COLONIZACION NEUMOCOCICA Y ESTADO DE PORTADOR: BASES MOLECULARES, PROFILAXIS Y MEDIDAS TERAPEUTICAS
SAF2012-39444-C02-02
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Nombre agencia financiadora Ministerio de Economía y Competitividad
Acrónimo agencia financiadora MINECO
Programa Programa Nacional de Investigación Fundamental
Subprograma Investigación fundamental no-orientada
Convocatoria Proyectos de Investigación Fundamental No-Orientada
Año convocatoria 2012
Unidad de gestión Dirección General de Investigación Científica y Técnica
Centro beneficiario INSTITUTO DE SALUD CARLOS III (ISCIII)
Centro realización SERVICIO DE BACTERIOLOGIA
Identificador persistente http://dx.doi.org/10.13039/501100003329
Publicaciones
Resultados totales (Incluyendo duplicados): 1
Encontrada(s) 1 página(s)
Encontrada(s) 1 página(s)
Apoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
- Martínez, Isidoro
- Oliveros, Juan C.
- Cuesta, Isabel
- Barrera, Jorge de la
- Ausina, Vicente
- Casals, Cristina
- Lorenzo, Alba de
- García, Ernesto
- García Fojeda, Belén
- Garmendia García, Juncal
- González Nicolau, Mar
- Lacoma, Alicia
- Menéndez, Margarita
- Moranta, David
- Nieto, Amelia
- Ortín, Juan
- Pérez González, Alicia
- Prat, Cristina
- Ramos Sevillano, Elisa
- Regueiro, Verónica
- Rodríguez Frandsen, Ariel
- Solís, Dolores
- Yuste, José R.
- Bengoechea Alonso, José Antonio
- Melero, José A.
Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here., The authors gratefully acknowledge financial support from the “CIBER
de Enfermedades Respiratorias” (CIBERES), an initiative of
the “Instituto de Salud Carlos III” (ISCIII), Spain. Research
activities in the participating laboratories received further
funding from the following sources: Centro Nacional de
Microbiología, ISCIII, PI15CIII/00024 and MINECO (SAF2015-
67033-R); Centro Nacional de Biotecnología, MINECO
(BFU2014-57797-R); Hospital Universitari Germans Trias
I Pujol, Spanish Society of Pneumology and Thoracic
Surgery (SEPAR 054/2011); Departamento de Bioquímica y
Biología Molecular I, MINECO (SAF2015-65307-R); Centro de
Investigaciones Biológicas, MINECO (SAF2012-39444-C01/02);
Fundación de Investigación Sanitaria de las Islas Baleares,
MINECO (SAF2012-39841); Instituto de Agrobiotecnología,
MINECO (SAF2015-66520-R); Instituto de Química Física
Rocasolano, MINECO (BFU2015-70052-R) and the Marie
Curie Initial Training Network GLYCOPHARM (PITN-GA-
2012-317297). Subprograma Estatal de Formación (BES-2013-
065355).
de Enfermedades Respiratorias” (CIBERES), an initiative of
the “Instituto de Salud Carlos III” (ISCIII), Spain. Research
activities in the participating laboratories received further
funding from the following sources: Centro Nacional de
Microbiología, ISCIII, PI15CIII/00024 and MINECO (SAF2015-
67033-R); Centro Nacional de Biotecnología, MINECO
(BFU2014-57797-R); Hospital Universitari Germans Trias
I Pujol, Spanish Society of Pneumology and Thoracic
Surgery (SEPAR 054/2011); Departamento de Bioquímica y
Biología Molecular I, MINECO (SAF2015-65307-R); Centro de
Investigaciones Biológicas, MINECO (SAF2012-39444-C01/02);
Fundación de Investigación Sanitaria de las Islas Baleares,
MINECO (SAF2012-39841); Instituto de Agrobiotecnología,
MINECO (SAF2015-66520-R); Instituto de Química Física
Rocasolano, MINECO (BFU2015-70052-R) and the Marie
Curie Initial Training Network GLYCOPHARM (PITN-GA-
2012-317297). Subprograma Estatal de Formación (BES-2013-
065355).