Resultados de investigación

This dataset contains processed audio samples coming from a hydraulic block from a biomedical equipment. The block mounts 3 Thomas SR10/30 DC standard perisltaltic pumps, which were filled with distilled water. Only one pump was running at the same time during these recordings. There are two different predictive maintenance scenarios. In the first one, the cassettes of the pumps were changed before each recording. We used cassettes with 2 different levels of degradation: NEW (unused) and OLD (lifetime already expired). We defined 3 different classes: Class 1 is STOP (no pump running), class 2 is NEW (one pump running with a new cassette), and class 3 is OLD (one pump running with an old cassette). In the second scenario, air bubbles were introduced into the tube. This second scenario also has 3 classes: Class 1 is STOP (no pump running), class 2 is NORMAL (no air bubbles), and class 3 is BUBBLE (air bubbles present). A single microphone was used for all recordings. The .wav audio files were processed using a 64 channel Neuromorphic Auditory Sensor (NAS) into .aedat files, which are the present in this dataset. This neuromorphic audio data were also converted into cochleogram images using the software pyNAVIS, and they are also present in this format (.png files)., There is one folder for each of the two scenarios (aging and bubble). Inside those folders there are 3 subfolders, one for each data type (AEDAT, PNG and WAV). For WAV and AEDAT, each file is a unique sample tagged with one class (1, 2 or 3). At the end of each filename this class is also included. For example, 0008_03.wav is the sample number 8, which corresponds to class 3 tagged data. PNG cochleogram images represent 500ms audio time each and are named after their source AEDAT file followed by their starting time mark in microseconds.

Tessellated cartilage is a distinctive composite tissue forming the bulk of the skeleton of cartilaginous fishes (e.g. sharks and rays), built from unmineralized cartilage covered at the surface by a thin layer of mineralized tiles called tesserae. The finescale structure and composition of elasmobranch tessellated cartilage has largely been investigated with electron microscopy, micro-computed tomography and histology, but many aspects of tissue structure and composition remain uncharacterized. In our study, we demonstrate that the tessellated cartilage of a stingray exhibits a strong and diverse autofluorescence, a native property of the tissue which can be harnessed as an effective label-free imaging technique. The autofluorescence signal was excited using a broad range of wavelengths in confocal and light sheet microscopy, comparing several sample preparations (fresh; demineralized and paraffin-embedded; non-demineralized and plastic-embedded) and imaging the tissue at different scales. Autofluorescence varied with sample preparation with the signal in both plastic- and paraffin-embedded samples strong enough to allow visualization of finescale (=¿1 µm) cellular and matrix structures, such as cell nuclei and current and former mineralization fronts, identifiable by globular mineralized tissue. A defined pericellular matrix (PCM) surrounding chondrocytes was also discernible, described here for the first time in elasmobranchs. The presence of a PCM suggests similarities with mammalian cartilage regarding how chondrocytes interact with their environment, the PCM in mammals acting as a transducer for biomechanical and biochemical signals. A posterior analysis of hyperspectral images by an MCR-ALS unmixing algorithm allowed identification of several distinct fluorescence signatures associated to specific regions in the tissue. Some fluorescence signatures identified could be correlated with collagen type II, the most abundant structural molecule of cartilage. Other fluorescence signatures, however, remained unidentified, spotlighting tissue regions that deserve deeper characterization and suggesting the presence of molecules still unidentified in elasmobranch skeletal cartilage. Our results show that autofluorescence can be a powerful exploratory imaging tool for characterizing less-studied skeletal tissues, such as tessellated cartilage. The images obtained are largely comparable with more commonly used techniques, but without the need for complicated sample preparations or external staining reagents standard in histology and electron microscopy (TEM, SEM)., Postprint (published version)

Postprint (author's final draft)

This dataset contains samples coming from a hydraulic block from a biomedical equipment. The block mounts 3 Thomas SR10/30 DC standard perisltaltic pumps, which were filled with distilled water. Only one pump was running at the same time during these recordings, always at maximum constant speed. The cassettes of the pumps were changed before each recording. We used cassettes with 2 different levels of degradation: NEW (unused) and OLD (lifetime already expired). We defined 3 different classes: Class 1 is STOP (no pump running), class 2 is NEW (one pump running with a new cassette), and class 3 is OLD (one pump running with an old cassette). The classified samples were recorded using several sensors: 3 accelerometers, 1 gyroscope, 1 magnetometer and 1 microphone. All data were recorded at the same time at the maximum available frequency using the device "ST SensorTile.box". The raw data has already been processed into sepparate different .csv files (.wav files for audio) using python code., Each sensor has its own folder. The sensor folder name starts with ACC for accelerometer data, GYRO for gyroscope data, MAG for magnetometer data or MIC for microphone data. After that, the name of the sensor. At the end, sampling frequency in Hz. For example: ACC_LISDW12_1600Hz folder contains data for the accelerometer named LISDW12 at a sampling rate of 1600Hz. Each sensor folder contains 17 .csv files except for the microphone folder, which contains 17 .wav files. Each file is a unique sample tagged with one class (1, 2 or 3). At the end of each filename this class is also included. For example, 0008_03.csv is the sample number 8, which corresponds to class 3 tagged data.

Anàlisis geoquímiques i fotos de visu i microscòpia de les mostres que integren la col·lecció de geostandards del Museu de Geologia Valentí Masachs (UPC Manresa). Análisis geoquímicas y fotos de visu y microscopio de las muestras que integran la colección de geostandares del Museo de Geología Valentí Masachs (UPC Manresa). Geochemical analyses and hand and microscopy pictures of the samples belonging to the geostandards collection of the Valenti Masachs Geology Museum (UPC Manresa). Analyses géochimiques et photographies au microscope et visu des échantillons qui forment la collection de geostandards du Musée de Géologie Valentí Masachs (UPC Manresa)., 1

We aimed to compare the efficacy and safety of maintaining or withdrawing abiraterone acetate plus prednisone (AAP) in patients with metastatic castration-resistant prostate cancer who had experienced cancer progression to this treatment and were beginning a docetaxel-based therapy. Phase II, randomised, open-label study conducted in patients with metastatic castration-resistant prostate cancer who were asymptomatic or mildly symptomatic. After open-label treatment with AAP, patients who had experienced cancer progression to AAP were randomised to 75 mg/m2 of docetaxel plus AAP or to receive 75 mg/m2 of docetaxel plus 10 mg of prednisone orally daily. The primary outcome was the radiographic progression-free survival rate at 12 months as evaluated by the investigators in all randomised patients. A total of 148 patients were included in open-label treatment with AAP, and of them, 94 patients were randomised to receive either docetaxel plus AAP (intervention group; n = 47) or docetaxel plus prednisone (control group; n = 47). The 12-month radiographic progression-free survival rates did not differ between the intervention group (34.9%; 95% CI 20.7-49.2) and the control group (33.9%; 95% CI 19.5-48.3). There were no significant differences in the time to radiographic progression and the overall survival between the intervention and control groups. Grade 3-5 neutropenia with the combination of docetaxel plus prednisone and AA was more frequent than with docetaxel plus prednisone (59.6% versus 27.7%). Our results indicate that the therapeutic strategy of maintaining AAP added to docetaxel in chemotherapy-naïve patients who have experienced cancer progression to AAP treatment should not be further evaluated and should be avoided in clinical practice., Si

Objective: To assess the impact of a telemedicine visit using the platform Diabetic compared with a face-to-face visit on clinical outcomes, patients' health-related quality of life (HRQoL), and physicians' satisfaction in patients with type 1 diabetes. Research design and methods: PLATEDIAN (Telemedicine on Metabolic Control in Type 1 Diabetes Mellitus Andalusian Patients) (NCT03332472) was a multicenter, randomized, 6-month follow-up, open-label, parallel-group controlled study performed in patients with type 1 diabetes with suboptimal metabolic control (HbA1c <8% [<64 mmol/mol]), treated with multiple daily injections. A total of 388 patients were assessed for eligibility; 379 of them were randomized 1:1 to three face-to-face visits (control cohort [CC]) (n = 167) or the replacement of an intermediate face-to-face visit by a telemedicine visit using Diabetic (intervention cohort [IC]) (n = 163). The primary efficacy end point was the mean change of HbA1c levels from baseline to month 6. Other efficacy and safety end points were mean blood glucose, glucose variability, episodes of hypoglycemia and hyperglycemia, patient-reported outcomes, and physicians' satisfaction. Results: At month 6, the mean change in HbA1c levels was -0.04 ± 0.5% (-0.5 ± 5.8 mmol/mol) in the CC and 0.01 ± 0.6% (0.1 ± 6.0 mmol/mol) in the IC (P = 0.4941). The number of patients who achieved HbA1c <7% (<53 mmol/mol) was 73 and 78 in the CC and IC, respectively. Significant differences were not found regarding safety end points at 6 months. Changes in HRQoL between the first visit and final visit did not differ between cohorts, and, regarding fear of hypoglycemia (FH-15 score ≥28), statistically significant differences observed at baseline remained unchanged at 6 months (P < 0.05). Conclusions: The use of telemedicine in patients with type 1 diabetes with HbA1c <8% (<64 mmol/mol) provides similar efficacy and safety outcomes as face-to-face visits., Si

Desarrollo tecnológico para determinar de forma cuantitativa, durante el tratamiento alcalino en NaOH (cocido) de aceitunas verdes al estilo sevillano, el porcentaje de penetración de la sosa en la pulpa y predecir el momento óptimo para finalizar el proceso. El sistema combina un protocolo de toma de muestras y acondicionamiento del fruto (corte, marcado con fenolftaleína y captura de imagen con iluminación constante) con algoritmos de visión artificial que calculan el porcentaje de cocido. A partir de la serie temporal de medidas, un interpolador estima el instante en el que se alcanzará un umbral objetivo (p.ej., 2/3 o 3/4 de penetración). Incluye además una aplicación web para gestión y trazabilidad del proceso (cloud computing) y evidencia de implantación industrial (TRL 9)., Estructura principal: - Cocido_aceitunas.docx: memoria descriptiva del desarrollo tecnológico (objetivo, descripción, impacto, evidencias). - Cocido Aceitunas.pptx: presentación técnica (metodología y resultados de ensayos). - Patente/3_ES-2394821_B2.pdf: patente antecedente (OEPM) ES-2394821 B2. - Contrato/CONTRATO.pdf: evidencia contractual FIUS–Pymesuma S.L. (23/07/2014) [contiene datos personales]. - Contrato/Contrato FIUS.txt: enlace a proyecto asociado (SISIUS idproy=26626). - README_*: ficheros de descripción para depósito en repositorio.

The tryptophan-kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease. We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk of HF and AF and to analyze a potential effect modification by the randomized interventions of the PREDIMED (Prevención con Dieta Mediterránea) trial with Mediterranean diet (MedDiet). Two case-control studies nested within the PREDIMED trial were designed. We selected 324 incident HF cases and 502 incident AF cases individually matched with ≤3 controls. Conditional logistic regression models were fitted. Interactions with the intervention were tested for each of the baseline plasma metabolites measured by LC-tandem MS. Higher baseline kynurenine:tryptophan ratio (OR for 1 SD: 1.20; 95% CI: 1.01, 1.43) and higher levels of kynurenic acid (OR: 1.19; 95% CI: 1.01, 1.40) were associated with HF. Quinolinic acid was associated with AF (OR: 1.15; 95% CI: 1.01, 1.32) and HF (OR: 1.25; 95% CI: 1.04, 1.49). The MedDiet intervention modified the positive associations of kynurenine (Pinteraction = 0.006), kynurenic acid (Pinteraction = 0.008), and quinolinic acid (Pinteraction = 0.033) with HF and the association between kynurenic acid and AF (Pinteraction = 0.02). We found that tryptophan-kynurenine pathway metabolites were prospectively associated with higher HF risk and to a lesser extent with AF risk. Moreover, an effect modification by MedDiet was observed for the association between plasma baseline kynurenine-related metabolites and the risk of HF, showing that the positive association of increased levels of these metabolites and HF was restricted to the control group., Sí