater) is drained directly to the drainpipes without differentiation from that with fecal contamination from toilets. Detergents are arguably the pollutants most frequently found in greywater from home appliances. Their concentrations vary in the successive stages in a wash cycle, which could be taken into account in a rational design of home appliances wastewater management. Analytical chemistry procedures are commonly used to determine the pollutant content in wastewater. They require collecting samples and their transport to properly equipped laboratories, which hampers real time wastewater management. In this paper, optofluidic devices based on planar Fabry-Perot microresonators operating in transmission mode in the visible and near infrared spectral ranges have been studied to determine the concentration of five brands of soap dissolved in water. It is found that the spectral positions of the optical resonances redshift when the soap concentration increases in the corresponding solutions. Experimental calibration curves of the optofluidic device were used to determine the soap concentration of wastewater from the successive stages of a washing machine wash cycle either loaded with garments or unloaded. Interestingly, the analysis of the optical sensor indicated that the greywater from the last water discharge of the wash cycle could be reused for gardening or agriculture. The integration of this kind of microfluidic devices into the home appliances design could lead to reduce our hydric environmental impact., Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion (ProID2020010067) ; Agencia Estatal de Investigacion (PID2019-107335RA-I00) ; European Regional Development Fund (PID2019-107335RA-I00, PID2019-110430GB-C21) ., Peer reviewed