BUSCADOR RECOLECTA

We investigated the interaction between a genetic score and an exercise intervention on brain health in children with overweight/obesity. One hundred one children with overweight/obesity (10.0 ± 1.5 yr, 59% girls) were randomized into a 20-wk combined exercise intervention or a control group. Several cognitive and academic outcomes were measured with validated tests. Hippocampal volume was quantified using magnetic resonance imaging. Six brain health-related polymorphisms [rs6265 (BDNF), rs2253206 (CREB1), rs2289656 (NTRK2), rs4680 (COMT), rs429358, and rs7412 (APOE)] were genotyped. Cognitive flexibility and academic skills improved significantly more in the exercise than in the control group only in the children with a “favorable” genetic profile [mean z-score, 0.41–0.67 (95% CI 0.11 to 1.18)], yet not in those with “less favorable” genetic profile. An individual response analysis showed that children responded to exercise in cognitive flexibility only in the “genetically favorable” group [i.e., 62% of them had a meaningful (≥0.2 Cohen d) increase in the exercise group compared with only 25% in the control group]. This finding was consistent in per-protocol and intention-to-treat analyses (P = 0.01 and P = 0.03, respectively). The results were not significant or not consistent for the rest of outcomes studied. Our findings suggest that having a more favorable genetic profile makes children with overweight/obesity more responsive to exercise, particularly for cognitive flexibility., The project was mainly funded by the Spanish Ministry of Economy and Competitiveness (Reference DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP) and by the Andalusian Operational Programme supported with European Regional Development Funds (ERDF in English, FEDER in Spanish, projects ref: B-CTS-355-UGR18 and A-CTS-614-UGR20) and Junta de Andalucia (P20_00158). Grant Endo-Map PID2021-12728OB-100 funded by MCIN/AEI/10.13039/501100011033 and ERFD A way of making Europe; Grant RYC-2016-21199, funded by MCIN/AEI/ 10.13039/501100011033 and by ESF Investing in your future. This study was supported in part by the Pediatric Exercise and Genomics Research Center (PERC) Systems Biology Fund. A.P.-F. is supported in part by NIH Grant No.: U01 TR002004 (REACH project). I.E.-C. is supported by the Spanish Ministries of Economy and Competitiveness (RTI2018-095284-J-100), and Science and Innovation (RYC2019-027287-I). F.J.O.-P. is supported by Margarita Salas program (Programa de recualificación del profesorado Universitario, Ministerio de Universidades). Additional support was obtained from the Unit of Excellence on EXERNET Research Network on Exercise and Health (DEP2005-00046/ACTI; 09/UPB/ 19; 45/UPB/20; 27/UPB/21); Alicia Koplowitz Foundation. This study has been partially funded by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR.

Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep— the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role., This work was funded by grants from the Spanish Ministry of Economy, Industry and Competitiveness (AGL2013-49137-C3-1-R and AGL2013-49137-C3-2-R), the Ministry of Science, Innovation and Universities (RTI2018-096172-B-C31 and RTI2018-096172-B-C33) and the Recognized Research Groups of Government of Aragón (A17_17R, Animal Health and Reproduction). RdM was a PhD student funded by the Department of Innovation, Research and University of Aragón. JA and ARL were PhD students funded by the Spanish Ministry of Science, Innovation and Universities (formerly Spanish Ministry of Education). IE was a PhD student funded by the Universidad Pública de Navarra.

Lack of physical activity is a global public health problem causing not only morbidity and premature mortality, but it is also a major economic burden worldwide. One of the cornerstones of a physically active lifestyle is motor competence (MC). MC is a complex biocultural attribute and therefore, its study requires a multi-sectoral, multi-, inter- and transdisciplinary approach. MC is a growing area of research, especially in children and adolescents due to its positive association with a plethora of health and developmental outcomes. Many questions, however, remain to be answered in this field of research, with regard to: (i) Health and Developmental-related Associations of MC; (ii) Assessment of MC; (iii) Prevalence and Trends of MC; (iv) Correlates and Determinants of MC; (v) MC Interventions, and (vi) Translating MC Research into Practice and Policy. This paper presents a narrative review of the literature, summarizing current knowledge, identifying key research gaps and presenting questions for future investigation on MC in children and adolescents. This is a collaborative effort from the International Motor Competence Network (IMCNetwork) a network of academics and researchers aiming to promote international collaborative research and knowledge translation in the expansive field of MC. The knowledge and deliverables generated by addressing and answering the aforementioned research questions on MC presented in this review have the potential to shape the ways in which researchers and practitioners promote MC and physical activity in children and adolescents across the world., Luís Lopes is supported by the Portuguese Foundation for Science and Technology (CEECIND/01089/2017 and FCT/UIDB/00617/2020); Rute Santos is supported by the Portuguese Foundation for Science and Technology (CEECIND/01069/2017 and FCT/UIDB/00617/2020); Jorge Mota, Carla Moreira, César Agostinis-Sobrinho, Pedro Silva and Eduarda Sousa-Sá are supported by the Portuguese Foundation for Science and Technology (FCT/UIDB/00617/2020); Erik Sigmund is supported by grant No. 19-03276S from the Czech Science Foundation; Irene Esteban-Cornejo is supported by the Spanish Ministry of Economy and Competitiveness (RTI2018-095284-J-100) and by the Spanish Ministry of of Science and Innovation (RYC2019-027287-I); Jaime Carcamo-Oyarzun is supported by the National Commission for Scientific Research and Technology of Chile (CONICYT—FONDECYT 11170525); Jonatan Ruiz is supported by the University of Granada Plan Propio de Investigación 2016 (Excellence actions: Unit of Excellence on Exercise and Health [UCEES]), by the European Regional Development Fund (ERDF), by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ref. SOMM17/6107/UGR); Antonio García-Hermoso is a Miguel Servet Fellow (Instituto de Salud Carlos III—FSE, CP18/0150).

Background & aims: exposure to a suboptimal environment during the fetal and early infancy period's results in long-term consequences for brain morphology and function. We investigated the associations of early life factors such as anthropometric neonatal data (i.e., birth length, birth weight and birth head circumference) and breastfeeding practices (i.e., exclusive and any breastfeeding) with white matter (WM) microstructure, and ii) we tested whether WM tracts related to early life factors are associated with academic performance in children with overweight/obesity. Methods: 96 overweight/obese children (10.03 ± 1.16 years; 38.7% girls) were included from the ActiveBrains Project. WM microstructure indicators used were fractional anisotropy (FA) and mean diffusivity (MD), derived from Diffusion Tensor Imaging. Academic performance was evaluated with the Battery III Woodcock–Muñoz Tests of Achievement. Regression models were used to examine the associations of the early life factors with tract-specific FA and MD, as well as its association with academic performance. Results: head circumference at birth was positively associated with FA of the inferior fronto-occipital fasciculus tract (0.441; p = 0.005), as well as negatively associated with MD of the cingulate gyrus part of cingulum (−0.470; p = 0.006), corticospinal (−0.457; p = 0.005) and superior thalamic radiation tract (−0.476; p = 0.001). Association of birth weight, birth length and exclusive breastfeeding with WM microstructure did not remain significant after false discovery rate correction. None tract related to birth head circumference was associated with academic performance (all p > 0.05). Conclusions: our results highlighted the importance of the perinatal growth in WM microstructure later in life, although its possible academic implications remain inconclusive., This study was supported by the Spanish Ministry of Economy and Competitiveness (DEP2013 -47540 , DEP2016-79512-R, and DEP2017-91544-EXP), the European Regional Development Fund, the European Commission (No 667302 ) and the Alicia Koplowitz Foundation. This study was partially funded by the UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme. Units of Scientific Excellence; Scientific Unit of Excellence on Exercise and Health (UCEES) and by the Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Entreprises and University and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. In addition, this study was further supported by the SAMID III network, RETICS, funded by the PN I+D+I 2017-2021 (Spain). Additional funding was obtained from the Andalusian Operational Programme supported with European Regional Development Funds (ERDF in English, FEDER in Spanish, project ref: B-CTS-355-UGR18). PS-U is supported by a grant from ANID /BECAS Chile/72180543. IE-C is supported by the Spanish Ministries of Economy and Competitiveness (RTI2018-095284-J-100), and Science and Innovation (RYC2019-027287-I). JV-R is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI -2017-33396). Funding for open access charge: Universidad de Granada / CBUA.