Resultados de investigación

This dataset contains processed audio samples coming from a hydraulic block from a biomedical equipment. The block mounts 3 Thomas SR10/30 DC standard perisltaltic pumps, which were filled with distilled water. Only one pump was running at the same time during these recordings. There are two different predictive maintenance scenarios. In the first one, the cassettes of the pumps were changed before each recording. We used cassettes with 2 different levels of degradation: NEW (unused) and OLD (lifetime already expired). We defined 3 different classes: Class 1 is STOP (no pump running), class 2 is NEW (one pump running with a new cassette), and class 3 is OLD (one pump running with an old cassette). In the second scenario, air bubbles were introduced into the tube. This second scenario also has 3 classes: Class 1 is STOP (no pump running), class 2 is NORMAL (no air bubbles), and class 3 is BUBBLE (air bubbles present). A single microphone was used for all recordings. The .wav audio files were processed using a 64 channel Neuromorphic Auditory Sensor (NAS) into .aedat files, which are the present in this dataset. This neuromorphic audio data were also converted into cochleogram images using the software pyNAVIS, and they are also present in this format (.png files)., There is one folder for each of the two scenarios (aging and bubble). Inside those folders there are 3 subfolders, one for each data type (AEDAT, PNG and WAV). For WAV and AEDAT, each file is a unique sample tagged with one class (1, 2 or 3). At the end of each filename this class is also included. For example, 0008_03.wav is the sample number 8, which corresponds to class 3 tagged data. PNG cochleogram images represent 500ms audio time each and are named after their source AEDAT file followed by their starting time mark in microseconds.

Cómo citar: Oliveira, Andrea; Zeler, Ileana & Ruiz-Mora,Isabel (Coord.). (2025, junio 02). Relaciones Públicas y Desinformación (No3) [Episodio de Audio Podcast.] En Relaciones Públicas al Descubierto., Descubre, con María-Isabel Míguez-González (Profesora Titular en el departamento de Comunicación Audiovisual y Publicidad en la Universidade de Vigo y grupo de investigación en comunicación para el servicio público (SEPCOM), María Laura García (Presidenta del Comité Empresarial del World Innovation and Change Management Institute ) y Leticia Rodríguez Fernández (Profesora Titular en el Departamento de Marketing y Comunicación y directora general de Comunicación Estratégica en la Universidad de Cádiz), cómo las Relaciones Públicas pueden ayudar a la sociedad a afrontar el reto de la desinformación con una visión crítica y prospectiva, Asociación de Investigadores en Relaciones Públicas (AIRP)

AGUDIZACIÓN DE LA EPOC (AEPOC), La Agudización de la Enfermedad Pulmonar Obstructiva Crónica (AEPOC) se define según la GesEPOC 2021 como un “episodio de inestabilidad clínica en un paciente EPOC como consecuencia del agravamiento de la limitación espiratoria al flujo aéreo o del proceso inflamatorio subyacente y se caracteriza por un empeoramiento agudo de los síntomas respiratorios respecto de la situación basal del individuo”., Yes

Post-translational modifications and naturally occurring mutations of cytochrome c have been recognized as a regulatory mechanism to control its biology. In this work, we investigate the effect of such in vivo chemical modifications of human cytochrome c on its redox properties in the adsorbed state onto an electrode. In particular, tyrosines 48 and 97 have been replaced by the non-canonical amino acid p-carboxymethyl-L-phenylalanine (pCMF), thus mimicking tyrosine phosphorylation. Additionally, tyrosine 48 has been replaced by a histidine producing the natural Y48H pathogenic mutant. Thermodynamics and kinetics of the interfacial electron transfer of wild-type cytochrome c and herein produced variants, adsorbed electrostatically under different local interfacial electric fields, were determined by means of variable temperature cyclic film voltammetry. It is shown that non-native cytochrome c variants immobilized under a low interfacial electric field display redox thermodynamics and kinetics similar to those of wild-type cytochrome c. However, upon increasing the strength of the electric field, the redox thermodynamics and kinetics of the modified proteins markedly differ from those of the wild-type species. The mutations promote stabilization of the oxidized form and a significant increase in the activation enthalpy values that can be ascribed to a subtle distortion of the heme cofactor and/or difference of the amino acid rearrangements rather than to a coarse protein structural change. Overall, these results point to a combined effect of the single point mutations at positions 48 and 97 and the strength of electrostatic binding on the regulatory mechanism of mitochondrial membrane activity, when acting as a redox shuttle protein., File name: Otras-figuras_Ms_BBA-Bioenergetics.docx Description: A Word file with the figure images File name: Raw_data.zip Description: .nox files with the raw data of voltammetry File name: Fig_2+3+6.jnb Description: A sigmaplot file with figures 2+3+6 File name: Fig_5.jnb Description: A sigmaplot file with figure 5

Surface reconstituted metal-organic frameworks (MOFs) offer appealing properties for electrocatalysis due to their unique structural and compositional advantages. In this work, a controlled potential-induced reconstruction of a two-dimensional cobalt metal-organic framework for boosting oxygen evolution reaction in alkaline media is reported. The current MOF is shown to undergo a partial structural transformation that generates a heterogeneous system, where the original MOF coexists with an oxyhydroxide phase. In fact, the potential-induced stabilization of Co(III) metal centers in the MOF is crucial for delaying its full degradation in alkaline media. This partial retention of the Co(III)MOF phase in the so-derived heterogeneous catalyst has been demonstrated to be decisive for boosting the alkaline electrocatalytic oxygen evolution reaction (OER), displaying superior OER activity in terms of both thermodynamic and kinetic merits compared to the benchmark IrO2 and RuO2 electrocatalysts and the prototypical cobalt (oxy)hydroxides, with a Tafel slope of 52 mV dec−1 and a turnover frequency (TOF) of 6.8 s−1 at 450 mV. Remarkably, the generated final product is stable, exhibiting high robustness and long durability for long-term OER electrolysis. This work provides new insight into the impact of the reconstruction of a MOF for alkaline OER under typical electrochemical conditions, which ultimately benefits the rational design of MOF-based catalysts with high electrocatalytic activity for oxidation reactions., File name: Otras-figuras_Ms_Catalysis-today.docx Description: A Word file with the figure images File name: Raw_data.zip Description: .nox files with the raw data of voltammetry File name: Fig_4.jnb Description: A sigmaplot file with figure 4. File name: Fig_5.jnb Description: A sigmaplot file with figure 5. File name: Fig_6.jnb Description: A sigmaplot file with figure 6. File name: Fig_7.jnb Description: A sigmaplot file with figure 7. File name: Fig_-2a,b.jnb Description: A sigmaplot file with figure 2.

Protein film voltammetry is a sensitive tool to characterize the electron transfer properties of redox proteins in a variety of environments and conformational states. Here, a detailed voltammetric study aimed to explore the effect of electrostatic immobilization on the electron transfer thermodynamics and kinetics of adsorbed human- and horse- cytochrome c was carried out. For this purpose, the two cytochromes were adsorbed on thiol monolayers (SAM) with different immobilization strengths and donor–acceptor distances. While thermodynamic redox parameters do not seem to be affected by the monolayer thickness and charge density, electron transfer kinetics are significantly modulated by the protein immobilization strength. Stronger protein–SAM electrostatic interactions result in lower electron transfer rates in both non-adiabatic and friction kinetic regimes. This behavior is further characterized by smaller pre-exponential factors and activation enthalpies in Arrhenius type plots. These kinetic results in the physiologically relevant non-adiabatic electron transfer regime are shown to be consistent with the recently developed Matyushov’s theoretical formulation of protein electron transfer. Moreover, a comparison between the kinetic parameters of the two cytochrome variants supports the hypothesis that differences between their electron transfer rates originate in their structural flexibility to accommodate the conformational changes required to form the precursor complex between cytochrome and a negatively charged redox partner., File name: Figuras_JEAC_2025.docx Description: A Word file with the figure images File name: Figuras.zip Description: A sigmaplot files with the figures File name: Raw_Data.zip Description: .nox files with the raw data

Metal-organic frameworks (MOFs) can be used as precursors for the directed synthesis of derived materials with enhanced performance for electrocatalysis. Herein, we report on an in-situ electrochemical strategy for the selective synthesis of hybrid electrocatalysts using a cobalt MOF (2D-CoMOF) as a precursor for constructing electrochemical sensors to monitor the glucose oxidation reaction (GOR). By using in-situ Raman spectroelectrochemistry, it is demonstrated that a precise control of the applied potential during amperometric treatment of 2D-CoMOF can promote the generation of derived heterostructures in which the original MOF coexists with metal oxides and/or oxyhydroxides (MOF-MOx) with different compositions. The so-prepared electrodes exhibit high electroactive surface areas, a high number of electrocatalytically active cobalt sites and an efficient charge transport across the catalytic film. Moreover, their composition-dependent electrocatalytic performance for the glucose oxidation reaction is examined, establishing a relationship between the applied potential, the macroscopic chemical composition of the heterostructure and the electrocatalytic performance for glucose sensing. In particular, the hybrid phases consisting of Co-MOF/Co3O4/CoOOH display superior electrocatalytic sensing performance with a wide linear concentration range and high sensitivity. The present work emphasizes the significance that the precise control of the applied potential has on the electrochemically-assisted MOF transformation for developing highly efficient MOF-derived electrocatalysts.

Metal–organic frameworks (MOFs) are attractive porous materials for electrocatalytic applications associated with carbon-free energy storage and conversion. This type of material usually requires a post-treatment to be used as electrocatalyst. The present work comprehensively investigates the electrochemical activation of a cobalt-MOF@Nafion composite that produces outstanding electrocatalytic performance for the water oxidation reaction at neutral pH. A detailed electrochemical characterization reveals that the electroactivation of the composite requires the participation of the oxygen evolution reaction (OER) and leads to a significant increase in the electroactive population of cobalt centers. It is shown that an increase of the applied activation potential in the OER region results in a faster electroactivation of the Co-MOF without affecting the intrinsic electrocatalytic properties of the active cobalt centers, as evidenced by the unique linear correlation between the electrocatalytic OER current and the population of electroactive cobalt. In addition, at structural level, it is shown that the electrochemical activation causes the partial disruption of the Nafion adlayer, as well as morphological changes of the Co–MOF particles from a compact, rounded morphology, before electrochemical activation, to a more open and expanded structure, after electroactivation; with the concomitant increase of the number of surface–exposed cobalt centers. Interestingly, these cobalt centers retain their coordinative chemistry and their laminar distribution in the nanosheets at the nanoscale, which is consistent with the preservation of their intrinsic electrocatalytic activity after potential–induced activation. In this scenario, these results suggest that only the electroactivated cobalt centers with good accessibility to the electrolyte are electrochemically active. This work provides a better understanding of the processes and structural changes underlying the electrochemical activation at neutral pH of a Co–MOF for boosting the electrocatalytic water oxidation reaction., File name:ASS_2023_Olloqui_Figuras.docx Description: A Word file with the figure images File name:Figure_1.jnb Description: A sigmaplot file with figure 1. File name:Figure_2.jnb Description: A sigmaplot file with figure 2. File name: Raw_data.zip Description: .nox files with the raw data of voltammetry

Metal-organic frameworks (MOFs) are receiving increased attention as new functional nanomaterials for the development of electrochemical sensors. Herein, we develop an electrochemical platform for non-enzymatic hydrogen peroxide detection built with a composite of two-dimensional cobalt MOF nanosheets and Nafion (2D-Co-MOF@Nafion). The feasibility of the 2D-Co-MOF@Nafion composite as active material for high performance hydrogen peroxide sensor was investigated by using cyclic voltammetry and chronoamperometry. Its voltammetric response reveals an efficient charge transport through the MOF composite, and rapid electron exchange between MOF and electrode. Notably, these MOF nanosheets exhibit enzyme-like activity for the non-common catalytic oxidation of hydrogen peroxide, leading to an electrochemical sensor with rapid quantitative detection, outstanding sensitivity, selectivity, stability, and durability at the desirable neutral pH. In particular, for a cobalt metal loading of 1.2 nanomol, the sensor yields amperometric H2O2 detection with characteristic electrocatalytic parameters of imax= 5.7 mA cm−2 and KM = 13 mM. Moreover, linear ranges of up to either 1 mM or 10 mM are achieved, with sensitivities as high as 570 ± 5 A cm−2 mM−1 or 395 ± 10 A cm−2 mM−1 for the low and high concentration ranges, respectively. The particular coordination chemistry of the MOF consisting of a regular arrangement of multiple Co(II) redox metal sites connected by appropriate organic ligands can provide inherent enzyme-mimicking properties, thereby explaining the higher oxidase-like activity of the present MOF. This work raises the new idea of using two-dimensional cobalt-based MOFs as active nanozymes, offering exciting opportunities in the design of non-enzymatic electrochemical sensing devices., File name: raw data.zip Description: .ocw files with the raw data File name: ASS_2023_Olloqui_Figuras.docx Description: A Word file with the figure images File name: Figure_2_S4.jnb Description: A sigmaplot file with figures 1 and S4. File name: Figure_3_y_4.jnb Description: A sigmaplot file with figures 3 and 4. File name: Figure_6.jnb Description: A sigmaplot file with figure 6. File name: Figure_S3.jnb Description: A sigmaplot file with figure S3.