Resultados de investigación

Producción: Vicerrectorado de Extensión Universitaria. Universidad de Granada. Dirección: Ángel García Roldán Productor: Victor Jesús Medina Flores. Fotografía: Ángel García Roldán Edición: Ángel García Roldán Sonido: Jesús García Roldán Asistente de producción: Jesica Mª Moreno García Colabora: Vera Icono Producciones. A. C. Asistencia técnica y equipos. Colaboradores/entrevistados: José Hernández Quero, María José Ariza Rubio, José Manuel Martín Martíín, Fernando Martínez Martínez, Jesús Galindo Zaldívar, Raquel Botubol Rivera, África García García, Antonio Cárdenas Cruz, María Angustias Navarro Guzmán. Duración: 42:29 min Fecha: 2020 Resolución: Full HD. 1920 x 1080p, La obra ha sido registrada en la Oficina de Transferencia de Resultados de la Investigación de la Universidad de Granada. Registro de Propiedad Intelectual: © 2009225407234, Recoge los testimonios de miembros de la comunidad universitaria afectados por la enfermedad (PDI, PAS y estudiantes de la Universidad), así como personal docente y sanitario asociado a la universidad que han tenido una implicación directa en distintas áreas clínicas con gran implicación y responsabilidad en la lucha contra la pandemia., It collects the testimonies of members of the university community affected by the illness (academic staff, administrative staff, and students), as well as teaching and healthcare personnel affiliated with the university who have been directly involved in various clinical areas, assuming significant responsibility and commitment in the fight against the pandemic., Vicerrectorado de Extensión Universitaria. Universidad de Granada

This is to display Eurostat data about the employed recent immigrants by origin: E.U or not EU. This brings to mind the factors identified in the literature regarding the decision to migrate, such as language, cultural ties, distance, wage levels, quality of life, and how immigrant communities are formed in Europe.

Study of immune correlates against malaria after vaccination with RTS,S/ASO1E: a comphrensive immunological arm of a Phase III double-blind, randomize, controlled multi-centre trial (MAL067)., Dades primàries associades a l'article publicat a NPJ Vaccines, vol. 5 [https://doi.org/10.1038/s41541-020-0192-7], The RTS,S/AS01E vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 26 clinical trial using a 3-dose immunization schedule. A fourth dose 18 months after the primary 27 vaccination was shown to restore the waning efficacy. However, only total IgG against the 28 immunodominant malaria vaccine epitope has been analyzed following the booster. To better 29 characterize the magnitude, nature and longevity of the immune response to the booster, we 30 measured levels of total IgM, IgG and IgG1-4 subclasses against three constructs of the 31 circumsporozoite protein (CSP) and the hepatitis B surface antigen (HBsAg, also present in RTS,S) 32 by quantitative suspension array technology in 50 subjects in the phase 3 trial in Manhiça, 33 Mozambique. To explore the impact of vaccination on naturally acquired immune responses, we 34 measured antibodies to P. falciparum antigens not included in RTS,S. We found increased IgG, 35 IgG1, IgG3 and IgG4, but not IgG2 nor IgM, levels against vaccine antigens one month after the 4th 36 dose. Overall, antibody responses to the booster dose were lower than the initial peak 37 response to primary immunization and children had higher IgG and IgG1 levels than infants. 38 Higher anti-Rh5 IgG and IgG1-4 levels were detected after the booster dose, suggesting that RTS,S 39 partial protection could increase some blood stage antibody responses. Our work shows that the 40 response to the RTS,S/AS01E booster dose is different from the primary vaccine immune 41 response and highlights the dynamic changes in subclass antibody patterns upon the vaccine 42 booster and with acquisition of adaptive immunity to malaria.

Dades primàries de l'article publicat a la revista Food Science and Technology 121: 108936, Dataset containing SPME-GC-MS raw analytical data (total ion chromatograms, not aligned) obtained and used by Quintanilla-Casas et al. (LWT - Food Science and Technology 121: 108936). Data correspond to the volatile fingerprint of 174 authentic and traceable virgin olive oil samples previously graded by six official sensory panels (data from 2 outlier samples are not included) in the framework of OLEUM project (EC H2020 Programme 2014–2020). Briefly, data correspond to SPME-GC-MS scan intensities of the total ion chromatogram at each retention time from 5.5 to 61.96 min. These data were aligned and used under a fingerprinting approach by Quintanilla-Casas et al. to develop a classification model (PLS-DA approach) to verify the sensory quality of virgin olive oils, and it was suggested as an instrumental method to support sensory panels., SPME-GC-MS data have been obtained by researchers in the OLEUM project This work was developed in the context of the project OLEUM “Advanced solutions for assuring authenticity and quality of olive oil at global scale”, funded by the European Commission within the Horizon 2020 Program (2014–2020, grant agreement no. 635690). The information and views set out in this article are those of the author(s) and do not necessarily reflect the official opinion of the European Union. Neither the European Union institutions and bodies nor any person acting on their behalf may be held responsible for the use which may be made of the information contained therein. The study was also supported by the Ministerio de Ciencia, Innovación y Universidades (MICINN) from Spain through the Juan de la Cierva and Ramon y Cajal programs (JCI-2012_13412 and RYC-2017-23601), and by the Ministerio de Educación, Cultura y Deporte (MECD) from Spain through the FPU pre-doctoral program (FPU16/01744).

Dades primàries associades a l'article publicat a Plos Neglected Tropical Diseases, vol. 14, num. 5, p. e0008155 [https://doi.org/10.1371/journal.pntd.0008155], Plasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators influence delivery outcomes. We measured the plasma concentrations of a set of thirty-one biomarkers, comprising cytokines, chemokines and growth factors, in 987 plasma samples from a cohort of 572 pregnant women from five malaria-endemic tropical countries and related these concentrations to delivery outcomes (birth weight and hemoglobin levels) and malaria infection. Samples were collected at recruitment (first antenatal visit) and delivery (periphery, cord and placenta), allowing a longitudinal analysis. At recruitment, we found that P. vivax–infected pregnant women had higher plasma concentrations of proinflammatory (IL-6, IL-1β, CCL4, CCL2, CXCL10) and TH1-related cytokines (mainly IL-12) than uninfected women. This biomarker signature was essentially lost at delivery and was not associated with birth weight nor hemoglobin levels. Antiinflammatory cytokines (IL-10) were positively associated with infection and poor delivery outcomes. CCL11 was the only biomarker to show a negative association with P. vivax infection and its concentration at recruitment was positively associated with hemoglobin levels at delivery. Birth weight was negatively associated with peripheral IL-4 levels at delivery. Our multi-biomarker multicenter study is the first comprehensive one to characterize the immunological signature of P. vivax infection in pregnancy thus far. In conclusion, data show that while TH1 and pro-inflammatory responses are dominant during P. vivax infection in pregnancy, antiinflammatory cytokines may compensate excessive inflammation avoiding poor delivery outcomes, and skewness toward a TH2 response may trigger worse delivery outcomes. CCL11, a chemokine largely neglected in the field of malaria, emerges as an important marker of exposure or mediator in this condition.

Dades primàries associades a un article sobre els motius associats a la pràctica d’activitat física, d’acord amb la satisfacció de les necessites bàsiques vinculades a l’esmentada pràctica així com la freqüència de realització de la mateixa., Dades primàries associades a un article publicat a la revista Frontiers in Psychology: https://doi.org/10.3389/fpsyg.2020.621065, Podeu consultar l'article publicat a: http://hdl.handle.net/2445/176635, Raw data from a study about understanding university students’ motives for physical activity (PA), and their relationships with Psychological Need Satisfaction (PNS) and characteristics of practice regularity (frequency, duration, team, competitive, coach, league, federation, and type of day of the week for PA).