Resultados de investigación

Derecho Para Tod@s 1x02 En la segunda entrega de este programa especializado en derecho, conducido por la profesora de la UAL María del Mar Gómez junto a las alumnas Nuria Martínez y Olga Belmonte, el tema central son las compras online. Además, en la sección de "Nuestros expertos", las acompañan las responsables de la comisión de derecho animal del Colegio de Abogados de Almería y en "Juristas noveles", conocemos a Ainhora Sánchez.

Derecho Para Tod@s 1x01 Un espacio dedicado al Derecho, con secciones de actualidad, entrevistas a expertos, contacto con noveles juristas, repaso a la cultura y un rincón para hablar de la igualdad de género en materia legislativa. En este programa se analiza el Derecho animal

Primer programa de la segunda temporada del espacio Derecho Para Tod@s UAL, que coordina la profesora de la UAL María del Mar Gómez. En este espacio colaboran de forma habitual Nuria Martínez y Olga Belmonte. El tema central en el podcast ha sido la Innovación. Además, en la sección "Nuestros Expertos", el profesor Víctor Bastante nos habla de la gamificación en la enseñanza del Derecho, una práctica de innovación docente.

Derecho Para Tod@s 1x03 Programa realizado por María del Mar Gómez, Nuria Martínez y Olga Belmonte. Invitada Mª Ángeles Vila. En el programa de hoy se analiza la legislación en torno a la alimentación.

Programa realizado por María del Mar Gómez, Nuria Martínez y Olga Belmonte. Invitado hoy: Miguel Luque.

Derecho para tod@s - UAL es un Boletín jurídico mensual, cuyo objetivo es divulgar temas jurídicos que puedan ser de interés para la comunidad universitaria y contribuir a la formación integral de los estudiantes de la UAL.

Familial chylomicronemia syndrome (FCS) is a rare metabolic disorder caused by mutations in lipoprotein lipase (LPL) or genes required for LPL functionality and is characterized by hyperchylomicronemia that results in recurrent episodes of acute pancreatitis. Owing to the rarity of FCS, there are few case series describing the phenotypic variability in FCS patients in detail. To provide baseline characteristics in the largest study population to date of patients with FCS. We analyzed baseline demographic and clinical characteristics of adult FCS patients in the phase 3 APPROACH study of volanesorsen sodium (antisense inhibitor of apolipoprotein C-III). Sixty-six patients were included in the analysis. Mean (SD) age was 46 (13) years; and mean body mass index was 24.9 (5.7) kg/m2. We identified causal mutations in 79% (52) of patients, with LPL mutations accounting for 62% (41) of cases. Median age at diagnosis was 24 years, 54% were females, and 81% were Caucasian. All patients followed a low-fat diet, 43% received fibrates, 27% fish oils, and 21% statins. Median fasting triglyceride levels (P25, P75) were 1985 (1179, 3047 mg/dL). Overall, 76% of patients reported ≥1 lifetime episode of acute pancreatitis; 23 patients reported a total of 53 pancreatitis events in the 5 years before enrollment. Our data emphasize the severe hypertriglyceridemia characteristic of FCS patients despite restrictive low-fat diets and frequent use of existing hypolipemic therapies. Acute pancreatitis and recurrent acute pancreatitis are frequent complications of FCS. Diagnosis at an older age suggests likely underdiagnosis and underappreciation of this rare disorder., Si

Despite considerable advances in our understanding of the pathophysiology of graft-versus-host disease (GVHD), its prediction remains unresolved and depends mainly on clinical data. The aim of this study is to build a predictive model based on clinical variables and cytokine gene polymorphism for predicting acute GVHD (aGVHD) and chronic GVHD (cGVHD) from the analysis of a large cohort of HLA-identical sibling donor allogeneic stem cell transplant (allo-SCT) patients. A total of 25 SNPs in 12 cytokine genes were evaluated in 509 patients. Data were analyzed using a linear regression model and the least absolute shrinkage and selection operator (LASSO). The statistical model was constructed by randomly selecting 85% of cases (training set), and the predictive ability was confirmed based on the remaining 15% of cases (test set). Models including clinical and genetic variables (CG-M) predicted severe aGVHD significantly better than models including only clinical variables (C-M) or only genetic variables (G-M). For grades 3-4 aGVHD, the correct classification rates (CCR1) were: 100% for CG-M, 88% for G-M, and 50% for C-M. On the other hand, CG-M and G-M predicted extensive cGVHD better than C-M (CCR1: 80% vs. 66.7%, respectively). A risk score was calculated based on LASSO multivariate analyses. It was able to correctly stratify patients who developed grades 3-4 aGVHD (P < .001) and extensive cGVHD (P < .001). The novel predictive models proposed here improve the prediction of severe GVHD after allo-SCT. This approach could facilitate personalized risk-adapted clinical management of patients undergoing allo-SCT., The authors would like to thank the Centro Nacional de Genotipado for help with genotyping. They would also like to acknowledge the patients who participated in this study, as well as the staff of the Hematology Department, Hospital General Universitario Gregorio Marañón (Madrid, Spain), who made the study possible. This study was partially supported by Ministry of Economy and Competitiveness ISCIII-FIS Grants PI08/1463, PI11/00708, PI14/01731, PI17/01880, and RD12/0036/0061 and cofinanced by the European Regional Development Fund from the European Commission, the “A way of making Europe” initiative, and grants from Fundación LAIR and Asociación Madrileña de Hematología y Hemoterapia, Si

Plano medio, de izquierda a derecha: José María Martínez Alonso, director de Gabinete del Instituto Cervantes; Eudald Carbonell i Roura, arqueólogo español miembro del Proyecto Atapuerca; Juan Luis Arsuaga, arqueólogo español miembro del Proyecto Atapuerca; José María Bermúdez de Castro, arqueólogo español miembro del Proyecto Atapuerca; Juan Manuel Bonet, director del Instituto Cervantes; María Cristina Juarranz, directora de Recursos Humanos del Instituto Cervantes, y Miguel Spottorno Robles, director del Gabinete Técnico de Secretaría General el Instituto Cervantes.

Plano general, de izquierda a derecha: Philippe Robertet Montesinos, subdirector de Análisis y Estrategia del Instituto Cervantes; José María Martínez Alonso, director de Gabinete del Instituto Cervantes; María Cristina Juarranz, directora de Recursos Humanos del Instituto Cervantes; Antonio Miguel Méndez Pozo, presidente de la Fundación Atapuerca; Juan Manuel Bonet, director del Instituto Cervantes; José María Rodríguez-Ponga Salamanca, secretario del Patronato de la Fundación Atapuerca; Jacinto Aramendi Ledesma, director de Comunicación y Promoción del Instituto Cervantes; Miguel Spottorno Robles, director del Gabinete Técnico de Secretaría General del Instituto Cervantes; Carmen Pastor Villalba, subdirectora Académica del Instituto Cervantes, y Almudena Pérez de Armiñán, técnica de Ciencia e Historia del Instituto Cervantes.