Resultados de investigación

Background The molecular effects involved in the cellular response to non-ioninzing electromagnetic radiation on marine and freshwater microalgae and fish cell lines are incompletely understood. Objectives The direct impact of non-ionizing electromagnetic radiation on marine and freshwater microalgae and fish cell lines was investigated. Methods Six microalgae species from different taxonomic groups were exposed to extremely low-frequency electromagnetic fields (ELF-EMF) for five days. Four fish cell lines (SAF-1, DLB-1, DLEC, and Fugu eye) were exposed to ultraviolet (UV) radiation, with SAF-1 demonstrating the highest sensitivity. In addition, three commercial antioxidants (2101, 3600, and 4004) were tested for their possible radioprotective effects. Results Although no statistically significant differences in cell density were observed, certain taxa (Chlorotylium sp., Mayamea sp., and Scenedesmus sp.) exhibited a declining trend compared to the controls, suggesting species-specific sensitivity to ELF-EMF. Principal component analysis revealed significant differences in physiological responses, particularly in photosynthetic variables such as electron transport rate and dissolved carbon. The total antioxidant capacity did not differ significantly between the control and exposed microalgae, and Chlorotylium sp. showed the highest basal levels. The photosystem II productivity index remained largely unaffected by ELF-EMF exposure, except for an increase in irradiated Scenedesmus sp. Low antioxidant concentrations (≤125 µg/ml) and short incubation times (6 h) of 2101 and 3600 induced proliferation or increased cell viability, particularly under irradiation. However, prolonged incubation time (24 h) or high antioxidant concentrations (≥250 µg/ml) resulted in significant cytotoxicity in all cell lines.

Es un archivo de datos textuales anonimizados obtenidos a través de la transcripción de grupos focales formados por docentes y familias pertenecientes a centros educativos que han participado en la validación de la plataforma coformacion.um.es realizada al amparo del proyecto I+D+i PID2020-113505RB-I00, Este documento recoge el proceso de validación inicial de la plataforma Coformación (https://coformacion.um.es/), una herramienta desarrollada por el grupo de investigación Compartimos Educación (E074-10 https://www.um.es/web/compartimos-educacion/) para que los centros educativos puedan autoevaluar la participación de las familias y acceder a recursos destinados a mejorarla. Con el fin de identificar fortalezas, limitaciones y propuestas de mejora, se realizaron grupos focales con docentes y familias de centros de Educación Infantil, Primaria y Secundaria previamente invitados a participar. Cada centro seleccionó libremente a las personas asistentes, siguiendo un muestreo por conveniencia adaptado a su disponibilidad. El documento presenta una descripción del propósito de la plataforma, el enfoque metodológico seguido y, de forma transparente, las transcripciones completas de las sesiones. Las opiniones recogidas se organizan en torno a tres dimensiones: aspectos tecnológicos de la plataforma, calidad y utilidad pedagógica de la información ofrecida, y posibilidades de comunicación entre los usuarios. El contenido permite conocer de primera mano la experiencia de quienes han utilizado Coformación y constituye la base para su mejora continua.

Glioblastoma (GB) is one of the most aggressive and treatment-resistant cancers due to its complex tumor microenvironment (TME). We previously showed that GB progression is dependent on the aberrant induction of chaperone-mediated autophagy (CMA) in pericytes (PCs), which promotes TME immunosuppression through the PC secretome