BUSCADOR RECOLECTA

Genes and pathways affected by expression and copy number changes in tumors across projects and cancer types.

Bioinformatics method to identify individual driver mutations.

This database contains the results of the driver analysis performed by the Cancer Genome Interpreter across 6,792 exomes of a pan-cancer cohort of 28 tumor types. Validated oncogenic mutations are identified according to the state-of-the-art clinical and experimental data, whereas the effect of the mutations of unknown significance is predicted by the OncodriveMUT method.

Mutations, genes and pathways involved in tumorigenesis across 4,623 cancer genomes/exomes from 13 cancer sites. IntOGen-mutations identifies cancer drivers across tumor types. Nature Methods 10, 2013, doi:10.1038/nmeth.2642

CGI drug prescription assigns targeted drugs to a tumor, based on its genomic alterations, according different levels of evidence (from pre-clinical assays to clinical guidelines).

Pru p 3-specific IgE values obtained by ImmunoCAP in LTP-allergic patients and tolerant controls., Peer reviewed

The difference in the localization / internalization of the toll-like receptors was determined by confocal microscopy and flow cytometre. These differences between both was due to the differential location of them, since the expression of TLR4 is at the cell surface, while TLR7 is at intracellular compartments, Peer reviewed

Peer reviewed

Data showed are changes in the maturation index of CD83, CD86 and PD-L1 in allergic patient and tolerant control., Peer reviewed

Production of cytokine into the culture supernatant. In the case of TLR4, only significant increases of IL-5 were observed in allergic patients compared to tolerant controls when stimulating with TLR4lig-Pp3 and TLR4lig plus Pp3 peptide in separately way. No differences in the induction of IL-10 production were observed in allergic patients compared to tolerant controls, Peer reviewed