Resultados de investigación

La Cátedra Fundación MAPFRE Guanarteme de Tecnología y Educación de la Universidad de La Laguna presenta la colección audiovisual “Testimonios sobre la Educación en Canarias”. Una nueva iniciativa destinada a recoger las voces de personajes relevantes en los acontecimientos de la Educación en Canarias. Este material audiovisual, en formato de entrevistas, ahonda en relatar desde la perspectiva de los propios protagonistas, momentos cruciales de la historia en Canarias que han permitido dar forma a la actual educación canaria. En esta entrevista Javier Marrero y Amador Guarro (Catedráticos de Didáctica y Organización Escolar de la Universidad de La Laguna) ofrecen su visión acerca de la creación de la primera consejería de educación de Canarias, ahondando en la creación de las autonomías educativas y cómo se gestionó y organizó esta estructura para mejorar la educación en Canarias. Estos agentes trabajaron en el gabinete de la reforma para ofrecer al alumnado universitario la mejor formación en el campo de la educación, consiguiendo la fusión de las escuelas y las facultades de magisterio.

En la imagen, de izquierda a derecha, Joaquín Estefanía, periodista español; Marta Sanz Pastor, escritora española; Jordi Gracia, filólogo y escritor español; Jorge Herralde, director de la Editorial Anagrama; y Luis García Montero, director del Instituto Cervantes, durante el acto homenaje para recordar el legado de Francisco Javier Pradera y Gortázar.

De izquierda a derecha, Marta Sanz Pastor, escritora española; Luis García Montero, director del Instituto Cervantes; y Jorge Herralde, director de la Editorial Anagrama, durante el acto de homenaje a Francisco Javier Pradera y Gortázar.

Data aproximada entre els anys 1998 a 2000, Primer pla de la Casa Javier Calicó. Aquesta comprèn les següents adreces: plaça de l'Àngel, 1-3, Via (Barcelona) Laietana, 25 i Tapineria, 2. El seu nivell de catalogació és el C.

[Description of methods used for collection/generation of data] Liver samples stabilized in RNAlater were homogenized using RLT (Qiagen), Lysing Matrix D and a FastPrep-24 instrument (MP Biochemicals); RNA purification was performed with the RNeasy Mini kit and RNase-Free DNase Set kit (Qiagen). "Poly(A)+ mRNA fraction was isolated from total RNA and cDNA libraries were obtained following Illumina´s recommendations. Briefly, poly(A)+ RNA was isolated on poly-T oligo-attached magnetic beads and chemically fragmented prior to reverse transcription and cDNA generation. The cDNA fragments then go through an end repair process, the addition of a single ‘A’ base to the 3’ end and then ligation of the adapters. Finally, the products are purified and enriched with PCR to create the indexed final double stranded cDNA library. The quality of the libraries was analyzed in Bioanalyzer 2100, High Sensitivity assay; the quantity of the libraries was determined by real-time PCR in LightCycler 480 (Roche). The pool of the libraries was sequenced by paired-end sequencing (100 × 2) in an Illumina HiSeq 2500 instrument.", [Methods for processing the data] Basecalls performed using bcl2fastq 1.8.4 BBDuk version 36.30 (BBMap tools) was applied to raw fastq files for quality trimming (Phred >= 20), filtering short reads (min length = 30) and removing adapter sequences BBMap version 36.30 was used to map the trimmed reads onto the reference genome; parameters: "maxindel=200k ambig=random intronlen=20" Bioconductor packages GenomicFeatures (v 1.24.5), GenomicAlignments (v 1.8.4) and the Oar_rambouillet_v1.0 annotation were used to calculate per gene read counts. Bioconductor package mygene was used to obtain the Entrez ID Differential expression analysis was conducted with the bioconductor package DESeq2 (v 1.12.4). TPM values were calculated according to Wagner et al. (2012; PMID 22872506) using DESeq2-normalized read counts GCF_002742125.1 The processed data file contains the results of the DESeq2 differential expression analysis, the TPM values for each sample/biological replicate and the Entrez annotation., [Purpose] The present study was designed to identify both differentially expressed (DE) genes in the liver tissues of fattening Merino lambs and differences in metabolites accumulated in plasma, thus trying to identify modified metabolic pathways as a consequence of dietary L-carnitine administration during the fattening period of early feed restricted lambs., [Methods] Twenty-two male Merino lambs, all of them milk restricted during the suckling period, were assigned to 2 different groups (n=11 per dietary treatment). The first group (CARN, carnitine group) were fed a completed pelleted diet ad libitum formulated with 3 g of L-carnitine/kg diet, and the control group (CTRL) received the same diet with no additive included. All the lambs were slaughtered with 34 kg. For transcriptomic analysis, 4 liver samples representative from each group (8 samples in total) were selected for RNA sequencing methodology (RNA-seq)., [Results] 104 DE annotated genes were identified by RNA-seq, with 36 DE genes being down-regulated and 68 up-regulated in the liver of CARN relative to the CTRL group (P < 0.05). In general, those genes and pathways related to ribosomes and translation, cholesterol, ATP-binding and ATPase activity, and ABC transporters were up-regulated in the CARN group, thus suggesting an improved metabolism of the muscle and a reduced absorption and increased excretion of cholesterol in these lambs., [Conclusions] According to the data obtained, the administration of 3 g of L-carnitine carnitine/ kg diet during the fattening period of early feed restricted lambs increases the expression of genes related to ribosomes and traslation and also those involved in the excretion of cholesterol into bile acids or a reduced cholesterol absorption in the intestine., This work was funded by Ministerio de Ciencia e Innovación (RTI2018-099329-B-I00, MCIN/AEI/10.13039/501100011033, “FEDER, Una manera de hacer Europa”); ACRONYM: CARNOVI Alba Martín gratefully acknowledges receipt of a pre-doctoral grant (PRE2019-089288) from Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033, “El FSE invierte en tu futuro”); CSIC is acknowledged for supporting Open Access publication., File List: DESeq2_Results_TPM_AbundanceValues.xlsx; SM004296_1_S1_L001_R2_001.fastq.gz; SM004296_8_S8_L003_R2_001.fastq.gz; SM004296_3_S3_L001_R2_001.fastq.gz; SM004296_4_S4_L001_R2_001.fastq.gz; SM004296_2_S2_L001_R2_001.fastq.gz; SM004296_6_S6_L003_R2_001.fastq.gz; SM004296_1_S1_L001_R1_001.fastq.gz; SM004296_8_S8_L003_R1_001.fastq.gz; SM004296_3_S3_L001_R1_001.fastq.gz; SM004296_4_S4_L001_R1_001.fastq.gz; SM004296_2_S2_L001_R1_001.fastq.gz; SM004296_6_S6_L003_R1_001.fastq.gz; SM004296_5_S5_L003_R2_001.fastq.gz; SM004296_5_S5_L003_R1_001.fastq.gz; SM004296_7_S7_L003_R2_001.fastq.gz; SM004296_7_S7_L003_R1_001.fastq.gz. Liver samples of lambs slaughtered with 34 kgs of live body weight., No

Agradecimiento a Justo Nieto del Colegio Mayor Universitario San Francisco Javier.

Javier Limón, posando delante de la Caja de las Letras del Instituto Cervantes de Madrid.

Conversación entre el compositor, productor y guitarrista Javier Limón, ganador de ocho premios Grammy; y Montserrat Iglesias Santos, directora de Cultura del Instituto Cervantes, durante el ciclo Encuentros en el Cervantes, una actividad que indaga en el perfil biográfico y creativo de los invitados, y en sus vínculos con la lengua y la lectura. Plano general largo del salón del actos durante la conversación.

Plano general de la conversación entre el compositor, productor y guitarrista Javier Limón, ubicado a la izquierda, ganador de ocho premios Grammy; y Montserrat Iglesias Santos, a la derecha, directora de Cultura del Instituto Cervantes, durante el ciclo Encuentros en el Cervantes, una actividad que indaga en el perfil biográfico y creativo de los invitados, y en sus vínculos con la lengua y la lectura.

Javier Limón, posando delante de la Caja de las Letras del Instituto Cervantes de Madrid.